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AIST-INDIA Diverse Assets & Applications International Laboratory


Project1:Validation of mortalin and CARF as a cancer targets: molecular understanding of their role in stress & cancer biology, and development of interventional tools and technologies
Researcher:Renu WADHWA

We have originally cloned two proteins, Mortalin and CARF, that are enriched in cancer cells and hence are proposed as targets for anti-cancer drugs. Currently, we are engaged in validation of (i) their role in stress, senescence and cancer biology, (ii) predictive value in stress and cancer diagnosis and (iii) use of their inhibitors for stress and cancer intervention

AIST-INDIA Diverse Assets & Applications International Laboratory02


Project2:Elucidation of dynamic life system based on molecular biomechanics
Researcher:Chikashi Nakamura, Tatsuro Akiba, Hyonchol Kim, Ayana Yamagishi

We achieve to understand molecular mechanisms for strict and flexible behaviors in living organisms with new perspectives by using our original nano-tools, nanoneedle (200 nm in diameter) and magcup (cup-shaped magnetic hemisphere). In detail, we challenge in cell analysis and manipulation of living cells using nanoneedle technology, analysis of mechanical functions of novel cancer markers involved in metastasis and development of diagnostic and therapeutic techniques targeting these markers, and accurate identification of rare cancer cells by using cup-shaped microsensors.

AIST-INDIA Diverse Assets & Applications International Laboratory03


Project3:Development of novel reporter gene assay systems for screening new functional secondary metabolites
Researcher:Tatsunosuke TOMITA

To explore novel functional compounds from natural products, we are setting up new reporter gene assay systems based on bioluminescence. This technique makes it possible to observe promoter activities of interests in the living cells for long time. We can now evaluate toxicity, immune response and circadian rhythms with the cell lines containing corresponding promoters-reporters we have already established. After finding new functional compounds, we focus on the molecular mechanisms further.

AIST-INDIA Diverse Assets & Applications International Laboratory04


Name Position
WADHWA Renu Leader, Cooperative Research Laboratory
NAKAMURA Chikashi Deputy Leader, Cooperative Research Laboratory
AKIBA Tatsuro Senior Researcher
TOMITA Tatsunosuke Senior Researcher
KIM Hyonchol Senior Researcher
YAMAGISHI Ayana Researcher
KAUL Sunil Invited Senior Researcher


