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Multicellular System Regulation Research Group


Project1:Development of glycan analytical technology
Researcher:Haruki Odaka, Hiroaki Tateno

Glycans cover the outermost layer of all cells and change depending on the cell type and condition (differentiation, cancer, etc.), thus they are called the “cell signature“. They are expected to be used for quality control of cells used in regenerative medicine and as drug targets for cancer and other diseases. We have constructed a recombinant lectin library and have been developing a technology for profiling glycans using this library. We have developed and used lectin arrays in which multiple lectins are immobilized on glass slides. Recently, we have also developed a glycan profiling by sequencing, and succeeded in establishing a technology (scGR-seq) for simultaneous analysis of glycan expression and gene expression in individual cells. We have also applied this technology to glycan profiling of microbiota. We will continue to further advance and apply this technology.

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Project2:Development of the quality control technology of stem cells
Researcher:Tomoko Watanabe, Yoshikazu Haramoto, Shuuji Mawaribuchi, Hiroaki Tateno

Human pluripotent cells and human mesenchymal stem cells are expected as cell sources for regenerative medicine. When transplanting these cells into humans, ensuring the safety and quality of the cells is extremely important. So far, we have succeeded in developing a technology for non-destructively detecting and removing the tumorigenic human pluripotent stem cells remaining in the cells for transplantation, and have successfully commercialized it in collaboration with a company. We will continue to develop new quality control technology.

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Project3:Development of diagnostic technology for cancer, diabetes, neuronal diseases, and mental disorders.
Researcher:Mawaribuchi Shuuji、Odaka Haruki、Kuwabara Tomoko、Tateno Hiroaki

The development of diagnostic techniques for cancer, diabetes, and psychiatric/neurological disorders is important for definitive diagnosis, decision of treatment policy, improvement of QOL, and early rehabilitation. We aim to develop a new diagnostic technology by analyzing the cell function and gene/glycan expression of diseased cells (prostate cancer, breast cancer, pancreatic cancer, diabetes, mental disorders).

Multicellular System Regulation Research Group04


Project4:Separation and purification of exosomes, and development of utilization technology
Researcher:Noriyuki Ishii, Haruki Odaka, Tomoko Watanabe, Hiroaki Tateno

Exosomes are membrane-bound extracellular vesicles (EVs) produced in the endosomal compartment of most eukaryotic cells that are transported to other cells by the systemic circulation, and function as an intercellular communication tool in Embryological, Physiological, and Pathological processes. We collaborate with researchers inside and outside the laboratory to advance the technology for preparing EVs that are in an intrinsic state immediately after they are secreted from cells, develop technology for their utilization, and understand the functions of glycans of EVs. We will try to clarify the essence of the mysterious exosome.

Multicellular System Regulation Research Group05


Project5:Elucidation of mechanisms for organ development and tissue regeneration
Researcher:Yoshikazu Haramoto

To develop the methodology to generate organs and tissues applicable in regenerative medicine, we study in vivo differentiation mechanisms of organs and tissues. Amphibians are known for high regenerative capability among the Vertebrata. We analyze their regenerative mechanism and aim to apply the obtained insights to medicine. In addition, adult stem cells with self-renewal ability and pluripotency play an important role in maintaining homeostasis by compensating for cells lost in various tissues, are expected as useful stem cells for regenerative medicine. We aim to search for adult stem cells and to elucidate the microenvironment and signals that are important for self-renewal and maintenance of undifferentiated state of adult stem cells.

Multicellular System Regulation Research Group06


Project6:Microwave-assisted synthesis of glycopeptides
Researcher:Hiroki SHIMIZU

Microwave, as used in microwave ovens, can heat material efficiently and is also used a tool to heat chemical reactions effectively. In addition, there have been many studies about the unique microwave non-thermal effects, but it tends to be questioned because many of reported papers developed their discussion based on inaccurate experiments and a certain expert researcher denied it.
Even though this background, we have researched the microwave non-thermal effect. Specifically, we successfully made “an impossible reaction into possible" in a synthesis of LeX trisaccharide by microwave irradiation at low temperatures. We successfully accelerated an enzymatic reaction by utilizing the conductive loss. To apply non-thermal microwave effect for glycopeptides syntheses, we have successfully improved both of stability and reactivity of expensive and valuable glyco-amino acid synthons and established unique methods for syntheses of complex glycopeptides in several tens of mg scales. Synthesized complex glycopeptides having variety of glycans have been applied for the secondary research, e.g. drug discovery research field.

Multicellular System Regulation Research Group07


Name Position
TATENO Hiroaki Research Group Leader
SHIMIZU Hiroki Senior Researcher
ISHII Noriyuki Senior Researcher
KUWABARA Tomoko Senior Researcher
HARAMOTO Yoshikazu Senior Researcher
MAWARIBUCHI Shuuji Senior Researcher
WATANABE Tomoko Senior Researcher
ODAKA Haruki Researcher


