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Molecular and Cellular Glycoproteomics Research Group

Project

Project1:Development of multi-omics technologies for integrated understanding of protein glycosylations
Researcher:KUNO Atsushi, KAJI Hiroyuki, NAGAI-OKATANI Chiaki

Protein glycosylation, which is one of the important post-translational modifications, has a pivotal role in the functional regulation of proteins via the modifications of their three-dimensional structures, subcellular localization, and interactions with other functional molecules. To better understand the biological roles of protein glycosylations, it is important to elucidate how physiological and pathological changes will alter the glycosylation machinery, and consequently, what sites of what proteins will be modified with what structure of glycans, at each level of proteins, cells, tissues, and organisms. To confront these important matters, this research group aims to develop multi-omics technologies, including glycoproteomics, glycomics, glyco-transcriptomics, and glyco-metabolomics, etc. These multi-omics data will be available in the public databases that we and our colleagues developed, which will contribute to the glycoscience community.

Molecular and Cellular Glycoproteomics Research Group02

Project2

Project2:Functional analysis of cellular glycosylation
Researcher:SATO Takashi, HIONO Takahiro

Many diseases such as cancer trigger changes in cell glycomes, known as "disease-related glycosylation alteration." We have previously developed various disease-biomarkers and molecular-targeted drugs by targeting this disease-related glycosylation alteration. On the other hand, the biological significance of the phenomena is yet not well understood. Our goal is reaching to a comprehensive understanding of the physiological and pathological "function of glycans" in tumors, virus infections, aging as well as immunities, reproductions, and other cell functions by using multi-omics approaches.

Molecular and Cellular Glycoproteomics Research Group03

Member

Name Position
KUNO Atsushi Research Group Leader
KAJI Hiroyuki Chief Senior Researcher
SATO Takashi Senior Researcher
OKATANI Chiaki Researcher
HIONO Takahiro Researcher
ANGATA Kiyohiko Invited Senior Researcher

Results

  • Yokose T, Kabe Y, Matsuda A, Kitago M, Matsuda S, Hirai M, Nakagawa T, Masugi Y, Hishiki T, Nakamura Y, Shinoda M, Yagi H, Abe Y, Oshima G, Hori S, Nakano Y, Honda K, Kashiro A, Morizane C, Nara S, Kikuchi S, Shibahara T, Itonaga M, Ono M, Minegishi N, Koshiba S, Yamamoto M, Kuno A, Handa H, Sakamoto M, Suematsu M, Kitagawa Y
    O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer
    Cancers (Basel) 12(9):E2469. (2020) doi: 10.3390/cancers12092469
  • Angata K, Sawaki H, Tsujikawa S, Ocho M, Togayachi A, Narimatsu H
    Glycogene Expression Profiling of Hepatic Cells by RNA-Seq Analysis for Glyco-Biomarker Identification.
    FRONTIERS IN ONCOLOGY 10 57-77; (2020) doi: 10.3389/fonc.2020.01224
  • Ito K, Angata K, Kuno A, Okumura A, Sakamoto K, Inoue R, Morita N, Watashi K, Wakita T, Tanaka Y, Sugiyama M, Mizokami M, Yoneda M, Narimatsu H
    Screening siRNAs against host glycosylation pathways to develop novel antiviral agents against hepatitis B virus
    HEPATOLOGY RESEARCH ; (2020) doi: 10.1111/hepr.13552
  • Hiono T, Kuno A
    C-Terminally tagged NA in replication-competent influenza A viruses reveals differences in glycan profiles between NA and HA
    Analyst. 145(17): 5845-5853. (2020) doi: 10.1039/d0an00770f
  • Angata K, Sawaki H, Tsujikawa S, Ocho M, Togayachi A, Narimatsu H.
    Glycogene expression profiling of hepatic cells by RNA-Seq analysis for glyco-biomarker identification.
    Frontiers In Oncology. 10:1224 (2020). doi: 10.3389/fonc.2020.01224
  • Hiono T and Kuno A.
    C-terminally tagged NA in replication competent influenza A viruses reveals differences in glycan profiles between NA and HA.
