1. ホーム>
  2. 研究成果>
  3. 論文発表 >
  4. 誌上発表(国際誌・査読有)2019年

研究成果

誌上発表(国際誌・査読有)2019年

重点課題1:

分子細胞育種研究グループ

  • Akizuki, K., Kinumi, T., Ono, A., Senga, Y., Osawa, J., Shigeri, Y., Ishida, A., Kameshita, I., Sueyoshi, N.: Autoactivation of C-terminally truncated Ca2+/calmodulin-dependent protein kinase (CaMK) Iδ via CaMK kinase-independent autophosphorylation. Arch. Biochem. Biophys., 15(668), 29-38 (2019).
  • Yageta, S., Imamura, H., Shibuya, R., Honda, S.: CH2 domain orientation of human immunoglobulin G in solution: Structural comparison of glycosylated and aglycosylated Fc regions using small-angle X-ray scattering. mAbs, 11(3), 453-462 (2019).
  • Senga, Y., Imamura, H., Ogura, T., Honda, S.: In-solution microscopic imaging of fractal aggregates of a stressed therapeutic antibody. Anal. Chem. (2019).
  • Shibakami, M., Shibata, K., Akashi, A., Onaka, N., Takezaki, J., Tsubouchi, G., Yoshikawa, H.: Creation of straight-chain cationic polysaccharide-based bile salt sequestrants made from euglenoid β-1,3-glucan as potential antidiabetic agents. Pharm. Res., 36(1), 23 (2019).
  • Nakabayashi, M., Kamachi, S., Malle, D., Yanamoto, T., Kishishita, S., Fujii, T., Inoue, H., Ishikawa, K.: Construction of thermostable cellobiohydrolase I from the fungus Talaromyces cellulolyticus by protein engineering. Protein Eng. Des. Sel. (2019).

構造生理研究グループ

  • Yamamoto, J., Kinjo, M.: Full fiber-optic fluorescence correlation spectroscopy. Opt. Express, 27(10), 14835-14841 (2019).
  • Sato, C., Sato, Y.M., Takeshima, H., Memtily, N., Hatano, Y., Tsukuba, T., Sakai, E.: Calcium phosphate mineralization in bone tissues directly observed in aqueous liquid by atmospheric SEM (ASEM) without staining: microfluidics crystallization chamber and immuno-EM. Sci Rep, 9(7352), 1-13 (2019).
  • Sato, C., Yamazawa, T., Ohtani, A., Maruyama, Y., Memtily, N., Sato, M., Hatano, Y., Shiga, T., Ebihara, T.: Primary cultured neuronal networks and type 2 diabetes model mouse fatty liver tissues in aqueous liquid observed by atmospheric SEM (ASEM): Staining preferences of metal solutions. Micron, 118, 9-21 (2019).
  • Kato, M., Hanyu, Y.: Single-step colony assay with autoinduction of scFv expression for the screening of antibody libraries. Biotechniques, 66(4), (2019).
  • Yonemoto, K., Chiba, A., Sugimoto, S., Sato, C., Saito, M., Kinjo, Y., Marumo, K., Mizunoe, Y.: Redundant and distinct roles of secreted protein eap and cell wall-anchored protein SasG in biofilm formation and pathogenicity of staphylococcus aureus. Infect. Immun. (2019).
  • Takahashi, S., Yamamoto, J., Kitamura, A., Kinjo, M., Sugimoto, N.: Characterization of intracellular crowding environments with topology-based DNA quadruplex sensors. Anal. Chem. (2019).

先端ゲノムデザイン研究グループ

  • Wu, C., Kurinomaru, T.: Development of the bioluminescent immunoassay for the detection of 5-hydroxymethylcytosine in dinoflagellate. Anal. Sci., 35(3) (2019).
  • Takeuchi, M., Ozaki, H., Hiraoka, S., Kamagata, Y., Sakata, S., Yoshioka, H., Iwasaki, W.: Possible cross-feeding pathway of facultative methylotroph Methyloceanibacter caenitepidi Gela4 on methanotroph Methylocaldum marinum S8. PLoS One (2019).

