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  4. 誌上発表(国際誌・査読有)2021年

研究成果 Research Result

誌上発表(国際誌・査読有)2021年

部門研究戦略1:生物機能解明

脳遺伝子研究グループ

  • Ozawa, K., Shinkai, Y., Kato, K., Fukamizu, A., Doi, M.: The molecular and neural regulation of ultraviolet light phototaxis and its food-associated learning behavioral plasticity in C. elegans. Neurosci. Lett. (2021).
  • Ochiishi, T., Kaku, M., Kajsongkram, T., Thisayakorn, K.: Mulberry fruit extract alleviates the intracellular amyloid-β oligomer-induced cognitive disturbance and oxidative stress in Alzheimer's disease model mice. Genes Cells, 11, 861-873 (2021).
  • Hata, S., Kano, K., Kikuchi, K., Kinoshita, S., Sobu, Y., Saito, H., Saito, T., Saido, T.C., Sano, Y., Taru, H., Aoki, J., Komano, H., Tomita, T., Natori, S., Suzuki, T.: Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid. J. Neurochem., 159(3), 603-617 (2021).
  • Nanaura, H., Kawamukai, H., Fujiwara, A., Uehara, T., Aiba, Y., Nakanishi, M., Shiota, T., Hibno, M, Wiriyasermkul, P., Kkuchi, S., Nagata, R., Matsubashi, M., Shinkai, Y., Niwa, T., Mannen, T., Morikawa, N., Iguchi, N., Kriyama, T., Morishima, K., Inoue, R., Sugiyama, M., Oda, T., Kodera, N., Toma-Fkai, S., Sato, M. Taguchi, H., Nagamoi, S., Shoji, O., Ishiori, K., Matsumura, H., Sugie, K., Saio, T., Yoshizawa, T., Mori, E.: C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers. Nat. Commun., 12(5301) (2021).
  • Mimura, M., Tomita, S., Sugai, H., Shinkai, Y., Ishihara, S., Kurita, R.: Uncharged Components of Single-Stranded DNA Modulate Liquid-Liquid Phase Separation With Cationic Linker Histone H1. Front. Cell. Dev. Biol., 9, 710729 (2021).
  • Mimura, M., Tomita, S., Shinkai, Y., Hosokai, T., Kumeta, H., Saio, T., Shiraki, K., Kurita, R.: Quadruplex Folding Promotes the Condensation of Linker Histones and DNAs via Liquid-Liquid Phase Separation. J. Am. Chem. Soc., 143(26), 9849-9857 (2021).
  • Ohzono, T., Katoh, K., Terentjev, E.M.: Microscopy of Diffuse Nematic–Isotropic Transition in Main-Chain Nematic Liquid-Crystal Elastomers. Macromolecules, 54(8), 3678-3688 (2021).
  • Wang, X., Shinkai, Y., Doi, M.: Retrogradely transmitted α-synuclein is taken up by the endophilin-independent endocytosis in the C. elegans neural circuit. Biochem. Biophys. Res. Commun., 552, 176-182 (2021).
  • Nakano, M., Mitsuishi, Y., Liu, L., Watanabe, N., Hibino, E., Hata, S., Saito, T., Saido, T.C., Murayama, S., Kasuga, K., Ikeuchi, T., Suzuki, T., Nishimura, M.: Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations. J. Alzheimers Dis., 80(1), 159-174 (2021).

脳機能調節因子研究グループ

  • Alberto-Silva, C., Prtaro, F.C.V., Kodama, R.T., Pantaleao, H.Q., Inagaki, H., Nihei, K., Konno, K.: Comprehensive Analysis and Biological Characterization of Venom Components from Solitary Scoliid Wasp Campsomeriella annulata annulata. Toxins, 13(12), 885 (2021).
  • Hagihara, H., Shoji, H., Otabi, H., Toyoda, A., Katoh, K., Namihira, M., Miyakawa, T.: Protein lactylation induced by neural excitation. Cell Rep., 37(2), 109820 (2021).
  • Iizumi, M., Oota-Ishigaki, A., Yamashita, M., Hayashi, T.: Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice. Front. Pharmacol., 12, 711737 (2021).
  • Kawai, T., Hashimoto, M., Eguchi, N., Nishino, J.M., Mori-Kreiner, R., Aspaker, M., Chiba, D., Ohtsuka, Y., Kawanabe, A., Nishino, A.S., Okamura, Y.: Heterologous functional expression of ascidian Nav1 channels and close relationship with the evolutionary ancestor of vertebrate Nav channels. J. Biol. Chem., 296, 100783 (2021).
  • Shigeri, Y., Nakata, M., Kubota, H., Tomari, N., Yamamoto, Y., Uegaki, K., Haramoto, Y., Bumb, C., Tanaka, Y., Kinumi, T., Inagaki, H.: Identification of Novel Proteins in Foam Nests of the Japanese Forest Green Tree Frog, Rhacophorus arboreus. Zool. Sci., 38(1), 8-19 (2020).
  • Ogura, C., Hirano, K., Mizumoto, S., Yamada, S., Nishihara, S.: Dermatan sulphate promotes neuronal differentiation in mouse and human stem cells. J. Biochem., 169(1), 55-64 (2021).