    Analyst. Accepted(2020). doi:10.1039/D0AN00770F
  • Silsirivanit A Matsuda A, Kuno A, Tsuruno C, Uenoyama Y, Seubwai W, Angata K, Teeravirote K, Wongkham C, Araki N, Takahama Y, Wongkham S, Narimatsu H.
    Multi-serum glycobiomarkers improves the diagnosis and prognostic prediction of cholangiocarcinoma.
    Clin Chim Acta. 510:142-149 (2020). doi: 10.1016/j.cca.2020.07.017
  • Yamada I, Shiota M, Shinmachi D, Ono T, Tsuchiya S, Hosoda M, Fujita A, Aoki NP, Watanabe Y, Fujita N, Angata K, Kaji H, Narimatsu H, Okuda S, Aoki-Kinoshita KF.
    The GlyCosmos Portal: a unified and comprehensive web resource for the glycosciences.
    Nat Methods.17: 649-650 (2020). doi: 10.1038/s41592-020-0879-8
  • Matsuda A, Kuno A#*, Yoshida M, Wagatsuma T, Sato T, Miyagishi M, Suematsu M, Kabe Y, Narimatsu H
    Comparative glycomic analysis of exosome subpopulations derived from pancreatic cancer cell lines.
    J Proteom Res 19: 2516-2524 (2020). doi.org/10.1021/acs.jproteome.0c00200
  • Ulaankhuu A, Bazarragchaa E, Okamatsu M, Hiono T, Bodisaikhan K, Amartuvshin T, Tserenjav J, Urangoo T, Buyantogtokh K, Matsuno K, Hattori T, Kondoh T, Sato M, Takadate Y, Torii S, Isono M, Okuya K, Saito T, Kasajima N, Kida Y, Maruyama J, Igarashi M, Takada A, Kida H, Batchuluun D, Sakoda Y.
    Genetic and Antigenic Characterization of H5 and H7 Avian Influenza Viruses Isolated From Migratory Waterfowl in Mongolia From 2017 to 2019
    Virus Genes. 19: 1-8 (2020). doi: 10.1007/s11262-020-01764-2
  • Xu Z, Ku X, Tomioka A, Xie W, Liang T, Zou X, Cui Y, Sato T, Kaji H, Narimatsu H, Yan W, Zhang Y
    O-linked N-acetylgalactosamine modification is present on the tumor suppressor p53
    Biochim Biophys Acta Gen Subj. 1864: 129635 (2020) doi: 10.1016/j.bbagen.2020.129635
  • Fuseya S, Suzuki R, Okada R, Hagiwara K, Sato T, Narimatsu H, Yokoi H, Kasahara M, Usui T, Morito N, Yamagata K, Kudo T, Takahashi S.
    Mice lacking core 1-derived O-glycan in podocytes develop transient proteinuria, resulting in focal segmental glomerulosclerosis.
    Biochem Biophys Res Commun. 523:1007-1013 (2020) doi: 10.1016/j.bbrc.2020.01.033
  • Kikutani Y, Masatoshi, Shoko, Takase-Yoden S, Hiono T, de Vries RP, Ryan, Keita, Hiroshi, Yoshihiro E190V substitution of H6 hemagglutinin is one of key factors for binding to sulfated sialylated glycan receptor and infection to chickens
    Microbiol. Immunol. 73: 171-174 (2020) doi: 10.1111/1348-0421.12773
  • Otani K, Tokudome T, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A, Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, Kangawa K.
    Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart
    Circulation. 141: 571-588 (2020). doi: 10.1161/CIRCULATIONAHA.119.039761
  • Shimazaki H, Ono A, Tsuruga M, Ueki A, Koseki-Kuno S, Toyoda T, Saito K, Sawakami K, Kariya M, Segawa O, Nakamura K, Koizuka M, Kuno A*
    GlycoBIST: A System for Automatic Glycan Profiling of a Target Protein Using Milli-Bead Array in a Tip
    Curr Protoc Protein Sci. 99: e103 (2020) doi: 10.1002/cpps.103
  • Wagatsuma T, Nagai-Okatani C#, Matsuda A, Masugi Y, Imaoka M, Yamazaki K, Sakamoto M, Kuno A*
    Discovery of Pancreatic Ductal Adenocarcinoma-Related Aberrant Glycosylations: A Multilateral Approach of Lectin Microarray-Based Tissue Glycomic Profiling With Public Transcriptomic Datasets
    Frontiers In Oncology 10: 338 (2020) doi: 10.3389/fonc.2020.00338
  • Zou X, Yao F, Yang F, Zhang F, Xu ZJ, Shi JJ, Kuno A, Zhao H, Zhang Y
    Glycomic Signatures of Plasma IgG Improve Preoperative Prediction of the Invasiveness of Small Lung Nodules
    Molecules 25: 28 (2020) doi: 10.3390/molecules25010028
  • Holdener BC, Percival CJ, Grady RC, Cameron DC, Berardinelli SJ, Zhang A, Neupane S, Takeuchi M, Jimenez-Vega JC, Uddin SMZ, Komatsu DE, Honkanen R, Dubail J, Apte SS, Sato T, Narimatsu H, McClain SA, Haltiwanger RS.
    ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome.
    Hum Mol Genet. 28: 4053-4066 (2019) doi: 10.1093/hmg/ddz225
  • Kurata I, Matsumoto I, Ohyama A, Osada A, Ebe H, Kawaguchi H, Kaneko S, Kondo Y, Tsuboi H, Tomioka A, Kaji H, Sumida T
    Potential involvement of OX40 in the regulation of autoantibody sialylation in arthritis
    Ann Rheum Dis. 78: 1488-1496 (2019) doi: 10.1136/annrheumdis-2019-215195
  • Nagai-Okatani C#*, Nishigori M, Sato T, Minamino N, Kaji H, Kuno A*
    Wisteria floribunda agglutinin staining for the quantitative assessment of cardiac fibrogenic activity in a mouse model of dilated cardiomyopathy
    Lab Invest. 99: 1749-1765 (2019) doi: 10.1038/s41374-019-0279-9
  • Shimazaki H, Saito K, Matsuda A, Sawakami K, Kariya M, Segawa O, , Miyashita Y, Ueda T, Koizuka M, Nakamura K, Kaji H, Tajima H, , Kuno A*
    Lectin Bead Array in a Single Tip Facilitates Fully Automatic Glycoprotein Profiling
    Anal Chem. 91: 11162-11169 (2019) doi: 10.1021/acs.analchem.9b01876
  • Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, , Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H
    Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation
    J. Allergy Clin Immunol. 144: 698-709 (2019) doi: 10.1016/j.jaci.2019.05.010
  • Takahama H, Nishikimi T, Takashio S, Hayashi T, Nagai-Okatani C, Asada T, Fujiwara A, Nakagawa Y, Amano M, Hamatani Y, Okada A, Amaki M, Hasegawa T, Kanzaki H, Nishimura K, Yasuda S, Kangawa K, Anzai T, Minamino N, Izumi C.
    Change in the NT-proBNP/Mature BNP Molar Ratio Precedes Worsening Renal Function in Patients With Acute Heart Failure: A Novel Predictor Candidate for Cardiorenal Syndrome
    J Am Heart Assoc. 8: e011468 (2019). doi: 10.1161/JAHA.118.011468
  • Nagai-Okatani C#, Aoki-Kinoshita KF, Kakuda S, Nagai M, Hagiwara K, Kiyohara K, Fujita N, Suzuki Y, Sato T, Angata K, Kuno A*
    LM-GlycomeAtlas Ver. 1.0: A Novel Visualization Tool for Lectin Microarray-Based Glycomic Profiles of Mouse Tissue Sections
    Molecules. 24: 2962 (2019) doi: 10.3390/molecules24162962
  • Takashio S, Takahama H, Nishikimi T, Hayashi T, Nagai-Okatani C, Matsuo A, Nakagawa Y, Amano M, Hamatani Y, Okada A, Amaki M, Hasegawa T, Kanzaki H, Yasuda S, Kangawa K, Anzai T, Minamino N, Izumi C.
