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  4. 誌上発表(国際誌・査読有)2019年

研究成果 Research Result

誌上発表(国際誌・査読有)2019年

部門研究戦略1:生物機能解明

脳遺伝子研究グループ

  • Ochiishi, T., Kaku, M., Kiyosue, K., Doi, M., Urabe, T., Hattori, N., Shimura, H., Ebihara, T.: New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers. Sci Rep, 9(1), 17368 (2019).
  • Ishida, K., Goto, S., Ishimura, M., Amanuma, M., Hara, Y., Suzuki, R., Katoh, K., Morita, E.: Functional correlation between subcellular localizations of Japanese encephalitis virus capsid protein and virus production. J. Virol., 93(19), e00612-19 (2019).
  • Yamamoto, K., Otomo, K., Nemoto, T., Ishihara, S., Haga, H., Nagasaki, A., Murakami, Y., Takahashi, M.: Differential contributions of nonmuscle myosin IIA and IIB to cytokinesis in human immortalized fibroblasts. Exp. Cell Res., 376(1), 67-76 (2019).
  • Kuramochi, M., Doi, M.: An excitatory/inhibitory switch from asymmetric sensory neurons defines postsynaptic tuning for a rapid response to NaCl in caenorhabditis elegans. Front Mol Neurosci.,11(484), e 00484 (2019).
  • Tanaka, M., Fujii, Y., Hirano, K., Higaki, T., Nagasaki, A., Ishikawa, R., Okajima, T., Katoh, K.: Fascin in lamellipodia contributes to cell elasticity by controlling the orientation of filamentous actin. 24(3), 202-213 (2019).

脳機能調節因子研究グループ

  • Tani, N., Kazuma, K., Ohtsuka, Y., Shigeri, Y., Masuko, K., Konno, K., Inagaki, H.: Mass spectrometry analysis and biological characterization of the predatory ant odontomachus monticola venom and venom sac components. Toxins, 11(1), 1-15 (2019).

細胞分子機能研究グループ

  • Sunarso, Tsuchiya, A., Toita, R., Tsuru, K., Ishikawa, K.: Enhanced osseointegration capability of poly(ether ether ketone) via combined phosphate and calcium surface-functionalization. Int. J. Mol. Sci., 21(1), 198 (2019).
  • Toita, R., Asai, D., Otani, K., Kawano, T., Murata, M., Kang, J-H.: Suppression of lysophosphatidylcholine-induced human aortic smooth muscle cell calcification by protein kinase A (PKA) inhibition. Lipids (2019).
  • Asai, D., Murata, M., Toita, R., Kawano, T., Nakashima, H., Kang, JH.: A high-affinity peptide substrate for G protein-coupled receptor kinase 2 (GRK2). Amino Acids (2019).
  • Mine, S., Watanabe, M.: Structural insights into the molecular evolution of the Archaeal Exo-β-d-Glucosaminidase. Int. J. Mol. Sci., 20(10), 2460 (2019).
  • Fukuda, N., Tsuchiya, A., Sunarso, Toita, R., Tsuru, K., Mori, Y., Ishikawa, K.: Surface plasma treatment and phosphorylation enhance the biological performance of poly(ether ether ketone). Colloid Surf. B-Biointerfaces, 173(1), 36-42 (2019).

