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  4. 誌上発表（国際誌・査読有）2020年

研究成果　Research Result

誌上発表（国際誌・査読有）2020年

部門研究戦略1：生物機能解明

脳遺伝子研究グループ
Molecular Neurobiology Research Group

  • Doi, M., Sato, M., Ohmiya, Y.: In Vivo Simultaneous Analysis of Gene Expression by Dual-Color Luciferases in Caenorhabditis elegans. Int. J. Mol. Sci., 22(1), 119 (2020).
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  • Higaki, T., Akita, K., Katoh, K.: Coefficient of variation as an image-intensity metric for cytoskeleton bundling. Sci Rep, 10, 22178 (2020).
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  • Suzuki, H., Inaba, M., Yamada, M., Uehara, T., Takenouchi, T., Mizuno, S., Kosaki, K., Doi, M.: Biallelic loss of OTUD7A causes severe muscular hypotonia, intellectual disability, and seizures. Am. J. Med. Genet. A (2020).
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  • Yamaguchi, H., Honda, S., Torii, S., Shimizu, K., Katoh, K., Miyake, K., Miyake, N., Fujikake, N., Tajima Sakurai, H., Arakawa, S., Shimizu, S.: Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Nature Communications (2020).
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  • Gotoh, N., Saito, Y., Hata, S., Saito, H., Ojima, D., Murayama, C., Shigeta, M., Abe, T., Konno, D., Matsuzaki, F., Suzuki, T., Yamamoto, T.: Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α–deficient mice. J. Biol. Chem., 295(28), 9650-9662 (2020).
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  • Kakuda, N., Yamaguchi, H., Akazawa, K., Hata, S., Suzuki, T., Hatsuta, H., Murayama, S., Funamoto, S., Ihara, Y.: γ-Secretase Activity Is Associated with Braak Senile Plaque Stages. Am. J. Pathol., 190(6), 1323-1331 (2020).
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  • Hasegawa, T., Takahashi, J., Nagasawa, S., Doi, M., Moriyama, A., Iwahashi, H.: DNA strand break properties of protoporphyrin IX by X-ray irradiation against melanoma. Int. J. Mol. Sci., 21(7), 2302 (2020).
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脳機能調節因子研究グループ
Molecular Neurophysiology Research Group

  • Inagaki, H., Haramoto, Y., Kubota, H., Shigeri, Y.: Complete mitochondrial genome sequence of Japanese forest green tree frog (Rhacophorus arboreus). Mitochondrial DNA Part B-Resour., 5(3), 3347-3348 (2020).
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  • Hirano, K., Kubo, M., Fukuyama, Y., Namihira, M.: Indonesian ginger (Bangle) extract promotes neurogenesis of human neural stem cells through WNT pathway activation. Int. J. Mol. Sci., 21(13), 4772 (2020).
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  • Ohtsuka, Y., Inagaki, H.: In silico identification and functional validation of linear cationic α-helical antimicrobial peptides in the ascidian Ciona intestinalis. Sci Rep., 10, 12619 (2020).
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  • Radis-Baptista, G., Dodou, H.V., Prieto-da Silva, A.R>B., Zaharenko A., Kazuma, K., Nihei, K., Inagaki, H., Mori-Yasumoto, K., Konno, K.: Comprehensive analysis of peptides and low molecular weight components of the giant ant Dinoponera quadriceps venom. Biol. Chem., 401(8), 945-954 (2020).
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  • Murotomi, K., Umeno, A., Sugino, S., Yoshida, Y.: Quantitative kinetics of intracellular singlet oxygen generation using a fluorescence probe. Sci Rep, 10, 10616 (2020).
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  • Umeno, A., Sakashita, M., Sugino, S., Murotomi, K., Okuzawa, T., Morita, N., Tomii, K., Tsuchiya, Y., Yamasaki, K., Horie, M., Takahara, K., Yoshida, Y.: Comprehensive analysis of PPARγ agonist activities of stereo-, regio-, and enantio-isomers of hydroxyoctadecadienoic acids. Biosci. Rep., 40(4), BSR20193767 (2020).
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  • Sasaki, N., Gomi, F., Hasegawa, F., Hirano, K., Fujiwara, M., Toyoda, M., Ishiwata, T.: Characterization of the metastatic potential of the floating cell component of MIA PaCa-2, a human pancreatic cancer cell line. Biochem. Biophys. Res. Commun., 522(4), 881-888 (2020).
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細胞分子機能研究グループ
Functional Biomolecular Research Group