    Superiority of Proatrial Natriuretic Peptide in the Prognostic Power in Patients With Acute Decompensated Heart Failure on Hospital Admission: Comparison With B-type Natriuretic Peptide and Other Natriuretic Peptide Forms
    Open Geart. 6: e001072 (2019). doi: 10.1136/openhrt-2019-001072
  • Nakane T, Angata K, Sato T, Kaji H, Narimatsu H
    Identification of mammalian glycoproteins with type-I LacdiNAc structures synthesized by the glycosyltransferase B3GALNT2
    J Biol Chem. 294: 7433-7444 (2019) doi: 10.1074/jbc.RA118.006892
  • Shan A, Lu J, Xu Z, Li X, Xu Y, Li W, Liu F, Yang F, Sato T, Narimatsu H, Zhang Y.
    Polypeptide N-acetylgalactosaminyltransferase 18 non-catalytically regulates the ER homeostasis and O-glycosylation.
    Biochim Biophys Acta Gen Subj. 1863: 870-882 (2019). doi: 10.1016/j.bbagen.2019.01.009
  • Nagai-Okatani C#, Nagai M, Sato T, Kuno A*
    An Improved Method for Cell Type-Selective Glycomic Analysis of Tissue Sections Assisted by Fluorescence Laser Microdissection
    Int J Mol Sci. 20: 700 (2019) doi: 10.3390/ijms20030700
  • Shirabe K, Bekki Y, Gantumur D, Araki K, Ishii N, Kuno A, Narimatsu H, Mizokami M
    Response to the letter by Dr. Naoya Yamada, and Dr. Koichi Mizuta regarding our manuscript
    J Gastroenterol. 54: 206-207 (2019) doi: 10.1007/s00535-018-1524-5
  • Matsumoto S, Ohara A, Nagai-Okatani C, Zhou YJ, Fujinaga D, Seike H, Nagata S
    Antagonistic Effect of Short Neuropeptide F on Allatotropin-Inhibited Feeding Motivation of the Silkworm Larva, Bombyx mori
    Zoolog Sci. 36: 58-67 (2019) doi: 10.2108/zs180119
  • Hiono T#*, Matsuda A, Wagatsuma T, Okamatsu M, Sakoda Y, Kuno A*
    Lectin microarray analyses reveal host cell-specific glycan profiles of the hemagglutinins of influenza A viruses
    Virology. 38: 103 (2019) doi: 10.1016/j.virol.2018.11.010
  • Matsuo A, Nagai-Okatani C, Nishigori M, Kangawa K, Minamino N
    Natriuretic peptides in human heart: Novel insight into their molecular forms, functions, and diagnostic use
    Peptides. 11: 453-462 (2019) doi: 10.1016/j.peptides.2018.08.006
  • Torii S, Matsuno K, Qiu Y, Mori-Kajihara A, Kajihara M, Nakao R, Nao N, Okazaki K, Sashika M, Hiono T, Okamatsu M, Sakoda Y, Ebihara H, Takada A, Sawa H.
    Infection of newly identified phleboviruses in ticks and wild animals in Hokkaido, Japan indicating tick-borne life cycles.
    Ticks Tick Borne Dis. 10: 328-335 (2019). doi: 10.1016/j.ttbdis.2018.11.012
  • Solovieva E, Shikanai T, Fujita N, Narimatsu H
    GGDonto ontology as a knowledge-base for genetic diseases and disorders of glycan metabolism and their causative genes.
