多細胞システム制御研究グループ

研究課題

糖鎖は全ての細胞の最も外側を覆い、細胞の種類や状態（分化、がん化）で変化することから「細胞の顔」と呼ばれ、再生医療に用いる細胞の品質管理や、がん等の疾患の創薬標的として期待されています。我々はこれまで組換えレクチンライブラリーを構築し、これらを用いることで糖鎖をプロファイリングする技術の開発に取り組んできました。まず複数のレクチンをスライドグラス上に固定化したレクチンアレイの開発と利用を進めてきました。また最近、シーケンシングによる糖鎖プロファイリング技術を開発し、１細胞ごとの糖鎖発現と遺伝子発現を同時解析する技術(scGR-seq)の確立に展開することに成功しました。さらに微生物叢の糖鎖プロファイリングにも応用しました。本技術の更なる高度化と応用を進めていきます。

研究課題

ヒト多能性細胞やヒト間葉系幹細胞は再生医療のための細胞源として期待されています。これら細胞をヒトに移植する際、細胞の安全性や品質の確保が極めて重要です。我々はこれまで、移植用細胞に残存する造腫瘍性のヒト多能性幹細胞を非破壊的に検出し、除去する技術を開発し、企業と共同で実用化することに成功しました。今後も新しい品質管理技術の開発を目指します。

研究課題

がん、糖尿病、精神・神経疾患の診断技術の開発は、確定診断・治療方針の決定・QOLの向上・早期の社会復帰のために重要です。我々は正常細胞と疾患細胞（前立腺がん、乳がん、膵癌、糖尿病、精神疾患）の細胞機能や遺伝子・糖鎖発現を比較解析することで、新規の診断技術の開発を目指しています。

研究課題

エクソソームは真核細胞のエンドソーム区画で産生される細胞膜結合性の細胞外小胞であり、体循環に乗って他の細胞へと運ばれ、発生、生理、病理的プロセスにおいて細胞間コミュニケーションツールとして機能しています。所内外と連携し、細胞から分泌された直後のインタクトな状態にある膜小胞の調製技術の高度化、活用技術の開発、糖鎖機能解明など、理工学的視点からナノサイズの未開拓領域である謎多きエクソソームの本質の解明に挑戦します。

研究課題

近年、マイクロ波は化学反応の効率加熱手段として多用されるが、低温での反応や精密な温度制御が要求される糖鎖や創薬活性物質の精密合成での利用展開は進んでいない。また、化学反応におけるマイクロ波の加熱特性以外の特有効果については疑問視する声も多く、 「まやかし」とも揶揄する学者も存在する。
我々は、１）冷却機能を備えたマイクロ波照射反応装置を製作し、精密な温度制御や低温での照射を可能とし、２）LeX３糖体合成やペプチド合成に適応させ、マイクロ波特有の効果を明確にした。そして３）高価で貴重な糖アミノ酸シントンの安定性と反応性両方の向上に成功し、世界に類のない複雑な糖鎖ペプチドの数十mgスケール合成法の確立、４）酵素反応を題材としてマイクロ波の分子選択活性化効果を考察し、マイクロ波効果の本質に迫る、などの研究をすすめている。

研究課題

生物は他個体との密接な社会的コミュニケーションの中で生活し、社会環境の変化は私たちの健康や寿命に対し正にも負にも大きな影響を及ぼしています。我々は複雑な社会性をもって生活する社会性昆虫を社会的ストレスの評価モデルとして確立し、社会環境と健康・寿命の連関機構を解明し、社会的ストレスの緩和と健康長寿社会の実現に貢献する研究を目指します。

