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  4. 誌上発表(国際誌・査読有)2020年

研究成果 Research Result

誌上発表(国際誌・査読有)2020年

部門研究戦略1:生物機能解明

脳遺伝子研究グループ

  • Hasegawa, T., Takahashi, J., Nagasawa, S., Doi, M., Moriyama, A., Iwahashi, H.: DNA strand break properties of protoporphyrin IX by X-ray irradiation against melanoma. Int. J. Mol. Sci., 21(7), 2302 (2020).

脳機能調節因子研究グループ

  • Hirano, K., Kubo, M., Fukuyama, Y., Namihira, M.: Indonesian ginger (Bangle) extract promotes neurogenesis of human neural stem cells through WNT pathway activation. Int. J. Mol. Sci., 21(13), 4772 (2020).
  • Ohtsuka, Y., Inagaki, H.: In silico identification and functional validation of linear cationic α-helical antimicrobial peptides in the ascidian Ciona intestinalis. Sci Rep., 10, 12619 (2020).
  • Murotomi, K., Umeno, A., Sugino, S., Yoshida, Y.: Quantitative kinetics of intracellular singlet oxygen generation using a fluorescence probe. Sci Rep, 10, 10616 (2020).
  • Umeno, A., Sakashita, M., Sugino, S., Murotomi, K., Okuzawa, T., Morita, N., Tomii, K., Tsuchiya, Y., Yamasaki, K., Horie, M., Takahara, K., Yoshida, Y.: Comprehensive analysis of PPARγ agonist activities of stereo-, regio-, and enantio-isomers of hydroxyoctadecadienoic acids. Biosci. Rep., 40(4), BSR20193767 (2020).
  • Sasaki, N., Gomi, F., Hasegawa, F., Hirano, K., Fujiwara, M., Toyoda, M., Ishiwata, T.: Characterization of the metastatic potential of the floating cell component of MIA PaCa-2, a human pancreatic cancer cell line. Biochem. Biophys. Res. Commun., 522(4), 881-888 (2020).

細胞分子機能研究グループ

  • Toita, R., Kang, J-H.: Long-term profile of serological biomarkers, hepatic inflammation, and fibrosis in a mouse model of non-alcoholic fatty liver disease. Toxicol. Lett., 332, 1-6 (2020).
  • Kiyooka, M., Shimizu, Y., Ohshima, T.: Histone deacetylase inhibition promotes regenerative neurogenesis after stab wound injury in the adult zebrafish optic tectum. Biochem. Biophys. Res. Commun., 529(2), 366-371 (2020).
  • Toita, R., Shimizu, E., Kang, J-H.: Unique cellular interaction of macrophage-targeted liposomes potentiates anti-inflammatory activity. Chem. Commun., 56, 8253-8256 (2020).
  • Asai, D., Kawano, T., Murata, M., Nakashima, H., Toita, R., Kang, J-H.: Effect of fetal bovine serum concentration on lysophosphatidylcholine-mediated proliferation and apoptosis of human aortic smooth muscle cells. J. Oleo Sci., 69(3), 255-260 (2020).
  • Kiyosue, K., Miwa, Y.: Epstein-Barr virus-derived vector suitable for long-term expression in neurons. Heliyon, 6(3), e03504 (2020).
  • Fujikawa, Y., Ishikawa-Fujiwara, T., Kuo, T., Shinkai, N., Shoji, T., Kawasaki, T., Kamei, T., Sakuraba, Y., Sato, A., Kinoshita, M., Gondo, Y., Yuba, S., Tsujimura, T., Sese, J., Todo, T.: Involvement of Rev1 in alkylating agent-induced loss of heterozygosity in Oryzias latipes. Genes Cells, 25(2), 124-138 (2020).
  • Sunarso, Toita, R., Tsuru, K., Ishikawa, K.: Ozone-gas-mediated surface hydrophilization enhances the cell responses to titanium. Mater. Lett., 261, 127168 (2020).