  • Ishii, N; Noguchi, K; Ikemoto, MJ; Yohda, M; Odahara, T.
    Optimizing Exosome Preparation Based on Size and Morphology: Insights From Electron Microscopy.
    MICROSC MICROANAL. 2023 Oct 13:ozad103. doi: 10.1093/micmic/ozad103
  • Ishii, N; Odahara, T.
    Investigation of the Efficacy of Lanthanoid Heavy Metal Acetates as Electron Staining Reagents for Biomembrane Vesicles.
    MICROSC MICROANAL. 2023 Oct 13:ozad107. doi: 10.1093/micmic/ozad107
  • Odaka, H.
    Target-Specific O-linked N-acetylglucosamine Modification with a Dual-Specificity Aptamer Reveals Functions of O-GlcNAcylation in beta-catenin.
    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. May 25, 2023; Volume 35(2023) Issue 205. doi: 10.4052/tigg.2309.6E
  • Watanabe, T, Tateno, H.
    Lectin Blotting of Cell Lysates.
    CURR PROTOC. 2023 May;3(5):e790. doi: 10.1002/cpz1.790
  • Kuroda, Y; Oda, T; Shimomura, O; Louphrasitthiphol, P; Mathis, BJ; Tateno, H, Hatano, K.
    Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: (18) F-labeled rBC2LCN lectin.
    CANCER SCI. 2023 May 19. doi: 10.1111/cas.15846
  • Odaka, H; Tateno, H.
    Single-Cell Glycan and RNA Sequencing (scGR-seq).
    CURR PROTOC. 2023 May;3(5):e777. doi: 10.1002/cpz1.777
  • Ikemoto, MJ; Aihara, Y; Ishii, N; Shigemori, H.
    3,4-Dihydroxybenzalacetone Inhibits the Propagation of Hydrogen Peroxide-Induced Oxidative Effect via Secretory Components from SH-SY5Y Cells.
    BIOL PHARM BULL. 2023;46(4):599-607. doi: 10.1248/bpb.b22-00727
  • Murata, Y; Jitsukawa, T; Iida, M; Furuta, T; Haramoto, Y; Shigeri, Y; Fujisaki, S.
    Liquid chromatography-mass spectrometry analyses of polyprenyl phosphates in Escherichia coli cells in which genes for isoprenoid synthesis are amplified.
    J BIOSCI BIOENG. 2023 Mar 1:S1389-1723(23)00047-6. doi: 10.1016/j.jbiosc.2023.02.003
  • Mawaribuchi, S; Ito, M; Ogata, M; Yoshimura, Y; Miura, I.
    Parallel Evolution of Sex-Linked Genes across XX/XY and ZZ/ZW Sex Chromosome Systems in the Frog Glandirana rugosa.
    GENES (Basel). 2023 Jan 18;14(2):257. doi: 10.3390/genes14020257
  • Sato, Y; Kato, Y; Iizumi, Y; Morimoto, T; Kobashi, K; Sugino, T; Tateno, H; Okazaki, T.
    Size distributions of cellulose nanocrystals in dispersions using the centrifugal sedimentation method.
    INT J BIOL MACROMOL. 2023 Feb 2:123520. doi: 10.1016/j.ijbiomac.2023.123520
  • Mawaribuchi, S; Shimomura, O; Oda, T; Hiemori, K; Shimizu, K; Yamase, K; Date, M; Tateno, H.
    rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma.
    GLYCOBIOLOGY. 2023 Feb 2:cwad009. doi: 10.1093/glycob/cwad009
  • Huang, T; Sato, Y; Kuramochi, A; Ohba, Y; Sano, M; Miyagishi, M; Tateno, H; Wadhwa, R; Kawasaki, K; Uchida, T; Ekdahl, KN; Nilsson, B; Chung, UI; Teramura, Y.
    Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells.
    REGEN THER. 2023 Jan 11;22:90-98. doi: 10.1016/j.reth.2022.12.007
  • Mawaribuchi, S; Haramoto, Y; Ikeda, N; Ito, M.
    Evolutionary features of ligands and their receptors via protein-protein interactions and essentiality in primates.
    GENES CELLS. 2023 Jan 9. doi: 10.1111/gtc.13006
  • Ishii, N.
    C-shaped dipper: A novel useful auxiliary tool for preparation of specimen grids for transmission electron microscopy.
    MICROSC RES TECH. 2022 Dec 29. doi: 10.1002/jemt.24283
  • Ando, M; Kawasaki, H; Tamura, S; Haramoto, Y; Shigeri, Y.
    Recent Advances in Gas Sensing Technology Using Non-Oxide II-VI Semiconductors CdS, CdSe, and CdTe.
    CHEMOSENSORS. 2022 10(11)482. doi: 10.3390/chemosensors10110482
  • Nagashima, I; Sugiyama, JI; Shimizu, H.
    Study of 400 MHz microwave conduction loss effect for a hydrolysis reaction by thermostable β-Glucosidase HT1.
    BIOSCI BIOTECHNOL BIOCHEM. 2022 Dec 6:zbac194. doi: 10.1093/bbb/zbac194
  • Kuroda, Y; Shimomura, O; Nakahashi, H; Miyazaki, Y; Nakajima, T; Tateno, H; Oda, T.
    Lectin-based photoimmunotherapy targeting cell surface glycans for pancreatic cancer.
    CANCER RESEARCH 82 (22). 2022 NOV 15. doi: 10.1158/1538-7445.PANCA22-B083