細胞分子機能研究グループ

  • Toita, R., Kawano, T., Murata, M., Kang, J-H.: Bioinspired macrophage-targeted anti-inflammatory nanomedicine: A therapeutic option for the treatment of myocarditis. Mater. Sci. Eng. C-Mater. Biol. Appl., 131, 112492 (2021).
  • Sunarso, Tsuchiya, A., Toita, R., Tsuru, K., Ishikawa, K.: Impact of surface functionalization with phosphate and calcium on the biological performance of Ti-6Al-4V. Mater. Lett., 304, 130716 (2021).
  • Nakai, N., Sato, K., Tani, T., Kawagishi, M., Ka, H., Saito, K., Terada, S.: Development of nanobody-based POLArIS orientation probes enabled multi-color/multi-target orientation imaging in living cells. Biochem. Biophys. Res. Commun., 565, 50-56 (2021).
  • Kim, C.W., Toita, R., Kang, J-H., Mori, T., Kishimura, A., Katayama, Y.: Protein Kinase C α-Responsive Gene Carrier for Cancer-Specific Transgene Expression and Cancer Therapy. ACS Biomater. Sci. Eng. (2021).
  • Tamesue, S., Saito, Y., Toita, R.: Salinity durable self-healing hydrogels as functional biomimetic systems based on the intercalation of polymer ions into mica. Polymer, 228, 123870 (2021).
  • Shimizu, Y., Kawasaki, T.: Differential regenerative capacity of the optic tectum of adult medaka and zebrafish. Front. Cell. Dev. Biol., 9:686755 (2021).
  • Shimizu, Y., Kawasaki, T.: Histone acetyltransferase EP300 regulates the proliferation and differentiation of neural stem cells during adult neurogenesis and regenerative neurogenesis in the zebrafish optic tectum. Neurosci. Lett., 756, 135978 (2021).
  • Tani, T., Koike-Tani, M., Tran, M.T., Shribak, M., Levic, S.: Postnatal structural development of mammalian Basilar Membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuning. Sci Rep, 11, 7581 (2021).
  • Shimizu, Y., Kiyooka, M., Ohshima, T.: Transcriptome Analyses Reveal IL6/Stat3 Signaling Involvement in Radial Glia Proliferation After Stab Wound Injury in the Adult Zebrafish Optic Tectum. Front. Cell. Dev. Biol. (2021).
  • Toita, R., Shimizu, E., Murata, M., Kang, J-H.: Protective and healing effects of apoptotic mimic-induced M2-like macrophage polarization on pressure ulcers in young and middle-aged mice. J. Control. Release, 330, 705-714 (2021).
  • Ishii, H., Tani, T., Dynamic organization of cortical actin filaments during the ooplasmic segregation of ascidian Ciona eggs. Mol. Biol. Cell, 32(3), 274-299 (2021).
  • Sugizaki, A., Sato, K., Chiba, K., Saito, K., Kawagishi, M., Tomabechi, Y., Mehta, S.B., Ishii, H., Sakai, N., Shirouzu, M., Tani, T., Terada, S.: POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos. Proc. Natl. Acad. Sci. U. S. A., 118(11), e2019071118 (2021).
  • Ishii, H., Tani, T., Dynamic organization of cortical actin filaments during the ooplasmic segregation of ascidian Ciona eggs. Mol. Biol. Cell, 32(3), 274-288 (2021).

