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研究成果　Research Result

誌上発表（国際誌・査読有）2022年

部門研究戦略1：生物機能解明

脳遺伝子研究グループ
Molecular Neurobiology Research Group

  • Sugawara, S., Okada, R., Loo, T.M., Tanaka, H., Miyata, K., Chiba, M., Kawasaki, H., Katoh, K., Kaji, S., Maezawa, Y., Yokote, K., Nakayama, M., Oshima, M., Nagao, K., Obuse, C., Nagayama, S., Takubo, K., Nakanishi, A., Kanemaki, M.T., Hara, E., Takahashi, A.: RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. Commun. Biol., 5(1), 1420 (2022).
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  • Saito, K., Shimasaki, K., Fukasawa, M., Suzuki, R., Okemoto-Nakamura, Y., Katoh, K., Takasaki, T., Hanada, K.: Establishment of Vero cell lines persistently harboring a yellow fever virus 17D subgenomic replicon. Virus Res., 322, 198935 (2022).
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  • Kuramochi, M., Zhu, S., Takanashi, C., Yang, Y., Arai, T., Shinkai, Y., Doi, M., Mio, K., Tsuda, S., Sasaki, Y.C.: A mutation to a fish ice-binding protein synthesized in transgenic Caenorhabditis elegans modulates its cold tolerance. Biochem. Biophys. Res. Commun., 628(5), 98-103 (2022).
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  • Guo, R., Fujito, R., Nagasaki, A., Okumura, M., Chihara, T., Hamao, K.: Dynamin-2 regulates microtubule stability via an endocytosis-independent mechanism. Cytoskeleton (2022).
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  • Kuramochi, M., Dong, Y., Yang, Y., Arai, T., Okada, R., Shinkai, Y., Doi, M., Aoyama, K., Sekiguchi, H., Mio, K., Tsuda, S., Sasaki, Y.C.: Dynamic motions of ice-binding proteins in living Caenorhabditis elegans using diffracted X-ray blinking and tracking. Biochem. Biophys. Rep., 29, 101224 (2022).
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  • Nagasaki, A., Katoh, K., Hoshi, M., Doi, M., Nakamura, C., Uyeda, T.Q.P.: Characterization of phalloidin-negative nuclear actin filaments in U2OS cells expressing cytoplasmic actin-EGFP. Genes Cells (2022).
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脳機能調節因子研究グループ
Molecular Neurophysiology Research Group

  • Sasaki, N., Hirano, K., Shichi, Y., Itakura, Y., Ishiwata, T., Toyoda, M.: PRC2-dependent regulation of ganglioside expression during dedifferentiation contributes to the proliferation and migration of vascular smooth muscle cells. Front. Cell. Dev. Biol., 10, 1003349 (2022).
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  • Hayashi, T.: Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation. Front. Synaptic Neurosci., 14, 921772 (2022).
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  • Oota-Ishigaki, A., Takao, K., Yamada, D., Sekiguchi, M., Itoh, M., Koshidata, Y., Abe, M., Natsume, R., Kaneko, M., Adachi, T., Kaizuka, T., Suzuki, N., Sakimura, K., Okuno, H., Wada, K., Mishina, M., Miyakawa, T., Hayashi, T.: Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice. Neuropsychopharmacology, 47, 2150-2159 (2022).
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  • Sasaki, N., Hirano, K., Shichi, Y., Gomi, F., Yoshimura, H., Matsushita, A., Toyoda, M., Ishiwata, T.: Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through H19 Long Non-Coding RNA Expression. Cancers, 14(9), 205 (2022).
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  • Hayashi, Y., Kashio, S., Murotomi, K., Hino, S., Kang, W., Miyado, K., Nakao, M., Miura, M., Kobayashi, S., Namihira, M.: Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis. Sci. Rep., 12(5593), 1-9 (2022).
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  • Niu, J., Holland, S.M., Ketschek, A., Collura, K.M., Hesketh, N.L., Hayashi, T., Gallo, G., Thomas, G.M.: Palmitoylation couples the kinases DLK and JNK3 to facilitate prodegenerative axon-to-soma signaling. Sci. Signal., 15(727), eabh2674 (2022).
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  • Murotomi, K., Tawara, H., Sutoh, M., Yasunaga, M.: Iron-accumulating splenocytes may exacerbate non-alcoholic steatohepatitis through the production of proinflammatory cytokines and reactive oxygen species. Exp. Biol. Med. (2022).
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  • Ogawa, H., Azuma, M., Umeno, A., Shimizu, M., Murotomi, K., Yoshida, Y., Nishioka, Y., Tsuneyama, K.: Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation. Allergol. Int., 71(3), 395-404 (2022).
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細胞分子機能研究グループ
Functional Biomolecular Research Group

