Cell Regulation Materials Research Group
Cell Regulation Materials Research Group Overview
There has been a particular need for cell industry in drug discovery and development, regenerative medicine, development of food and alternative protein industries, and the environmental fields. Research and development of technologies to control cellular function are required to accelerate the cell industry. We are committed to the research and development of cell manipulation technologies and materials that modulate cellular functions, and have performed research into their application and practical use. Our technologies and materials will contribute to the cell industry and help realize a sustainable society and prolong the healthy life of mankind.
Research Project
Project 1:Technology to manipulate cells and tissues with artificial materials
Researcher: SUMARU Kimio, TAKAGI Toshiyuki, YOSHIHARA Erika
We have developed technologies for sequencing, sorting, and designing cultured cells as desired using functional polymers; and for fluorinated lipids, which are expected to be deployed for functionalization of cells.
Project 2:Technology to regulate cell functions with biomaterials
Researcher: TERAMURA Yuji, OBUCHI Satoe, SATO Yuya
The use of highly biocompatible amphiphilic polymers and lipid nanoparticles has been found to enable modification of cell surfaces and modulation of cell functions. We conduct the applied research and social implementation research using the technology.
Member
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Research Group Leader TERAMURA Yuji |
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Chief Senior Researcher SUMARU Kimio |
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Senior Researcher TAKAGI Toshiyuki |
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Researcher YOSHIHARA Erika |
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Researcher OBUCHI Satoe |
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Researcher SATO Yuya |
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Results
- Zhang, W; Obuchi, S; Teramura, Y.
Analysis of cellular responses following interaction with extracellular vesicles derived from HEK293T and human adipose derived stem cells.
SCI REP. 2025 Apr 7;15(1):11835. doi:10.1038/s41598-025-95559-w - Teramura, Y; Cabral, H.
Foreword to the focus issue: frontline research on biomaterials-based bioengineering for future therapy.
SCI TECHNOL ADV MATER. 2025 Feb 21;26(1):2471206. doi:10.1080/14686996.2025.2471206 - Kurosu, J; Sakamaki, T; Kanai, K; Morishita, K; Sumaru, K; Tsutsumi, J.
Spatiotemporal dynamics of microscopic biological barrier visualized by electric-double-layer modulation imaging.
BIOSENS BIOELECTRON. 2024 Aug 30;266:116721. doi: 10.1016/j.bios.2024.116721 - Inuzuka, N; Shobayashi, Y; Tateshima, S; Sato, Y; Ohba, Y; Ishihara, K; Teramura, Y.
Stable and Thin-Polymer-Based Modification of Neurovascular Stents with 2-Methacryloyloxyethyl Phosphorylcholine Polymer for Antithrombogenicity.
BIOENGINEERING (Basel). 2024 Aug 15;11(8):833. doi: 10.3390/bioengineering11080833 - Sato, Y; Baba, T; Uchida, T; Chung, UI; Teramura, Y.
Cell membrane fusion induced by surface modification with cell-penetrating peptide–lipid conjugates that facilitates close contact between distinct membranes.
Mater. Adv. 2024 May 11. doi: 10.1039/D4MA00193A - Sato, Y; Zhang, WX; Baba, T; Chung, UI; Teramura, Y.
Extracellular vesicle-liposome hybrids via membrane fusion using cell-penetrating peptide-conjugated lipids.
REGENERATIVE THERAPY. 2024 Jul 29. doi: 10.1016/j.reth.2024.07.006 - Ma, ST; Yoda, H; Dang, T; Yang, JQ; Ando, I; Sato, Y; Teramura, Y; Tabata, H; Matsui, H.
Light Polarization Effects of Chemical Sensing in the Mid-Infrared Region Using ZnO: Ga-Based Plasmonic Surface Lattice Resonances.
