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Healthy Food Science Research Group


Project1:Development of antiaging technology using chrono-nutrition
Researcher:Katsutaka Oishi and Tomoyuki Sato

Japan is a super-aged society. In order to achieve an extension of the healthy life expectancy, it is important to prevent aging-related diseases such as sleep disorders and impaired cognition. Recent studies have revealed that circadian clock is involved in the onset of these aging-related diseases. This “Chrono-nutrition” project is focused on the development of natural substances and technologies for the prevention of sleep disorders, psychiatric diseases, impaired cognition, and metabolic diseases such as obesity and diabetes.

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Project2:Research of natural products maintaining health for metabolic syndrome and heart diseases
Researcher:Papawee Saiki and Yasuhiro Kawano

Recently, we are in an aging society, the development of functional substances that help to lead a healthy life is an important research topic. Therefore, we are developing a bioassay system based on luminescence imaging to search for various health-maintaining functional substances, and searching for functional substances that are effective in metabolic syndrome, allergic response, mental syndrome, etc.

Healthy Food Science Research Group03


Project3:Development of novel diet therapy for skeletal muscle health
Researcher:Yuri Hashimoto, Tomoki Abe

Skeletal muscle comprises about 40% of body weight in human and plays important roles in regulate energy metabolism and brain function. We aim to develop a novel diet therapy to improve quality and quantity of skeletal muscle.

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Name Position
OOISHI Katsutaka Research Group Leader
KAWANO Yasuhiro Senior Researcher
YASUNO Rie Senior Researcher
SAIKI Papawee Researcher
ABE Tomoki Researcher
HASHIMOTO Yuri Researcher
SATO Tomoyuki Researcher