  • Li, X; Wang, J; Zhang, H; Xiao, L; Lei, Z; Kaul, SC; Wadhwa, R; Zhang, Z.
    Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties.
    J FUNGI (Basel). 2021 Apr 28;7(5):342. doi: 10.3390/jof7050342
  • Penedo, M; Shirokawa, T; Alam, MS; Miyazawa, K; Ichikawa, T; Okano, N; Furusho, H; Nakamura, C; Fukuma, T.
    Cell penetration efficiency analysis of different atomic force microscopy nanoneedles into living cells.
    SCI REP. 2021 Apr 8;11(1):7756. doi: 10.1038/s41598-021-87319-3
  • Kalra, RS; Kumar, V; Dhanjal, JK; Garg, S; Li, X; Kaul, SC; Sundar, D; Wadhwa, R.
    COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays.
    J BIOMOL STRUCT DYN. 2021 Apr 2:1-14. doi: 10.1080/07391102.2021.1902858
  • Sari AN, Elwakeel A, Dhanjal JK,Kumar V, Sundar D, Kaul SC, Wadhwa R
    Identification and Characterization of Mortaparib(Plus)-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms.
    CANCERS (Basel). 2021 Feb 17;13(4):835. doi: 10.3390/cancers13040835
  • Malik V, Kumar V, Kaul SC, Wadhwa R, Sundar D
    Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers.
    BIOMOLECULES. 2021 Jan 26;11(2):160. doi: 10.3390/biom11020160
  • Maejima A, Ishibashi K, Kim H, Kumagai I, Asano R
    Evaluation of intercellular cross-linking abilities correlated with cytotoxicities of bispecific antibodies with domain rearrangements using AFM force-sensing.
    BIOSENS BIOELECTRON. 2021 Jan 27;178:113037. doi: 10.1016/j.bios.2021.113037
  • Wadhwa R, Yadav NS, Katiyar SP, Yaguchi T, Lee C, Ahn H, Yun CO, Kaul SC, Sundar D
    Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane.
    SCI REP. 2021 Jan 27;11(1):2352. doi: 10.1038/s41598-021-81729-z
  • Landeira JM, Liu BB, Omura T, Akiba T, Tanaka Y
    Salinity effects on the first larval stage of the invasive crab Hemigrapsus takanoi: Survival and swimming patterns
    ESTUARINE COASTAL AND SHELF SCIENCE 245; (2020) doi: 10.1016/j.ecss.2020.106976
  • Konar A, Kalra RS, Chaudhary A, Nayak A, Guruprasa KP, Satyamoorthy K, Ishida Y, Terao K, Kaul SC, Wadhwa R
    Identification of Caffeic Acid Phenethyl Ester (CAPE) as a Potent Neurodifferentiating Natural Compound That Improves Cognitive and Physiological Functions in Animal Models of Neurodegenerative Diseases
    Front Aging Neurosci. 2020 Nov 10;12:561925. doi: 10.3389/fnagi.2020.561925
  • Nishihara R, Niwa K, Tomita T, Kurita R
    Coelenterazine Analogue with Human Serum Albumin-Specific Bioluminescence
    Bioconjug Chem. 2020 Nov 25. doi: 10.1021/acs.bioconjchem.0c00536
  • Kim H, Ishibashi K, Iijima M, Kuroda S, Nakamura C
    Influence of Nivolumab for Intercellular Adhesion Force between a T Cell and a Cancer Cell Evaluated by AFM Force Spectroscopy
    Sensors (Basel) 20(19):E5723. (2020)doi: 10.3390/s20195723
  • Priyanka, Wadhwa R, Chaudhuri R, Nag TC, Seth P
    Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis
    J Neuroinflammation.;17(1):276. (2020) doi: 10.1186/s12974-020-01912-3
  • Yu Y, Yang X, Reghu S, Kaul SC, Wadhwa R, Miyako E
    Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes
    Nat Commun. 11:4117 (2020) doi: 10.1038/s41467-020-17768-3
  • Wang J, Bhargava P, Yu Y, Sari AN, Zhang H, Ishii N, Yan K, Zhang Z, Ishida Y, Terao K, Kaul SC, Miyako E, Wadhwa R
    Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells
    Cancers (Basel). 12(9):E2370. (2020) doi: 10.3390/cancers12092370
  • Malik V, Garg S, Afzal S, Dhanjal JK, Yun CO, Kaul SC, Sundar D, Wadhwa R
    Bioinformatics and Molecular Insights to Anti-Metastasis Activity of Triethylene Glycol Derivatives
    Int J Mol Sci. 21(15):E5463. (2020) doi: 10.3390/ijms21155463