  • Toita, R, Kang, J-H., Tsuchiya, A.: Phosphatidylserine liposome multilayers mediate the M1-to-M2 macrophage polarization to enhance bone tissue regeneration. Acta Biomater., S1742-7061(22)00681-X (2022).
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  • Takizawa, M., Osuga, Y., Ishida, R., Mita, M., Harada, K., Ueda, H., Kitaguchi, T., Tsuboi, T.: Development of a red fluorescent protein-based cGMP indicator applicable for live-cell imaging. Commun. Biol., 5(1), 833 (2022).
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  • Masui, K., Nawa, Y., Tokumitsu, S., Nagano, T., Kawarai, M., Tanaka, H., Hamamoto, T., Minoshima, W., Tani, T., Fujita, S., Ishitobi, H., Hosokawa, C., Inouye, Y.: Detection of Glutamate Encapsulated in Liposomes by Optical Trapping Raman Spectroscopy. ACS Omega, 7(11), 9701-97096 (2022).
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  • Shimizu,Y., Kawasaki, T.: Stab Wound Injury Model of the Adult Optic Tectum using Zebrafish and Medaka for the Comparative Analysis of Regenerative Capacity. J. Vis. Exp., 10 (180) (2022).
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  • Shimizu, Y., Kawasaki, T., Deguchi, T.: Gfap transgenic medaka as a novel reporter line for neural stem cells. Gene, 820, 146213 (2022).
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部門研究戦略2：生物機能計測

バイオアナリティカル研究グループ
Bioanalytical Research Group

  • Sasaki, A., Ohmiya, Y.: Standardization of luminescence, fluorescence measurements, and light microscopy: Current situation and perspectives. Biophys. Physicobiol., 19, e190037 (2022).
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  • Morikawa-Ichinose, T., Fujimura, Y., Kumazoe, M., Onda, H., Miura, D., Tachibana, H.: Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment. Food Chem. Toxicol., 169:113421 (2022).
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  • Furuhata, Y., Sasaki, A.: Monitoring Molecular Properties of a Fluorescence Light-Up Aptamer Using Fluorescence Cross-Correlation Spectroscopy. Appl. Sci.-Basel, 12(4) (2022).
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  • Kazuki, Y., Gao, F.J., Yamakawa, M., Hirabayashi, M., Kazuki, K., Kajitani, N., Miyagawa-Tomita, S., Abe, S., Sanbo, M., Hara, H., Kuniishi, H., Ichisaka, S., Hata, Y., Koshima, M., Takayama, H., Takehara, S., Nakayama, Y., Hiratsuka, M., Iida, Y., Matsukura, S., Noda, N., Li, Y., Moyer, A.J., Cheng, B., Singh, N., Richtsmeier J.T., Oshimura, M., Reeves, R.H.: A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features. Am. J. Hum. Genet., 109(2), 328-344 (2022).
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  • Tourlousse, D.M., Narita, K., Miura, T., Ohashi, A., Matsuda, M., Ohyama, Y., Shimamura, M., Furukawa, M., Kasahara, K., Kameyama, K., Saito, S., Goto, M., Shimizu, R., Mishima, R., Nakayama, J., Hosomi, K., Kunisawa, J., Terauchi, J., Sekiguchi, Y., Kawasaki, H.: Characterization and Demonstration of Mock Communities as Control Reagents for Accurate Human Microbiome Community Measurements. Microbiol. Spectr., 10(2), e0191521 (2022).
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細胞・生体医工学研究グループ
Medical and Biological Engineering Research Group

