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  4. 誌上発表（国際誌・査読有）2024年

研究成果　Research Result

誌上発表（国際誌・査読有）2024年

部門研究戦略1：生物機能解明

脳遺伝子研究グループ
Molecular Neurobiology Research Group

  • Shimasaki, K., Okemoto-Nakamura, Y., Saito, K., Fukasawa, M., Katoh, K., Hanada, K. A high-resolution phase-contrast microscopy system for label-free imaging in living cells. Cell Struct. Funct., 49(1) (2024).
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  • Wada, M., Higa, T., Katoh, K., Moritoki, N., Nakai, T., Nishino, Y., Miyazawa, A., Shibata, S., Mineyuki, Y.: Chloroplast-actin filaments decide the direction of chloroplast avoidance movement under strong light in Arabidopsis thaliana. J. Plant Res. (2024).
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脳機能調節因子研究グループ
Molecular Neurophysiology Research Group

  • Suzuki, N., Oota-Ishigaki, A., Kaizuka, T., Itoh, M., Yamazaki, M., Natsume, R., Abe, M., Sakimura, K., Mishina, M., Hayashi, T.: Limb-Clasping Response in NMDA Receptor Palmitoylation-Deficient Mice. Mol. Neurobiol., 61(11), 9125-9135 (2024).
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細胞分子機能研究グループ
Functional Biomolecular Research Group

  • Toita, R., Shimizu, Y., Shimizu, E., Deguchi, T., Tsuchiya, A., Kang, J-H., Kitamura, M., Kato, A., Yamada, H., Yamaguchi, S., Kasahara, S.: Collagen patches releasing phosphatidylserine liposomes guide M1-to-M2 macrophage polarization and accelerate simultaneous bone and muscle healing. Acta Biomater. (2024).
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  • Toita, R., Kitamura, M., Tsuchiya, A., Kang, J-H., Kasahara, S.: Releasable, Immune-Instructive, Bioinspired Multilayer Coating Resists Implant-Induced Fibrosis while Accelerating Tissue Repair. Adv. Healthc. Mater., 2302611 (2024).
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  • Kang, J-H., Kawano, T., Murata, M., Toita, R.: Vascular calcification and cellular signaling pathways as potential therapeutic targets. Life Sci., 336, 122309 (2024).
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  • Tsuno, S., Harada, K., Horikoshi, M., Mita, M., Kitaguchi, T., Yokota Hirai, M., Matsumoto, M., Tsuboi, T.: Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes. FEBS Open Bio, 14(1), 79-95 (2024).
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部門研究戦略2：生物機能計測

バイオアナリティカル研究グループ
Bioanalytical Research Group

  • Jiang, Y-N., Tamiya-Ishitsuka, H., Aoi, R., Okabe, T., Yokota, A., Noda, N.: MazEF Homologs in Symbiobacterium thermophilum Exhibit Cross-Neutralization with Non-Cognate MazEFs. Toxins, 16(2), 81 (2024).
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  • Okabe, T., Aoi, R., Yokota, A., Tamiya-Ishitsuka, H., Jiang, Y., Sasaki, A., Tsuneda, S., Noda, N.: Arg-73 of the RNA endonuclease MazF in Salmonella enterica subsp. arizonae contributes to guanine and uracil recognition in the cleavage sequence. J. Biol. Chem., 300(2), 105636 (2024).
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  • Miura, D., Tsurigami, R., Kato, H., Wariishi, H., Shimizu, M.: Pathway crosstalk between the central metabolic and heme biosynthetic pathways in Phanerochaete chrysosporium. Appl. Microbiol. Biotechnol., 108(1), 37 (2024).
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細胞・生体医工学研究グループ
Medical and Biological Engineering Research Group

  • Okuda, T.: Characterization of antibodies induced by immunization of mice with isoglobotrihexosylceramide (iGb3). Biochem. Biophys. Rep., 40, 101855 (2024).
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部門研究戦略3：生物機能応用