  • Kalra RS, Tomar D, Meena AS, Kandimalla R
    SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings
    Pathogens. 9: 0 (2020) doi: 10.3390/pathogens9070546
  • Kumar V, Dhanjal JK, Bhargava P, Kaul A, Wang J, Zhang H, Kaul SC, Wadhwa R, Sundar D
    Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells
    J. Biomolecular Structure 21: 0 (2020) doi: 10.1080/07391102.2020.1775704
  • Asano K, Kim HJ, Sakaki K, Nakamura YM, Wang YM, Isobe S, Doi M, Fujita A, Maejima N, Machida A, Watanuki T, Westerwaal RJ, Schreuders H, Dam B
    Metallurgical Synthesis of Mg2FexSi1-x Hydride: Destabilization of Mg2FeH6 Nanostructured in Templated Mg2Si
    Inorganic Chemistry 59: 2758-2764 (2020) doi: 10.1021/acs.inorgchem.9b03117
  • Kumar V, Dhanjal JK, Bhargava P, Kaul A, Wang J, Zhang H, Kaul SC, Wadhwa R, Sundar D.
    Withanone and withaferin-A Are Predicted to Interact with Transmembrane Protease Serine 2 (TMPRSS2) and Block Entry of SARS-CoV-2 Into Cells
    J Biomol Struct Dyn. 1-27 (2020) doi: 10.1080/07391102.2020.1775704
  • Kumar V, Dhanjal JK, Kaul SC, Wadhwa R, Sundar D
    Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (Mpro) of SARS-CoV-2 and inhibit its activity
    J Biomol Struct Dyn 1-13 (2020) doi: 10.1080/07391102.2020.1772108
  • Kim H, Hoshi M, Iijima M, Kuroda S, Nakamura C
    Development of a universal method for the measurement of binding affinities of antibody drugs towards a living cell based on AFM force spectroscopy
    Anal Methods (2020) doi: 10.1039/d0ay00788a
  • Sari AN, Bhargava P, Dhanjal JK, Putri JF, Radhakrishnan N, Shefrin S, Ishida Y, Terao K, Sundar D, Kaul SC, Wadhwa R
    Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action
    Cancers 12(5): E1160 (2020). doi: 10.3390/cancers12051160
  • Omar A, Kalra RS, Putri J, Elwakeel A, Kaul SC, Wadhwa R
    Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells
    Sci Rep. 10: 6323 (2020) doi: 10.1038/s41598-020-62953-5
  • Kalra RS, Chaudhary A, Omar A, Cheung CT, Garg S, Kaul SC, Wadhwa R
    Stress-induced changes in CARF expression determine cell fate to death, survival, or malignant transformation
    Cell Stress Chaperones 25(3): 481-494 (2020). doi: 10.1007/s12192-020-01088-y
  • Kurinomaru T, Inagaki A, Hoshi M, Nakamura C, Yamazoe H
    Protein microswimmers capable of delivering cells for tissue engineering applications
    Materials Horizons 7 7: 877-884 (2020) doi: 10.1039/c9mh01799b
  • Afzal S, Garg S, Adiga D, Ishida Y, Terao K, Kaul SC, Wadhwa R
    Anti-stress, Glial- and Neuro-differentiation Potential of Resveratrol: Characterization by Cellular, Biochemical and Imaging Assays
    Nutrients 12(3): 671 (2020). doi: 10.3390/nu12030671
  • Kim H, Ishibashi K, Okada T, Nakamura C
    Adhesion strengths between cancer cells with different malignancies and endothelial cells measured using atomic force microscopy
    Jpn J Appl Phys 59: SDDE01 (2020) doi: 10.7567/1347-4065/ab51ad
  • Garg S, Huifu H, Kumari A, Sundar D, Kaul SC, Wadhwa R
    Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential
    J Gerontol A Biol Sci Med Sci. 75(6):1031-1041 (2020). doi: 10.1093/gerona/glz077
  • Putri JF, Bhargava P, Dhanjal JK, Yaguchi T, Sundar D, Kaul SC, Wadhwa R
    Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
    J Exp Clin Cancer Res. 38(1): 499 (2019). doi: 10.1186/s13046-019-1500-9
  • Tomita T, Mori T, Onishi Y
    beta-Arrestin 1 (ARRB1) serves as a molecular marker of the peripheral circadian rhythm
    Int J Oral Sci. 11: 32 (2019) doi: 10.1038/s41368-019-0065-y
  • Chaudhary A, Kalra RS, Malik V, Katiyar SP, Sundar D, Kaul SC, Wadhwa R
