Featured Research
2024
Next-Generation Medical Infrastructure
We promote the development of high-quality, high-function, and high-precision therapeutic and diagnostic technologies that contribute to improved quality of life (QoL), foundational technologies for diagnosis and health assessment through the integrated use of biodata, and research and development in biopharmaceuticals and regenerative medicine. These efforts support extended healthy life expectancy and the establishment of next-generation medical systems.
- Supports multi-throughput circulating culture
- Application of the developed prototype device to shear-stress-loaded culture of vascular endothelial cells
→(Reference: AIST-INDIA Diverse Assets & Applications International Laboratory)
- Improved chip visibility using machine-learning-based analysis
- Development of organ-on-a-chip technology as an alternative to animal experiments
- Validated AI-driven optimization using blood pump experiments
- Aiming to develop extracorporeal organ perfusion devices for severe cardiac disease
→(Reference: Medical Devices Research Group, Health and Medical Research Institute)
- Achieved approximately double the cardiac function preservation compared with conventional perfusion methods
- Aiming for 24-hour extracorporeal heart perfusion preclinical trials
Advanced Utilization of Biological Resources
By fully utilizing biological resources such as plants and microorganisms, we aim to elucidate life phenomena from multilayered perspectives including genetic engineering, biochemistry, information science, and environmental engineering and apply these findings to advance technologies toward the realization of a sustainable bioeconomy society.
of Biodegradable Plastics
- Proposed a simplified real-environment seawater immersion test
- Aiming to establish international standardization of real-sea-area immersion test methods
- Commercialized under the product name CENII (catalog-listed)
- Established a high-efficiency production platform for various industrial enzymes
- Introduction of RNPs and plasmid DNA in solution
- Contributing to the development of foundational technologies for plant breeding
- Enhanced wastewater treatment through functional analysis of microbial predation and parasitism
- Established technologies aimed at stable, efficient treatment and reduction of excess biomass key challenges in wastewater processing
→(Reference: Microbial Ecology and Technology Research Team, Biomanufacturing Process Research Center)
Advanced Bio-Analytical Technologies
We promote the development of advanced, high-sensitivity measurement, analysis, and evaluation technologies in the life sciences, including new techniques for measuring biological substances previously difficult to detect. These technologies support quality control of biopharmaceuticals, establishment of bio-measurement standards, and next-generation biomanufacturing.
- Concurrent acquisition of approximately 10,000 glycan and gene expression data points for individual cells
- Contributing to the identification of drug discovery targets for various diseases and to the optimization of standards and manufacturing processes for regenerative medicine cells
- Achieved over 10-fold concentration of viruses from dilute solutions
- Enables prediction of disease outbreaks based on presence and abundance of viruses and bacteria in environmental water
- Analytical technology using an array of fluorescent molecular probes and machine learning (“chemical tongue”)
- Enables simple and accurate detection of differences and changes in diverse biological samples
- Rapid identification from a database of 30,000 species and 200,000 microbial records
- Developed technology for acquiring microbial groups beneficial to human health