業績リスト

• Mawaribuchi, S; Iida, M; Haramoto, Y.
  Fusion of breast cancer MCF-7 cells with mesenchymal stem cells rearranges interallelic gene expression and enhances cancer malignancy.
  BIOCHEM BIOPHYS RES COMMUN. 2024 Oct 23:736:150887. doi: 10.1016/j.bbrc.2024.150887
• Hayashi, Y; Tajiri, K; Ozawa, T; Angata, K; Sato, T; Togayachi, A; Nagashima, I; Shimizu, H; Murayama, A; Muraishi, N; Narimatsu, H; Yasuda, I.
  Impact of preS1 Evaluation in the Management of Chronic Hepatitis B Virus Infection.
  MEDICINA (Kaunas). 2024 Aug 16;60(8):1334. doi: 10.3390/medicina60081334
• Satoh, T; Yagi-Utsumi, M; Ishii, N; Mizushima, T; Yagi, H; Kato, R; Tateno, H; Matsuo, I; Kato, K; Suzuki, T; Yoshida, Y.
  Structural basis of sugar recognition by SCFFBS2 ubiquitin ligase involved in NGLY1 deficiency.
  FEBS LETTERS. 2024 Aug 22. doi: 10.1002/1873-3468.15003
　　　　　　　　　　　　　　　
• Páez-Watson, T; Tomás-Martínez, S; de, Wit R; Keisham, S; Tateno, H; van, Loosdrecht MCM; Lin, Y.
  Sweet Secrets: Exploring Novel Glycans and Glycoconjugates in the Extracellular Polymeric Substances of “Candidatus Accumulibacter”.
  ACS ES T WATER. 2024 Jul 12;4(8):3391-3399. doi: 10.1021/acsestwater.4c00247
• Yamasaki, K; Tsuzuki, S; Tateno, H.
  Stabilization of the Protein Structure by the Many-Body Cooperative Effect in the NH/π Hydrogen-bonding Tryptophan Triad.
  J PHYS CHEM B. 2024 Jul 17. doi: 10.1021/acs.jpcb.4c02391
• Arai, J; Hayakawa, Y; Tateno, H; Fujiwara, H; Kasuga, M; Fujishiro, M.
  The role of gastric mucins and mucin-related glycans in gastric cancers.
  CANCER SCI. 2024 Jul 19. doi: 10.1111/cas.16282
• Wang, ZG; Yang, ZH; Shishido, M; Daoudi, K; Hidaka, M; Tateno, H; Futai, E; Ogawa, T.
  Microcystis viridis NIES-102 Cyanobacteria Lectin (MVL) Interacts with SARS-CoV-2 Spike Protein Receptor Binding Domains (RBDs) via Protein-Protein Interaction.
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024 Jun 18;25(12):6696. doi: 10.3390/ijms25126696
• Nie, H; Saini, P; Miyamoto, T; Liao, L; Zielinski, RJ; Liu, H; Zhou, W; Wang, C; Murphy, B; Towers, M; Yang, T; Qi, Y; Kannan, T; Kossenkov, A; Tateno, H; Claiborne, DT; Zhang, N; Abdel-Mohsen, M; Zhang, R.
  Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade.
  NAT COMMUN. 2024 Apr 2;15(1):2853. doi: 10.1038/s41467-024-47069-y
• Arai, J; Hayakawa, Y; Tateno, H; Murakami, K; Hayashi, T; Hata, M; Matsushita, Y; Kinoshita, H; Abe, S; Kurokawa, K; Oya, Y; Tsuboi, M; Ihara, S; Niikura, R; Suzuki, N; Iwata, Y; Shiokawa, T; Shiomi, C; Uekura, C; Yamamoto, K; Fujiwara, H; Kawamura, S; Nakagawa, H; Mizuno, S; Kudo, T; Takahashi, S; Ushiku, T; Hirata, Y; Fujii, C; Nakayama, J; Shibata, S; Woods, S; Worthley, DL; Hatakeyama, M; Wang, TC; Fujishiro, M.
  Impaired glycosylation of gastric mucins drives gastric tumorigenesis and serves as a novel therapeutic target.
  GASTROENTEROLOGY. 2024 Apr 5:S0016-5085(24)00363-9. doi: 10.1053/j.gastro.2024.03.037
• Miura, I; Shams, F; Ohki, J; Tagami, M; Fujita, H; Kuwana, C; Nanba, C; Matsuo, T Ogata, M; Mawaribuchi, S; Shimizu, N; Ezaz, T.
  Multiple Transitions between Y Chromosome and Autosome in Tagos Brown Frog Species Complex.
  GENES (Basel). 2024 Feb 26;15(3):300. doi: 10.3390/genes15030300
• Nakahashi, H; Oda, T; Shimomura, O; Akashi, Y; Takahashi, K; Miyazaki, Y; Furuta, T; Kuroda, Y; Louphrasitthiphol, P; Mathis, BJ; Tateno, H.
  Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations.
  J ONCOL. 2024 Mar 18;2024:1529449. doi: 10.1155/2024/1529449
• Nagashima, I; Shimizu, H.
  Preparation of Mucin Glycopeptides by Organic Synthesis.
  METHODS MOL BIOL. 2024;2763:187-199. doi: 10.1007/978-1-0716-3670-1_16
• Chen, LM; Keisham, S; Tateno, H; van, Ede J; Pronk, M; van, Loosdrecht MCM; Lin, Y.
  Alterations of Glycan Composition in Aerobic Granular Sludge during the Adaptation to Seawater Conditions.
  ACS ES T WATER. 2023 Dec 27;4(1):279-286. doi: 10.1021/acsestwater.3c00625