  • Yamamoto K, Honda T, Yokoyama S, Ma L, Kato A, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Kawashima H, Ishigami M, Tsuji NM, Fujishiro M
    Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine
    Dig Liver Dis. 2021 Mar 13:S1590-8658(21)00081-5. doi: 10.1016/j.dld.2021.02.013
  • Ueoka R, Hashimoto J, Kozone I, Hashimoto T, Kudo K, Kagaya N, Suenaga H, Ikeda H, Shin-Ya K
    A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900.
    BIOSCI BIOTECHNOL BIOCHEM. 2020 Dec 22:zbaa111. doi: 10.1093/bbb/zbaa111
  • Saito S, Kakizaki N, Okuno A, Maekawa T, Tsuji NM
    Lactococcus lactis subsp. Cremoris C60 restores T Cell Population in Small Intestinal Lamina Propria in Aged Interleukin-18 Deficient Mice
    Nutrients.12(11):E3287. (2020) doi: 10.3390/nu12113287
  • Ueoka R, Shinzato N, Kagaya N, Suenaga H, Shin-Ya K
    Pseudoalteropeptide A, a novel lipopeptide from the marine bacterium Pseudoalteromonas piscicida SWA4_PA4 isolated from marine seaweed
    J Antibiot (Tokyo). 2020 Oct 15. (2020) doi: 10.1038/s41429-020-00377-z
  • Saiki P, Kawano Y, Ogi T, Klungsupya P, Muangman T, Phantanaprates W, Kongchinda P, Pinnak N, Miyazaki K
    Purified Gymnemic Acids from Gymnema inodorum Tea Inhibit 3T3-L1 Cell Differentiation into Adipocytes
    Nutrients. ;12(9):E2851. (2020) doi: 10.3390/nu12092851
  • Abe T, Yamamoto S, Konishi T, Takahashi Y, Oishi K
    Maternal fish oil supplementation ameliorates maternal high-fructose diet-induced dyslipidemia in neonatal mice with suppression of lipogenic gene expression in livers of postpartum mice
    Nutr Res.;82:34-43. (2020) doi: 10.1016/j.nutres.2020.07.003
  • Li X, Wang X, Ito A, Tsuji NM
    A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity
    Nat Commun. 11:3858.(2020) doi: 10.1038/s41467-020-17637-z
  • Sakamoto K, Higo-Yamamoto S, Egi Y, Miyazaki K, Oishi K.
    Memory dysfunction and anxiety-like behavior in a mouse model of chronic sleep disorders.
    BIOCHEM BIOPHYS RES COMMUN. 529:175-179. (2020) doi:10.1016/j.bbrc.2020.05.218
  • Hishiki H, Kawashima T, Tsuji NM, Ikari N, Takemura R, Kido H, Shimojo N
    A Double-Blind, Randomized, Placebo-Controlled Trial of Heat-Killed Pediococcus acidilactici K15 for Prevention of Respiratory Tract Infections among Preschool Children
    Nutrients. 12: 0 (2020) doi:10.3390/nu12071989
  • Kimura Y, asuno R, Watanabe M, Kobayashi M, Iwaki T, Fujimura C, Ohmiya Y, Yamakage K, Nakajima Y, Kobayashi M, Mashimo N, Takagi Y, Omori T, Corsini E, Germolec D, Inoue T, Rogen EL, Kojima H, Aiba S
    An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals
    Toxicol In Vitro 66: 104832 (2020) doi: 10.1016/j.tiv.2020.104832
  • Prapaipat K, Saiki P, Bhusita, W, Supatjaree R, Thanchanok M, Nantana B, Weerasak, T
    Probiotic property and biological activities of Bifidobacterium animalis subsp. lactis TISTR 2591 isolated from Thai population.
    WJARR 5: 149-162 (2020) doi: 10.30574/wjarr.2020.5.3.0072
  • Hashimoto T, Kozone I, Hashimoto J, Ueoka R, Kagaya N, Fujie M, Sato N, Ikeda H, Shin-ya K
    Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908
    J. Antibiotics 73: 171-174 (2020) doi: 10.1038/s41429-019-0265-x
  • Okauchi H, Higo-Yamamoto S, Sowa T, Oike H, Yamamoto S, Wada N, Sakamoto K, Oishi K
    Chronically skipping breakfast impairs hippocampal memory-related gene expression and memory function accompanied by reduced wakefulness and body temperature in mice
    Biochem Biophys Res Commun. 524: 129-134 (2020) doi: 10.1016/j.bbrc.2020.01.077