部門研究戦略2:生物機能計測

バイオアナリティカル研究グループ

  • Chihara, K., Bischler, T., Barquist, L., Monzon, V.A., Noda, N., Vogel, J., Tsuneda, S.: Conditional Hfq association with small noncoding RNAs in Pseudomonas aeruginosa revealed through comparative UV cross-linking immunoprecipitation followed by high-throughput sequencing. mSystems (2019).
  • Ishikawa, D., Suzuki, Y., Kurokawa, C., Ohara, M., Tsuchiya, M., Morita, M., Yanagisawa, M., Endo, M., Kawano, R., Takinoue, M.: DNA Origami nanoplate‐based emulsion with nanopore function. Angew. Chem.-Int. Edit., 58, 15299-15303 (2019).
  • Hayakawa, E., Ohgidani, M., Fujimura, Y., Kanba, S., Miura, D., Kato, T.A.: Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus. Schizophr. Res., 210, 326-328 (2019).
  • Morikawa-Ichinose, T., Fujimura, Y., Murayama, F., Yamazaki, Y., Yamamoto, T., Wariishi, H., Miura, D.: Improvement of sensitivity and reproducibility for imaging of endogenous metabolites by matrix-assisted laser desorption/ionization-mass spectrometry. J. Am. Soc. Mass Spectrom., 30(8), 1512-1520 (2019).
  • Sasaki, A., Halter, M., Elliott, J.T.: Fluorescence correlation methods for determining absolute numbers of molecules from microscopy images. Bioimages, 27, 13-22 (2019).
  • Ota, Y., Saito, K., Takagi, T., Matsukura, S., Morita, M., Tsuneda, S., Noda, N.: Fluorescent nucleic acid probe in droplets for bacterial sorting (FNAP-sort) as a high-throughput screening method for environmental bacteria with various growth rates. PLoS One, 14(4), e0214533 (2019).
  • Watahiki, S., Kimura, N., Yamazoe, A., Miura, T., Sekiguchi, Y., Noda, N., Matsukura, S., Kasai, D., Takahata, Y., Nojiri, H., Fukuda, M.: Ecological impact assessment of a bioaugmentation site on remediation of chlorinated ethylenes by multi-omics analysis. J. Gen. Appl. Microbiol. (2019).
  • Morita, M., Ota, Y., Katoh, K., Noda, N.: Bacterial cell culture at the single-cell level inside giant vesicles. J. Vis. Exp. (2019).

細胞・生体医工学研究グループ

  • Kurihara, K., Homma, T., Kobayashi, S., Shichiri, M., Fujiwara, H., Fujii, S., Yamada, KI., Nakane, M., Kawamae, K., Fujii, J.: Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice. J. Clin. Biochem. Nutr., 65(3), 209-216 (2019).
  • Dwiranti, A., Takata, H., Fukui, K.: Reversible changes of chromosome structure upon different concentrations of divalent cations. Microsc. microanal., 25(3), 817-821 (2019).
  • Yamazoe, H.: Antibody immobilization technique using protein film for high stability and orientation control of the immobilized antibody. Mater. Sci. Eng. C-Mater. Biol. Appl., 100, 209-214(2019).
  • Shichiri, M., Ishida, N., Hagihara, Y., Yoshida, Y., Kume, A., Suzuki, H.: Probucol induces the generation of lipid peroxidation products in erythrocytes and plasma of male cynomolgus macaques. J. Clin. Biochem. Nutr., 64(2), 129-142 (2019).

次世代メディカルデバイス研究グループ

  • Kurinomaru, T., Kojima, N., Kurita, R.: Sequential assessment of multiple epigenetic modifications of cytosine in whole genomic DNA by surface plasmon resonance. Anal. Chem., 91(21), 13933-13939 (2019).