  • Kuroda, Y; Oda, T; Shimomura, O; Hashimoto, S; Akashi, Y; Miyazaki, Y; Furuya, K; Furuta, T; Nakahashi, H; Louphrasitthiphol, P; Mathis, BJ; Nakajima,T; Tateno, H.
    Lectin-based phototherapy targeting cell surface glycans for pancreatic cancer.
    INT J CANCER. 2022 Nov 22. doi: 10.1002/ijc.34362
  • Tasaki, M; Tateno, H; Sato, T; Narimatsu, H; Saito, K; Nakagawa, Y; Aoki, T; Kamimura, M; Ushiki, T; Takahashi, K; Tomita, Y.
    Hyporesponsiveness against donors ABO antigens of renal grafts after ABO-incompatible kidney transplantation.
    CLIN EXP NEPHROL. 2022 Oct 8. doi: 10.1007/s10157-022-02280-3
  • Kosaka, T; Yamaguchi, S; Izuta, S; Yamahira, S; Shibasaki, Y; Tateno, H; Okamoto, A.
    Bioorthogonal Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications.
    AM CHEM SOC. 2022 Sep 20. doi: 10.1021/jacs.2c07321
  • Yamasaki, K; Adachi, N; Ngwe Tun, MM; Ikeda, A; Moriya, T; Kawasaki, M; Yamasaki, T; Kubota, T; Nagashima, I; Shimizu, H; Tateno, H; Morita, K.
    Core fucose-specific Pholiota squarrosa lectin (PhoSL) as a potent broad-spectrum inhibitor of SARS-CoV-2 infection.
    FEBS J. 2022 Aug 25. doi: 10.1111/febs.16599
  • Katsumi, T; Shams, F; Yanagi, H; Ohnishi, T; Toda, M; Lin, SM; Mawaribuchi, S; Shimizu, N; Ezaz, T; Miura, I.
    Highly rapid and diverse sex chromosome evolution in the Odorrana frog species complex.
    DEV GROWTH DIFFER. 2022 Jul 26. doi: 10.1111/dgd.12800
  • Numakawa, T; Odaka, H.
    The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022 Jul 13;23(14):7726. doi: 10.3390/ijms23147726
  • Kokubu, R; Ohno, S; Kuratani, H; Takahashi, Y; Manabe, N; Shimizu, H; Chiba, Y; Denda-Nagai, K; Tsuiji, M; Irimura, T; Yamaguchi, Y.
    O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations.
    INT J MOL SCI. 2022 Jul 16;23(14):7855. doi: 10.3390/ijms23147855
  • Nagae, M; Hirata, T; Tateno, H; Mishra, SK; Manabe, N; Osada, N; Tokoro, Y; Yamaguchi, Y; Doerksen, RJ; Shimizu, T; Kizuka, Y.
    Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A).
    COMMUN BIOL. 2022 Jul 19;5(1):695. doi: 10.1038/s42003-022-03661-w
  • Odaka, H.
    Genome-wide CRISPR/Cas9 Screening Identifies KDM2B as a Modifier of Heparan Sulfate-Protein Interactions.
    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. 2022 Volume 34 Issue 199 Pages E63. doi: 10.4052/tigg.2203.6E
  • Tsukano, K; Yamamoto, T; Watanabe, T; Michiue, T.
    Xenopus Dusp6 modulates FGF signaling to precisely pattern pre-placodal ectoderm.
    DEVELOPMENTAL BIOLOGY. 2022 May 16. doi: 10.1016/j.ydbio.2022.05.009
  • Oinam, L; Tateno, H.
    Glycan Profiling by Sequencing to Uncover Multicellular Communication: Launching Glycobiology in Single Cells and Microbiomes.
    FRONT CELL DEV BIOL. 2022 May 27;10:919168. doi: 10.3389/fcell.2022.919168
  • Yang, Y; Akashi, Y; Shimomura, O; Tateno, H; Saito, S; Hiemori, K; Miyazaki, Y; Furuta, T; Kitaguchi, D; Kuroda, Y; Pakavarin, L; Oda, T.
    Glycan expression profile of signet ring cell gastric cancer cells and potential applicability of rBC2LCN-targeted lectin drug conjugate therapy.
    GASTRIC CANCER. 2022 Jun 17. doi: 10.1007/s10120-022-01312-x
  • Miura, I; Shams, F; Jeffries, DL; Katsura, Y; Mawaribuchi, S; Perrin, N; Ito, M; Ogata, M; Ezaz, T.
    Identification of ancestral sex chromosomes in the frog Glandirana rugosa bearing XX-XY and ZZ-ZW sex-determining systems.
    MOL ECOL. 2022 Jun 12. doi: 10.1111/mec.16551
  • Odaka, H; Hiemori, K; Shimoda, A; Akiyoshi, K; Tateno, H.
    CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma.
    BMC GASTROENTEROLOGY. 2022 Mar 28;22(1):153. doi: 10.1186/s12876-022-02228-7
  • Hayashi, Y; Yimiti, D; Sanada, Y; Ding, C; Omoto, T; Ogura, T; Nakasa, T; Ishikawa, M; Hiemori, K; Tateno, H; Miyaki, S; Adachi, N.
    The therapeutic capacity of bone marrow MSC-derived extracellular vesicles in Achilles tendon healing is passage-dependent and indicated by specific glycans.
    FEBS LETTERS. 2022 Apr;596(8):1047-1058. doi: 10.1002/1873-3468.14333