    2, 3-Dihydro-3beta-methoxy Withaferin-A Lacks Anti-Metastasis Potency: Bioinformatics and Experimental Evidences
    Sci Rep. 9(1):17344 (2019). doi: 10.1038/s41598-019-53568-6
  • Garg S, Wu C, Ohmiya Y, Kaul SC, Wadhwa R
    Express ELISA for detection of mortalin
    Biotechniques. 67(4):166-171 (2019). doi: 10.2144/btn-2018-0158
  • Kim H, Ishibashi K, Okada T, Nakamura C
    Mechanical Property Changes in Breast Cancer Cells Induced by Stimulation with Macrophage Secretions in Vitro
    Micromachines 10: 738 (2019) doi: 10.3390/mi10110738
  • Konar A, Gupta R, Shukla RK, Maloney B, Khanna VK, Wadhwa R, , Lahiri DK, Thakur MK
    M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera
    Sci Rep. 9(1):13990 (2019). doi: 10.1038/s41598-019-48238-6
  • Kim H, Ishibashi K, Matsuo K, Kira A, Okada T, Watanabe K, Inada, M, Nakamura C
    Quantitative Measurements of Intercellular Adhesion Strengths between Cancer Cells with Different Malignancies Using Atomic Force Microscopy
    Anal Chem 91: 10557-10563 (2019) doi: 10.1021/acs.analchem.9b01569
  • Yu Y, Wang J, Kaul SC, Wadhwa R, Miyako E
    Folic Acid Receptor-Mediated Targeting Enhances the Cytotoxicity, Efficacy, and Selectivity of Withania somnifera Leaf Extract: In vitro and in vivo Evidence
    Front Oncol. 9: 602 (2019). doi: 10.3389/fonc.2019.00602
  • Garg S, Afzal S, Elwakeel A, Sharma D, Radhakrishnan N, Dhanjal JK, Sundar D, Kaul SC, Wadhwa R
    Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence
    Mar Drugs. 17(6): 338 (2019). doi: 10.3390/md17060338
  • Wadhwa R, Li L, Singh R, Wang J, Gao R, Nigam N, Forestier S, Ando N, Kaul SC
    Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin
    Evid Based Complement Alternat Med. 10: 800-805 (2019) doi: 10.1155/2019/9848969
  • Yamagishi A, Susaki M, Takano Y, Mizusawa M, Mishima M, Iijima M, Kuroda S, Okada T, Nakamura C
    The Structural Function of Nestin in Cell Body Softening is Correlated with Cancer Cell Metastasis
    INTERNATIONAL J. Biological Sciences 15: 1546-1556 (2019) doi: 10.7150/ijbs.33423
  • Irie H, Ito K, Fujioka Y, Oguchi K, Fujioka A, Hashimoto A, , Ohsawa H, Tanaka K, Funabashi K, Araki H, Kawai Y, Shimamura T, , Wadhwa R, Ohkubo S, Matsuo K
    TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models
    Mol Cancer Ther. 18: 733-742 (2019) doi: 10.1158/1535-7163. MCT-18-1085
  • Kalra RS, Bapat SA
    Proteomics to Predict Loss of RXR-gamma During Progression of Epithelial Ovarian Cancer
    Methods Mol Biol. 19: 0 (2019) doi: 10.1007/978-1-4939-9585-1_1
  • Yamagishi A, Matsumoto D, Kato Y, Honda Y, Morikawa M, Iwata F, , Kobayashi T, Nakamura C
    Direct Delivery of Cas9-sgRNA Ribonucleoproteins into Cells Using a Nanoneedle Array
    Applied Sciences-Basel 9: 10 (2019) doi: 10.3390/app9050965
  • Afzal S, Garg S, Ishida Y, Terao K, Kaul SC, Wadhwa R
    Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin
    Mar Drugs. 17(3):189 (2019). doi: 10.3390/md17030189
  • Furuhata Y, Sakai A, Murakami T, Morikawa M,Nakamura C,Yoshizumi, T, Fujikura U, Nishida K, Kato Y
    A method using electroporation for the protein delivery of Cre recombinase into cultured Arabidopsis cells with an intact cell wall
    Scientific Reports 509: 943-948 (2019) doi: 10.1038/s41598-018-38119-9
  • Odaka M, Kim H, Nakamura Y, Hattori A, Matsuura K, Iwamura M, Miyagi Y, Yasuda K
    Size Distribution Analysis with On-Chip Multi-Imaging Cell Sorter for Unlabeled Identification of Circulating Tumor Cells in Blood
    Micromachines10:154 (2019) doi: 10.3390/mi10020154
  • Sundar D, Yu Y, Katiyar SP, Putri JF, Dhanjal JK, Wang J, Sari AN, Kolettas E, Kaul SC, Wadhwa R