分子細胞デザイン研究グループ
Molecular and Cellular Design Research Group

構造創薬研究グループ
Structure-Based Drug Discovery Research Group

  • Yanagawa, K., Kuma, A., Hamasaki, M., Kita, S., Yamamuro, T., Nishino, K., Nakamura, S., Omori, H., Kaminishi, T., Oikawa, S., Kato, Y., Edahiro, R., Kawagoe, R., Taniguchi, T., Tanaka, Y., Shima, T., Tabata, K., Iwatani, M., Bekku, N., Hanayama, R., Okada, Y., Akimoto, T., Kosako, H., Takahashi, A., Shimomura, I., Sakata, Y., Yoshimori, T.: The Rubicon–WIPI axis regulates exosome biogenesis during ageing. Nat. Cell Biol., 26, 1558-1570 (2024).
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  • Furuhata, Y., Kimura, M., Sakai, A., Murakami, T., Egi, E., Sakuma, T., Yamamoto, T., Yoshizumi, T., Kato, Y.: Direct protein delivery into intact Arabidopsis cells for genome engineering. Sci Rep, 14(1), 22568 (2024).
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  • Yamasaki, K., Tsuzuki, S., Tateno, H.: Stabilization of the Protein Structure by the Many-Body Cooperative Effect in the NH/π Hydrogen-bonding Tryptophan Triad. J. Phys. Chem. B, 128(30), 7401-7406 (2024).
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  • Kataoka, S., Kawamoto, S., Kitagawa, S., Kugimiya, W., Tsumura, K., Akutsu, Y., Kubota, T., Ishikawa, K.: Structural and functional insights into the enzymatic activities of lipases from Burkholderia stagnalis and Burkholderia plantarii. FEBS Lett., 598(11), 1411-1421 (2024).
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生体分子創製研究グループ
Biomolecule Design Research Group

  • Watanabe, M., Nakamichi, Y., Mine, S.: Elucidation of d-allulose recognition mechanism in ketose 3-epimerase. J. Biosci. Bioeng., 138(6), 488-494 (2024).
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  • Kagawa, Y., Oohora, K., Himiyama, T., Suzuki, A., Hayashi, T.: Redox Engineering of Myoglobin by Cofactor Substitution to Enhance Cyclopropanation Reactivity. Angew. Chem.-Int. Edit., 63(36), e202403485 (2024).
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  • Hino, S., Masui, A., Okamura, H., Kawasaki, N., Yamano, N., Nakayama, A.: Porphyrin as Photosensitizers for Controlling Marine Biodegradation of Polymer Composites. Biomacromolecules, 25(10), 6395-6402 (2024).
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  • Ihara, M., Tsuchida, N., Sumida, M., Himiyama, T., Kitayama, T., Shirasaka, N., Fukuta, Y.: Crystal Structure of the Native Chromoprotein from Pleurotus salmoneostramineus Provides Insights into the Pigmentation Mechanism. J. Agric. Food Chem., 72(31), 17626-17632 (2024).
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  • Chuma, S., Kiyosue, K., Akiyama, T., Kinoshita, M., Shimazaki, Y., Uchiyama, S., Sotoma, S., Okabe, K., Harada, Y.: Implication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature. Nat. Commun., 15(3473) (2024).
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  • Yakaryo, H., Nakayama, A., Kawasaki, N., Yamano, N., Ida, S., Tokiwa, Y.: Synthesis and Biodegradation of Atactic Polymer Based on 3-Hydroxybutanoic Acid. Chem. Lett., 53(3) (2024).
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  • Omura, T., Isobe, N., Miura, T., Ishii, S., Mori, M., Ishitani, Y., Kimura, S., Hidaka, K., Komiyama, K., Suzuki, M., Kasuya, K., Nomaki, H., Nakajima, R., Tsuchiya, M., Kawagucci, S., Mori, H., Nakayama, A., Kunioka, M., Kamino, K., Iwata, T.: Microbial decomposition of biodegradable plastics on the deep-sea floor. Nat. Commun., 15, 568-584 (2024).
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先端ゲノムデザイン研究グループ
Advance Genome Design Research Group