  • Tasaki, M; Tateno, H; Sato, T; Tomioka, A; Kaji, H; Narimatsu, H; Saito, K; Nakagawa, Y; Aoki, T; Kamimura, M; Ushiki, T; Okada, M; Miwa, Y; Hotta, K; Yoshida, Y; Takahashi, K; Tomita, Y.
    A Novel Method of CD31-Combined ABO Carbohydrate Antigen Microarray Predicts Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.
    TRANSPL INT. 2022 Mar 23;35:10248. doi: 10.3389/ti.2022.10248
  • Oinam, L; Hayashi, R; Hiemori, K; Kiyoi, K; Sage-Ono, K; Miura, K; Ono, M; Tateno, H.
    Quantitative evaluation of glycan-binding specificity of recombinant Concanavalin A produced in lettuce (Lactuca sativa).
    BIOTECHNOL BIOENG. 2022 Apr 8. doi: 10.1002/bit.28099
  • Ishii, N.
    Systematic Investigation of Lanthanoid Transition Heavy Metal Acetates as Electron Staining Reagents for Protein Molecules in Biological Transmission Electron Microscopy.
    MICROSC MICROANAL. 2022 Apr 1:1-10. doi: 10.1017/S1431927622000411
  • Seo, N; Nakamura, J; Kaneda, T; Tateno, H; Shimoda, A; Ichiki, T; Furukawa, K; Hirabayashi, J; Akiyoshi, K; Shiku, H.
    Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method.
    J EXTRACELL VESICLES. 2022 Mar;11(3):e12205. doi: 10.1002/jev2.12205
  • Odaka, H; Ozaki, H; Tateno, H.
    scGR-seq: Integrated analysis of glycan and RNA in single cells.
    STAR PROTOC. 2022 Feb 18;3(1):101179. doi: 10.1016/j.xpro.2022.101179. eCollection
  • Irumagawa, S; Hiemori, K; Saito, S; Tateno, H; Arai, R.
    Self-Assembling Lectin Nano-Block Oligomers Enhance Binding Avidity to Glycans.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (2);doi: 10.3390/ijms23020676 JAN
  • Oinam, L; Tateno, H.
    Evaluation of Glycan-Binding Specificity by Glycoconjugate Microarray with an Evanescent-Field Fluorescence Detection System.
    METHODS MOL BIOL. 2022;2460:25-32. doi: 10.1007/978-1-0716-2148-6_2
  • Kaifu, T; Yabe, R; Maruhashi, T; Chung, SH; Tateno, H; Fujikado, N; Hirabayashi, J; Iwakura, Y.
    DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.
    J EXP MED. 2021 Dec 6;218(12):e20210435. doi: 10.1084/jem.20210435. Epub 2021 Nov
  • Shimoda, A; Miura, R; Tateno, H; Seo, N; Shiku, H; Sawada, S; Sasaki, Y; Akiyoshi, K.
    Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications.
    SMALL METHODS; doi: 10.1002/smtd.202100785
  • Tulin, EKC; Nakazawa, C; Nakamura, T; Saito, S; Ohzono, N; Hiemori, K; Nakakita, SI; Tateno, H; Tonozuka, T; Nishikawa, A.
    Glycan detecting tools developed from the Clostridium botulinum whole hemagglutinin complex.
    SCI REP. 2021 Nov 9;11(1):21973. doi: 10.1038/s41598-021-01501-1
  • Kaigawa, H; Tateno, H; Arai, R.
    Self-Assembling Functional Complexes of Protein Nanobuilding Blocks with a Trimeric Lectin.
    PROTEIN SCIENCE 30 158-159; OCT
  • Irumagawa, S; Tateno, H; Arai, R.
    Self-Assembling Lectin Nano-Building Blocks Enhance Avidity to Glycans through Polyvalent Effect.
    PROTEIN SCIENCE 30 173-174; OCT
  • Hoshi, K; Ito, H; Abe, E; Fuwa, TJ; Kanno, M; Murakami, Y; Abe, M; Murakami, T, Yoshihara, A, Ugawa, Y, Saito, T, Saido, TC, Matsumoto, K, Yamaguchi, Y, Furukawa, K, Arai, H, Kanai, M, Miyajima, M, Arai, H, Ogawa, N, Akatsu, H, Hashizume, Y, Tateno, H, Honda, T, Hashimoto, Y.
    Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimers Disease.
    METABOLITES. 2021 Sep 10;11(9):616. doi: 10.3390/metabo11090616
  • Minoshima, F; Ozaki, H; Odaka, H; Tateno, H.
    Integrated analysis of glycan and RNA in single cells.
    ISCIENCE. 2021 Jul 17;24(8):102882. doi: 10.1016/j.isci.2021.102882. eCollection
  • Watanabe, T; Takeda, K; Hiemori, K; Minamisawa, T; Tateno, H.
    A glycosaminoglycan microarray identifies the binding of SARS-CoV-2 spike protein to chondroitin sulfate E.
    FEBS LETT. 2021 Aug 10. doi: 10.1002/1873-3468.14173
  • Haramoto, Y.
    First person - Yoshikazu Haramoto.
    BIOLOGY OPEN 10 (4);doi: 10.1242/bio.058759 APR
  • Ogita, Y; Tamura, K; Mawaribuchi, S; Takamatsu, N; Ito, M.
    Independent pseudogenizations and losses of sox15 during amniote diversification following asymmetric ohnolog evolution.
    BMC ECOL EVOL. 2021 Jun 30;21(1):134. doi: 10.1186/s12862-021-01864-z
