Cellular Function Analysis RG_AIST_HMRI:Health and Medical Research Institute

Cellular Function Analysis Research Group

Research Outline

Cell Response–Driven Platform for Biological Function Analysis and Functional Component Discovery

We harness cellular responses to reveal biological functions. Using advanced cell-based platforms—such as luminescent reporter cells and olfactory receptor assays—we enable sensitive and quantitative evaluation of bioactivity in natural materials and nanoparticles. Our approach uncovers mechanisms of action, including immune modulation, and identifies key bioactive compounds. We also investigate cancer-related processes such as epithelial–mesenchymal transition EMT and novel functions mediated by olfactory receptors. These insights drive innovation in healthcare and food applications.

Cell-basedluminescent reporterassays,Component analysisand structuraldetermination,Healthcare technologiesusing ectopic olfactoryreceptor,Immune responseanalysis of naturalproducts,Analysis of plant-derived nanoparticles,Analysis of EMT

Members

Web of Science

Google Scholar

Name

-Research Topics

WoS

G.S.

ABE Hiroko, Group Leader

-Development of yeast strains with enhanced immunostimulatory effects
-Exploration of natural compounds with immunomodulatory properties
-Development of yeast for the production of functional glycoprotein

WoS

G.S.

NAKAJIMA Yoshihiro, Chief Senior Researcher

-Mechanistic analysis of cellular stress responses
- Development of cell-based assay systems using luminescent reporters
- Construction of evaluation systems for toxicity, food functionality, and drug efficacy

WoS

G.S.

TABEI Yosuke, Senior Researcher

- Elucidation of toxicity mechanisms of nanoparticle
- Development of technologies for evaluating biological effects of nanoparticles
- Analysis of mechanisms of ferroptosis inhibition

SHIOTA Yusuke, Senior Researcher

- Development of healthcare technologies based on extra-nasal olfactory receptors
- Exploration and evaluation of bioactive compounds targeting olfactory receptors
- Development of evaluation technologies for physiological activities

WoS

MIYATA Ryo, Researcher

- Visualization of chemical space in food materials through network analysis
- Structural elucidation of functional components in food materials using analytical techniques
- Evaluation of bioactivity of functional food ingredients

SASAKI Daisuke, Researcher

- Evaluation of bioactivity of plant-derived nanoparticles
- Development of in vitro assays using luminescent reporter systems
- Development of toxicity testing methods

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