  • Toita, R., Kang, J-H.: Long-term profile of serological biomarkers, hepatic inflammation, and fibrosis in a mouse model of non-alcoholic fatty liver disease. Toxicol. Lett., 332, 1-6 (2020).
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  • Kiyooka, M., Shimizu, Y., Ohshima, T.: Histone deacetylase inhibition promotes regenerative neurogenesis after stab wound injury in the adult zebrafish optic tectum. Biochem. Biophys. Res. Commun., 529(2), 366-371 (2020).
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  • Toita, R., Shimizu, E., Kang, J-H.: Unique cellular interaction of macrophage-targeted liposomes potentiates anti-inflammatory activity. Chem. Commun., 56, 8253-8256 (2020).
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  • Koike-Tani, M., Tominaga, T., Oldenbourg, R., Tani, T.: Birefringence Changes of Dendrites in Mouse Hippocampal Slices Revealed with Polarizing Microscopy. Biophys. J., 118(10), 2366-2384 (2020).
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  • Asai, D., Kawano, T., Murata, M., Nakashima, H., Toita, R., Kang, J-H.: Effect of fetal bovine serum concentration on lysophosphatidylcholine-mediated proliferation and apoptosis of human aortic smooth muscle cells. J. Oleo Sci., 69(3), 255-260 (2020).
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  • Kiyosue, K., Miwa, Y.: Epstein-Barr virus-derived vector suitable for long-term expression in neurons. Heliyon, 6(3), e03504 (2020).
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  • Fujikawa, Y., Ishikawa-Fujiwara, T., Kuo, T., Shinkai, N., Shoji, T., Kawasaki, T., Kamei, T., Sakuraba, Y., Sato, A., Kinoshita, M., Gondo, Y., Yuba, S., Tsujimura, T., Sese, J., Todo, T.: Involvement of Rev1 in alkylating agent-induced loss of heterozygosity in Oryzias latipes. Genes Cells, 25(2), 124-138 (2020).
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  • Sunarso, Toita, R., Tsuru, K., Ishikawa, K.: Ozone-gas-mediated surface hydrophilization enhances the cell responses to titanium. Mater. Lett., 261, 127168 (2020).
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部門研究戦略2：生物機能計測

バイオアナリティカル研究グループ
Bioanalytical Research Group

  • Kataoka, Y., Iimori, M., Fujisawa, R., Morikawa-Ichinose, T., Niimi, S., Wakasa, T., Saeki, H., Oki, E., Miura, D., Tsurimoto, T., Maehara, Y., Kitao, H.: DNA Replication Stress Induced by Trifluridine Determines Tumor Cell Fate According to p53 Status. Mol. Cancer Res., 18(6), 1354-1356 (2020).
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  • Kazuki, Y., Gao, FJ., Li, Y., Moyer, A.J., Devenney, B., hiramatsu, K., Miyagawa-Tomita, S., Abe, S., Kazuki, K., Kajitani, N., Uno, N., Takehara, S., Takiguchi, M., Yamakawa, M., Hasegawa, A., Shimizu, R., Matsukura, S., Noda, N., Ogonuki, N., Inoue, K., Matoba, S., Ogura, A., Florea, L.D., Savonenko, A., Xiao, M., Wu, D., Batista, D.A., Yang, J., Qiu, Z., Singh, N., Richtsmeier, J.T., Takeuchi, T., Oshimura, M., Reeves, R.H.: A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21. eLife (2020).
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  • Aoi, R., Miyamoto, T., Yokota, A., Ota, Y., Fujitani, H., Tsuneda, S., Noda, N.: MazF endoribonucleolytic toxin conserved in Nitrospira specifically cleaves the AACU, AACG, and AAUU motifs. Toxins, 12(5), 287 (2020).
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  • Tourlousse, D.M., Sakamoto, M., Miura, T., Narita, K., Ohashi, A., Uchino, Y., Yamazoe, A., Kameyama, K., Terauchi, J., Ohkuma, M., Kawasaki, H., Sekiguchi, Y.: Complete genome sequence of Flavonifractor plautii JCM 32125T. Microbiology Resource Announcements, 9(17), e00135-20 (2020).
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  • Tourlousse, D.M., Sakamoto, M., Miura, T., Narita, K., Ohashi, A., Uchino, Y., Yamazoe, A., Kameyama, K., Terauchi, J., Ohkuma, M., Kawasaki, H., Sekiguchi, Y.: Complete genome sequence of megamonas funiformis JCM 14723T. Microbiology Resource Announcements, 9(16), e00142-20 (2020).
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  • Tourlousse, D.M., Sakamoto, M., Miura, T., Narita, K., Ohashi, A., Uchino, Y., Yamazoe, A., Kameyama, K., Terauchi, J., Ohkuma, M., Kawasaki, H., Sekiguchi, Y.: Complete genome sequence of Collinsella aerofaciens JCM 10188T. Microbiology Resource Announcements, 9(16), e00134-20 (2020).
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  • Tourlousse, D.M., Sakamoto, M., Miura, T., Narita, K., Ohashi, A., Uchino, Y., Yamazoe, A., Kameyama, K., Terauchi, J., Ohkuma, M., Kawasaki, H., Sekiguchi, Y.: Complete genome sequence of Blautia producta JCM 1471T. Microbiology Resource Announcements, 9(17), e00141-20 (2020).
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  • Morikawa-Ichinose, T., Miura, D., Zhang, L., Kim, S-J., Maruyama-Nakashita, A.: Involvement of BGLU30 in glucosinolate catabolism in the Arabidopsis leaf under dark conditions. Plant Cell Physiol., 61(6), 1095-1106 (2020).
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細胞・生体医工学研究グループ
Medical and Biological Engineering Research Group