部門研究戦略2:生物機能計測

バイオアナリティカル研究グループ

  • Fukuoka, H., Andou, T., Moriya, T., Narita, K., Kasahara, K., Miura, D., Sekiguchi, Y., Suzuki, S., Nakagawa, K., Ozawa, M., Ishibe, A., Endo, I.: Sulphur metabolism in colon cancer tissues: a case report and literature review. J. Int. Med. Res., 49(11) (2021).
  • Tamiya-Ishitsuka, H., Tsuruga, M., Noda, N., Yokota, A.: Conserved Amino Acid Moieties of Candidatus Desulforudis audaxviator MazF Determine Ribonuclease Activity and Specificity. Front. Microbiol., 12 (2021).
  • Hamano, F., Tokuoka, S., Ishibashi, M., Yokoi, Y., Tourlousse, D.M., Kita, Y., Sekiguchi, Y., Yasui, H., Shimizu, T., Oda, Y.: Multi-Omics Analysis to Generate Hypotheses for Mild Health Problems in Monkeys. 11(10), 701 (2021).
  • Saito, K., Ota, Y., Tourlousse, D.M., Matsukura, S., Fujitani, H., Morita, M., Tsuneda, S., Noda, N.: Microdroplet-based system for culturing of environmental microorganisms using FNAP-sort. Sci Rep., 11, 9506 (2021).
  • Tourlousse, D.M., Narita, K., Miura, T., Sakamoto, M., Ohashi, A., Shiina, K., Matsuda, M., Miura, D., Shimamura, M., Ohyama, Y., Yamazoe, A., Uchino, Y., Kameyama, K., Arioka, S., Kataoka, J., Hisada, T., Fujii, K., Takahashi, S., Kuroiwa, M., Rokushima, M., Nishiyama, M., Tanaka, Y., Fuchikami, T., Aoki, H., Kira, S., Koyanagi, R., Naito, T., Nishiwaki, M., Kumagai, H., Konda, M., Kasahara, K., Ohkuma, M., Kawasaki, H., Sekiguchi, Y., Terauchi, J.: Validation and standardization of DNA extraction and library construction methods for metagenomics-based human fecal microbiome measurements. Microbiome, 9(1), 95 (2021).
  • Chihara, K., Barquist, L., Takasugi, K., Noda, N., Tsuneda, S.: Global identification of RsmA/N binding sites in Pseudomonas aeruginosa by in vivo UV CLIP-seq. RNA Biol. (2021).
  • Morita, M., Noda, N.: Membrane Shape Dynamics-Based Analysis of the Physical Properties of Giant Unilamellar Vesicles Prepared by Inverted Emulsion and Hydration Techniques. Langmuir, 37(7), 2268-2275 (2021).

細胞・生体医工学研究グループ

  • Shichiri, M., Ishida, N., Aoki, Y., Koike, T., Hagihara, Y.: Stress-activated leukocyte 12/15-lipoxygenase metabolite enhances struggle behaviour and tocotrienols relieve stress-induced behaviour alteration. Free Radic. Biol. Med., 1(175), 171-183 (2021).
  • Zhang, Y., Li, Z., Sun, Q., Li, Z., Zhi, Y., Nie, R., Xia, H., Yu, Y., Liu, X.: Light-Emitting Conjugated Organic Polymer as an Efficient Fluorescent Probe for Cu2+ Ions Detection and Cell Imaging. Macromol. Rapid Commun., 42(19), 2100469 (2021).
  • Horio, Y., Shichiri, M., Isegawa, Y.: Development of a Method to Evaluate Influenza Virus RNA-dependent RNA Polymerase Activity Through Real-time Reverse Transcription Polymerase Chain Reaction. Virol. J., 18(1), 177 (2021).
  • Kibria M.G., Akazawa-Ogawa, Y., Hagihara, Y., Kuroda, Y.: Immune response with long-term memory triggered by amorphous aggregates of misfolded anti-EGFR V HH-7D12 is directed against the native V HH-7D12 as well as the framework of the analogous V HH-9G8. Eur. J. Pharm. Biopharm., 165, 13-21 (2021).
  • Kibria, M.G., Fukutani, A., Akazawa-Ogawa, Y., Hagihara, Y., Kuroda, Y.: Anti-EGFR V HH Antibody under Thermal Stress Is Better Solubilized with a Lysine than with an Arginine SEP Tag. Biomolecules, 11(6), 810 (2021).
  • Anegawa, D., Sugiura, Y., Matsuoka, Y., Sone, M., Shichiri, M., Otsuka, R., Ishida, N., Yamada, K., Suematsu, M., Miura, M., Yamaguchi, Y.: Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol. Commun. Biol., 4(1), 796 (2021).
  • Noji, M., Samejima, T., Yamaguchi, K., So, M., Yuzu, K., Chatani, E., Akazawa-Ogawa, Y., Hagihara, Y., Kawata, Y., Ikenaka, K., Mochizuki, H., Kardos, J., Otzen, D., Bellotti, V., Buchner, J., Goto, Y.: Breakdown of supersaturation barrier links protein folding to amyloid formation. Commun. Biol., 4(1), 120 (2021).
  • Soeta, Y., Onogawa, E.: Multidimensional Psychological Evaluation of Air Conditioner Sounds and Prediction via Correlation Parameters. Front. Built Environ., 7(1), 659115 (2021).
  • Yano, H., Soeta, Y.: Induced brain magnetic activities related to salient birdsong under noisy conditions. Neuroreport, 32(2), 82-87 (2021).