  • Frerscura, A., Lee, P.J., Soeta, Y., Ariki, A.: Effects of spatial characteristics of footsteps sounds and non-acoustic factors on annoyance in lightweight timber buildings. Build. Environ., 222, 109405 (2022).
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  • Yamazoe, H., Kurinomaru, T., Inagaki, A.: Potential of the Coordinated Actions of Multiple Protein-Based Micromachines for Medical Applications. ACS Appl. Mater. Interfaces, 14(29), 32927-32936 (2022).
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  • Wan, J., Shi, W., Li, Y., Yu, Y., Wu, X., Li, Z., Lee, S.Y., Lee, K.H.: Excellent Crystallinity and Stability Covalent–Organic Frameworks with High Emission and Anions Sensing. Macromol. Rapid Commun., 43(20), 2200393 (2022).
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  • Yamazoe, H., Kominami, C., Abe, H.: Superior Adhesion of a Multifunctional Protein-Based Micropatch to Intestinal Tissue by Harnessing the Hydrophobic Effect. Small Methods (2022).
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  • Shimokura, R., Soeta, Y.: Estimation of reaction time for birdsongs and effects of background noise and listener’s age. Appl. Acoust., 194, 108785 (2022).
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  • Li, K., You, F., Zhang, Q., Yuan, R., Yuan, Q., Fu, X., Ren, Y., Wang, Q., Li, X., Zhang, Z., Shichiri, M., Yu, Y.: Chemical and Biological Evidence of the Efficacy of Shengxian Decoction for Treating Human Lung Adenocarcinoma. Front. Oncol., 12, 849579 (2022).
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  • Nakamura, M.: Dynamic patterns formed by heterogeneous boid model composed of agent groups moving reversely. Artif. Life Robot., 27, 1 (2022).
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  • Hanada, A., Morimoto, R., Horio, Y., Shichiri, M., Nakashima, A., Ogawa, T., Suzuki, K., Sumitani, H., Ogata, T., Isegawa, Y.: Influenza virus entry and replication inhibited by 8‐prenylnaringenin from Citrullus lanatus var. citroides (wild watermelon). Food Sci. Nutr., 10(3), 926-935 (2022).
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  • Ando, M., Inagaki, K., Kawasaki, H., Shigeri, Y.: Reversible sensing of nitrogen dioxide using photoluminescent CdSe/ZnS quantum dots and enhanced response by combination with noble metals. 130(1), 180-186 (2022).
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部門研究戦略3：生物機能応用

分子細胞デザイン研究グループ
Molecular and Cellular Design Research Group

  • Shibakami, M.: Preparation of Paramylon Multifilament by Using the Viscose Method. Chemistry Select, 7, e202200494 (2022).
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  • Shibakami, M., Kawata, Y.: Viscoelastic Effects of Long-Chain Acyl-Group Substituents on Molten Paramylon Mixed Esters. J. Polym. Environ., 30, 2270-2279 (2022).
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構造創薬研究グループ
Structure-Based Drug Discovery Research Group

  • Takeshita, D.: Protein expression and purification, molecular interaction, and X-ray crystallographic analysis of baculovirus protein PK2. Protein Expr. Purif. (2022).
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  • Yamasaki, K., Adachi, N., Tun, M.M.N., Ikeda, A., Moriya, T., Kawasaki, M., Yamasaki, T., Kubota, T., Nagashima, I., Shimizu, H., Tateno, H., Morita, K.: Core fucose-specific Pholiota squarrosa lectin (PhoSL) as a potent broad-spectrum inhibitor of SARS-CoV-2 infection. FEBS J. (2022).
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  • Kozome, D., Uechi, K., Taira, T., Fukada, H., Kubota, T., Ishikawa, K.: Structural Analysis and Construction of a Thermostable Antifungal Chitinase. Appl. Environ. Microbiol., 88(12), e0065222(2022).
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  • Liu, Y., Takagi, Y., Sugijanto, M., Nguyen, K.D.M., Hirata, A., Hori, H., Ho, C.K.: Genetic and Functional Analyses of Archaeal ATP-Dependent RNA Ligase in C/D Box sRNA Circularization and Ribosomal RNA Processing. Front. Mol. Biosci. (2022).
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  • Ibrahim, M.A., Yamasaki, T., Furukawa, K., Yamasaki, K.: Fragment-Based Drug Discovery for Trypanosoma brucei Glycosylphosphatidylinositol-Specific Phospholipase C through Biochemical and WaterLOGSY-NMR Methods. J. Biochem. (2022).
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  • Takagi, Y., Sato, M., Naya, M., Sato, C.: Differentiating Trypanosoma cruzi in a Host Mammalian Cell Imaged in Aqueous Liquid by Atmospheric Scanning Electron Microscopy. Microbiol. Spectr., 10(1), e0141321 (2022).
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生体分子創製研究グループ
Biomolecule Design Research Group