部門研究戦略3:生物機能応用

分子細胞デザイン研究グループ

  • Shibakami, M., Sohma, M., Kijima, N., Nemoto, T.: Melt spinnabilities of thermoplastic paramylon mixed esters. Heliyon, 5(11), e02843 (2019).
  • Watanabe, H., Yoshida, C., Ooishi, A., Nakai, Y., Ueda, M., Isobe, Y., Honda, S.: Histidine-mediated intramolecular electrostatic repulsion for controlling pH-dependent protein-protein interaction. ACS Chem. Biol., 14(12), 2729-2736 (2019).
  • Shibuya, R., Miyafusa, T., Honda, S.: Stabilization of backbone‐circularized protein is attained by synergistic gains in enthalpy of folded structure and entropy of unfolded structure. FEBS J., 15092 (2019).
  • Nasrin, S.R., Kabir, A.M.R., Konagaya, A., Ishihara, T., Sada, K., Kakugo, A.: Stabilization of microtubules by cevipabulin. Biochem. Biophys. Res. Commun., 516(3), 760-764 (2019).
  • Akizuki, K., Kinumi, T., Ono, A., Senga, Y., Osawa, J., Shigeri, Y., Ishida, A., Kameshita, I., Sueyoshi, N.: Autoactivation of C-terminally truncated Ca2+/calmodulin-dependent protein kinase (CaMK) Iδ via CaMK kinase-independent autophosphorylation. Arch. Biochem. Biophys., 15(668), 29-38 (2019).
  • Yageta, S., Imamura, H., Shibuya, R., Honda, S.: CH2 domain orientation of human immunoglobulin G in solution: Structural comparison of glycosylated and aglycosylated Fc regions using small-angle X-ray scattering. mAbs, 11(3), 453-462 (2019).
  • Senga, Y., Imamura, H., Ogura, T., Honda, S.: In-solution microscopic imaging of fractal aggregates of a stressed therapeutic antibody. Anal. Chem. (2019).
  • Shibakami, M., Shibata, K., Akashi, A., Onaka, N., Takezaki, J., Tsubouchi, G., Yoshikawa, H.: Creation of straight-chain cationic polysaccharide-based bile salt sequestrants made from euglenoid β-1,3-glucan as potential antidiabetic agents. Pharm. Res., 36(1), 23 (2019).
  • Nakabayashi, M., Kamachi, S., Malle, D., Yanamoto, T., Kishishita, S., Fujii, T., Inoue, H., Ishikawa, K.: Construction of thermostable cellobiohydrolase I from the fungus Talaromyces cellulolyticus by protein engineering. Protein Eng. Des. Sel. (2019).

構造創薬研究グループ

  • Akutsu, Y., Doi, M., Furukawa, K., Takagi, Y.: Introducing a Gene Knockout Directly Into the Amastigote Stage of Trypanosoma cruzi Using the CRISPR/Cas9 System. J. Vis. Exp., 149, e59962 (2019).
  • Yamasaki, K., Kubota, T., Yamasaki, T., Nagashima, I., Shimizu, H., Terada, RI, Nishigami, H., Kang, J., Tateno, M., Tateno, H.: Structural basis for specific recognition of core fucosylation in N-glycans by Pholiota squarrosa lectin (PhoSL). GLYCOBIOLOGY, 29(7), 576-587 (2019).
  • Nishigami, H., Kang, J., Terada, R., Kino, H., Yamasaki, K., Tateno, M.: Is it possible for short peptide composed of positively- and negatively-charged “hydrophilic” amino acid residue-clusters to form metastable “hydrophobic” packing?. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 21(19), 9683-9693 (2019).
  • Phillips, R.E., Yang, Y., Smith, R.C., Thompson, B.M., Yamasaki, T., Sato-Feliciano, Y.M., Funato, K., Liang, Y., Garcia-Bermudez, J., Wang, X., Garcia, B.A., Yamasaki, K., McDonald, J.G., Birsoy, K., Tabar, V., Allis, C.D.: Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc. Natl. Acad. Sci. U. S. A., 116(16), 7957-7962 (2019).
  • Nishigami, H., Kang, J., Yamasaki, K., Tateno, M.: Specific coordination mode and electrostatic Ion atmosphere effects of divalent cations regulating spatially crossing configurations of DNA duplexes. J. Phys. Soc. Jpn., 88, 44801 (2019).
  • Furuhata, Y., Kobayashi, M., Maruyama, R., Sato, Y., Makino, K., Michiue, T., Yui, H., Nishizawa, S., Yoshimoto, K.: Programmable RNA detection with a fluorescent RNA aptamer using optimized three-way junction formation. RNA (2019).
  • Furuhata, Y., Sakai, A., Murakami, T., Morikawa, M., Nakamura, C., Yoshizumi, T., Fujikura, U., Nishida, K., Kato, Y.: A method using electroporation for the protein delivery of Cre recombinase into cultured Arabidopsis cells with an intact cell wall. Sci Rep, 9, 2163 (2019).
  • Takagi, Y., Akutsu, Y., Doi, M., Furukawa, K.: Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi. Plos Neglect. Trop. Dis. (2019).