生体分子創製研究グループ

  • Fukuda, N., Senga, Y., Honda, S.: Anxa2‐ and Ctsd‐knockout CHO cell lines to diminish the risk of contamination with host cell proteins. Biotechnol. Prog. (2019).
  • Mizui, T., Hattori, K., Ishiwata, S., Hidese, S., Yoshida, S., Kunugi, H., Kojima, M.: Cerebrospinal fluid BDNF pro-peptide levels in major depressive disorder and schizophrenia. J. Psychiatr. Res., 113, 190-198 (2019).

重点課題2:

生物時計研究グループ

  • Oishi, K., Okauchi, H.: Functional CLOCK is not essentially associated with metabolic disruption caused by sleep phase feeding in mice. Biol. Pharm. Bull., 42, 1038-1043 (2019).
  • Ohkura, N., Kihara-Negishi, F., Fujii, A., Kanouchi, H., Oishi, K., Atsumi, G., Nagano, M.: Effects of fermented rice vinegar Kurozu and its sediment on inflammation-induced plasminogen activator inhibitor 1 (PAI-1) increase. Food and Nutrition Sciences, 9, 235-246 (2018).
  • Higo-Yamamoto, S., Yamamoto, S., Miyazaki, K., Nakakita, Y., Kaneda, H., Takata, Y., Nakamura, T., Oishi, K.: Dietary heat-killed Lactobacillus brevis SBC8803 attenuates chronic sleep disorders induced by psychophysiological stress in mice. J. Nutr. Sci. Vitaminol., 65(2), 164-170 (2019).
  • Akimoto, H., Oshima, S., Sugiyama, T., Negishi, A., Nemoto, T., Kobayashi, D.: Changes in brain metabolites related to stress resilience: Metabolomic analysis of the hippocampus in a rat model of depression. Behav. Brain Res., 359, 342-352 (2019).
  • Okachi, H., Hashimoto, C., Nakao, R., Oishi, K.: Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice. Chronobiol. Int., 36(1), 57-74 (2019).v

健康維持機能物質開発研究グループ

      
  • Gabriel, G.V.M., Yasuno, R., Mitani, Y., Ohmiya, Y., Viviani, V.R.: Novel application of Macrolampis sp2 firefly luciferase for intracellular pH-biosensing in mammalian cells. Photochem. Photobiol. Sci. (2019).

DAILAB

  • Garg, S., Afzal, S., Elwakeel, A., Sharma, D., Radhakrishnan, N., Dhanjal, J.K., Sundar, D., Kaul, S.C., Wadhwa, R.: Marine carotenoid fucoxanthin possesses anti-metastasis activity: Molecular evidence. Mar. Drugs, 17(6), 338 (2019).
  • Wadhwa, R., Li, L., Singh, R., Wang, J., Gao, R., Nigam, N., Forestier, S., Ando, N., Kaul, S.C.: Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin. Evid.-based Complement Altern. Med., 2019, 1-11 (2019).
  • Kalra, R., Bapat, S.A.: Proteomics to predict loss of RXR-γ during progression of epithelial ovarian cancer. Methods in Molecular Biology (2019).
  • Irie, I., Ito, K., Fujioka, Y., Oguchi, K., Fujioka, A., Hashimoto, A., Ohsawa, H., Tanaka, K., Funabashi, K., Araki, H., Kawai, Y., Shimamura, T., Wadhwa, R., Ohkubo, S., Matsuo, K.: TAS0728, A Covalent-binding, HER2-selective Kinase inhibitor shows potent antitumor activity in preclinical models. Mol. Cancer Ther., 18(4), 733-742 (2019).
  • Sundar,D., Katiyar, S.P., Putri, J.F., Dhanjal, J.K., Wang, J., Sari, A.N., Kolettas, E., Kaul, S.C., Wadhwa, R.: Wild type p53 function in p53Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence. J. Exp. Clin. Cancer Res. 38, 103 (2019).
  • Bhargava, P., Malik, V., Liu, Y., Ryu, J., Kaul, S.C., Sundar, D., Wadhwa, R.: Molecular insights to Withaferin-A induced senescence: Bioinformatics and experimental evidence to the role of NF-kappa B and CARF. J. Gerontol. Ser. A-Biol. Sci. Med., 74(2), 183-191 (2019).

