Cellular Presymptomatic Engineering Research Group

Research Project

Aging is a risk factor for various neurological diseases such as ALS and Alzheimer's disease. In recent years, there has been a growing interest in the development of methods to control and visualize liquid-liquid phase separation for the fundamental treatment and early diagnosis of neurological diseases associated with this aging process. Using the short-lived nematode C. elegans, I am developing a high-throughput evaluation system for human cells. In addition, I am also exploring functional substances that contribute to disease prevention and preemptive measures by utilizing these evaluation systems.

Japan is a super-aged society. In order to achieve an extension of the healthy life expectancy, it is important to prevent aging-related diseases such as sleep disorders and impaired cognition. Recent studies have revealed that circadian clock is involved in the onset of these aging-related diseases. This “Chrono-nutrition” project is focused on the development of natural substances and technologies for the prevention of sleep disorders, psychiatric diseases, impaired cognition, and metabolic diseases such as obesity and diabetes.

Elucidation of the mechanisms between depression and related multiple disorders. Identification of gene expression mechanism, cell regulatory systems in multiple organs. Development of diagnostic techniques for diabetes, psychiatric and neurological disorders. Establishment of innovative strategies for diagnosis, prevention, and treatment of depression and related disorders.

Skeletal muscle comprises about 40% of body weight in human and plays important roles in regulate energy metabolism and brain function. We aim to develop a novel diet therapy to improve quality and quantity of skeletal muscle.

Psychological stress is known to increase the risk of developing liver and heart diseases. This project aims to elucidate the effects of psychological stress on the liver and heart using mainly social psychological stress model mice, and to develop pre-disease markers that can predict disease onset. In addition, we are working on elucidating the mechanisms of onset of liver and neurological diseases using cultured cells and isolated mitochondria, as well as developing intervention methods based on lifestyle habits.

In super-aged societies, extending healthy life expectancy is a critical issue. Aging is known to increase the risk of various diseases such as cancer and dementia. To address this, our research aims to elucidate the molecular mechanisms of aging by exploring aging-related factors using aging-accelerated model mice. Furthermore, we focus on exercise, which is believed to support health from the pre-disease stage and conduct exercise intervention experiments using laboratory animals. In parallel, we are also developing exercise-mimicking technologies at the cellular level to replicate its physiological effects. Through these studies, we aim to uncover novel molecular mechanisms involved in aging and pre-disease progression, as well as to clarify the scientific basis for the health benefits of exercise.

Results

• Ohkura, N; Morimoto-Kamata ,R; Kamikubo, Y; Takahashi, Y; Oishi, K.
  Hypofibrinolytic phenotype in Tsumura Suzuki Obese Diabetes (TSOD) mice unrelated to hyperglycemia.
  Drug Discov Ther. 2023 Nov 18;17(5):346-350. doi: 10.5582/ddt.2023.01064
• Ohkura, N; Morimoto-Kamata, R; Oishi, K; Higo-Yamamoto, S; Fujinami, A; Inoue, KI; Ohta, M.
  Supplementation with Ashitaba (Angelica keiskei) yellow stem exudate prevents aging-induced thrombotic tendencies and systemic inflammation without affecting body weight gain in mice.
  J Med Food. 2023 Nov;26(11):843-848. doi: 10.1089/jmf.2023.K.0140
• Oishi, K; Yajima, Y; Yoshida, Y; Hagihara, H; Miyakawa, T; Higo-Yamamoto, S; Toyoda, A.
  Metabolic profiles of saliva in male mouse models of chronic sleep disorders induced by psychophysiological stress.
  Sci Rep. 2023;13(1):11156. doi: 10.1038/s41598-023-38289-1
• Hagihara, H; Shoji, H; Hattori, S; Sala, G; Takamiya, Y; Tanaka, M; Ihara, M; Shibutani, M; Hatada, I; Hori, K;... Oishi, K; ... Miyakawa, T.
  Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
  Elife. 2024 Mar 26:12:RP89376. doi: 10.7554/eLife.89376
• Kanie, S; Wu, C; Kihira, K; Yasuno, R; Mitani, Y; Ohmiya, Y.