  • Oishi K, Okauchi H, Yamamoto S, Higo-Yamamoto S
    Dietary natural cocoa ameliorates disrupted circadian rhythms in locomotor activity and sleep-wake cycles in mice with chronic sleep disorders caused by psychophysiological stress
    Nutrition. 75-76: 110751 (2020) doi: 10.1016/j.nut.2020.110751
  • Nakao R, Abe T, Yamamoto S, Oishi K
    Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice
    Sci Rep. 9: 19652 (2019) doi: 10.1038/s41598-019-56166-8
  • Abe T, Kazama R, Okauchi H, Oishi K
    Food deprivation during active phase induces skeletal muscle atrophy via IGF-1 reduction in mice
    Arch Biochem Biophys. 677: 1080160 (2019) doi: 10.1016/
  • Oike H, Ogawa Y, Oishi K
    Simple and Quick Visualization of Periodical Data Using Microsoft Excel
    Methods Protoc. 2: 81 (2019) doi: 10.3390/mps2040081
  • Saiki P, Kawano Y, Nakajima Y, Van Griensven LJLD, Miyazaki K
    Novel and Stable Dual-Color IL-6 and IL-10 Reporters Derived from RAW 264.7 for Anti-Inflammation Screening of Natural Products
    Int J Mol Sci. 20: 4620 (2019) doi: 10.3390/ijms20184620
  • Mitani Y, Yasuno R, Futahashi R, Oakley TH, Ohmiya Y
    Luciferase gene of a Caribbean fireworm (Syllidae) from Puerto Rico
    Sci Rep. 9: 13015 (2019) doi: 10.1038/s41598-019-49538-7
  • Wang XP, Ihara S, Li X, Ito A, Sogo Y, Watanabe Y, Yamazaki A, , Tsuji NM, Ohno T
    Rod-Scale Design Strategies for Immune-Targeted Delivery System toward Cancer Immunotherapy
    Acs Nano 13: 7705-7715 (2019) doi: 10.1021/acsnano.9b01271
  • Gabriel GVD, Yasuno R, Mitani Y, Ohmiya Y, Viviani VR
    Novel application of Macrolampis sp2 firefly luciferase for intracellular pH-biosensing in mammalian cells
    Photochemical 18: 1212-1217 (2019) doi: 10.1039/c8pp00573g
  • Katsuki R, Sakata S, Nakao R, Oishi K, Nakamura Y
    Lactobacillus curvatus CP2998 Prevents Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes
    J Nutr Sci Vitaminol 65: 455-458 (2019) doi: 10.3177/jnsv.65.455
  • Ohta M, Fujinami A, Oishi K, Kobayashi N, Ohnishi K, Ohkura N
    Ashitaba (Angelica Keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice
    J Diet Suppl. 16: 331-344 (2019) doi: 10.1080/19390211.2018.1458366
  • Higo-Yamamoto S, Yamamoto S, Miyazaki K, Nakakita Y, Kaneda H, Takata Y, Nakamura T, Oishi K
    Dietary Heat-Killed Lactobacillus brevis SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice
    J Nutr Sci Vitaminol 65: 164-170 (2019) doi: 10.3177/jnsv.65.164
  • Adachi T, Yoshikawa S, Tezuka H, Tsuji NM, Ohteki T, Karasuyama H, Kumazawa T
    Propolis induces Ca2+ signaling in immune cells
    Biosci Microbiota Food Health 38: 141-149 (2019) doi: 10.12938/bmfh.19-011
  • Oishi K, Okauchi H
    Functional CLOCK Is Not Essentially Associated with Metabolic Disruption Caused by Sleep Phase Feeding in Mice
    Biol Pharm Bull. 42: 1038-1043 (2019) doi: 10.1248/bpb.b19-00018
  • Akimoto H, Oshima S, Sugiyama T, Negishi A, Nemoto T, Kobayashi D
    Changes in brain metabolites related to stress resilience: Metabolomic analysis of the hippocampus in a rat model of depression
    Behav Brain Res. 34: 89-94 (2019) doi: 10.1016/j.bbr.2018.11.017
  • Wang X, Ihara S, Li X, Ito A, Sogo Y, Watanabe Y, Tsuji NM, Yamazaki A
    Si-doping increases the adjuvant activity of hydroxyapatite nanorods
    Colloids Surf B Biointerfaces. 174: 300-307 (2019) doi: 10.1016/j.colsurfb.2018.11.026
  • Okauchi H, Hashimoto C, Nakao R, Oishi K
    Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice
    Chronobiol Int. 36: 57-74 (2019) doi: 10.1080/07420528.2018.1516672