次世代メディカルデバイス研究グループ

  • Inoue, T., Chihara, Y., Kiba, K., Hirano, S., Tanaka, M., Yoneda, T., Saka, T., Beppu, K., Furubayashi, K., Takashima, M., Nagai, H., Kobayashi, H., Fujimoto, K.: Rapid multiplex PCR assay for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis in genitourinary samples: A 30-minute assay. J. Microbiol. Methods, 180, 106103 (2021).

部門研究戦略3:生物機能応用

分子細胞デザイン研究グループ

  • Yamaki, H., Kuromiya, T., Ito, H., Ando, N., Munekata, Y., Nagasawa, A., Sakamoto, N., Shibakami, M.: Fluorine-Free Amphiphobic Film Former with Long-Lasting Foundation Efficacy. Journal of Society of Cosmetic Chemists of Japan, 55(4), 359-370 (2021).
  • Shibakami, M.: Organic-solvent-dispersible paramylon nanofibers: Hygroscopicity and extended dye release from its cast films. Polymer, 230, 124082 (2021).
  • Shibakami. M.: Nanofibers made from acetylparamylons by a soaking method. Polymer, 220, 123563 (2021).

構造創薬研究グループ

  • Yamasaki, K., Yamasaki, T., Takahashi, M., Suematsu, H.: A mixing microfluidic chip for real-time NMR monitoring of macromolecular reaction. J. Biochem. (2021)
  • Furuhata, Y., Kato, Y.: Asymmetric Roles of Two Histidine Residues in Streptococcus pyogenes Cas9 Catalytic Domains upon Chemical Rescue. Biochemistry, 60(3), 194-200 (2021).
  • Nonaka, M., Mabashi-Asazuma, H., Jarvis, D.L., Yamasaki, K., Akama, T.O., Nagaoka, M., Sasai, T., Kimura-Takagi, I., Suwa, Y., Yaegashi, T., Huang, C-T., Nishizawa-Harada, C., Fukuda, M.N.: Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides. PLoS One, 16(1), e0241157 (2021).

生体分子創製研究グループ

  • Sasamoto, K., Himiyama, T., Moriyoshi, K., Ohmoto, T., Uegaki, K., Nishiya, Y., Nakamura, T.: Crystal structure of acetylxylan esterase from Caldanaerobacter subterraneus subsp. Tengcongensis. Acta Crystallogr. F-Struct. Biol. Commun., 77(11), 399-406 (2021).
  • Shimozawa, Y., Himiyama, T., Nakamura, T., Nishiya, Y.: Increasing loop flexibility affords low-temperature adaptation of a moderate thermophilic malate dehydrogenase from Geobacillus stearothermophilus. Protein Eng. Des. Sel., 34, gzab026 (2021).
  • Kawasaki, R., Kawamura, S., Hino, S., Yamana, K., Ikeda, A.: Water solubilization of paclitaxel using polypeptides for cancer therapy. Mater. Adv., 3(1), 467-473 (2021).
  • Shimozawa, Y., Himiyama, T., Nakamura, T., Nishiya, Y.:Structural analysis and reaction mechanism of malate dehydrogenase from Geobacillus stearothermophilus. J. Biochem., 170(1), 97-105 (2021).
  • Zahir, L., Kida, T., Tanaka, R., Nakayama, Y., Shiono, T., Kawasaki, N., Yamano, N., Nakayama, A.: Synthesis of thermoplastic elastomers with high biodegradability in seawater. Polym. Degrad. Stabil., 184, 109467 (2021).
  • Zahir, L., Kida, T., Tanaka, R., Nakayama, Y., Shiono, T., Kawasaki, N., Yamano, N., Nakayama, A.: Synthesis, Properties, and Biodegradability of Thermoplastic Elastomers Made from 2-Methyl-1,3-propanediol, Glutaric Acid and Lactide. Life, 11(1), 43 (2021).
  • Himiyama, T., Tsuchiya, Y., Yonezawa, Y., Nakamura, T.: Rebuilding Ring-Type Assembly of Peroxiredoxin by Chemical Modification. Bioconjugate Chem., 32(1), 153-160 (2020).

