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細胞制御マテリアル研究グループ

研究概要

細胞産業の必要性は、創薬・医薬品開発、再生医療、食品・代替タンパク質産業の発展、環境分野にて高まっており、特に、近年では細胞機能の制御技術の研究開発が求められています。 我々は、細胞操作技術や細胞機能を改変するマテリアルの研究開発に取り組み、その応用・実用化研究を進めています。我々の技術やマテリアルは、細胞産業の貢献に寄与し、持続可能な社会の実現や人類の健康寿命延伸に貢献します。

細胞制御マテリアル研究グループの紹介

研究課題

研究課題1:人工材料で細胞・組織を操る技術
研究担当者:須丸 公雄、高木 俊之、吉原 栄理佳

機能性ポリマーを用いて培養細胞を思いのままに配列・選別・デザインする技術、細胞の機能化への展開が期待されるフッ素化脂質を開発しました。

細胞制御マテリアル研究グループ1

研究課題2:バイオマテリアルで細胞機能を制御する技術
研究担当者:寺村 裕治、小淵 里恵、佐藤 佑哉

生体適合性の高い両親媒性高分子や脂質のナノ粒子を利用することで、細胞表面の改質や細胞機能の改変が可能になることが分かってきました。この細胞改変技術を用いて、応用研究や社会実装研究を進めています。

細胞制御マテリアル研究グループ2

グループの構成メンバー

　　　　　　　　　　　　　　　
顔写真 所属・役職および名前 専門分野 その他、etc
寺村グループ長の写真 研究グループ長 寺村 裕治
  • 細胞操作・エクソソーム送達のための表面修飾材料
  • 医療機器用コート剤開発
  