  • Furuta, T; Oda, T; Kiyoi, K; Ozawa, Y; Kimura, S; Kurimori, K; Miyazaki, Y; Yu, Y; Furuya, K; Akashi, Y; Shimomura, O; Tateno, H
    Carcinoembryonic antigen as a specific glycoprotein ligand of rBC2LCN lectin on pancreatic ductal adenocarcinoma cells
    Cancer Sci. 2021 Jun 11. doi: 10.1111/cas.15023
  • Numakawa, T; Odaka, H.
    Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimers Disease: Beneficial Effects of Flavonoids for Neuroprotection.
    INT J MOL SCI. 2021 May 27;22(11):5719. doi: 10.3390/ijms22115719
  • Haramoto, Y; Sakata, M; Kobayashi, S.
    Visualization of X chromosome reactivation in mouse primordial germ cells in vivo.
    BIOL OPEN. 2021 Apr 15;10(4):bio058602. doi: 10.1242/bio.058602. Epub 2021 Apr 29
  • Watanabe, T; Tateno, H.
    Elimination of cells deviated from human induced pluripotent stem cells with a photoactivatable IR700-labelled antibody.
    BIOCHEM BIOPHYS RES COMMUN. 2021 Mar 25;554:13-18. doi: 10.1016/j.bbrc.2021.03.078
  • Furuta T, Tateno H, Kiyoi K, Miyazaki Y, Kimura S, Kurimori K, Shimomura O, Oda T
    Glycans on CEA as a targeting ligand of pancreatic ductal adenocarcinoma in novel lectin-drug conjugated therapy.
    CANCER SCIENCE 112 718-718; FEB
  • Odaka H, Numakawa T, Soga M, Kido J, Matsumoto S, Kajihara R, Okumiya T, Tani N, Tanoue Y, Fukuda T, Furuya H, Inoue T, Era T
    An iPSC-based neural model of sialidosis uncovers glycolytic impairment-causing presynaptic dysfunction and deregulation of Ca(2+) dynamics
    Neurobiol Dis. 2021 Jan 28:105279. doi: 10.1016/j.nbd.2021.105279
  • Kimura S, Oda T, Shimomura O, Enomoto T, Hashimoto S, Kuroda Y, Yu Y, Kurimori K, Furuta T, Miyazaki Y, Tateno H
    Novel Pancreatic Cancer Therapy Targeting Cell Surface Glycans by Liposomes Modified with rBC2LCN Lectin
    Eur Surg Res. 2021 Jan 27:1-10. doi: 10.1159/000513430
  • Inagaki H, Haramoto Y, Kubota HY, Shigeri Y
    Complete mitochondrial genome sequence of Japanese forest green tree frog (Rhacophorus arboreus.
    Mitochondrial DNA B Resour 2020 Sep 16;5(3):3347-3348. doi: 10.1080/23802359.2020.1820396
  • Odaka H, Hiemori K, Shimoda A, Akiyoshi K, Tateno H
    Platelet-derived extracellular vesicles are increased in sera of Alzheimers disease patients, as revealed by Tim4-based assays.
    FEBS OPEN BIO 2020 Dec 20. doi: 10.1002/2211-5463.13068
  • Hasehira K, Furuta T, Shimomura O, Asada M, Oda T, Tateno H
    Quantitative structural analysis of glycans expressed within tumors derived from pancreatic cancer patient-derived xenograft mouse models
    Biochem Biophys Res Commun. 2020 Dec 4:S0006-291X(20)32131-8. doi: 10.1016/j.bbrc.2020.11.087
  • Kitaguchi D, Oda T, Enomoto T, Ohara Y, Owada Y, Akashi Y, Furuta T, Yu Y, Kimura S, Kuroda Y, Kurimori K, Miyazaki Y, Furuya K, Shimomura O, Tateno H
    Lectin Drug Conjugate Therapy for Colorectal Cancer
    Cancer Sci. 2020 Oct 15. (2020) doi: 10.1111/cas.14687
  • Inagaki H, Haramoto Y, Kubota HY, Shigeri Y
    Complete mitochondrial genome sequence of Japanese forest green tree frog (Rhacophorus arboreus)
    MITOCHONDRIAL DNA PART B-RESOURCES 5 (3) 3365-3366; (2020) doi:10.1080/23802359.2020.1820396
  • Watanabe T, Kakuta J, Saito S, Hasehira K, Kiyoi K, Imai T, Tateno H
    Monoclonal antibodies specific for podocalyxin expressed on human induced pluripotent stem cells.
    Biochem Biophys Res Commun. 2020 Sep 7:S0006-291X(20)31692-2. (2020) doi:10.1016/j.bbrc.2020.08.092
  • Giron LB, Colomb F, Papasavvas E, Azzoni L, Yin X, Fair M, Anzurez A, Damra M, Mounzer K, Kostman JR, Tebas P, ODoherty U, Tateno H, Liu Q, Betts MR, Montaner LJ, Abdel-Mohsen M
    Interferon-α alters host glycosylation machinery during treated HIV infection
    EBioMedicine. 59:102945. (2020) doi: 10.1016/j.ebiom.2020.102945
  • Wang J, Bhargava P, Yu Y, Sari AN, Zhang H, Ishii N, Yan K, Zhang Z, Ishida Y, Terao K, Kaul SC, Miyako E, Wadhwa R
    Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells
    Cancers (Basel). 12(9):E2370. (2020) doi: 10.3390/cancers12092370