    J Biomed Semantics.9: 14 (2018). doi:10.1186/s13326-018-0182-0
  • Narimatsu H, Kaji H, Vakhrushev SY, Clausen H, Zhang H, Noro E, Togayachi A, Nagai-Okatani C, Kuno A, Zou X, Cheng L, Tao SC, Sun Y
    Current Technologies for Complex Glycoproteomics and Their Applications to Biology/Disease-Driven Glycoproteomics
    J Proteome Res. 17: 4097-4112 (2018) doi: 10.1021/acs.jproteome.8b00515
  • Nagai-Okatani C#, Nagata S, Nagasawa H
    Tissue distribution and biochemical characteristics of receptors for sinus gland peptide VII as a crustacean hyperglycemic hormone and vitellogenesis-inhibiting hormone of the kuruma prawn, Marsupenaeus japonicus
    Gen Comp Endocrinol. 266: 157-165 (2018) doi: 10.1016/j.ygcen.2018.05.010
  • Wagatsuma T, Kuno A, Angata K, Tajiri K, Takahashi J, Korenaga M, Mizokami M, Narimatsu H
    Highly Sensitive Glycan Profiling of Hepatitis B Viral Particles and a Simple Method for Dane Particle Enrichment
    Anal Chem. 90: 10196-10203 (2018) doi: 10.1021/acs.analchem.8b01030
  • Takahama H, Takashio S, Nishikimi T, Hayashi T, Nagai-Okatani C, Nakagawa Y, Amaki M, Ohara T, Hasegawa T, Sugano Y, Kanzaki H, Yasuda S, Kangawa K, Minamino N, Anzai T.
    Ratio of pro-B-type Natriuretic Peptide (BNP) to Total BNP Is Decreased in Mild, but Not Severe, Acute Decompensated Heart Failure Patients: A Novel Compensatory Mechanism for Acute Heart Failure.
    Int J Cardiol. 258: 165-171 (2018). doi: 10.1016/j.ijcard.2017.12.047
  • Matsuura R, Kaji H, Tomioka A, Sato T, Narimatsu H, Moriwaki Y, Misawa H, Imai K, Tsuji S
    Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1
    Sci Rep. 8: 14251 (2018) doi: 10.1038/s41598-018-32534-8
  • Shirabe K, Bekki Y, Gantumur D, Araki K, Ishii N, Kuno A, Narimatsu H, Mizokami M
    Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis
    J Gastroenterol. 53: 819-826 (2018) doi: 10.1007/s00535-017-1425-z
  • Wang ZJ, Kikutani Y, Nguyen LT, Hiono T, Matsuno K, Okamatsu M, Krauss S, Webby R, Lee YJ, Kida H, Sakoda Y.
    H13 influenza viruses in wild birds have undergone genetic and antigenic diversification in nature.
    Virus Genes. 54: 543-549 (2018). doi: 10.1007/s11262-018-1573-0
  • Togayachi A, Tomioka A, Fujita M, Sukegawa M, Noro E, Takakura D, Miyazaki M, Shikanai T, Narimatsu H, Kaji H
    Identification of Poly-N-Acetyllactosamine-Carrying Glycoproteins from HL-60 Human Promyelocytic Leukemia Cells Using a Site-Specific Glycome Analysis Method, Glyco-RIDGE
    J Am Soc Mass Spectrom. 29: 1138-1152 (2018) doi: 10.1007/s13361-018-1938-6
  • Narimatsu H, Sato T
    Wisteria floribunda agglutinin positive glycobiomarkers: a unique lectin as a serum biomarker probe in various diseases
    Expert Rev Proteomics. 15: 183-190 (2018) doi: 10.1080/14789450.2018.1419066
  • Wakui H, Fuseya S, Suzuki R, Shimbo M, Okada R, Hamada M, Kuno A, , Hagiwara K, Sato T, Narimatsu H, Kudo T, Takahashi S
    Incomplete clearance of apoptotic cells by core 1-derived O-glycan-deficient resident peritoneal macrophages
    Biochem Biophys Res Commun. 495: 2017-2023 (2018) doi: 10.1016/j.bbrc.2017.12.066
  • Suzuki R, Fujimoto Z, Kaneko S, Hasegawa T, and Kuno A*.
    Enhanced azidolysis by the formation of stable Ser-His catalytic dyad in a glycoside hydrolase family 10 xylanase mutant.
    J Appl Glycosci 65: 1-8 (2018). doi.org/10.5458/jag.jag.JAG-2017_011
  • Suzuki M, Okamatsu M, Hiono T, Matsuno K, Sakoda Y.
    Potency of an inactivated influenza vaccine prepared from A/duck/Hokkaido/162/2013 (H2N1) against a challenge with A/swine/Missouri/2124514/2006 (H2N3) in mice.
