Bioimaging Research Group
Currently, we are conducting research and development on the following imaging and sensing platforms including devices, materials, and methodologies. In addition, we will actively pursue the social implementation of our outcomes.
- Development of a scanning electron-assisted dielectric microscopy (SE-ADM) that enables direct observation of samples in aqueous solutions
- Establishment of technology for quantification of intra-/inter-cellular substances based on fluorescence correlation spectroscopy (FCS)
- Construction of nanostructured biointerfaces and in situ scanning probe microscope (SPM) observation in solutions
- Synthetic probe design to visualize the target protein, cholesterol.
- Design of nanocarbon electrode materials that can expand the possibility of electroanalysis
Fig. 1. Experimental set-up of SE-ADM system.
(T. Okada, T. Ogura, Sci. Rep. (2016)
Fig. 2 High-resolution SE-ADM images of osteoblasts.
(T. Iwayama, T. Okada et al., Sci. Adv. (2019))
Development of new detection, quantification and imaging techniques based on optical technology
Fig. 1 Structure of surface modification materials for construction of biocompatible interfaces. PC: phosphorylcholine, SB: sulfobetaine
Fig. 2 (a) EC-STM in situ image of a nanostructured molecular film of C12PC. One bright spot corresponds to a single C12PC molecule. (b) Schematic illustration of the interfacial structure of molecular arrangements and orientations.