  • Watanabe T, Saito S, Hiemori K, Kiyoi K, Mawaribuchi S, Haramoto Y, Tateno H
    SSEA-1-positive fibronectin is secreted by cells deviated from the undifferentiated state of human induced pluripotent stem cells
    Biochem Biophys Res Commun. 529 (3) 575-581;(2020) doi:10.1016/j.bbrc.2020.06.074
  • Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M
    Sialyl-Lewis(X) Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy
    Cell Rep. Aug 4;32(5):107991. (2020) doi: 10.1016/j.celrep.2020.107991
  • Oinam L, Changarathil G, Raja E, Ngo YX, Tateno H, Sada A, Yanagisawa H
    Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging
    Aging Cell. 35: 0 (2020) doi:10.1111/acel.13190
  • Haramoto Y, Onuma Y, Mawaribuchi S, Nakajima Y, Aiki Y, Higuchi K, Shimizu M, Tateno H, Hirabayashi J, Ito Y.
    A technique for removing tumourigenic pluripotent stem cells using rBC2LCN lectin.
    Regen Ther. 14: 306-314 (2020) doi: 10.1016/j.reth.2020.03.017
  • Tateno H*
    Expression and Purification of a Human Pluripotent Stem Cell-Specific Lectin Probe, rBC2LCN
    Methods Mol Biol. 9084: 30080-8 (2020) doi: 10.1007/978-1-0716-0430-4_44
  • Mawaribuchi S, Haramoto Y, Tateno H, Onuma Y, Aiki Y, Ito Y
    rBC2LCN lectin as a potential probe of early-stage HER2-positive breast carcinoma
    FEBS Open Bio 10: 1056-1064 (2020) doi: 10.1002/2211-5463.12852
  • Giron LB, Tanes CE, Schleimann MH, Engen PA, Mattei LM, Anzurez A, Damra M, Zhang HJ, Bittinger K, Bushman F, Kossenkov A, Denton PW, Tateno H, Keshavarzian A, Landay AL, Abdel-Mohsen M
    Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection
    Mucosal Immunology 129: 215-222 (2020) doi: 10.1038/s41385-020-0279-5
  • Giron LB, Papasavvas E, Azzoni L, Yin XF, Anzurez A, Damra M, Mounzer K, Kostman JR, Sanne I, Firnhaber CS, Tateno H, Liu Q, Montaner LJ, Abdel-Mohsen M
    Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint
    Aids 34 34: 681-686 (2020) doi: 10.1097/QAD.0000000000002476
  • Tateno H*, Hiemori K, Minoshima F, Kiyoi K, Matoba K, Katayama J, Kumada Y
    Oriented immobilization of rBC2LCN lectin for highly sensitive detection of human pluripotent stem cells using cell culture supernatants
    J Biosci Bioeng. 129: 215-222 (2020) doi: 10.1016/j.jbiosc.2019.08.003
  • Ogita Y, Mawaribuchi S, Nakasako K, Tamura K, Matsuda M, Katsumura T, Oota H, Watanabe G, Yoneda S, Takamatsu N, Ito M
    Parallel Evolution of Two dmrt1-Derived Genes, dmy and dm-W, for Vertebrate Sex Determination
    iScience 23: 100757 (2020) doi: 10.1016/j.isci.2019.100757
  • Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A
    Clec10a regulates mite-induced dermatitis
    Science Immunology 4 4: 0 (2019) doi: 10.1126/sciimmunol.aax6908
  • Ogawa T, Sato R, Naganuma T, Liu K, Lakudzala AE, Muramoto K, Osada M, Yoshimi K, Hiemori K, Hirabayashi J, Tateno H
    Glycan Binding Profiling of Jacalin-Related Lectins from the Pteria Penguin Pearl Shell
    Int J Mol Sci. 20: 0 (2019) doi: 10.3390/ijms20184629
  • Mawaribuchi S*, Ito Y, Ito M*
    Independent evolution for sex determination and differentiation in the DMRT family in animals
    Biology Open 8: 10 (2019) doi: 10.1242/bio.041962
  • Mawaribuchi S, Aiki Y, Ikeda N, Ito Y
    mRNA and miRNA expression profiles in an ectoderm-biased substate of human pluripotent stem cells
    Scientific Reports 189: 233-248 (2019) doi: 10.1038/s41598-019-48447-z
  • Yamasaki K, Kubota T, Yamasaki T, Nagashima I, Shimizu H, Terada RI, Nishigami H, Kang J, Tateno M, Tateno H
    Structural basis for specific recognition of core fucosylation in N-glycans by Pholiota squarrosa lectin (PhoSL
    Glycobiology. 29: 576-587 (2019) doi: 10.1093/glycob/cwz025
  • Oguma K, Sato T, Kawahara T, Haramoto Y, Yamanishi Y
    Identification of Aquatic Organisms Using a Magneto-Optical Element
    Sensors 19: 3254 (2019) doi: 10.3390/s19153254
  • Khummuang S, Chuensirikulchai K, Pata S, Laopajon W, Chruewkamlow N, Mahasongkram K, Sugiura N, Watanabe H, Tateno H, Kamuthachad L, Wongratanacheewin S, Takheaw N, Kasinrerk W