  • Carreras J, Lopez-Guillermo A, Kikuti YY, Itoh J, Masashi M, Ikoma H, Tomita S, Hiraiwa S, Hamoudi R, Rosenwald A, Leich E, Martinez A, Roncador G, Villamor N, Colomo L, Perez P, Tsuji NM, Campo E, Nakamura N.
    High TNFRSF14 and low BTLA are associated with poor prognosis in Follicular Lymphoma and in Diffuse Large B-cell Lymphoma transformation.
    J Clin Exp Hematop. 59: 1-16 (2019) doi: 10.3960/jslrt.19003
  • Shibakami M, Sohma M, Kijima N, Nemoto T
    Melt spinnabilities of thermoplastic paramylon mixed esters
    Heliyon. 5: e02843 (2019) doi: 10.1016/j_heliyon_2019.e02843
  • 藤原 正子, 安藤 一郎, 根本 直, 石田 亜希, 阿部 未奈, 大槻 剛, 宍戸 洋, 今井 潤, 寺脇 博之
    血液濾過透析が糖尿病性腎臓病 (diabetic kidney disease: DKD) 由来腎不全患者のアミノ酸動態に及ぼす影響 : 予備的検討
    日本透析医学会雑誌 52: 457-462 (2019) doi: 10.4009/jsdt52.457
  • Shibakami M, Nemoto T, Sohoma M.
    Dependence of dissolution, dispersion, and aggregation characteristics of cationic polysaccharides made from euglenoid β-1,3-glucan on degree of substitution
    CELLULOSE 25: 2217-2234 (2018) doi: 10.1007/s10570-018-1740-4
  • Akimoto H, Oshima S, Michiyama Y, Negishi A, Nemoto T, Kobayashi D
    Metabolic Profiling of the Hippocampus of Rats Experiencing Nicotine-Withdrawal Symptoms
    Biol Pharm Bull. 41: 1879-1884 (2018) doi: 10.1248/bpb.b18-00486
  • Saiki P, Nakajima Y, Van Griensven LJLD, Miyazaki K
    Real-time monitoring of IL-6 and IL-10 reporter expression for anti-inflammation activity in live RAW 264.7cells
    Biochem Biophys Res Commun. 505: 885-890 (2018) doi: 10.1016/j.bbrc.2018.09.173
  • Oishi K, Hashimoto C
    Short-term time-restricted feeding during the resting phase is sufficient to induce leptin resistance that contributes to development of obesity and metabolic disorders in mice
    Chronobiol Int. 35: 1576-1594 (2018) doi: 10.1080/07420528.2018.1496927
  • Lv Y, Cui M, Lv Z, Lu J, Zhang X, Zhao Z, Wang Y, Gao L, Tsuji NM, Yan H
    Expression and significance of peripheral myeloid-derived suppressor cells in chronic hepatitis B patients
    Clin Res Hepatol Gastroenterol. 42: 462-469 (2018) doi: 10.1016/j.clinre.2018.04.002
  • Wada T, Ichihashi Y, Suzuki E, Kosuge Y, Ishige K, Uchiyama T, Makishima M, Nakao R, Oishi K, Shimba S
    Deletion of Bmal1 Prevents Diet-Induced Ectopic Fat Accumulation by Controlling Oxidative Capacity in the Skeletal Muscle
    Int J Mol Sci. 19: 2813 (2018) doi: 10.3390/ijms19092813
  • Mitani Y, Yasuno R, Isaka M, Mitsuda N, Futahashi R, Kamagata Y, Ohmiya Y
    Novel gene encoding a unique luciferase from the fireworm Odontsyllis undecimdonta
    Sci Rep. 8: 12789 (2018) doi: 10.1038/s41598-018-31086-1
  • Yasuno R, Mitani Y, Ohmiya Y
    Effects of N-Glycosylation Deletions on Cypridina Luciferase Activity
    Photochem Photobiol. 94: 338-342 (2018) doi: 10.1111/php.12847
  • Kawashima T, Ikari N, Kouchi T, Kowatari Y, Kubota Y, Shimojo N, Tsuji NM
    The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial
    Sci Rep. 8: 5065 (2018) doi: 10.1038/s41598-018-23404-4
  • Oishi K, Konishi T, Hashimoto C, Yamamoto S, Takahashi Y, Shiina Y
    Dietary fish oil differentially ameliorates high-fructose diet-induced hepatic steatosis and hyperlipidemia in mice depending on time of feeding
    J Nutr Biochem. 42: 462-469 (2018) doi: 10.1016/j.jnutbio.2017.09.024
  • Oishi KOishi K, Ohyama S, Higo-Yamamoto S
    Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice
    Biochem Biophys Res Commun. 495: 2616-2621 (2018) doi: 10.1016/j.bbrc.2017.12.158
  • Kawashima T, Ikari N, Watanabe Y, Kubota Y, Yoshio S, Kanto T, , Motohashi S, Shimojo N, Tsuji NM