  Bioluminescence of (R)-Cypridina Luciferin with Cypridina Luciferase.
  INT J MOL SCI. 2024 Feb 26;25(5):2699. doi: 10.3390/ijms25052699
• Sato, T; Oishi, K.
  Time-restricted feeding has a limited effect on hepatic lipid accumulation, inflammation and fibrosis in a choline-deficient high-fat diet-induced murine NASH model.
  PLOS ONE. 2024 Jan 29;19(1):e0296950. doi: 10.1371/journal.pone.0296950
• Sato, T; Ochiishi, T; Higo-Yamamoto, S; Oishi, K.
  Circadian and sleep phenotypes in a mouse model of Alzheimers disease characterized by intracellular accumulation of amyloid β oligomers.
  EXP ANIM. 2023 Dec 14. doi: 10.1538/expanim.23-0104
• Roberts, MD; McCarthy, JJ; Hornberger, TA; Phillips, SM; Mackey, AL; Nader, GA; Boppart, MD; Kavazis, AN; Reidy, PT; Ogasawara, R, Libardi, CA; Ugrinowitsch, C; Booth, FW; Esser, KA.
  Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.
  PHYSIOL REV. 2023 Jun 29. doi: 10.1152/physrev.00039.2022
• Zhuang, HT; Fujikura, Y, Ohkura, N; Higo-Yamamoto, S; Mishima, T; Oishi, K.
  A ketogenic diet containing medium-chain triglycerides reduces REM sleep duration without significant influence on mouse circadian phenotypes.
  FOOD RESEARCH INTERNATIONAL. 2023 Jul;169:112852. doi: 10.1016/j.foodres.2023.112852
• Abe, T, Sato, T, Murotomi, K.
  Sudachitin and Nobiletin Stimulate Lipolysis via Activation of the cAMP/PKA/HSL Pathway in 3T3-L1 Adipocytes.
  FOODS. 2023 May 10;12(10):1947 doi: 10.3390/foods12101947
• Ato, S; Matsunami, H;Ogasawara, R.
  Aging is associated with impaired postprandial response of skeletal muscle protein synthesis to high-intensity muscle contraction in mice.
  J GERONTOL A BIOL SCI MED SCI. 2023 Jan 12:glad014. doi: 10.1093/gerona/glad014
• Yoshida, Y; Yajima, Y; Fujikura, Y; Zhuang, H; Higo-Yamamoto, S; Toyoda, A; Oishi, K.
  Identification of salivary microRNA profiles in male mouse model of chronic sleep disorder.
  Stress. 2022;26(1):21-28. doi: 10.1080/10253890.2022.2156783
• Yoshida, Y; Yajima, Y; Kawakami, K; Nakamura, S; Tsukahara, T; Oishi, K; Toyoda, A.
  Salivary microRNA and metabolic profiles in a mouse model of subchronic and mild social defeat stress.
  Int J Mol Sci. 2022;23:14479. doi: 10.3390/ijms232214479
• Horikawa, K; Hashimoto, C; Kikuchi, Y; Makita, M; Oishi, K.
  Wheat alkylresorcinol increases fecal lipid excretion and suppresses feed efficiency in mice depending on the time of supplementation.
  Nutrition. 2022;103-104:111796. doi: 10.1016/j.nut.2022.111796
• Ohkura, N; Taniguchi, M; Oishi, K; Inoue, K; Ohta, M.
  Angelica keiskei (Ashitaba) has potential as an antithrombotic health food.
  Food Res. 2022;6(2):18-24. doi: 10.26656/fr.2017.6(2).121
• Abe, T.
  Timing of Medium-Chain Triglyceride Consumption Modulates Effects in Mice with Obesity Induced by a High-Fat High-Sucrose Diet.
  NUTRIENTS. 2022 Dec 1;14(23):5096. doi: 10.3390/nu14235096
• Fujikura, Y; Yamanouchi, K; Sugihara, H; Hatakeyama, M; Abe, T; Ato, S; Oishi, K.
  Ketogenic diet containing medium-chain triglyceride ameliorates transcriptome disruption in skeletal muscles of rat models of duchenne muscular dystrophy.