先端ゲノムデザイン研究グループ

  • Nguyen, T., Itayama, T., Ramaraj, R., Iwami, N., Shimizu, K., Dao, T., Pham, T, Maseda, H.: Chronic ecotoxicology and statistical investigation of ciprofloxacin and ofloxacin to Daphnia magna under extendedly long-term exposure. Environ. Pollut., 291, 118095 (2021).
  • Takeuchi, M., Fujiwara- Nagata, E., Katayama, T., Suetake, H.: Skin bacteria of rainbow trout antagonistic to the fish pathogen Flavobacterium psychrophilum. Sci Rep, 11, 7518 (2021).
  • Takeuchi, M., Yoshioka, H.: Acetate excretion by a methanotroph, Methylocaldum marinum S8, under aerobic conditions. Biosci. Biotechnol. Biochem. (2021).
  • Mukae, T., Yoshii, K., Watanabe, T., Tagami, T.; Oishi, I.: Production and characterization of eggs from hens with ovomucoid gene mutation. Poult. Sci., 100(2), 452-460 (2021).

部門長・副部門長・首席研究員・総括研究員

  • Miyafusa, T., Watanabe, H., Honda, S.: Local disorder of the C-terminal segment of the heavy chain as a common sign of stressed antibodies evidenced with a peptide affinity probe specific to non-native IgG. Int. J. Biol. Macromol., 182, 1697-1703 (2021).
  • Shibuya, R., Miyafusa, T., Imamura, H., Ooishi, A., Honda, S.: Effect of backbone circularization on colloidal stability: Compaction of unfolded structures improves aggregation resistance of granulocyte colony-stimulating factor. Int. J. Pharm., 605, 120774 (2021).
  • Sonoi, R., Hagihara, Y.: Tight junction stabilization prevents HepaRG cell death in drug-induced intrahepatic cholestasis. Biol. Open, 10(6), 1-8 (2021).
  • Inoue, N., Hagihara, Y., Wada, I.: Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion. eLife, e66313 (2021).
  • Sonoi, R., Yamakawa, T., Nakatani, N., Kokubo, M., Hagihara,Y.: Noninvasive Evaluation of HepaRG Aggregates during Drug-Induced Intrahepatic Cholestasis Using Optical Coherence Tomography. Advanced Biology, 5(2), 2000198 (2021).
  • Takemura, Y., Sekiguchi, Y., Syutsubo, K., Harada, H., Omura, T., Li, Y., Kubota, K.: Sequence-Specific Capture of Oligonucleotide Probes (SCOPE): a Simple and Rapid Microbial rRNA Quantification Method Using a Molecular Weight Cutoff Membrane. Appl. Environ. Microbiol., 87(20), e0116721 (2021).
  • Fukuoka, H., Andou, T., Moriya, T., Narita, K., Kasahara, K., Miura, D., Sekiguchi, Y., Suzuki, S., Nakagawa, K., Ozawa, M., Ishibe, A., Endo, I.: Sulphur metabolism in colon cancer tissues: a case report and literature review. J. Int. Med. Res., 49(11), 3000605211059936 (2021).
  • Ogoh, K., Futahashi, R., Ohmiya, Y.: Intraspecific nucleotide polymorphisms in seven complete sequences of mitochondrial DNA of the luminous ostracod, Vargula hilgendorfii (Crustacea, Ostracoda). Gene Rep., 23, 101074 (2021).
  • Kanie, S., Miura, D., Jimi, N., Hayashi, T., Nakamura, K., Sakata, M., Ogoh, K., Ohmiya, Y., Mitani, Y.: Violet bioluminescent Polycirrus sp. (Annelida: Terebelliformia) discovered in the shallow coastal waters of the Noto Peninsula in Japan. Sci. Rep., 11(1), 19097 (2021).
  • Suzuka, J., Tsuda, M., Wang, L., Kohsaka, S., Kishida, K., Semba, S., Sugino, H., Aburatani, S., Frauenlob, M., Kurokawa, T., Kojima, S., Ueno, T., Ohmiya, Y., Mano, H., Yasuda, K., Gong, J.P., Tanaka, S.: Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nat. Biomed. Eng. 8, 914-925 (2021).