    J Vet Med Sci. 79: 1815-1821 (2017). doi: 10.1292/jvms.17-0312
  • Nguyen LT, Nishi T, Shichinohe S, Chu DH, Hiono T, Matsuno K, Okamatsu M, Kida H, Sakoda Y.
    Selection of antigenic variants of an H5N1 highly pathogenic avian influenza virus in vaccinated chickens.
    Virology. 510: 252-261 (2017. doi: 10.1016/j.virol.2017.07.030
  • Kanai Y, Yasoda A, Mori KP, Watanabe-Takano H, Nagai-Okatani C, , Yamashita Y, Hirota K, Ueda Y, Yamauchi I, Kondo E, Yamanaka S, , Sakane Y, Nakao K, Fujii T, Yokoi H, Minamino N, Mukoyama M, , Mochizuki N, Inagaki N
    Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance
    J. Clin Invest. 127: 4136-4147 (2017) doi: 10.1172/JCI94912
  • Hiono T#, Okamatsu M, Matsuno K, Haga A, Iwata R, Nguyen LT, Suzuki M, Kikutani Y, Kida H, Onuma M, Sakoda Y.
    Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild and captive birds in the winter season of 2016-2017 in Northern Japan.
    Microbiol Immunol. 61: 387-397 (2017). doi: 10.1111/1348-0421.12506
  • Matsuda A, Higashi M, Nakagawa T, Yokoyama S, Kuno A*, Yonezawa S, Narimatsu H
    Assessment of tumor characteristics based on glycoform analysis of membrane-tethered MUC1
    Lab Invest. 97: 1103-1113 (2017) doi: 10.1038/labinvest.2017.53
  • Nguyen LT, Nakaishi K, Motojima K, Ohkawara A, Minato E, Maruyama J, Hiono T, Matsuno K, Okamatsu M, Kimura T, Takada A, Kida H, Sakoda Y.
    Rapid and broad detection of H5 hemagglutinin by an immunochromatographic kit using novel monoclonal antibody against highly pathogenic avian influenza virus belonging to the genetic clade 2.3.4.4.
    PLoS One. 12: e0182228 (2017). doi: 10.1371/journal.pone.0182228
  • Togayachi A, Iwaki J, Kaji H, Matsuzaki H, Kuno A, Hirao Y, Nomura M, Noguchi M, Ikehara Y, Narimatsu H.
    Glycobiomarker, Fucosylated Short-Form Secretogranin III Levels Are Increased in Serum of Patients with Small Cell Lung Carcinoma.
    J Proteome Res. 16: 4495-4505 (2017). doi: 10.1021/acs.jproteome.7b00484
  • Enkhbold B, Shatar M, Wakamori S, Tamura T, Hiono T, Matsuno K, Okamatsu M, Umemura T, Damdinjav B, Sakoda Y.
    Genetic and virulence characterization of classical swine fever viruses isolated in Mongolia from 2007 to 2015.
    Virus Genes. 53: 418-425 (2017). doi: 10.1007/s11262-017-1442-2
  • Nagai-Okatani C#, Kangawa K, Minamino N
    Three molecular forms of atrial natriuretic peptides: quantitative analysis and biological characterization
    J. Pept Sci. 121: 16964-16969 (2017) doi: 10.1002/psc.2969
  • Okamatsu M, Ozawa M, Soda K, Takakuwa H, Haga A, Hiono T, Matsuu A, Uchida Y, Iwata R, Matsuno K, Kuwahara M, Yabuta T, Usui T, Ito H, Onuma M, Sakoda Y, Saito T, Otsuki K, Ito T, Kida H.
    Characterization of Highly Pathogenic Avian Influenza Virus A(H5N6), Japan, November 2016.
    Emerg Infect Dis. 23: 691-695 (2017). doi: 10.3201/eid2304.161957
  • Nakatsukasa A, Kuruma K, Okamatsu M, Hiono T, Suzuki M, Matsuno K, Kida H, Oyamada T, Sakoda Y.
    Potency of whole virus particle and split virion vaccines using dissolving microneedle against challenges of H1N1 and H5N1 influenza viruses in mice.