部門研究戦略2:生物機能計測

バイオアナリティカル研究グループ

  • Kazuki, Y., Gao, FJ., Li, Y., Moyer, A.J., Devenney, B., hiramatsu, K., Miyagawa-Tomita, S., Abe, S., Kazuki, K., Kajitani, N., Uno, N., Takehara, S., Takiguchi, M., Yamakawa, M., Hasegawa, A., Shimizu, R., Matsukura, S., Noda, N., Ogonuki, N., Inoue, K., Matoba, S., Ogura, A., Florea, L.D., Savonenko, A., Xiao, M., Wu, D., Batista, D.A., Yang, J., Qiu, Z., Singh, N., Richtsmeier, J.T., Takeuchi, T., Oshimura, M., Reeves, R.H.: A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21. eLife (2020).
  • Tourlousse, D.M., Sakamoto, M., Miura, T., Narita, K., Ohashi, A., Uchino, Y., Yamazoe, A., Kameyama, K., Terauchi, J., Ohkuma, M., Kawasaki, H., Sekiguchi, Y.: Complete genome sequence of Flavonifractor plautii JCM 32125T. Microbiology Resource Announcements, 9(17), e00135-20 (2020).
  • Tourlousse, D.M., Sakamoto, M., Miura, T., Narita, K., Ohashi, A., Uchino, Y., Yamazoe, A., Kameyama, K., Terauchi, J., Ohkuma, M., Kawasaki, H., Sekiguchi, Y.: Complete genome sequence of megamonas funiformis JCM 14723T. Microbiology Resource Announcements, 9(16), e00142-20 (2020).
  • Tourlousse, D.M., Sakamoto, M., Miura, T., Narita, K., Ohashi, A., Uchino, Y., Yamazoe, A., Kameyama, K., Terauchi, J., Ohkuma, M., Kawasaki, H., Sekiguchi, Y.: Complete genome sequence of Collinsella aerofaciens JCM 10188T. Microbiology Resource Announcements, 9(16), e00134-20 (2020).
  • Tourlousse, D.M., Sakamoto, M., Miura, T., Narita, K., Ohashi, A., Uchino, Y., Yamazoe, A., Kameyama, K., Terauchi, J., Ohkuma, M., Kawasaki, H., Sekiguchi, Y.: Complete genome sequence of Blautia producta JCM 1471T. Microbiology Resource Announcements, 9(17), e00141-20 (2020).
  • Morikawa-Ichinose, T., Miura, D., Zhang, L., Kim, S-J., Maruyama-Nakashita, A.: Involvement of BGLU30 in glucosinolate catabolism in the Arabidopsis leaf under dark conditions. Plant Cell Physiol., 61(6), 1095-1106 (2020).

細胞・生体医工学研究グループ

  • Kibria, M.G., Akazawa-Ogawa, Y., Rahman, N., Hagihara, Y., Kuroda, Y.: The immunogenicity of an anti-EGFR single domain antibody (VHH) is enhanced by misfolded amorphous aggregation but not by heat-induced aggregation. Eur. J. Pharm. Biopharm., 152, 164-174 (2020).
  • Akazawa-Ogawa, Y., Komatsu, Y., Nakajima, Y., Kojima, N., Hagihara, Y.: PCR-based approach for site-specific conjugation of long double-stranded DNA to a single-domain VHH antibody. J. Biochem., 168(1), 63-72 (2020).
  • Horio, Y., Sogabe, R., Shichiri, M., Ishida, N., Morimoto, R., Ohshima, A., Isegawa, Y.: Induction of a 5-lipoxygenase product by daidzein is involved in the regulation of influenza virus replication. J. Clin. Biochem. Nutr., 66(1), 36-42 (2020).
  • Soeta, Y., Kagawa, H.: Three dimensional psychological evaluation of aircraft noise and prediction by physical parameters. 167, 106445 (2020).