  BIOCHEM BIOPHYS REP. 2022 Nov 11;32:101378. doi: 10.1016/j.bbrep.2022.101378
• Miyazaki, K; Itoh, N; Saiki, P; Kuroki, Y.
  Supplementation with Eurycoma longifolia Extract Modulates Diurnal Body Temperature Fluctuation and Sleep Rhythm in Mice.
  J NUTR SCI VITAMINOL (Tokyo). 2022;68(4):342-347. doi: 10.3177/jnsv.68.342
• Yasuno, R; Mitani, Y; Ohmiya, Y.
  Gene Cloning and Functional Analysis of the Luciferase from Luminous Syllids of the Genus Odontosyllis.
  METHODS MOL BIOL. 2022;2524:3-15. doi: 10.1007/978-1-0716-2453-1_1
• Fujikura, Y; Kimura, K; Yamanouchi, K; Sugihara, H; Hatakeyama, M; Zhuang, H; Abe, T; Daimon, M; Morita, H; Komuro, I; Oishi, K.
  A medium-chain triglyceride containing ketogenic diet exacerbates cardiomyopathy in a CRISPR/Cas9 gene-edited rat model with Duchenne muscular dystrophy.
  SCI REP. 2022 Jul 8;12(1):11580. doi: 10.1038/s41598-022-15934-9
• Mitani, Y; Yasuno, R; Kihira, K; Chung, KM; Mitsuda, N; Kanie, S; Tomioka, A; Kaji, H; Ohmiya, Y.
  Host-Dependent Producibility of Recombinant Cypridina noctiluca Luciferase With Glycosylation Defects.
  FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10;doi: 10.3389/fbioe.2022.774786 FEB 7
• Saiki, P; Yoshihara, M; Kawano, Y; Miyazaki, H; Miyazaki, K.
  Anti-Inflammatory Effects of Heliangin from Jerusalem Artichoke (Helianthus tuberosus) Leaves Might Prevent Atherosclerosis.
  BIOMOLECULES 12 (1); doi:10.3390/biom12010091 JAN
• Konishi, T; Takahashi, Y; Shiina, Y; Oike, H; Oishi, K.
  Time-of-day effects of consumption of fish oil-enriched sausages on serum lipid parameters and fatty acid composition in normolipidemic adults: A randomized, double-blind, placebo-controlled, and parallel-group pilot study.
  Nutrition. 2021;90:111247. doi: 10.1016/j.nut.2021.111247
• Fujikura, Y; Sugihara, H; Hatakeyama, M; Oishi, K; Yamanouchi, K.
  Ketogenic diet with medium-chain triglycerides restores skeletal muscle function and pathology in a rat model of Duchenne muscular dystrophy.
  FASEB J. 2021 Sep;35(9):e21861. doi: 10.1096/fj.202100629R
• Yamamoto K, Honda T, Yokoyama S, Ma L, Kato A, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Kawashima H, Ishigami M, Tsuji NM, Fujishiro M
  Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine
  Dig Liver Dis. 2021 Mar 13:S1590-8658(21)00081-5. doi: 10.1016/j.dld.2021.02.013
• Ueoka R, Hashimoto J, Kozone I, Hashimoto T, Kudo K, Kagaya N, Suenaga H, Ikeda H, Shin-Ya K
  A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900.