    Characterization and functional analysis of novel circulating NK cell sub-populations
    Int Immunol. 31: 515-530 (2019) doi: 10.1093/intimm/dxz027
  • Tateno H*
    Human Stem Cell Glycome: From Structural Elucidation to Social Implementation
    Trends In Glycoscience And Glycotechnology 31: 0 (2019) doi: 10.4052/tigg.1939.2SE
  • Mawaribuchi S, Onuma Y, Aiki Y, Kuriyama Y, Mutoh M, Fujii G, Ito, Y
    The rBC2LCN-positive subpopulation of PC-3 cells exhibits cancer stem-like properties
    Biochem Biophys Res Commun. 515: 176-182 (2019) doi: 10.1016/j.bbrc.2019.05.108
  • Matsunami M, Suzuki M, Haramoto Y, Fukui A, Inoue T, Yamaguchi K, Uchiyama I, Mori K, Tashiro K, Ito Y, Takeuchi T, Suzuki KT, Agata K, Shigenobu S, Hayashi T
    A comprehensive reference transcriptome resource for the Iberian ribbed newt Pleurodeles waltl, an emerging model for developmental and regeneration biology
    DNA Res. 26: 217-229 (2019) doi: 10.1093/dnares/dsz003
  • Dion J, Minoshima F, Saito S, Kiyoi K, Hasehira K, Tateno H*
    Photoactivable Elimination of Tumorigenic Human Induced Pluripotent Stem Cells by Using a Lectin-Doxorubicin Prodrug Conjugate
    Chembiochem. 20: 1606-1611 (2019) doi: 10.1002/cbic.201900086
  • Yamazaki T, Inui M, Hiemori K, Tomono S, Itoh M, Ichimonji I, Nakashima A, Takagi H, Biswas M, Izawa K, Kitaura J, Imai T, Sugiura N, Tateno H, Akashi-Takamura S
    Receptor-destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis
    J Biol Chem. 294: 6659-6669 (2019) doi: 10.1074/jbc.RA118.006375
  • Kondo M, Matsuo M, Igarashi K, Haramoto Y, Yamamoto T, Yasuoka Y, Taira M
    De novo transcription of multiple Hox cluster genes takes place simultaneously in early Xenopus tropicalis embryos
    Biology Open 8: bio038422 (2019) doi: 10.1242/bio.038422
  • Yokoyama H, Moreno-Andres D, Astrinidis SA, Hao Y, Weberruss M, Schellhaus AK, Lue H, Haramoto Y, Gruss OJ, Antonin W
    Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome
    Life Sci Alliance. 2: e201800120 (2019) doi: 10.26508/lsa.201800120
  • Sakai K, Hiemori K, Tateno H, Hirabayashi J, Gonoi T
    Fucose-specific lectin of Aspergillus fumigatus: binding properties and effects on immune response stimulation
    Med Mycol. 57: 71-83 (2019) doi: 10.1093/mmy/myx163
  • Omata Y, Aoki R, Aoki-Yoshida A, Hiemori K, Toyoda A, Tateno H, Suzuki C, Takayama Y
    Reduced fucosylation in the distal intestinal epithelium of mice subjected to chronic social defeat stress
    Sci Rep. 8: 13199 (2018) doi: 10.1038/s41598-018-31403-8
  • Unno H, Nakamura A, Mori S, Goda S, Yamaguchi K, Hiemori K, Tateno H, Hatakeyama T
    Identification, Characterization, and X-ray Crystallographic Analysis of a Novel Type of Lectin AJLec from the Sea Anemone Anthopleura japonica
    Sci Rep. 8: 11516 (2018) doi: 10.1038/s41598-018-29498-0
  • Hirabayashi J, Hu D, Tateno H, Kuwabara N, Kato R, Yagi F
    Carbohydrate Recognition Mechanism of the Mushroom Galectin ACG
    Trends In Glycoscience And Glycotechnology 30: 0 (2018) doi: 10.4052/tigg.1736.1SE
  • Yamasaki K, Yamasaki T, Tateno H
    The trimeric solution structure and fucose-binding mechanism of the core fucosylation-specific lectin PhoSL
    Sci Rep. 8: 7740 (2018) doi: 10.1038/s41598-018-25630-2
  • Nakagawa Y, Tateno H, Ebara M
    Investigation of Selective Recognition of Sugars Using Lectin-inspired Temperature-responsive Polymers
    Chemistry Letters 47: 134-137 (2018) doi: 10.1246/cl.170967
  • Saito S, Hiemori K, Kiyoi K, Tateno H*
    Glycome analysis of extracellular vesicles derived from human induced pluripotent stem cells using lectin microarray
    Sci Rep. 8: 3997 (2018) doi: 10.1038/s41598-018-22450-2
  • Shimomura O, Oda T, Tateno H, Ozawa Y, Kimura S, Sakashita S, Noguchi M, Hirabayashi J, Asashima M, Ohkohchi N
    A Novel Therapeutic Strategy for Pancreatic Cancer: Targeting Cell Surface Glycan Using rBC2LC-N Lectin-Drug Conjugate (LDC
    Mol Cancer Ther. 17: 183-195 (2018) doi: 10.1158/1535-7163.MCT-17-0232
  • Ishii N
