有機反応化学研究グループ

研究概要

有機合成を基盤に、複数のチーム型研究・個人型研究を展開しています。
1. 二酸化炭素を原料とする含酸素化学品合成技術の開発
2. 使用済タイヤのケミカルリサイクル技術の開発
3. シリコーン・シロキサン・有機ケイ素材料の精密合成技術の開発
の他にも下記の研究テーマを実施しています。

研究テーマ

糖・糖鎖の精密変換法

金糖が多数持つ水酸基（-OH）を選択的に変換する反応開発を行っています。これにより、保護基を利用することなく、糖や糖鎖を生物活性分子等の高付加価値物質へと変換することができます

二酸化炭素とエポキシドの共重合

反応性の高いエポキシドをコモノマーとすることで、脱水剤などの追加の反応剤が不要な1段階の反応でポリカーボネートを得ることができます。

論文

2025

• Shotaro Ito,* Kazuhiro Matsumoto,* Hiroaki Sato, and Hirohmi Watanabe
  “Photoionization Mass Spectrometry Unveils Siloxane Sequence Isomers: Advancing Molecular Tagging Applications”
  J. Polym. Sci. 63, 2626–2638 (2025).
• Wahyu S. Putro, Akira Ikeda, Toshihide Yamamoto, Satoshi Hamura, Jun-Chul Choi,* and Norihisa Fukaya*
  “Breaking the equilibrium limit: synthesis of diethyl carbonate from CO₂ using regenerable bis-/tris-triethoxysilane substrates”
  RSC Sustain. 3, 565–571 (2025).
　

2024

• Haruki Nagae, Hiroki Koizumi, Katsuhiko Takeuchi, Satoshi Hamura, Toshihide Yamamoto, Kazuhiro Matsumoto, Yoshihiro Kamimura, Sho Kataoka, Norihisa Fukaya, and Jun-Chul Choi*
  “Zirconium Catalyst Grafted on Ceria-Coated Silica for Transformation of Carbon Dioxide to Diethyl Carbonate”
  ChemCatChem, 16, e202400673 (2024).
• Takahiro Kawatsu, Hiroyuki Minamikawa, Kazuhiko Sato, and Kazuhiro Matsumoto*
  “Building-block approach to discrete and sequence-specific oligosiloxanes”
  Polym. Chem., 15, 2740–2746 (2024).
• Hiroki Koizumi,* Haruki Nagae, Katsuhiko Takeuchi, Kazuhiro Matsumoto, Norihisa Fukaya, Yoshiaki Inoue, Satoshi Hamura, Takahiro Masuda, and Jun-Chul Choi*
  “Dialkyl Carbonate Synthesis Using Atmospheric Pressure of CO₂”
  ACS Omega, 9, 25879–25886 (2024).
• Katsuhiko Takeuchi,* Hiroki Koizumi, Haruki Nagae, Kazuhiro Matsumoto, Norihisa Fukaya, Kazuhiko Sato, and Jun-Chul Choi*
  ＜Review＞ “Direct use of low-concentration CO₂ in the synthesis of dialkyl carbonates, carbamate acid esters, and urea derivatives”
  J. CO2 Util., 83, 102814 (2024).
• Yoshifumi Hashikawa,* Koki Fujimura, Yoshihiro Ueda, Norihisa Fukaya, Takeo Kawabata, and Yasujiro Murata*
  “Chiroptical Response of Carbon Nanocages Enhanced by Achiral Guests”
  Angew. Chem. Int. Ed., 64, e202421859 (2024).
• Yoshihiro Ueda,* and Takeo Kawabata
  ＜Perspective＞ “Streamlined Synthesis of Ellagitannins: Site-Selective Functionalization of the Glucose Core and Stereodivergent Construction of the Hexahydroxydiphenoic Groups”
  J. Agric. Food Chem., 72, 24191 (2024).
　

2023

• Katsuhiko Takeuchi, Kei Takahashi, Yusuke Ishizaka, Hiroki Koizumi, Haruki Nagae, Kazuhiro Matsumoto, Norihisa Fukaya, Junpei Kuwabara, Takaki Kanbara, and Jun-Chul Choi*
  “Effect of Substituent on Phenanthroline Ligands in Zinc Complex-catalyzed Synthesis of Organic Carbamate from CO₂ Using Tetramethyl Orthosilicate”
  J. Jpn. Petrol. Inst., 66, 185–188 (2023).
• Hiroki Koizumi, Katsuhiko Takeuchi,* Kazuhiro Matsumoto, Norihisa Fukaya, Kazuhiko Sato, Masahito Uchida, Seiji Matsumoto, Satoshi Hamura, Junya Hirota, Makoto Nakashige, and Jun-Chul Choi*
  “Direct Conversion of Low-Concentration CO₂ into N‑Aryl and N‑Alkyl Carbamic Acid Esters Using Tetramethyl Orthosilicate with Amidines as a CO₂ Capture Agent and a Catalyst”
  J. Org. Chem., 88, 5015–5024 (2023).
• Xiao-Tao Lin, Yusuke Ishizaka, Yoshifumi Maegawa, Katsuhiko Takeuchi, Shinji Inagaki,* Kazuhiro Matsumoto,* and Jun-Chul Choi*
  “1,10-Phenanthroline-based periodic mesoporous organosilica: from its synthesis to its application in the cobalt-catalyzed alkyne hydrosilylation”
  RSC Adv., 13, 7828–7833 (2023).