  • Kawamura, S., Kawasaki, R., Hino, S., Yamana, K., Okuno, M., Eto, T., Ikeda, A.: Formulation of water-dispersible hydrophobic compound nanocomplexes with polypeptides via a supramolecular approach using a high-speed vibration milling technique. RSC Adv., 12(49), 32012-32019 (2022).
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  • Shimozawa, Y., Matsuhisa, H., Nakamura, T., Himiyama, T., Nishiya, Y.: Reducing substrate inhibition of malate dehydrogenase from Geobacillus stearothermophilus by C-terminal truncation. Protein Eng. Des. Sel., 35, gzac008 (2022).
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  • Sasamoto, K., Himiyama, T., Moriyoshi, K., Ohmoto, T., Uegaki, K., Nakamura, T., Nishiya, Y.: Functional analysis of the N-terminal region of acetylxylan esterase from Caldanaerobacter subterraneus subsp. Tengcongensis. FEBS Open Bio (2022).
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  • Shimada, R., Hino, S., Yamana, K., Kawasaki, R., Konishi, T., Ikeda, A.: Improvement of Photodynamic Activity by a Stable System Consisting of a C 60 Derivative and Photoantenna in Liposomes. ACS Med. Chem. Lett. (2022).
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先端ゲノムデザイン研究グループ
Advance Genome Design Research Group

  • Kim, S., Masai, S., Murakami, K., Azuma, M., Kataoka, K., Sebe, M., Shimizu, K., Itayama, T., Whangchai, N., Whangchai, K., Ihara, I., Maseda, H.: Characteristics of Antibiotic Resistance and Tolerance of Environmentally Endemic Pseudomonas aeruginosa. Antibiotics-Basel, 11(8), 1120 (2022).
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  • Gotore, O., Itayama, T., Dang, B., Nguyen, T., Ramaraj, R., Osamu, N., Shuji, T., Maseda, H.: Adsorption analysis of ciprofloxacin and delafloxacin onto the corn cob derived-biochar under different pyrolysis conditions. Biomass Convers. Biorefinery (2022).
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  • Nguyen, T., Itayama, T., Ramaraj, R., Iwami, N., Shimizu, K., Dao, T., Pham, T.L., Maseda, H.: Physiological response of Simocephalus vetulus to five antibiotics and their mixture under 48-h acute exposure. Sci. Total Environ., 829, 154585 (2022).
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  • Fukuda, N., Takeuchi, M.: Complete dominant inheritance of intracellular leucine accumulation traits in polyploid yeasts. Yeast (2022).
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部門長・副部門長・首席研究員・総括研究員・招聘研究員
Director, Deputy Director, Prime Senior Researcher, Principal Research Manager, Honda Lab.

  • Kunimi, T., Saikusa, K., Kato, M., Kojima, R., Igarashi, C., Noda, N., Honda, S.: Characterization and value assignment of a monoclonal antibody reference material, NMIJ RM 6208a, AIST-MAB. Front. Mol. Biosci., 9, 802041 (2022).
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  • Sonoi, R., Hagihara, Y.: Quantitative understanding of HepaRG cells during drug-induced intrahepatic cholestasis through changes in bile canaliculi dynamics. Pharmacol. Res. Perspect., 10(3), e00960 (2022).
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  • Senga, Y., Doi, M., Onitsuka, M., Honda, S.: Live-cell imaging to analyze intracellular aggregation of recombinant IgG in CHO cells. Cell Chem. Biol., 29(1), 120-132 (2022).
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  • Watthaisong, P., Kamutira, P., Kesornpun, C., Pongsupasa, V., Phonbuppha, J., Tinikul, R., Maenpuen, S., Wongnate, T., Nishihara, R., Ohmiya, Y., Chaiyen, P.: Luciferin Synthesis and Pesticide Detection by Luminescence Enzymatic Cascades. Angew. Chem.-Int. Edit., 61(16), e202116908 (2022).
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  • Mitani, Y., Yasuno, R., Kihira, K., Chung, K., Mitsuda, N., Tomioka, A., Kaji, H., Ohmiya, Y.: Host-Dependent Producibility of Recombinant Cypridina noctiluca Luciferase With Glycosylation Defects. Front. Bioeng. Biotechnol., 10, 774786 (2022).
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