  • Dwiranti, A., Arifudin, F.S., Takata, H., Ohmido, N., Fukui, K.: Application of the Chromosome Image Analyzing System (CHIAS) for Straightening Cation‐treated Bent Chromosomes. Microsc. Res. Tech., 83(11), 1411-1416 (2020).
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  • Soeta, Y., Ariki, A.: Subjective Salience of Birdsong and Insect Song with Equal Sound Pressure Level and Loudness. Int. J. Environ. Res. Public Health, 17(23), 8858 (2020).
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  • Nakamura, M.: Two extensions of heterogeneous boid model to avoid metastable patterns. Artificial life and robotics, 25, 578-587 (2020).
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  • Yu, Y., Yang, Xi., Reghu, S., Kaul, S.C., Wadhwa, R., Miyako, E.: Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes. Nat. Commun. (2020).
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  • Lucherelli, M.A., Yu, Y., Reina, G., Abellan, G., Miyako, E., Bianco, A.: Rational Chemical Multifunctionalization of Graphene Interface Enhances Targeted Cancer Therapy. Angew. Chem.-Int. Edit., 59(33), 14034-14039 (2020).
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  • Wako, T., Yoshida, A., Kato, J., Otsuka, Y., Ogawa, S., Kaneyoshi, K., Takata, H., Fukui, K.: Human metaphase chromosome consists of randomly arranged chromatin fibres with up to 30-nm diameter. Sci. Rep., 10(1), 8948 (2020).
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  • Kibria, M.G., Akazawa-Ogawa, Y., Rahman, N., Hagihara, Y., Kuroda, Y.: The immunogenicity of an anti-EGFR single domain antibody (VHH) is enhanced by misfolded amorphous aggregation but not by heat-induced aggregation. Eur. J. Pharm. Biopharm., 152, 164-174 (2020).
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  • Akazawa-Ogawa, Y., Komatsu, Y., Nakajima, Y., Kojima, N., Hagihara, Y.: PCR-based approach for site-specific conjugation of long double-stranded DNA to a single-domain VHH antibody. J. Biochem., 168(1), 63-72 (2020).
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  • Horio, Y., Sogabe, R., Shichiri, M., Ishida, N., Morimoto, R., Ohshima, A., Isegawa, Y.: Induction of a 5-lipoxygenase product by daidzein is involved in the regulation of influenza virus replication. J. Clin. Biochem. Nutr., 66(1), 36-42 (2020).
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  • Soeta, Y., Kagawa, H.: Subjective preferences for birdsong and insect song in equal sound pressure level. Appl. Sci., 10(3), 849 (2020).
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  • Soeta, Y., Kagawa, H.: Three dimensional psychological evaluation of aircraft noise and prediction by physical parameters. 167, 106445 (2020).
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  • Shen, Y., Tanaka, N., Yamazoe, H., Furutani, S., Nagai, H., Kawai, T., Tanaka, Y.: Flow analysis on microcasting with degassed polydimethylsiloxane micro-channels for cell patterning with cross-linked albumin. PLoS One., 15(5), e0232518 (2020).
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  • Kurinomaru, T., Inagaki, A., Hoshi, M., Nakamura, C., Yamazoe, H.: Protein microswimmers capable of delivering cells for tissue engineering applications. Mater. Horizons, 3, 877-884 (2020).
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部門研究戦略3：生物機能応用