    Wild type p53 function in p53(Y220C) mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence
    J Exp Clin Cancer Res. 38(1): 103 (2019). doi: 10.1186/s13046-019-1099-x
  • Bhargava P, Malik V, Liu Y, Ryu J, Kaul SC, Sundar D, Wadhwa R
    Molecular Insights into Withaferin-A-Induced Senescence: Bioinformatics and Experimental Evidence to the Role of NFkappaB and CARF
    J Gerontol A Biol Sci Med Sci. 74: 183-191 (2019) doi: 10.1093/gerona/gly107
  • Garg S, Kaul SC, Wadhwa R
    Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence
    Ann Neurosci. 25: 201-209 (2018) doi: 10.1159/000490693
  • Ishida Y, Gao R, Shah N, Bhargava P, Furune T, Kaul SC, Terao K, Wadhwa R
    Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With gamma-Cyclodextrin
    Integr Cancer Ther. 17: 867-873 (2018) doi: 10.1177/1534735417753545
  • Bhargava P, Kumari A, Putri JF, Ishida Y, Terao K, Kaul SC, Sundar D, Wadhwa R
    Caffeic acid phenethyl ester (CAPE) possesses pro-hypoxia and anti-stress activities: bioinformatics and experimental evidences
    Cell Stress Chaperones. 23: 1055-1068 (2018) doi: 10.1007/s12192-018-0915-0
  • Hasako S, Terasaka M, Abe N, Uno T, Ohsawa H, Hashimoto A, Fujita R, Tanaka K, Okayama T, Wadhwa R, Miyadera K, Aoyagi Y, Yonekura K, Matsuo K
    TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations
    Mol Cancer Ther. 17: 1648-1658 (2018) doi: 10.1158/1535-7163.MCT-17-1206
  • Garg S, Huifu H, Kaul SC, Wadhwa R
    Integration of conventional cell viability assays for reliable and reproducible read-outs: experimental evidence
    BMC Res Notes. 11: 403 (2018) doi: 10.1186/s13104-018-3512-5
  • Nagasaki A, Kato Y, Meguro K, Yamagishi A, Nakamura C, Uyeda TQP
    A genome editing vector that enables easy selection and identification of knockout cells
    Plasmid. 9: 3829 (2018) doi: 10.1016/j.plasmid.2018.08.005
  • Yu Y, Nishikawa M, Liu M, Tei T, Kaul SC, Wadhawa R, Zhang MF, Takahashi J, Miyako E
    Self-assembled nanodiamond supraparticles for anticancer chemotherapy
    Nanoscale 10: 8969-8978 (2018) doi: 10.1039/c8nr00641e
  • Kalra RS, Chaudhary A, Yoon AR, Bhargava P, Omar A, Garg S, Yun, CO, Kaul SC, Wadhwa R
    CARF enrichment promotes epithelial-mesenchymal transition via Wnt/beta-catenin signaling: its clinical relevance and potential as a therapeutic target
    Oncogenesis. 7(5): 39 (2018). doi: 10.1038/s41389-018-0048-4
  • Kaur A, Singh B, Ohri P, Wang J, Wadhwa R, Kaul SC, Pati PK, Kaur A
    Organic cultivation of Ashwagandha with improved biomass and high content of active Withanolides: Use of Vermicompost
    PLoS One. 13(4): e0194314 (2018). doi: 10.1371/journal.pone.0194314
  • Nishio M, Yamagishi A, Tsukakoshi K, Kato Y, Nakamura C, Ikebukuro, K
    Selection and Characterization of DNA Aptamers Against FokI Nuclease Domain
    Zinc Finger Proteins 509: 943-948 (2018) doi: 10.1007/978-1-4939-8799-3_12
  • Oh E, Garg S, Liu Y, Afzal S, Gao R, Yun CO, Kaul SC, Wadhwa R
    Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
    Front Oncol. 8: 552 (2018). doi: 10.3389/fonc.2018.00552
  • Bhargava P, Grover A, Nigam N, Kaul A, Doi M, Ishida Y, Kakuta H, Kaul SC, Terao K, Wadhwa R
    Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action
    Int J Oncol. 52: 925-932 (2018) doi: 10.3892/ijo.2018.4249
  • Garg S, Kaul SC, Wadhwa R
    Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review
    Int J Oncol. 52: 19-37 (2018) doi: 10.3892/ijo.2017.4203.
  • Li L, Gao R, Yu Y, Kaul Z, Wang J, Kalra RS, Zhang Z, Kaul SC, Wadhwa R
    Tumor suppressor activity of miR-451: Identification of CARF as a new target
    Sci Rep. 8: 375 (2018) doi: 10.1038/s41598-017-18559-5