    Folding and Binding Properties of Human Complement Receptor Type 1 Extracellular Domain
    Peripheral Membrane Proteins 1: 105-122, (2018) doi:10.5772/intechopen.75120
  • Hasehira K, Hirabayashi J, Tateno H*
    Structural and quantitative evidence of alpha2-6-sialylated N-glycans as markers of the differentiation potential of human mesenchymal stem cells
    Glycoconj J. 34: 797-806 (2017) doi: 10.1007/s10719-016-9699-6
  • Nagae M, Mishra SK, Hanashima S, Tateno H, Yamaguchi Y
    Distinct roles for each N-glycan branch interacting with mannose-binding type Jacalin-related lectins Orysata and Calsepa
    Glycobiology. 27: 1120-1133 (2017) doi: 10.1093/glycob/cwx081
  • Dion J, Advedissian T, Storozhylova N, Dahbi S, Lambert A, Deshayes F, Viguier M, Tellier C, Poirier F, Teletchea S, Dussouy C, Tateno H, Hirabayashi J, Grandjean C
    Development of a Sensitive Microarray Platform for the Ranking of Galectin Inhibitors: Identification of a Selective Galectin-3 Inhibitor
    Chembiochem. 18: 2428-2440 (2017) doi: 10.1002/cbic.201700544
  • Fujimaki S, Kuwabara T
    Diabetes-Induced Dysfunction of Mitochondria and Stem Cells in Skeletal Muscle and the Nervous System
    Int J Mol Sci. 18: 0 (2017) doi: 10.3390/ijms18102147
  • Fujimaki S, Kuwabara T
    Diabetes-Induced Dysfunction of Mitochondria and Stem Cells in Skeletal Muscle and the Nervous System
    INTERNATIONAL J. Molecular Sciences 18: 10 (2017) doi: 10.3390/ijms18102147
  • Yagi H, Tateno H, Hayashi K, Hayashi T, Takahashi K, Hirabayashi J, Kato K, Tsuboi M
    Lectin microarray analysis of isolated polysaccharides from Sasa veitchii
    Biosci Biotechnol Biochem. 81: 1687-1689 (2017) doi: 10.1080/09168451.2017.1340089
  • Hatakeyama T, Ichise A, Unno H, Goda S, Oda T, Tateno H, , Hirabayashi J, Sakai H, Nakagawa H
    Carbohydrate recognition by the rhamnose-binding lectin SUL-I with a novel three-domain structure isolated from the venom of globiferous pedicellariae of the flower sea urchin Toxopneustes pileolus
    Protein Science 26: 1574-1583 (2017) doi: 10.1002/pro.3185
  • Tateno H*, Saito S
    Engineering of a Potent Recombinant Lectin-Toxin Fusion Protein to Eliminate Human Pluripotent Stem Cells
    Molecules. 22: 0 (2017) doi: 10.3390/molecules22071151
  • Haramoto Y, Saijyo T, Tanaka T, Furuno N, Suzuki A, Ito Y, Kondo M, Taira M, Takahashi S
    Identification and comparative analyses of Siamois cluster genes in Xenopus laevis and tropicalis
    Dev Biol. 426: 374-383 (2017) doi: 10.1016/j.ydbio.2016.07.015
  • Itakura Y, Nakamura-Tsuruta S, Kominami J, Tateno H, Hirabayashi J
    Sugar-Binding Profiles of Chitin-Binding Lectins from the Hevein Family: A Comprehensive Study
    INTERNATIONAL J. Molecular Sciences 18: 10 (2017) doi: 10.3390/ijms18061160
  • Sato T, Tateno H, Kaji H, Chiba Y, Kubota T, Hirabayashi J, Narimatsu H
    Engineering of recombinant Wisteria floribunda agglutinin specifically binding to GalNAcbeta1,4GlcNAc (LacdiNAc
    Glycobiology. 0: 0 (2017) doi: 10.1093/glycob/cwx038
  • Nakata H, Lin CY, Abolhassani M, Ogawa T, Tateno H, Hirabayashi J, Muramoto K
    Isolation of Rice Bran Lectins and Characterization of Their Unique Behavior in Caco-2 Cells
    Int J Mol Sci. 18: 0 (2017) doi: 10.3390/ijms18051052
  • Ishii N
    Electron microscopic and physicobiochemical studies of chaperonin GroEL and GroES complexes.
    Microscopy and imaging science: practical approaches to applied research and education 7: 112-119 (2017)
  • Ishii N
    GroEL and the GroEL-GroES Complex
    Macromolecular Protein Complexes: Structure And Function 83: 483 (2017) doi: 10.1007/978-3-319-46503-6_17
  • Ishii N
    GroEL and the GroEL-GroES Complex
    Subcell Biochem. 7: 11563 (2017) doi: 10.1007/978-3-319-46503-6_17
  • Yamamoto YY, Uno Y, Sha E, Ikegami K, Ishii N, Dohmae N, Sekiguchi H, Sasaki YC, Yohda M
    Asymmetry in the function and dynamics of the cytosolic group II chaperonin CCT/TRiC
    PloS One. 12: 0 (2017) doi: 10.1371/journal.pone.0176054
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