生体分子創製研究グループ

  • Yamano, N., Kawasaki, N., Ida, S., Nakayama, A.: Biodegradation of polyamide 4 in seawater. Polym. Degrad. Stabil., 166, 230-236 (2019).
  • Himiyama, T., Oshima, M., Uegaki, K., Nakamura, T.: Distinct molecular assembly of homologous peroxiredoxins from Pyrococcus horikoshii and Thermococcus kodakaraensis. J. Biochem., 106(1), 89-95 (2019).
  • Masui, A., Ikawa, S., Kawasaki, N., Yamano, N., Nakayama, A.: Biodegradation control of a polyamide 4–visible-light-sensitive TiO2 composite by a fluorescent light irradiation. Polym. Degrad. Stabil., 167, 44-49 (2019).
  • Nakayama, A., Yamano, N., Kawasaki, N.: Biodegradation in seawater of aliphatic polyesters. Polym. Degrad. Stabil., 166, 290-299 (2019).
  • Kojima, M., Matsui, K., Mizui, T.: BDNF Pro-Peptide: Physiological Mechanisms and Implications for Depression. Cell Tissue Res., 377(1), 73-79 (2019).
  • Fukuda, N., Senga, Y., Honda, S.: Anxa2‐ and Ctsd‐knockout CHO cell lines to diminish the risk of contamination with host cell proteins. Biotechnol. Prog. (2019).
  • Mizui, T., Hattori, K., Ishiwata, S., Hidese, S., Yoshida, S., Kunugi, H., Kojima, M.: Cerebrospinal fluid BDNF pro-peptide levels in major depressive disorder and schizophrenia. J. Psychiatr. Res., 113, 190-198 (2019).

先端ゲノムデザイン研究グループ

  • Saito, E., Isogai, S., Deguchi, T., Ishida, K. Nozaki, T., Ishiama, E., Wayama, M., Shimoda, H.: Intraperitoneal dye injection method for visualizing the functioning lymphatic vascular system in zebrafish and medaka. Dev. Dyn. (2019).
  • Shin, M., Nozaki, T., Idrizi, F. Isogai, S., Ogasawara, K., Ishida, K., Yuge, S., Roscoe, B., Wolfe, S.A., Fukuhara, S., Mochizuki, N., Deguchi, T., Lawson, N.D.: Valves are a conserved feature of the zebrafish lymphatic system. Dev. Cell, 51(3), 374-386 (2019).
  • Hao, L., Okano, K., Zhang, C., Zhang, Z., Lei, Z., Feng, C., Utsumi, M., Ihara, I., Maseda, H., Shimizu, K.: Effects of levofloxacin exposure on sequencing batch reactor (SBR) behavior and microbial community changes. Sci. Total Environ., 672, 227-238 (2019).
  • Wu, C., Kurinomaru, T.: Development of the bioluminescent immunoassay for the detection of 5-hydroxymethylcytosine in dinoflagellate. Anal. Sci., 35(3) (2019).
  • Takeuchi, M., Ozaki, H., Hiraoka, S., Kamagata, Y., Sakata, S., Yoshioka, H., Iwasaki, W.: Possible cross-feeding pathway of facultative methylotroph Methyloceanibacter caenitepidi Gela4 on methanotroph Methylocaldum marinum S8. PLoS One (2019).

部門幹部・部門付き

  • Tomita, T., Mori, T., Onishi, Y.: β-Arrestin 1 (ARRB1) serves as a molecular marker of the peripheral circadian rhythm. Int. J. Oral Sci., 11(4), 32 (2019).
  • Watthaison, P., Pongpamorn, P., Pimviriyakul, P., Maenpuen, S., Ohmiya, Y., Chaiyen, P.: A Chemo-Enzymatic Cascade for the Smart Detection of Nitro- and Halogenated Phenols. Angewandte Chemie. 131(38), 13388-13392 (2019).
  • Zheng, Y., Saitou, A., Wang, C., Toyoda, A., Minakuchi, Y., Sekiguchi, Y., Ueda, K., Ueda, K., Takano, H., Sakai, Y., Abe, K., Yokota, A., Yabe, S.: Genome features and secondary metabolites biosynthetic potential of the glass Ktedonobacteria. Front. Microbiol., 10, 893 (2019).