須丸上級主任研究員の写真 上級主任研究員 須丸 公雄
  • バイオ機能性・光応答性ポリマーの開発と応用
  
高木主任研究員の写真 主任研究員 高木 俊之
  • 創薬ツールとしてのフッ素化脂質の開発
  • 光機能性材料の開発
  • 光応答性遺伝子送達キャリアの開発
  
吉原研究員の写真 研究員 吉原 栄理佳
  • 長期留置可能な生体材料を用いたフェムテック
  • 脂質膜捕捉材料の開発
  
小淵研究員の写真 研究員 小淵 里恵
  • 核酸導入のための脂質ナノ粒子の研究開発
  • エクソソーム新規精製技術の開発
  
佐藤研究員の写真 研究員 佐藤 佑哉
  • 細胞の表面改質と膜融合のための新規材料開発

業績リスト

  • Zhang, W; Obuchi, S; Teramura, Y.
    Analysis of cellular responses following interaction with extracellular vesicles derived from HEK293T and human adipose derived stem cells.
    SCI REP. 2025 Apr 7;15(1):11835. doi:10.1038/s41598-025-95559-w
  • Teramura, Y; Cabral, H.
    Foreword to the focus issue: frontline research on biomaterials-based bioengineering for future therapy.
    SCI TECHNOL ADV MATER. 2025 Feb 21;26(1):2471206. doi:10.1080/14686996.2025.2471206
  • Kurosu, J; Sakamaki, T; Kanai, K; Morishita, K; Sumaru, K; Tsutsumi, J.
    Spatiotemporal dynamics of microscopic biological barrier visualized by electric-double-layer modulation imaging.
    BIOSENS BIOELECTRON. 2024 Aug 30;266:116721. doi: 10.1016/j.bios.2024.116721
  • Inuzuka, N; Shobayashi, Y; Tateshima, S; Sato, Y; Ohba, Y; Ishihara, K; Teramura, Y.
    Stable and Thin-Polymer-Based Modification of Neurovascular Stents with 2-Methacryloyloxyethyl Phosphorylcholine Polymer for Antithrombogenicity.
    BIOENGINEERING (Basel). 2024 Aug 15;11(8):833. doi: 10.3390/bioengineering11080833
  • Sato, Y; Baba, T; Uchida, T; Chung, UI; Teramura, Y.
    Cell membrane fusion induced by surface modification with cell-penetrating peptide–lipid conjugates that facilitates close contact between distinct membranes.
    Mater. Adv. 2024 May 11. doi: 10.1039/D4MA00193A
  • Sato, Y; Zhang, WX; Baba, T; Chung, UI; Teramura, Y.
    Extracellular vesicle-liposome hybrids via membrane fusion using cell-penetrating peptide-conjugated lipids.
    REGENERATIVE THERAPY. 2024 Jul 29. doi: 10.1016/j.reth.2024.07.006
  • Ma, ST; Yoda, H; Dang, T; Yang, JQ; Ando, I; Sato, Y; Teramura, Y; Tabata, H; Matsui, H.
    Light Polarization Effects of Chemical Sensing in the Mid-Infrared Region Using ZnO: Ga-Based Plasmonic Surface Lattice Resonances.
    JOURNAL OF PHYSICAL CHEMISTRY C. July 15, 2024. doi: 10.1021/acs.jpcc.4c02354
  • Inuzuka, N; Shobayashi, Y; Tateshima, S; Sato, Y; Ohba, Y; Ekdahl, KN; Nilsson, B; Teramura, Y.
    Stent coating containing a charged silane coupling agent that regulates protein adsorption to confer antithrombotic and cell-adhesion properties.
    SCI REP. 2024 Jul 10;14(1):15178. doi: 10.1038/s41598-024-65832-5
  • Shu, Y; Otake, M; Seta, Y; Hori, K; Kuramochi, A; Ohba, Y; Teramura, Y.
    Activation of cellular antioxidative stress and migration activities by purified components from immortalized stem cells from human exfoliated deciduous teeth.
    SCI REP. 2024 Jul 3;14(1):15340. doi: 10.1038/s41598-024-66213-8
  • Hasegawa, T; Nakagawara, A; Takagi, T; Shimoaka, T; Shioya, N; Sonoyama, M.
    Phonon modes controlled by primary chemical structure of partially fluorinated dimyristoylphosphatidylcholine (DMPC) revealed by multiple-angle incidence resolution spectrometry (MAIRS).
    J CHEM PHYS. 2024 Feb 14;160(6):064704. doi: 10.1063/5.0190441
  • Miyazaki, M; Arisaka, C; Nakagawara, A; Sasaki, N; Takahashi, H; Takagi, T; Amii, H; Sonoyama, M.
    Thermodynamic study on hydrated bilayers of ether-linked phosphatidylcholines with terminal perfluorobutyl group.
    BIOCHIM BIOPHYS ACTA BIOMEMBR. 2023 Dec 13:184261. doi: 10.1016/j.bbamem.2023.184261
  • Adler, A; Fritsch, M; Fromell, K; Leneweit, G; Ekdahl, KN; Nilsson, B; Teramura, Y.
    Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro.
    J MATER CHEM B. 2023 Nov 13. doi: 10.1039/d3tb01721d
  • Tsuyukubo, A; Morishita, K; Kanamori, T; Sumaru, K.
    Construction of a spheroid array culture system on a suspended permeable hydrogel membrane scaffold for improving the expression of a liver-specific drug-metabolizing enzyme of HepG2 cells.
    BIOMATER SCI. 2023 Jun 22. doi: 10.1039/d3bm00071k
  • Nakagawa, Y; Hishida, T; Sumaru, K; Morishita, K; Kirito, K; Yokojima, S; Sakamoto, Y; Nakamura, S; Uchida, K.