  • Kim H, Ishibashi K, Matsuo K, Kira A, Onomura Y, Okada T, Nakamura C
    Adhesion strength of a living cell to various substrates measured using a cup-attached AFM chip
    Jpn J Appl Phys 57: 03EB01 (2018) doi: 10.7567/JJAP.57.03EB01
  • Ryu, S, Matsumoto Y, Matsumoto T, Ueno T, Silberberg YR, Nakamura C
    Improved efficiency of nanoneedle insertion by modification with a cell-puncturing protein
    Jpn J Appl Phys 57: 03EB02 (2018) 10.7567/JJAP.57.03EB02
  • Kawamura R, Miyazaki M, Shimizu K, Matsumoto Y, Silberberg YR, Sathuluri RR, Iijima M, Ruroda S, Iwata F, Kobayashi T, Nakamura C
    A New Cell Separation Method Based on Antibody-Immobilized Nanoneedle Arrays for the Detection of Intracellular Markers
    Nano Lett. 17: 7117-7124 (2017) doi: 10.1021/acs.nanolett.7b03918
  • Chaudhary A, Kalra RS, Huang C, Prakash J, Kaul SC, Wadhwa R
    2,3-Dihydro-3beta-methoxy Withaferin-A Protects Normal Cells against Stress: Molecular Evidence of Its Potent Cytoprotective Activity
    J Nat Prod. 80: 2756-2760 (2017) doi: 10.1021/acs.jnatprod.7b00573
  • Lee WJ, Ahn HM, Na Y, Wadhwa R, Hong J, Yun CO
    Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids
    Sci Rep. 7(1):12957(2017) doi: 10.1038/s41598-017-13485-y
  • Putri JF, Widodo N, Sakamoto K, Kaul SC, Wadhwa R
    Induction of senescence in cancer cells by 5-Aza-2-deoxycytidine: Bioinformatics and experimental insights to its targets
    Comput Biol Chem. 125: 168-174 (2017) doi: 10.1016/j.compbiolchem.2017.08.003
  • Wadhwa R, Kalra RS, Kaul SC
    CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis
    Mech Ageing Dev. 14: 3025-3035 (2017) doi: 10.1016/j.mad.2017.07.008
  • Kim H, Yamagishi A, Imaizumi M, Onomura Y, Nagasaki A, Miyagi Y, Okada T, Nakamura C
    Quantitative measurements of intercellular adhesion between a macrophage and cancer cells using a cup-attached AFM chip
    Colloids Surf B Biointerfaces 37: 366-372 (2017) doi: 10.1016/j.colsurfb.2017.04.039
  • Girault M, Kim H,, Arakawa H, Matsuura K, Odaka M, Hattori A, Terazono H, Yasuda K
    An on-chip imaging droplet-sorting system: a real-time shape recognition method to screen target cells in droplets with single cell resolution
    Sci Rep 7: 40072 (2017) doi: 10.1038/srep40072
  • Nishio M, Matsumoto D, Kato Y, Abe K, Lee J, Tsukakoshi K, Yamagishi A, Nakamura C,, Ikebukuro K
    DNA aptamers against FokI nuclease domain for genome editing applications
    Biosens. Bioelectron. 93: 26-31 (2017) doi: 10.1016/j.bios.2016.11.042
  • Tomita T, Kurita R, Onishi Y
    Epigenetic regulation of the circadian clock: role of 5-aza-2-deoxycytidine
    Biosci Rep. 37: 0 (2017) doi: 10.1042/BSR20170053
  • Nagasaki A, T Kijima S, Yumoto T, Imaizumi M, Yamagishi A, Kim H, Nakamura C, Q P Uyeda T
    The Position of the GFP Tag on Actin Affects the Filament Formation in Mammalian Cells
    Cell Struct Funct. 42: 131-140 (2017) doi: 10.1247/csf.17016
  • Singh P, Guleri R, Angurala A, Kaur K, Kaur K, Kaul SC, Wadhwa R, Pati PK
    Addressing Challenges to Enhance the Bioactives of Withania somnifera through Organ, Tissue, and Cell Culture Based Approaches
    Biomed Res Int. 486: 539-544 (2017) doi: 10.1155/2017/3278494
  • Yu Y, Katiyar SP, Sundar D, Kaul Z, Miyako E, Zhang Z, Kaul SC, Reddel RR, Wadhwa R
    Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences
    Cell Death Dis. 8(4): e2755 (2017). doi: 10.1038/cddis.2017.33
  • Yun CO, Bhargava P, Na Y, Lee JS, Ryu J, Kaul SC, Wadhwa R.
    Relevance of Mortalin to Cancer Cell Stemness and Cancer Therapy
    Sci. Rep. (2017) 7: 42016. doi: 10.1038/srep42016
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