次世代メディカルデバイス研究グループ

  • Shen, Y., Tanaka, N., Yamazoe, H., Furutani, S., Nagai, H., Kawai, T., Tanaka, Y.: Flow analysis on microcasting with degassed polydimethylsiloxane micro-channels for cell patterning with cross-linked albumin. PLoS One., 15(5), e0232518 (2020).
  • Kurinomaru, T., Inagaki, A., Hoshi, M., Nakamura, C., Yamazoe, H.: Protein microswimmers capable of delivering cells for tissue engineering applications. Mater. Horizons, 3, 877-884 (2020).
  • Kubo, I., Kajiya, M., Aramaki, N., Furutani, S.: Detection of salmonella enterica in egg yolk by PCR on a microfluidic disc device using immunomagnetic beads. Sensors, 20(4), 1060 (2020).

部門研究戦略3:生物機能応用

分子細胞デザイン研究グループ

  • Shibakami, M., Sohma, M.: Effects of long-chain acyl substituents on the thermoplasticity and mechanical properties of paramylon mixed sters. J. Polym. Environ., 2020(28), 2263-2276 (2020).
  • Shibuya, R., Miyafusa, T., Honda, S.: Stabilization of backbone-circularized protein is attained by synergistic gains in enthalpy of folded structure and entropy of unfolded structure. FEBS J., 287(8), 1554-1575 (2020).

構造創薬研究グループ

  • Takagi, Y., Kuwabara, N., Dang, T.T., Furukawa, K., Ho, C.K.: Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5' end of the RNA substrate. J. Biol. Chem. (2020).
  • Yamasaki, K., Akutsu, Y., Yamasaki, T., Miyagishi, M., Kubota, T.: Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts. Nucleic Acids, Res. (2020).
  • Furuhata, Y., Sakai, A., Murakami, T., Nagasaki, A., Kato, Y.: Bioluminescent imaging of Arabidopsis thaliana using an enhanced Nano-lantern luminescence reporter system. Plos One, 15(1), e0227477 (2020).

生体分子創製研究グループ

  • Nakayama, Y., Watanabe, K., Tanaka, R., Shiono, T., Kawasaki, N., Yamano, N., Nakayama, A.: Synthesis, properties, and biodegradation of sequential poly(ester amide)s containing γ-aminobutyric acid. Int. J. Mol. Sci., 21(10), 3674 (2020).
  • Himiyama, T., Nakamura, T.: Disassembly of the ring‐type decameric structure of peroxiredoxin from Aeropyrum pernix K1 by amino acid mutation. Protein Sci., 29(5), 1138-1147 (2020).
  • Kawasaki, N., Yamano, N., Nakayama, A.: Synthesis, properties, and biodegradability of three‐branched copolyamide (4/6). J. Appl. Polym. Sci., 137(39) (2020).
  • Nakayama, Y., Yagumo, W., Tanaka, R., Shiono, T., Inumaru, K., Tsutsumi, C., Kawasaki, N., Yamano, N., Nakayama, A.: Synthesis, properties and biodegradation of periodic copolyesters composed of hydroxy acids, ethylene glycol, and terephthalic acid. Polym. Degrad. Stabil., 174, 109095 (2020).

先端ゲノムデザイン研究グループ

  • Okano, K., Shimizu, K., Saito, T., Maseda, H., Utsumi, H., Itayama, T., Sugiura, N.: Draft Genome Sequence of the Microcystin-Degrading Bacterium Novosphingobium sp. Strain MD-1. Microbiology Resource Announcements. (2020).

  • Anh, H.T.L., Kawata, Y., Tam, L.T., Thom, L.T., Ha, N.C., Hien, H.T.M., Thu, N.T.H., Huy, P.Q., Hong, D.D.: Biocharacteristics and draft genome sequence of Halomonas hydrothermalis C22, a pyruvate-producing halophilic bacterium isolated from a commercial Spirulina culture in Vietnam. Arch. Microbiol. (2020).

  • Anh, H.T.L., Kawata, Y., Tam, L.T., Thom. L.T., Ha, N.C., Hien, H.T.M., Thu, N.T.H., Huy, P.Q., Hong, D. D.: Production of pyruvate from Ulva reticulata using the alkaliphilic, halophilic bacterium Halomonas sp. BL6. J. Appl. Phycol. (2020).