    Phototunable Cell Killing by Photochromic Diarylethene of Thiazoyl and Thienyl Derivatives.
    JOURNAL OF MEDICINAL CHEMISTRY. 2023, 66 (8) 5937-5949. doi: 10.1021/acs.jmedchem.3c00164
  • Rangasami, VK; Asawa, K; Teramura, Y; Le, Blanc K; Nilsson, B; Hilborn, J; Varghese, OP; Oommen, OP.
    Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function.
    BIOMATER ADV. 2023 Feb 8;147:213331. doi: 10.1016/j.bioadv.2023.213331
  • Huang, T; Sato, Y; Kuramochi, A; Ohba, Y; Sano, M; Miyagishi, M; Tateno, H; Wadhwa, R; Kawasaki, K; Uchida, T; Ekdahl, KN; Nilsson, B; Chung, UI; Teramura, Y.
    Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells.
    REGEN THER. 2023 Jan 11;22:90-98. doi: 10.1016/j.reth.2022.12.007
  • Suzuki, H; Adler, A; Huang, T; Kuramochi, A; Ohba, Y; Sato, Y; Nakamura, N; Manivel, VA; Ekdahl, KN; Nilsson, B; Ishihara, K; Teramura, Y.
    Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions.
    SCI TECHNOL ADV MATER. 2022 Dec 8;23(1):845-857. doi: 10.1080/14686996.2022.2146466
  • Ekdahl, KN; Fromell, K; Mannes, M; Grinnemo, KH; Huber-Lang, M;Teramura, Y; Nilsson, B.
    Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop.
    IMMUNOL REV. 2022 Oct 18. doi: 10.1111/imr.13148
  • Sano, M; Morishita, K; Onizawa, Y; Takagi, T; Sumaru, K.
    Rapid and Highly Sensitive Method for Evaluating Surface Coatings against an Enveloped RNA Virus.
    ACS APPL BIO MATER. 2022 Oct 14. doi: 10.1021/acsabm.2c00613
  • Adler, A; Manivel, VA; Fromell, K; Teramura, Y; Ekdahl, KN; Nilsson, B.
    A Robust Method to Store Complement C3 With Superior Ability to Maintain the Native Structure and Function of the Protein.
    FRONT IMMUNOL. 2022 May 3;13:891994. doi: 10.3389/fimmu.2022.891994
  • Nakagawa, Y; Hishida, T; Hatano, E; Sumaru, K; Morishita, K; Morimoto, M; Yokojima, S; Nakamura, S; Uchida, K.
    Photoinduced cytotoxicity of photochromic symmetric diarylethene derivatives: the relation of structure and cytotoxicity.
    ORGANIC & BIOMOLECULAR CHEMISTRY. 2022 Apr 13;20(15):3211-3217. doi: 10.1039/d2ob00224h
  • Goel, I; Noiri, M; Yamauchi, Y; Kato, K; Chung, UI; Teramura, Y.
    Enhancement of intercellular interaction between iPSC-derived neural progenitor cells and activated endothelial cells using cell surface modification with functional oligopeptides.
    BIOMATER SCI. 2022 Jan 11. doi: 10.1039/d1bm01503f
  • Hurd, MD; Goel, I; Sakai, Y; Teramura, Y.
    Current status of ischemic stroke treatment: From thrombolysis to potential regenerative medicine.
    REGENERATIVE THERAPY 18 408-417; doi:10.1016/j.reth.2021.09.009 DEC
  • Adler, A; Inoue, Y; Ekdahl, KN; Baba, T; Ishihara, K; Nilsson, B; Teramura, Y.
    Effect of liposome surface modification with water-soluble phospholipid polymer chain-conjugated lipids on interaction with human plasma proteins.
    J MATER CHEM B. 2021 Oct 7. doi: 10.1039/d1tb01485d
  • Sano, M; Morishita, K; Oikawa, S; Akimoto, T; Sumaru, K; Kato, Y.
    Live-cell imaging of microRNA expression with post-transcriptional feedback control.
    MOL THER NUCLEIC ACIDS. 2021 Aug 26;26:547-556. doi: 10.1016/j.omtn.2021.08.018
  • Sato, Y; Asawa, K; Huang, T; Noiri, M; Nakamura, N; Ekdahl, KN; Nilsson, B; Ishihara, K; Teramura, Y.
    Induction of Spontaneous Liposome Adsorption by Exogenous Surface Modification with Cell-Penetrating Peptide-Conjugated Lipids.
    LANGMUIR. 2021 Aug 3. doi: 10.1021/acs.langmuir.1c01072
  • Adler, A; Inoue, Y; Sato, Y; Ishihara, K; Ekdahl, KN; Nilsson, B; Teramura, Y.
    Synthesis of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated lipids and their characterization and surface properties of modified liposomes for protein interactions.
    BIOMATER SCI. 2021 Jul 20. doi: 10.1039/d1bm00570g
  • Hashimoto, M; Murai, Y; Morita, K; Kikukawa, T; Takagi, T; Takahashi, H; Yokoyama, Y; Amii, H; Sonoyama, M.
    Comparison of functionality and structural stability of bacteriorhodopsin reconstituted in partially fluorinated dimyristoylphosphatidylcholine liposomes with different perfluoroalkyl chain lengths.
    BIOCHIM BIOPHYS ACTA BIOMEMBR. 2021 Jun 25;1863(10):183686. doi: 10.1016/j.bbamem.2021.183686

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