分子細胞デザイン研究グループ
Molecular and Cellular Design Research Group

  • Shibakami, M., Sohma, M.: Effects of long-chain acyl substituents on the thermoplasticity and mechanical properties of paramylon mixed sters. J. Polym. Environ., 2020(28), 2263-2276 (2020).
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  • Shibuya, R., Miyafusa, T., Honda, S.: Stabilization of backbone-circularized protein is attained by synergistic gains in enthalpy of folded structure and entropy of unfolded structure. FEBS J., 287(8), 1554-1575 (2020).
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構造創薬研究グループ
Structure-Based Drug Discovery Research Group

  • Nonaka, M., Mabashi-Asazuma, H., Jarvis, D.L., Yamasaki, K., Akam ,T.O., Nagaoka, M., Sasai, T., Kimura-Takagi, I., Suwa, Y., Yaegashi, T., Huang, C., Nishizawa-Harada, C., Fukuda, M.N.: Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides. PLos One, (1), e0241157 (2021).
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  • Nonaka, M., Suzuki-Anekoji, M., Nakayama, J., Mabashi-Asazuma, H., Jarvis, D.L., Yeh, J-C., Yamasaki, K., Akama, T.O., Huang, C-T., Campos, A.R., Nagaoka, M., Sasai, T., Kimura-Takagi, I., Suwa, Y., Yaegashi, T., Shibata, T., Sugihara, K., Nishizawa-Harada, C., Fukuda, M., Fukuda, M.N.: Overcoming the blood-brain barrier by Annexin A1-binding peptide to target brain tumours. Br. J. Cancer (2020).
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  • Takagi, Y., Kuwabara, N., Dang, T.T., Furukawa, K., Ho, C.K.: Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5' end of the RNA substrate. J. Biol. Chem. (2020).
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  • Yamasaki, K., Akutsu, Y., Yamasaki, T., Miyagishi, M., Kubota, T.: Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts. Nucleic Acids, Res. (2020).
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  • Furuhata, Y., Sakai, A., Murakami, T., Nagasaki, A., Kato, Y.: Bioluminescent imaging of Arabidopsis thaliana using an enhanced Nano-lantern luminescence reporter system. Plos One, 15(1), e0227477 (2020).
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生体分子創製研究グループ
Biomolecule Design Research Group

  • Fukuda, N., Honda, S., Fujiwara, M., Yoshimura, Y., Nakamura, T.: Polyploid engineering by increasing mutant gene dosage in yeasts. Microb. Biotechnol., 0(0), 1-14 (2020).
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  • Fukuda, N.: Crossbreeding of Yeasts Domesticated for Fermentation: Infertility Challenges. Int. J. Mol. Sci., 21(21), 7985 (2020).
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  • Zahir, L., Kida, T., Tanaka, R., Nakayama, Y., Shiono, T., Kawasaki, N., Yamano, N., Nakayama, A.: Synthesis and properties of biodegradable thermoplastic elastomers using 2-Methyl-1,3-propanediol, succinic acid and lactide. Polym. Degrad. Stabil., 181, 109353 (2020).
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  • Fukuda, N.: A new scheme to artificially alter yeast mating-types without autodiploidization. Fungal Genet. Biol., 144, 103442 (2020).
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  • Kojima, M., Ishii, C., Sano, Y., Mizui, T., Furuichi, T.: Journey of brain-derived neurotrophic factor: from intracellular trafficking to secretion. Cell Tissue Res., 382(1), 125-134 (2020).
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  • Kojima, M., Otabi, H., Kumanogoh, H., Toyoda, A., Ikawa, M., Okabe, M., Mizui, T.: Reduction in BDNF from Inefficient Precursor Conversion Influences Nest Building and Promotes Depressive-Like Behavior in Mice. 21(11), 3984 (2020).
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  • Nakayama, Y., Watanabe, K., Tanaka, R., Shiono, T., Kawasaki, N., Yamano, N., Nakayama, A.: Synthesis, properties, and biodegradation of sequential poly(ester amide)s containing γ-aminobutyric acid. Int. J. Mol. Sci., 21(10), 3674 (2020).
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  • Himiyama, T., Nakamura, T.: Disassembly of the ring‐type decameric structure of peroxiredoxin from Aeropyrum pernix K1 by amino acid mutation. Protein Sci., 29(5), 1138-1147 (2020).
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  • Kawasaki, N., Yamano, N., Nakayama, A.: Synthesis, properties, and biodegradability of three‐branched copolyamide (4/6). J. Appl. Polym. Sci., 137(39) (2020).
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  • Nakayama, Y., Yagumo, W., Tanaka, R., Shiono, T., Inumaru, K., Tsutsumi, C., Kawasaki, N., Yamano, N., Nakayama, A.: Synthesis, properties and biodegradation of periodic copolyesters composed of hydroxy acids, ethylene glycol, and terephthalic acid. Polym. Degrad. Stabil., 174, 109095 (2020).
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先端ゲノムデザイン研究グループ
Advance Genome Design Research Group