  BIOSCI BIOTECHNOL BIOCHEM. 2020 Dec 22:zbaa111. doi: 10.1093/bbb/zbaa111
• Saito S, Kakizaki N, Okuno A, Maekawa T, Tsuji NM
  Lactococcus lactis subsp. Cremoris C60 restores T Cell Population in Small Intestinal Lamina Propria in Aged Interleukin-18 Deficient Mice
  Nutrients.12(11):E3287. (2020) doi: 10.3390/nu12113287
• Ueoka R, Shinzato N, Kagaya N, Suenaga H, Shin-Ya K
  Pseudoalteropeptide A, a novel lipopeptide from the marine bacterium Pseudoalteromonas piscicida SWA4_PA4 isolated from marine seaweed
  J Antibiot (Tokyo). 2020 Oct 15. (2020) doi: 10.1038/s41429-020-00377-z
• Saiki P, Kawano Y, Ogi T, Klungsupya P, Muangman T, Phantanaprates W, Kongchinda P, Pinnak N, Miyazaki K
  Purified Gymnemic Acids from Gymnema inodorum Tea Inhibit 3T3-L1 Cell Differentiation into Adipocytes
  Nutrients. ;12(9):E2851. (2020) doi: 10.3390/nu12092851
• Abe T, Yamamoto S, Konishi T, Takahashi Y, Oishi K
  Maternal fish oil supplementation ameliorates maternal high-fructose diet-induced dyslipidemia in neonatal mice with suppression of lipogenic gene expression in livers of postpartum mice
  Nutr Res.;82:34-43. (2020) doi: 10.1016/j.nutres.2020.07.003
• Li X, Wang X, Ito A, Tsuji NM
  A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity
  Nat Commun. 11:3858.(2020) doi: 10.1038/s41467-020-17637-z
• Sakamoto K, Higo-Yamamoto S, Egi Y, Miyazaki K, Oishi K.
  Memory dysfunction and anxiety-like behavior in a mouse model of chronic sleep disorders.
  BIOCHEM BIOPHYS RES COMMUN. 529:175-179. (2020) doi:10.1016/j.bbrc.2020.05.218
• Hishiki H, Kawashima T, Tsuji NM, Ikari N, Takemura R, Kido H, Shimojo N
  A Double-Blind, Randomized, Placebo-Controlled Trial of Heat-Killed Pediococcus acidilactici K15 for Prevention of Respiratory Tract Infections among Preschool Children
  Nutrients. 12: 0 (2020) doi:10.3390/nu12071989
• Kimura Y, Yasuno R, Watanabe M, Kobayashi M, Iwaki T, Fujimura C, Ohmiya Y, Yamakage K, Nakajima Y, Kobayashi M, Mashimo N, Takagi Y, Omori T, Corsini E, Germolec D, Inoue T, Rogen EL, Kojima H, Aiba S
  An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals
  Toxicol In Vitro 66: 104832 (2020) doi: 10.1016/j.tiv.2020.104832
• Prapaipat K, Saiki P, Bhusita, W, Supatjaree R, Thanchanok M, Nantana B, Weerasak, T
  Probiotic property and biological activities of Bifidobacterium animalis subsp. lactis TISTR 2591 isolated from Thai population.
  WJARR 5: 149-162 (2020) doi: 10.30574/wjarr.2020.5.3.0072
• Hashimoto T, Kozone I, Hashimoto J, Ueoka R, Kagaya N, Fujie M, Sato N, Ikeda H, Shin-ya K
  Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908
  J. Antibiotics 73: 171-174 (2020) doi: 10.1038/s41429-019-0265-x
• Okauchi H, Higo-Yamamoto S, Sowa T, Oike H, Yamamoto S, Wada N, Sakamoto K, Oishi K
  Chronically skipping breakfast impairs hippocampal memory-related gene expression and memory function accompanied by reduced wakefulness and body temperature in mice
  Biochem Biophys Res Commun. 524: 129-134 (2020) doi: 10.1016/j.bbrc.2020.01.077
• Oishi K, Okauchi H, Yamamoto S, Higo-Yamamoto S
  Dietary natural cocoa ameliorates disrupted circadian rhythms in locomotor activity and sleep-wake cycles in mice with chronic sleep disorders caused by psychophysiological stress
  Nutrition. 75-76: 110751 (2020) doi: 10.1016/j.nut.2020.110751
• Nakao R, Abe T, Yamamoto S, Oishi K
  Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice
  Sci Rep. 9: 19652 (2019) doi: 10.1038/s41598-019-56166-8
• Abe T, Kazama R, Okauchi H, Oishi K
  Food deprivation during active phase induces skeletal muscle atrophy via IGF-1 reduction in mice
  Arch Biochem Biophys. 677: 1080160 (2019) doi: 10.1016/j.abb.2019.108160
• Oike H, Ogawa Y, Oishi K
  Simple and Quick Visualization of Periodical Data Using Microsoft Excel
  Methods Protoc. 2: 81 (2019) doi: 10.3390/mps2040081
• Saiki P, Kawano Y, Nakajima Y, Van Griensven LJLD, Miyazaki K
  Novel and Stable Dual-Color IL-6 and IL-10 Reporters Derived from RAW 264.7 for Anti-Inflammation Screening of Natural Products
  Int J Mol Sci. 20: 4620 (2019) doi: 10.3390/ijms20184620
• Mitani Y, Yasuno R, Futahashi R, Oakley TH, Ohmiya Y
  Luciferase gene of a Caribbean fireworm (Syllidae) from Puerto Rico
  Sci Rep. 9: 13015 (2019) doi: 10.1038/s41598-019-49538-7
• Wang XP, Ihara S, Li X, Ito A, Sogo Y, Watanabe Y, Yamazaki A, , Tsuji NM, Ohno T
  Rod-Scale Design Strategies for Immune-Targeted Delivery System toward Cancer Immunotherapy
  Acs Nano 13: 7705-7715 (2019) doi: 10.1021/acsnano.9b01271
• Gabriel GVD, Yasuno R, Mitani Y, Ohmiya Y, Viviani VR
  Novel application of Macrolampis sp2 firefly luciferase for intracellular pH-biosensing in mammalian cells
  Photochemical 18: 1212-1217 (2019) doi: 10.1039/c8pp00573g
• Katsuki R, Sakata S, Nakao R, Oishi K, Nakamura Y
  Lactobacillus curvatus CP2998 Prevents Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes
  J Nutr Sci Vitaminol 65: 455-458 (2019) doi: 10.3177/jnsv.65.455
• Ohta M, Fujinami A, Oishi K, Kobayashi N, Ohnishi K, Ohkura N
  Ashitaba (Angelica Keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice
  J Diet Suppl. 16: 331-344 (2019) doi: 10.1080/19390211.2018.1458366
• Higo-Yamamoto S, Yamamoto S, Miyazaki K, Nakakita Y, Kaneda H, Takata Y, Nakamura T, Oishi K
  Dietary Heat-Killed Lactobacillus brevis SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice
  J Nutr Sci Vitaminol 65: 164-170 (2019) doi: 10.3177/jnsv.65.164
• Adachi T, Yoshikawa S, Tezuka H, Tsuji NM, Ohteki T, Karasuyama H, Kumazawa T
  Propolis induces Ca2+ signaling in immune cells
  Biosci Microbiota Food Health 38: 141-149 (2019) doi: 10.12938/bmfh.19-011
• Oishi K, Okauchi H
  Functional CLOCK Is Not Essentially Associated with Metabolic Disruption Caused by Sleep Phase Feeding in Mice
  Biol Pharm Bull. 42: 1038-1043 (2019) doi: 10.1248/bpb.b19-00018
• Akimoto H, Oshima S, Sugiyama T, Negishi A, Nemoto T, Kobayashi D
  Changes in brain metabolites related to stress resilience: Metabolomic analysis of the hippocampus in a rat model of depression
  Behav Brain Res. 34: 89-94 (2019) doi: 10.1016/j.bbr.2018.11.017
• Wang X, Ihara S, Li X, Ito A, Sogo Y, Watanabe Y, Tsuji NM, Yamazaki A
  Si-doping increases the adjuvant activity of hydroxyapatite nanorods
  Colloids Surf B Biointerfaces. 174: 300-307 (2019) doi: 10.1016/j.colsurfb.2018.11.026
• Okauchi H, Hashimoto C, Nakao R, Oishi K
  Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice
  Chronobiol Int. 36: 57-74 (2019) doi: 10.1080/07420528.2018.1516672
• Carreras J, Lopez-Guillermo A, Kikuti YY, Itoh J, Masashi M, Ikoma H, Tomita S, Hiraiwa S, Hamoudi R, Rosenwald A, Leich E, Martinez A, Roncador G, Villamor N, Colomo L, Perez P, Tsuji NM, Campo E, Nakamura N.
  High TNFRSF14 and low BTLA are associated with poor prognosis in Follicular Lymphoma and in Diffuse Large B-cell Lymphoma transformation.