重点課題3:

脳遺伝子研究グループ

  • Kuramochi, M., Doi, M.: An excitatory/inhibitory switch from asymmetric sensory neurons defines postsynaptic tuning for a rapid response to NaCl in caenorhabditis elegans. Front Mol Neurosci.,11(484), e 00484 (2019).
  • Tanaka, M., Fujii, Y., Hirano, K., Higaki, T., Nagasaki, A., Ishikawa, R., Okajima, T., Katoh, K.: Fascin in lamellipodia contributes to cell elasticity by controlling the orientation of filamentous actin. 24(3), 202-213 (2019).

脳機能調節因子研究グループ

  • Tani, N., Kazuma, K., Ohtsuka, Y., Shigeri, Y., Masuko, K., Konno, K., Inagaki, H.: Mass spectrometry analysis and biological characterization of the predatory ant odontomachus monticola venom and venom sac components. Toxins, 11(1), 1-15 (2019).

分子複合医薬研究グループ

  • Moriyama, A., Takahashi, U., Mizuno, Y., Takahashi, J., Horie, M., Iwahashi, H.: The truth of toxicity caused by yttrium oxide nanoparticles to yeast cells. J. Nanosci. Nanotechnol., 19(9), 5418-5425 (2019).
  • Yook, J.S., Rakwal, R., Shibato, J., Takahashi, J., Koizumi, H., Shima, T., Ikemoto, M.J., Oharomari, L.K., McEwen, B.S., Soya, H.: Leptin in hippocampus mediates benefits of mild exercise by an antioxidant on neurogenesis and memory. Proc. Natl. Acad. Sci. U. S. A., 116(22), 10988-10993 (2019).
  • Connelly, C.M., Numata, T., Boer, R.E., Moon, M.H., Sinniah, R.S., Barchi, J.J., Ferre-D'Amare, A.R., Schneekloth Jr, J.S.: Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat. Commun., 10, 1501 (2019).
  • Takeshita, D., Sato, M., Inanaga, H., Numata, T.: Crystal structures of Csm2 and Csm3 in the Type III-A CRISPR–Cas effector complex. J. Mol. Biol., 431(4), 748-763 (2019).
  • Hibi, A., Ohno, T., Moriyama, A., Himaki, T., Takahashi, J., Iwahashi, H.: Evaluation of the effect of high pressure carbon dioxide-pasteurized food on animal health. High Pressure Res., 39(2), 357-366 (2019).

構造創薬研究グループ

  • Yamasaki, K., Kubota, T., Yamasaki, T., Nagashima, I., Shimizu, H., Terada, R., Nishigami, H., Kang, J., Tateno, M., Tateno, H.: Structural basis for specific recognition of core fucosylation in N-glycans by Pholiota squarrosa lectin (PhoSL) . Glycobiology (2019).
  • Phillips, R.E., Yang, Y., Smith, R.C., Thompson, B.M., Yamasaki, T., Sato-Feliciano, Y.M., Funato, K., Liang, Y., Garcia-Bermudez, J., Wang, X., Garcia, B.A., Yamasaki, K., McDonald, J.G., Birsoy, K., Tabar, V., Allis, C.D.: Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc. Natl. Acad. Sci. U. S. A., 116(16), 7957-7962 (2019).
  • Nishigami, H., Kang, J., Terada, R., Kino, H., Yamasaki, K., Tateno, M.: Is it possible for short peptide composed of positively- and negatively-charged “hydrophilic” amino acid residue-clusters to form metastable “hydrophobic” packing? . Phys. Chem. Chem. Phys., 10.1039/C9CP00103D (2019).
  • Nishigami, H., Kang, J., Yamasaki, K., Tateno, M.: Specific coordination mode and electrostatic Ion atmosphere effects of divalent cations regulating spatially crossing configurations of DNA duplexes. J. Phys. Soc. Jpn., 88, 44801 (2019).
  • Furuhata, Y., Kobayashi, M., Maruyama, R., Sato, Y., Makino, K., Michiue, T., Yui, H., Nishizawa, S., Yoshimoto, K.: Programmable RNA detection with a fluorescent RNA aptamer using optimized three-way junction formation. RNA (2019).
  • Furuhata, Y., Sakai, A., Murakami, T., Morikawa, M., Nakamura, C., Yoshizumi, T., Fujikura, U., Nishida, K., Kato, Y.: A method using electroporation for the protein delivery of Cre recombinase into cultured Arabidopsis cells with an intact cell wall. Sci Rep, 9, 2163 (2019).
  • Takagi, Y., Akutsu, Y., Doi, M., Furukawa, K.: Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi. Plos Neglect. Trop. Dis. (2019).

