Cell Dynamics System Research Group
Cell Dynamics System Research Group Overview
In the cell industry, including bio-pharmaceuticals, regenerative medicine, and cell-based foods, new cell control technologies are required, distinct from traditional manufacturing processes. To optimize product development and manufacturing processes in the cell industry, we aim to integrate the cell/animal dynamics analysis and omics data analysis, and develop new technologies necessary for cell manipulation, modification, and quality control.
Research Project
Project 1:Development of technology for the manipulation and management of industrial cells
Researcher: MAWARIBUCHI Shuuji
We are developing cell manipulation and management technologies for manufacturing processes in industries that use cells, such as regenerative medicine and cellular food.
Project 2:Development and application of algorithm inferring cell phenotype determining factors
Researcher: KUMAGAI Yutaro
We are developing algorithm to infer factors determining cell phenotype from multimodal omics data. We apply the algorithms to control cell phenotype.
Project 3:Development of technology to analyze dynamic properties in cellular regulatory networks
Researcher: KAWATA Kentaro
Various kinds of molecules consist of cells, and they transmit information to determine the cellular state. In this research, we are developing technologies to elucidate precisely how the molecular network alters accompanied by cell differentiation and adaptation to the extracellular environment, and how the changes of the network affect the cellular state. Through these studies, we promote highly accurate regulation of differentiation in pluripotent stem cells.
Project 4:Development of an RNA vector for efficient gene delivery and biological applications
Researcher: SANO Masayuki
We have been developing the efficient gene delivery system that leads to high transduction efficiency, long-term expression of coding- and non-coding genes, and control of transgene expression using the persistent RNA vector. The vector system can be used to facilitate cell visualization, regulation of endogenous gene expression, and cell reprogramming and differentiation.
Project 5:Making a “society of health and longevity” a reality: etiology of chronic inflammatory diseases
Researcher: SASAKI Yasunori
We have been working on a protein that involves in a battery of biological processes and diseases. Mice lack this protein suffer impairment of the intestinal barrier that leads to many chronic inflammatory diseases. This mouse would be a versatile tool to investigate various diseases caused by chronic inflammation, e. g. inflammatory bowel disease.
Staff Members
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Research Group Leader MAWARIBUCHI Shuuji |
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Senior Researcher SASAKI Yasunori |
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Senior Researcher SANO Masayuki |
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Senior Researcher KUMAGAI Yutaro |
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Attached to Research Group KAWATA Kentaro |
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