    Vaccine. 35: 2855-2861 (2017). doi: 10.1016/j.vaccine.2017.04.009
  • Ohkawara A, Okamatsu M, Ozawa M, Chu DH, Nguyen LT, Hiono T, Matsuno K, Kida H, Sakoda Y.
    Antigenic diversity of H5 highly pathogenic avian influenza viruses of clade 2.3.4.4 isolated in Asia.
    Microbiol Immunol. 61: 149-158 (2017). doi: 10.1111/1348-0421.12478
  • Bekki Y, Yoshizumi T, Shimoda S, Itoh S, Harimoto N, Ikegami T, Kuno A, Narimatsu H, Shirabe K, Maehara Y
    Hepatic stellate cells secreting WFA(+) -M2BP: Its role in biological interactions with Kupffer cells
    J Gastroenterol Hepatol. 32: 1387-1393 (2017) doi: 10.1111/jgh.13708
  • Sato T#, Tateno H, Kaji H, Chiba Y, Kubota T, Hirabayashi J, Narimatsu H
    Engineering of recombinant Wisteria floribunda agglutinin specifically binding to GalNAcbeta1,4GlcNAc (LacdiNAc)
    Glycobiology. 27: 743-754 (2017) doi: 10.1093/glycob/cwx038
  • Mitani Y, Oshima Y, Mitsuda N, Tomioka A, Sukegawa M, Fujita M, Kaji H, Ohmiya Y
    Efficient production of glycosylated Cypridina luciferase using plant cells
    Protein Expr Purif. 133: 102-109 (2017) doi: 10.1016/j.pep.2017.03.008
  • Shimbo M, Suzuki R, Fuseya S, Sato T, Kiyohara K, Hagiwara K, Okada R, Wakui H, Tsunakawa Y, Watanabe H, Kimata K, Narimatsu H, Kudo T, Takahashi S
    Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2
    PloS One. 12: e0190333 (2017) doi: 10.1371/journal.pone.0190333 56
  • Tsuji S, Washimi K, Kageyama T, Yamashita M, Yoshihara M, Matsuura R, Yokose T, Kameda Y, Hayashi H, Morohoshi T, Tsuura Y, Yusa T, Sato T, Togayachi A, Narimatsu H, Nagasaki T, Nakamoto K, Moriwaki Y, Misawa H, Hiroshima K, Miyagi Y, Imai K.
    HEG1 Is a Novel Mucin-Like Membrane Protein That Serves as a Diagnostic and Therapeutic Target for Malignant Mesothelioma
    Sci Rep 7: 45768 (2017). doi: 10.1038/srep45768
  • Zou X, Yoshida M, Nagai-Okatani C#, Iwaki J, Matsuda A, Tan B, Hagiwara K, Sato T, Itakura Y, Noro E, Kaji H, Toyoda M, Zhang Y, Narimatsu H, Kuno A*.
    A Standardized Method for Lectin Microarray-Based Tissue Glycome Mapping
    Sci Rep 7: 43560 (2017). doi: 10.1038/srep43560
  • Tamaki N, Kuno A, Matsuda A, Tsujikawa H, Yamazaki K, Yasui Y, Tsuchiya K, Nakanishi H, Itakura J, Korenaga M, Mizokami M, Kurosaki M, Sakamoto M, Narimatsu H, Izumi N.
    Serum Wisteria Floribunda Agglutinin-Positive Sialylated Mucin 1 as a Marker of Progenitor/Biliary Features in Hepatocellular Carcinoma
    Sci Rep 7: 244 (2017). doi: 10.1038/s41598-017-00357-8
  • Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Minami T, Kuwabara Y, Yamada C, Yamada Y, Tokudome T, Nagai-Okatani C, Minamino N, Nakao YM, Yasuno S, Ueshima K, Sone M, Kimura T, Kangawa K, Nakao K.
    Endothelium-Derived C-Type Natriuretic Peptide Contributes to Blood Pressure Regulation by Maintaining Endothelial Integrity
    Hypertension. 69: 286-296 (2017) doi: 10.1161/HYPERTENSIONAHA.116.08219
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