細胞分子機能研究グループ

  • Asai, D., Murata, M., Toita, R., Kawano, T., Nakashima, H., Kang, JH.: A high-affinity peptide substrate for G protein-coupled receptor kinase 2 (GRK2). Amino Acids (2019).
  • Mine, S., Watanabe, M.: Structural insights into the molecular evolution of the Archaeal Exo-β-d-Glucosaminidase. Int. J. Mol. Sci., 20(10), 2460 (2019).
  • Sato, T.: Conserved 2nd residue of helix 8 of GPCR may confer the subclass-characteristic and distinct roles through a rapid initial interaction with specific G proteins. Int. J. Mol. Sci., 20(7), 1752 (2019).
  • Fukuda, N., Tsuchiya, A., Sunarso, Toita, R., Tsuru, K., Mori, Y., Ishikawa, K.: Surface plasma treatment and phosphorylation enhance the biological performance of poly(ether ether ketone). Colloid Surf. B-Biointerfaces, 173(1), 36-42 (2019).

重点課題4:

バイオアナリティカル研究グループ

  • Sasaki, A., Halter, M., Elliott, J.T.: Fluorescence correlation methods for determining absolute numbers of molecules from microscopy images. Bioimages, 27, 13-22 (2019).
  • Ota, Y., Saito, K., Takagi, T., Matsukura, S., Morita, M., Tsuneda, S., Noda, N.: Fluorescent nucleic acid probe in droplets for bacterial sorting (FNAP-sort) as a high-throughput screening method for environmental bacteria with various growth rates. PLoS One, 14(4), e0214533 (2019).
  • Watahiki, S., Kimura, N., Yamazoe, A., Miura, T., Sekiguchi, Y., Noda, N., Matsukura, S., Kasai, D., Takahata, Y., Nojiri, H., Fukuda, M.: Ecological impact assessment of a bioaugmentation site on remediation of chlorinated ethylenes by multi-omics analysis. J. Gen. Appl. Microbiol. (2019).
  • Morita, M., Ota, Y., Katoh, K., Noda, N.: Bacterial cell culture at the single-cell level inside giant vesicles. J. Vis. Exp. (2019).

