Group Introduction

Molecular and Cellular Glycoproteomics Research Group

Proteins, one of the major components of our bodies, fulfill their function with a post-translational event “glycosylation.” This is the reason why we must analyze protein glycosylation, whereas the “real world” has still been black box caused by lack-of-technology. Our team attempts the open door to know the structure-function relationship using an original “Molecular & Cellular Glycoproteome Network” with fruitful international collaborations, resulting in the contribution to medicine.

Applied Molecular Function Research Group

To meet increasing needs to control cell cultures sophisticatedly, we have developed new technologies to manipulate cells using photoresponsive polymers and fluorinated lipids, and through gene delivery. Also we have established new technologies to mass-produce, functionalize and analyze glycoproteins, spotlighted biomolecules playing significant roles in biological systems.

Stem Cell Biotechnology Research Group

Research and Development：Stem cell engineering can contribute not only to regenerative medicine but also to various research fields such as drug discovery and food development. Our group conducts research and development for cell induction methods and in vitro tissue reconstruction using stem cells.
technical support：In addition to basic research, our research group conducts joint research and technical consulting in response to requests from private companies, universities, and research institutes.

Multicellular System Regulation Research Group

In our group, we will build a new platform to analyze glycomes and transcriptomes with single cell granularity. By analyzing cells, tissues, organoids, and individual organisms, we will elucidate the mechanism of stem cell self-renewal and maintenance of undifferentiated state, and glycan functions in multicellular / multiorgan interactions. In addition, we will clarify the actual state of exosomes using a cryo-electron microscope. Ultimately, we aim to develop and put into practical use new stem cell quality control technology and early diagnosis technology for cancer and mental / neurodegenerative diseases by conducting integrated analysis of the obtained data and conducting verification.

Healthy Food Science Research Group

In order to sustain health in the rapidly increasing aging society, we are trying to elucidate the molecular mechanisms of mental disorders such as sleep loss and depression, and lifestyle & stress-related pathologies such as metabolic syndrome. We are endeavoring to develop novel diagnostic techniques to detect these disorders at their early stages and to develop advanced, natural and safe substances and technologies for their prevention by undertaking multidimensional research projects on food functionality and host homeostasis.

Leading-edge Biotechnology Research Group

The aim of our laboratory is the development of the wide-range of technologies such as the most advanced genome application, application of analytical instruments and informatics technology, which are applicable for the elucidation of life phenomena, and for the production of industrial useful substances in microorganisms, plants and animals. Using the world's largest natural product library, we perform molecular target base and phenotype screening to discover various useful bioactive substances including clinical drugs, agrochemicals and so on.

Biological Data Science Research Group

In our group, we consolidate measurement data in consideration of federation with useful public data, and measure/share omics data by ongoing internal and external projects. Using these data, we develop data-driven analysis technology based on molecular profile, molecular simulation of complex structure and construction of workflow analysis platform, aiming at Bio-IT fusion leading to drug discovery.

AIST-INDIA Diverse Assets & Applications International Laboratory

We are using integrated cell culture, biochemical, molecular, imaging, bioengineering and bioinformatics approaches to understand the molecular biology of stress, aging & cancer, and develop unique tools and technologies for their intervention. We aim to contribute to the understanding of cell proliferation controls in human normal cells, and their breakdown during carcinogenesis by analyzing biological and mechanical properties of cells. For our research projects, we collaborate with several Indian academic institutions and host a variety of training programs for students and young researchers. Please refer to http://web.iitd.ac.in/~sundar/dailab/ http://web.iitd.ac.in/~sundar/dailab/ AIST-INDIA Diverse Assets & Applications International Laboratory

Page Top

Cellular and Molecular Biotechnology Research Institute Web Site