    Double-Stranded RNA Derived from Lactic Acid Bacteria Augments Th1 Immunity via Interferon-beta from Human Dendritic Cells
    Front Immunol. 9: 27 (2018) doi: 10.3389/fimmu.2018.00027
  • Ohkura N, Kihara-Negishi F, Fujii A, Kanouchi H, Oishi K, Atsumi G, Nagano M
    Effects of fermented rice vinegar Kurozu and its sediment on inflammation-induced plasminogen activator inhibitor 1 (PAI-1) increase.
    Food and Nutrition Sciences 9: 235-246 (2018). doi: 10.4236/fns.2018.93018
  • Wang XP, Li X, Ito A, Sogo Y, Watanabe Y, Tsuji NM, Ohno T
    Biodegradable Metal Ion-Doped Mesoporous Silica Nanospheres Stimulate Anticancer Th1 Immune Response in Vivo
    Acs Applied Materials 9: 43538-43544 (2017) doi: 10.1021/acsami.7b16118
  • Saiki P, Kawano Y, Van Griensven LJLD, Miyazaki K
    The anti-inflammatory effect of Agaricus brasiliensis is partly due to its linoleic acid content
    Food Funct. 8: 4150-4158 (2017) doi: 10.1039/c7fo01172e
  • Wang X, Li X, Ito A, Sogo Y, Watanabe Y, Tsuji NM
    Hollow ZnO Nanospheres Enhance Anticancer Immunity by Promoting CD4(+) and CD8(+) T Cell Populations In Vivo
    Small. 13: 1701816 (2017) doi: 10.1002/smll.201701816
  • Akimoto H, Oshima S, Ohara K, Negishi A, Hiroyama H, Nemoto T, Kobayashi D
    High-Resolution Magic-Angle Spinning-(1)H-NMR Spectroscopy-Based Metabolic Profiling of Hippocampal Tissue in Rats with Depression-Like Symptoms
    Biol Pharm Bull. 40: 789-796 (2017) doi: 10.1248/bpb.b16-00783
  • Nakao R, Okauchi H, Hashimoto C, Wada N, Oishi K
    Determination of reference genes that are independent of feeding rhythms for circadian studies of mouse metabolic tissues
    Mol Genet Metab. 121: 190-197 (2017) doi: 10.1016/j.ymgme.2017.04.001
  • Nakao R, Shimba S, Oishi K
    Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis
    Sci Rep. 7: 2885 (2017) doi: 10.1038/s41598-017-03119-8
  • Oishi K, Ohkura N, Yasumoto Y, Yamamoto S
    Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice
    Chronobiol Int. 34: 254-259 (2017) doi: 10.1080/07420528.2016.1256299
  • Lu JH, Lv Y, Dai EH, Liu YZ, Gao HX, Tsuji NM, Yan H
    Profile and clinical relevance of autoantibodies in patients with chronic hepatitis B infection
    Int. J. Clin. Exp. Med. 10: 3568-3574 (2017) doi:
  • Akitomo S, Egi Y, Nakamura Y, Suetsugu Y, Oishi K, Sakamoto K
    Genome-wide microarray screening for Bombyx mori genes related to transmitting the determination outcome of whether to produce diapause or nondiapause eggs
    Insect Sci. 24: 187-193 (2017) doi: 10.1111/1744-7917.12297
  • Horikawa K, Hashimoto C, Kukuchi Y, Makita M, Fukudome S, Okita K, Wada N, Oishi K
    Wheat alkylresorcinols reduce micellar solubility of cholesterol in vitro and increase cholesterol excretion in mice.
    Nat Prod Res 31: 578-582 (2017). doi: 10.1080/14786419.2016.1198347
  • Oishi K, Yamamoto S, Oike H, Ohkura N, Taniguchi M
    Cinnamic acid shortens the period of the circadian clock in mice.
    Biochem Biophys Rep 9: 232-237 (2017). doi: 10.1016/j.bbrep.2016.12.008
  • Oishi K, Yasumoto Y, Higo-Yamamoto S, Yamamoto S, Ohkura N
    Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: differences between endogenous and exogenous insulin effects.
    Biochem Biophys Res Commun 483: 165-170 (2017). doi: 10.1016/j.bbrc.2016.12.173
  • Nakao R, Nikawa T, Oishi K
    The skeletal muscle circadian clock: current insights.
    ChronoPhysiology and Therapy 7: 47-57 (2017). doi: 10.2147/CPT.S116569
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