  • Mukae, T., Yoshii, K., Oishi, I.: Application of Recombinant Monoclonal Antibodies from Transgenic Chicken Bioreactors in Enzyme-Linked Immunosorbent Assay. Biol. Pharm. Bull., 47(9), 1532-1541 (2024).
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  • Nguyen, T., Itayama, T., Iwami, N., Shimizu, K., Dao, T., Pham, T.L., Tra, V.Q., Maseda, H.: Toxicity of ciprofloxacin and ofloxacin to Moina macrocopa and investigation of p-value adjustments for (eco)toxicological studies. Drug Chem. Toxicol., 47(5), 662-673 (2024).
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  • Fukuda, N., Takeuchi, M.: Removal of undesirable genes using yeast backcrossing. J. Biosci. Bioeng. (2024).
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  • Asama, R., Tominaga, M., Ito, S., Ito, Y., Takemura, K., Sakuraba, S., Katsurada, K., Fukuda, N., Kondo, A., Ishii, J.: Screening of protein-based inhibitors for the intracellular domain of epidermal growth factor receptor by directed evolution using the yeast Gγ recruitment system. J. Biosci. Bioeng. (2024).
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  • Hitsuda, Y., Koto, Y., Kawahara, H., Kurata, K., Yoshikiyo, K., Nishimura, K., Hashiguchi, A., Maseda, H., Okano, K., Sugiura, N., Shimizu, K., Shimizu, H.: Increased Prorenin Expression in the Kidneys May Be Involved in the Abnormal Renal Function Caused by Prolonged Environmental Exposure to Microcystin-LR.. Toxics, 12(8), 547 (2024).
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  • You, J., Andriamanohiarisaamanana, F.J., Farghali, M., Yoshida, G., Shimizu, K., Maseda, H., Umetsu, K., Ihara, I.: Unveiling antibiotic resistance dynamics in single and two-stage anaerobic digestion of dairy cow manure: Implications for environmental health. Process Saf. Environ. Protect., 190, 522-534 (2024).
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  • Takeuchi, M., Fujiwara-Nagata, E., Kuroda, K., Sakata, K., Narihiro, T., Kikuchi, J.: Fecal metagenomic and metabolomic analyses reveal non-invasive biomarkers of Flavobacterium psychrophilum infection in ayu (Plecoglossus altivelis). mSphere, 9(7) (2024).
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部門長・副部門長・首席研究員・総括研究員・招聘研究員
Director, Deputy Director, Prime Senior Researcher, Principal Research Manager, Honda Lab.

  • Matsuda, T., Akazawa-Ogawa, Y., Komaba, L-K., Kiyose, N., Miyazaki, N., Mizuguchi, Y., Fukuta, T., Ito, Y., Hagihara, Y.: Prediction of antigen-responding VHH antibodies by tracking the evolution of antibody along the time course of immunization. Front. Immunol., 14 (2024).
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  • Sakata, S., Li, J., Yasuno, Y., Shinada, T., Shin-Ya, K., Katsuyama, Y., Ohnishi, Y.: Identification of the Cirratiomycin Biosynthesis Gene Cluster in Streptomyces Cirratus: Elucidation of the Biosynthetic Pathways for 2,3-Diaminobutyric Acid and Hydroxymethylserine. Chemistry, 30(28), e202400271 (2024).
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  • Kudo, K., Nishimura, T., Izumikawa, M., Kozone, K., Hashimoto, J., Fujie, M., Suenaga, H., Ikeda, H., Satoh, N., Shin-ya, K.: Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds. J. Antibiot., 77, 288-298 (2024).
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  • Nishimura, T., Kudo, K., Izumikawa, M., Kozone, K., Hashimoto, J., Kagaya, N., Suenaga, H., Takeuchi, K., Shin-ya, K.: Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster. Chem. Pharm. Bull., 72(5), 475-479 (2024).
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  • Goto, Y., Miyafusa, T., Honda, S.: Designing monomeric IFNγ: The significance of domain-swapped dimer structure in IFNγ immune responses. J. Biol. Chem., 300(7), 107464 (2024).
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  • Watanabe, H., Hayashida, N.,, Sato, M., Honda, S.: Biosensing-based quality control monitoring of the higher-order structures of therapeutic antibody domains. Anal. Chim. Acta, 1303, 342439 (2024).
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