  • Mukae, T., Okumura, S., Watanobe, T., Yoshii, K., Tagami, T., Oishi, I.: Production of Recombinant Monoclonal Antibodies in the Egg White of Gene-Targeted Transgenic Chickens. Genes, 12(1) (2020).
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  • Wang, K-Y., Wu, C., Shimajiri, S., Enomoto, T., Kubota, H., Akiyama, H., Ohmiya, Y.: Quantitative immunohistochemistry using an antibody-fused bioluminescent protein. Biotechniques, 69(4) (2020).
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  • Dang, B-T., Gotore, O., Ramaraj, R., Unpaprom, Y., Whangchai, N., Bui, X-T., Maseda, H., Itayama, T.: Sustainability and application of corncob-derived biochar for removal of fluoroquinolones. Biomass Convers. Biorefinery, 1-11 (2020).
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  • Okano, K., Shimizu, K., Saito, T., Maseda, H., Utsumi, H., Itayama, T., Sugiura, N.: Draft Genome Sequence of the Microcystin-Degrading Bacterium Novosphingobium sp. Strain MD-1. Microbiology Resource Announcements. (2020).
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  • Anh, H.T.L., Kawata, Y., Tam, L.T., Thom, L.T., Ha, N.C., Hien, H.T.M., Thu, N.T.H., Huy, P.Q., Hong, D.D.: Biocharacteristics and draft genome sequence of Halomonas hydrothermalis C22, a pyruvate-producing halophilic bacterium isolated from a commercial Spirulina culture in Vietnam. Arch. Microbiol. (2020).
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  • Anh, H.T.L., Kawata, Y., Tam, L.T., Thom. L.T., Ha, N.C., Hien, H.T.M., Thu, N.T.H., Huy, P.Q., Hong, D. D.: Production of pyruvate from Ulva reticulata using the alkaliphilic, halophilic bacterium Halomonas sp. BL6. J. Appl. Phycol. (2020).
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部門長・副部門長・首席研究員・総括研究員・招聘研究員
Director, Deputy Director, Prime Senior Researcher, Principal Research Manager, Honda Lab.

  • Fujitani H., Momiuchi, K., Ishii, K., Nomachi, M., Kikuchi, S., Ushiki, N., Sekiguchi, Y., Tsuneda, S.: Genomic and Physiological Characteristics of a Novel Nitrite-Oxidizing Nitrospira Strain Isolated From a Drinking Water Treatment Plant. Front. Microbiol. (2020).
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  • Ishii, K., Fujitani, H., Sekgiguchi, Y., Tsuneda, S.: Physiological and genomic characterization of a new ‘Candidatus Nitrotoga’ isolate. Environ. Microbiol., 22(6), 2365-2382 (2020).
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  • Sonoi, R., Hagihara, Y.: Switching of cell fate through the regulation of cell growth during drug-induced intrahepatic cholestasis. J. Biosci. Bioeng., 130(6), 659-665 (2020).
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  • Semba, S., Kitamura, N., Tsuda, M., Goto, K., Kurono, S., Ohmiya, Y., Kurokawa, T., Gong, J.P., Yasuda, K., Tanaka, S.: Synthetic poly(2‐acrylamido‐2‐methylpropanesulfonic acid) gel induces chondrogenic differentiation of ATDC5 cells via a novel protein reservoir function. J. Biomed. Mater. Res. Part A, (2020).
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