JOURNAL OF PHYSICAL CHEMISTRY C. July 15, 2024. doi: 10.1021/acs.jpcc.4c02354 - Inuzuka, N; Shobayashi, Y; Tateshima, S; Sato, Y; Ohba, Y; Ekdahl, KN; Nilsson, B; Teramura, Y.
Stent coating containing a charged silane coupling agent that regulates protein adsorption to confer antithrombotic and cell-adhesion properties.
SCI REP. 2024 Jul 10;14(1):15178. doi: 10.1038/s41598-024-65832-5 - Shu, Y; Otake, M; Seta, Y; Hori, K; Kuramochi, A; Ohba, Y; Teramura, Y.
Activation of cellular antioxidative stress and migration activities by purified components from immortalized stem cells from human exfoliated deciduous teeth.
SCI REP. 2024 Jul 3;14(1):15340. doi: 10.1038/s41598-024-66213-8 - Hasegawa, T; Nakagawara, A; Takagi, T; Shimoaka, T; Shioya, N; Sonoyama, M.
Phonon modes controlled by primary chemical structure of partially fluorinated dimyristoylphosphatidylcholine (DMPC) revealed by multiple-angle incidence resolution spectrometry (MAIRS).
J CHEM PHYS. 2024 Feb 14;160(6):064704. doi: 10.1063/5.0190441 - Miyazaki, M; Arisaka, C; Nakagawara, A; Sasaki, N; Takahashi, H; Takagi, T; Amii, H; Sonoyama, M.
Thermodynamic study on hydrated bilayers of ether-linked phosphatidylcholines with terminal perfluorobutyl group.
BIOCHIM BIOPHYS ACTA BIOMEMBR. 2023 Dec 13:184261. doi: 10.1016/j.bbamem.2023.184261 - Adler, A; Fritsch, M; Fromell, K; Leneweit, G; Ekdahl, KN; Nilsson, B; Teramura, Y.
Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro.
J MATER CHEM B. 2023 Nov 13. doi: 10.1039/d3tb01721d - Tsuyukubo, A; Morishita, K; Kanamori, T; Sumaru, K.
Construction of a spheroid array culture system on a suspended permeable hydrogel membrane scaffold for improving the expression of a liver-specific drug-metabolizing enzyme of HepG2 cells.
BIOMATER SCI. 2023 Jun 22. doi: 10.1039/d3bm00071k - Nakagawa, Y; Hishida, T; Sumaru, K; Morishita, K; Kirito, K; Yokojima, S; Sakamoto, Y; Nakamura, S; Uchida, K.
Phototunable Cell Killing by Photochromic Diarylethene of Thiazoyl and Thienyl Derivatives.
JOURNAL OF MEDICINAL CHEMISTRY. 2023, 66 (8) 5937-5949. doi: 10.1021/acs.jmedchem.3c00164 - Rangasami, VK; Asawa, K; Teramura, Y; Le, Blanc K; Nilsson, B; Hilborn, J; Varghese, OP; Oommen, OP.
Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function.
BIOMATER ADV. 2023 Feb 8;147:213331. doi: 10.1016/j.bioadv.2023.213331 - Huang, T; Sato, Y; Kuramochi, A; Ohba, Y; Sano, M; Miyagishi, M; Tateno, H; Wadhwa, R; Kawasaki, K; Uchida, T; Ekdahl, KN; Nilsson, B; Chung, UI; Teramura, Y.
Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells.
REGEN THER. 2023 Jan 11;22:90-98. doi: 10.1016/j.reth.2022.12.007 - Suzuki, H; Adler, A; Huang, T; Kuramochi, A; Ohba, Y; Sato, Y; Nakamura, N; Manivel, VA; Ekdahl, KN; Nilsson, B; Ishihara, K; Teramura, Y.
Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions.
SCI TECHNOL ADV MATER. 2022 Dec 8;23(1):845-857. doi: 10.1080/14686996.2022.2146466 - Ekdahl, KN; Fromell, K; Mannes, M; Grinnemo, KH; Huber-Lang, M;Teramura, Y; Nilsson, B.
Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop.
IMMUNOL REV. 2022 Oct 18. doi: 10.1111/imr.13148 - Sano, M; Morishita, K; Onizawa, Y; Takagi, T; Sumaru, K.
Rapid and Highly Sensitive Method for Evaluating Surface Coatings against an Enveloped RNA Virus.
ACS APPL BIO MATER. 2022 Oct 14. doi: 10.1021/acsabm.2c00613 - Adler, A; Manivel, VA; Fromell, K; Teramura, Y; Ekdahl, KN; Nilsson, B.
A Robust Method to Store Complement C3 With Superior Ability to Maintain the Native Structure and Function of the Protein.
FRONT IMMUNOL. 2022 May 3;13:891994. doi: 10.3389/fimmu.2022.891994 - Nakagawa, Y; Hishida, T; Hatano, E; Sumaru, K; Morishita, K; Morimoto, M; Yokojima, S; Nakamura, S; Uchida, K.
Photoinduced cytotoxicity of photochromic symmetric diarylethene derivatives: the relation of structure and cytotoxicity.
ORGANIC & BIOMOLECULAR CHEMISTRY. 2022 Apr 13;20(15):3211-3217. doi: 10.1039/d2ob00224h - Goel, I; Noiri, M; Yamauchi, Y; Kato, K; Chung, UI; Teramura, Y.
Enhancement of intercellular interaction between iPSC-derived neural progenitor cells and activated endothelial cells using cell surface modification with functional oligopeptides.
BIOMATER SCI. 2022 Jan 11. doi: 10.1039/d1bm01503f - Hurd, MD; Goel, I; Sakai, Y; Teramura, Y.
Current status of ischemic stroke treatment: From thrombolysis to potential regenerative medicine.
REGENERATIVE THERAPY 18 408-417; doi:10.1016/j.reth.2021.09.009 DEC - Adler, A; Inoue, Y; Ekdahl, KN; Baba, T; Ishihara, K; Nilsson, B; Teramura, Y.
Effect of liposome surface modification with water-soluble phospholipid polymer chain-conjugated lipids on interaction with human plasma proteins.
J MATER CHEM B. 2021 Oct 7. doi: 10.1039/d1tb01485d - Sano, M; Morishita, K; Oikawa, S; Akimoto, T; Sumaru, K; Kato, Y.
Live-cell imaging of microRNA expression with post-transcriptional feedback control.
MOL THER NUCLEIC ACIDS. 2021 Aug 26;26:547-556. doi: 10.1016/j.omtn.2021.08.018 - Sato, Y; Asawa, K; Huang, T; Noiri, M; Nakamura, N; Ekdahl, KN; Nilsson, B; Ishihara, K; Teramura, Y.
Induction of Spontaneous Liposome Adsorption by Exogenous Surface Modification with Cell-Penetrating Peptide-Conjugated Lipids.
LANGMUIR. 2021 Aug 3. doi: 10.1021/acs.langmuir.1c01072 - Adler, A; Inoue, Y; Sato, Y; Ishihara, K; Ekdahl, KN; Nilsson, B; Teramura, Y.
Synthesis of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated lipids and their characterization and surface properties of modified liposomes for protein interactions.
BIOMATER SCI. 2021 Jul 20. doi: 10.1039/d1bm00570g - Hashimoto, M; Murai, Y; Morita, K; Kikukawa, T; Takagi, T; Takahashi, H; Yokoyama, Y; Amii, H; Sonoyama, M.
Comparison of functionality and structural stability of bacteriorhodopsin reconstituted in partially fluorinated dimyristoylphosphatidylcholine liposomes with different perfluoroalkyl chain lengths.
BIOCHIM BIOPHYS ACTA BIOMEMBR. 2021 Jun 25;1863(10):183686. doi: 10.1016/j.bbamem.2021.183686