  J Clin Exp Hematop. 59: 1-16 (2019) doi: 10.3960/jslrt.19003
• Shibakami M, Sohma M, Kijima N, Nemoto T
  Melt spinnabilities of thermoplastic paramylon mixed esters
  Heliyon. 5: e02843 (2019) doi: 10.1016/j_heliyon_2019.e02843
• 藤原 正子, 安藤 一郎, 根本 直, 石田 亜希, 阿部 未奈, 大槻 剛, 宍戸 洋, 今井 潤, 寺脇 博之
  血液濾過透析が糖尿病性腎臓病 (diabetic kidney disease: DKD) 由来腎不全患者のアミノ酸動態に及ぼす影響 : 予備的検討
  日本透析医学会雑誌 52: 457-462 (2019) doi: 10.4009/jsdt52.457
• Shibakami M, Nemoto T, Sohoma M.
  Dependence of dissolution, dispersion, and aggregation characteristics of cationic polysaccharides made from euglenoid β-1,3-glucan on degree of substitution
  CELLULOSE 25: 2217-2234 (2018) doi: 10.1007/s10570-018-1740-4
• Akimoto H, Oshima S, Michiyama Y, Negishi A, Nemoto T, Kobayashi D
  Metabolic Profiling of the Hippocampus of Rats Experiencing Nicotine-Withdrawal Symptoms
  Biol Pharm Bull. 41: 1879-1884 (2018) doi: 10.1248/bpb.b18-00486
• Saiki P, Nakajima Y, Van Griensven LJLD, Miyazaki K
  Real-time monitoring of IL-6 and IL-10 reporter expression for anti-inflammation activity in live RAW 264.7cells
  Biochem Biophys Res Commun. 505: 885-890 (2018) doi: 10.1016/j.bbrc.2018.09.173
• Oishi K, Hashimoto C
  Short-term time-restricted feeding during the resting phase is sufficient to induce leptin resistance that contributes to development of obesity and metabolic disorders in mice
  Chronobiol Int. 35: 1576-1594 (2018) doi: 10.1080/07420528.2018.1496927
• Lv Y, Cui M, Lv Z, Lu J, Zhang X, Zhao Z, Wang Y, Gao L, Tsuji NM, Yan H
  Expression and significance of peripheral myeloid-derived suppressor cells in chronic hepatitis B patients
  Clin Res Hepatol Gastroenterol. 42: 462-469 (2018) doi: 10.1016/j.clinre.2018.04.002
• Wada T, Ichihashi Y, Suzuki E, Kosuge Y, Ishige K, Uchiyama T, Makishima M, Nakao R, Oishi K, Shimba S
  Deletion of Bmal1 Prevents Diet-Induced Ectopic Fat Accumulation by Controlling Oxidative Capacity in the Skeletal Muscle
  Int J Mol Sci. 19: 2813 (2018) doi: 10.3390/ijms19092813
• Mitani Y, Yasuno R, Isaka M, Mitsuda N, Futahashi R, Kamagata Y, Ohmiya Y
  Novel gene encoding a unique luciferase from the fireworm Odontsyllis undecimdonta
  Sci Rep. 8: 12789 (2018) doi: 10.1038/s41598-018-31086-1
• Yasuno R, Mitani Y, Ohmiya Y
  Effects of N-Glycosylation Deletions on Cypridina Luciferase Activity
  Photochem Photobiol. 94: 338-342 (2018) doi: 10.1111/php.12847
• Kawashima T, Ikari N, Kouchi T, Kowatari Y, Kubota Y, Shimojo N, Tsuji NM
  The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial
  Sci Rep. 8: 5065 (2018) doi: 10.1038/s41598-018-23404-4
• Oishi K, Konishi T, Hashimoto C, Yamamoto S, Takahashi Y, Shiina Y
  Dietary fish oil differentially ameliorates high-fructose diet-induced hepatic steatosis and hyperlipidemia in mice depending on time of feeding
  J Nutr Biochem. 42: 462-469 (2018) doi: 10.1016/j.jnutbio.2017.09.024
• Oishi KOishi K, Ohyama S, Higo-Yamamoto S
  Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice
  Biochem Biophys Res Commun. 495: 2616-2621 (2018) doi: 10.1016/j.bbrc.2017.12.158
• Kawashima T, Ikari N, Watanabe Y, Kubota Y, Yoshio S, Kanto T, , Motohashi S, Shimojo N, Tsuji NM
  Double-Stranded RNA Derived from Lactic Acid Bacteria Augments Th1 Immunity via Interferon-beta from Human Dendritic Cells
  Front Immunol. 9: 27 (2018) doi: 10.3389/fimmu.2018.00027
• Ohkura N, Kihara-Negishi F, Fujii A, Kanouchi H, Oishi K, Atsumi G, Nagano M
  Effects of fermented rice vinegar Kurozu and its sediment on inflammation-induced plasminogen activator inhibitor 1 (PAI-1) increase.