ナノバイオデバイス研究グループ

  • Kamata, T., Kato, D., Niwa, O.: Electrochemical performance at sputter-deposited nanocarbon film with different surface nitrogen-containing groups. Nanoscale, 21(11), 10239-10246 (2019).
  • Kamata, T., Sumimoto, M., Shiba, S., Kurita, R., Niwa, O., Kato, D.: Increased electrode activity during geosmin oxidation provided by Pt nanoparticle-embedded nanocarbon film. Nanoscale, 18(11), 8845-8854 (2019).
  • Sugai, H., Tomita, S., Ishihara, S., Kurita, R.: One-component array based on a dansyl-modified polylysine: Generation of differential fluorescent signatures for the discrimination of human cells. ACS Sens., 4(4), 827-831 (2019).
  • Shiba, S., Takahashi, S., Kamata, T., Hachiya, H., Kato, D., Niwa, O.: Selective au electrodeposition on au nanoparticles embedded in carbon film electrode for Se(IV) detection. Sens. Mater., 31(4), 1135-1146 (2019).
  • Tomita, S., Ishihara, S., Kurita, R.: Biomimicry recognition of proteins and cells using a small array of block copolymers appended with amino acids and fluorophores. ACS Appl. Mater. Interfaces, 11(7), 6751-6758 (2019).
  • Sugai, H., Tomita, S., Ishihara, S., Kurita, R.: Fingerprint-based protein identification in cell culture medium using environment-sensitive turn-on fluorescent polymer. Sens. Mater., 31(1), 1-11 (2019).
  • Mimura, M., Tomita, S., Kurita, R., Shiraki, K.: Array-based generation of response patterns with common fluorescent dyes for identification of proteins and cells. Anal. Sci., 35(1), 99-102 (2019).
  • Minamiki, T., Kurita, R.: Potentiometric detection of biogenic amines utilizing affinity on a 4-mercaptobenzoic acid monolayer. Anal. Methods (2019).
  • Minamiki, T., Sekine, T., Aiko, M., Shiwei, S., Minami, T.: An organic FET with an aluminum oxide extended gate for pH sensing. Sens. Mater., 31(1), 99-106 (2019).
  • Minamiki, T., Tokito, S., Minami, T.: Fabrication of a flexible biosensor based on an organic field-effect transistor for lactate detection. Anal. Sci., 35(1), 103-106 (2019).

セルメカニクス研究グループ

      
  • Yamagishi, A., Susaki, M., Takano, Y., Mizusawa, M., Mishima, M., Iijima, M., Kuroda, S., Okada, T., Nakamura, C.: The Structural function of nestin in cell body softening is correlated with cancer cell metastasis. Int. J. Biol. Sci., 15(7), 1546-1556 (2019).
  • Umeki, N., Shibata, K., Noguchi, T.Q.P., Hirose, K., Sako, Y., Uyeda, T.Q.P.: K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins. Sci. Rep., 9, 5353 (2019).
  • Yamagishi, A., Matsumoto, D., Kato, Y., Honda, Y., Morikawa, M., Iwata, F., Kobayashi, T., Nakamura, C.: Direct Delivery of Cas9-sgRNA Ribonucleoproteins into Cells Using a Nanoneedle Array. Appl. Sci.-Basel, 9(5), 965 (2019).,
  • Yamamoto, K., Otomo, K., Nemoto, T., Ishihara, S., Haga, H., Nagasaki, A., Murakami, Y., Takahashi, M.: Differential contributions of nonmuscle myosin IIA and IIB to cytokinesis in human immortalized fibroblasts. Exp. Cell Res., 376(1), 67-76 (2019).
  • Odaka, M., Kim, H., Nakamura, Y., Hattori, A., Matsuura, K., Iwamura, M., Miyagi, Y., Yasuda, K.: Size distribution analysis with on-chip multi-imaging cell sorter for unlabeled identification of circulating tumor cells in blood. Micromachines, 10(2), 154 (2019).
  • Nomura, M., Atsuji, K., Hirose, K., Shiba, K., Yanase, R., Nakayama, T., Ishida, K., Inaba, K.: Microtubule stabilizer reveals requirement of Ca2+-dependent conformational changes of microtubules for rapid coiling of haptonema in haptophyte algae. Biol. Open, 8(2), bio036590 (2019).

細胞・生体医工学研究グループ

      
  • Yamazoe, H.: Antibody immobilization technique using protein film for high stability and orientation control of the immobilized antibody. Mater. Sci. Eng. C-Mater. Biol. Appl., 100, 209-214(2019).
  • Shichiri, M., Ishida, N., Hagihara, Y., Yoshida, Y., Kume, A., Suzuki, H.: Probucol induces the generation of lipid peroxidation products in erythrocytes and plasma of male cynomolgus macaques. J. Clin. Biochem. Nutr., 64(2), 129-142 (2019).

その他