  Food and Nutrition Sciences 9: 235-246 (2018). doi: 10.4236/fns.2018.93018
• Wang XP, Li X, Ito A, Sogo Y, Watanabe Y, Tsuji NM, Ohno T
  Biodegradable Metal Ion-Doped Mesoporous Silica Nanospheres Stimulate Anticancer Th1 Immune Response in Vivo
  Acs Applied Materials 9: 43538-43544 (2017) doi: 10.1021/acsami.7b16118
• Saiki P, Kawano Y, Van Griensven LJLD, Miyazaki K
  The anti-inflammatory effect of Agaricus brasiliensis is partly due to its linoleic acid content
  Food Funct. 8: 4150-4158 (2017) doi: 10.1039/c7fo01172e
• Wang X, Li X, Ito A, Sogo Y, Watanabe Y, Tsuji NM
  Hollow ZnO Nanospheres Enhance Anticancer Immunity by Promoting CD4(+) and CD8(+) T Cell Populations In Vivo
  Small. 13: 1701816 (2017) doi: 10.1002/smll.201701816
• Akimoto H, Oshima S, Ohara K, Negishi A, Hiroyama H, Nemoto T, Kobayashi D
  High-Resolution Magic-Angle Spinning-(1)H-NMR Spectroscopy-Based Metabolic Profiling of Hippocampal Tissue in Rats with Depression-Like Symptoms
  Biol Pharm Bull. 40: 789-796 (2017) doi: 10.1248/bpb.b16-00783
• Nakao R, Okauchi H, Hashimoto C, Wada N, Oishi K
  Determination of reference genes that are independent of feeding rhythms for circadian studies of mouse metabolic tissues
  Mol Genet Metab. 121: 190-197 (2017) doi: 10.1016/j.ymgme.2017.04.001
• Nakao R, Shimba S, Oishi K
  Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis
  Sci Rep. 7: 2885 (2017) doi: 10.1038/s41598-017-03119-8
• Oishi K, Ohkura N, Yasumoto Y, Yamamoto S
  Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice
  Chronobiol Int. 34: 254-259 (2017) doi: 10.1080/07420528.2016.1256299
• Lu JH, Lv Y, Dai EH, Liu YZ, Gao HX, Tsuji NM, Yan H
  Profile and clinical relevance of autoantibodies in patients with chronic hepatitis B infection
  Int. J. Clin. Exp. Med. 10: 3568-3574 (2017) doi:
• Akitomo S, Egi Y, Nakamura Y, Suetsugu Y, Oishi K, Sakamoto K
  Genome-wide microarray screening for Bombyx mori genes related to transmitting the determination outcome of whether to produce diapause or nondiapause eggs
  Insect Sci. 24: 187-193 (2017) doi: 10.1111/1744-7917.12297
• Horikawa K, Hashimoto C, Kukuchi Y, Makita M, Fukudome S, Okita K, Wada N, Oishi K
  Wheat alkylresorcinols reduce micellar solubility of cholesterol in vitro and increase cholesterol excretion in mice.
  Nat Prod Res 31: 578-582 (2017). doi: 10.1080/14786419.2016.1198347
• Oishi K, Yamamoto S, Oike H, Ohkura N, Taniguchi M
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