• Keisham, S; Saito, S; Kowashi, S; Tateno, H.
  Droplet-Based Glycan and RNA Sequencing for Profiling the Distinct Cellular Glyco-States in Single Cells.
  SMALL METHODS. 2024 Jan 2:e2301338. doi: 10.1002/smtd.202301338
• Yonezawa, A; Mizushima, K; Hirai, Y; Tateno, H; Muto, A; Igarashi, K; Takag, T; Naito, Y; Higashimura, Y.
  Involvement of transcription repressor Bach1 in function of intestinal goblet cells.
  ANNALS OF NUTRITION AND METABOLISM. 2023 ;79 (suppl 1) 1170-1170; AUG. doi: 10.1159/000530786
• Ishii, N; Noguchi, K; Ikemoto, MJ; Yohda, M; Odahara, T.
  Optimizing Exosome Preparation Based on Size and Morphology: Insights From Electron Microscopy.
  MICROSC MICROANAL. 2023 Oct 13:ozad103. doi: 10.1093/micmic/ozad103
• Ishii, N; Odahara, T.
  Investigation of the Efficacy of Lanthanoid Heavy Metal Acetates as Electron Staining Reagents for Biomembrane Vesicles.
  MICROSC MICROANAL. 2023 Oct 13:ozad107. doi: 10.1093/micmic/ozad107
• Odaka, H.
  Target-Specific O-linked N-acetylglucosamine Modification with a Dual-Specificity Aptamer Reveals Functions of O-GlcNAcylation in beta-catenin.
  TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. May 25, 2023; Volume 35(2023) Issue 205. doi: 10.4052/tigg.2309.6E
• Watanabe, T, Tateno, H.
  Lectin Blotting of Cell Lysates.
  CURR PROTOC. 2023 May;3(5):e790. doi: 10.1002/cpz1.790
• Kuroda, Y; Oda, T; Shimomura, O; Louphrasitthiphol, P; Mathis, BJ; Tateno, H, Hatano, K.
  Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: (18) F-labeled rBC2LCN lectin.
  CANCER SCI. 2023 May 19. doi: 10.1111/cas.15846
• Odaka, H; Tateno, H.
  Single-Cell Glycan and RNA Sequencing (scGR-seq).
  CURR PROTOC. 2023 May;3(5):e777. doi: 10.1002/cpz1.777
• Ikemoto, MJ; Aihara, Y; Ishii, N; Shigemori, H.
  3,4-Dihydroxybenzalacetone Inhibits the Propagation of Hydrogen Peroxide-Induced Oxidative Effect via Secretory Components from SH-SY5Y Cells.
  BIOL PHARM BULL. 2023;46(4):599-607. doi: 10.1248/bpb.b22-00727
• Murata, Y; Jitsukawa, T; Iida, M; Furuta, T; Haramoto, Y; Shigeri, Y; Fujisaki, S.
  Liquid chromatography-mass spectrometry analyses of polyprenyl phosphates in Escherichia coli cells in which genes for isoprenoid synthesis are amplified.
  J BIOSCI BIOENG. 2023 Mar 1:S1389-1723(23)00047-6. doi: 10.1016/j.jbiosc.2023.02.003
• Mawaribuchi, S; Ito, M; Ogata, M; Yoshimura, Y; Miura, I.
  Parallel Evolution of Sex-Linked Genes across XX/XY and ZZ/ZW Sex Chromosome Systems in the Frog Glandirana rugosa.
  GENES (Basel). 2023 Jan 18;14(2):257. doi: 10.3390/genes14020257
• Sato, Y; Kato, Y; Iizumi, Y; Morimoto, T; Kobashi, K; Sugino, T; Tateno, H; Okazaki, T.
  Size distributions of cellulose nanocrystals in dispersions using the centrifugal sedimentation method.
  INT J BIOL MACROMOL. 2023 Feb 2:123520. doi: 10.1016/j.ijbiomac.2023.123520
• Mawaribuchi, S; Shimomura, O; Oda, T; Hiemori, K; Shimizu, K; Yamase, K; Date, M; Tateno, H.
  rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma.
  GLYCOBIOLOGY. 2023 Feb 2:cwad009. doi: 10.1093/glycob/cwad009
• Huang, T; Sato, Y; Kuramochi, A; Ohba, Y; Sano, M; Miyagishi, M; Tateno, H; Wadhwa, R; Kawasaki, K; Uchida, T; Ekdahl, KN; Nilsson, B; Chung, UI; Teramura, Y.
  Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells.
  REGEN THER. 2023 Jan 11;22:90-98. doi: 10.1016/j.reth.2022.12.007
• Mawaribuchi, S; Haramoto, Y; Ikeda, N; Ito, M.
  Evolutionary features of ligands and their receptors via protein-protein interactions and essentiality in primates.
  GENES CELLS. 2023 Jan 9. doi: 10.1111/gtc.13006
• Ishii, N.
  C-shaped dipper: A novel useful auxiliary tool for preparation of specimen grids for transmission electron microscopy.
  MICROSC RES TECH. 2022 Dec 29. doi: 10.1002/jemt.24283
• Ando, M; Kawasaki, H; Tamura, S; Haramoto, Y; Shigeri, Y.
  Recent Advances in Gas Sensing Technology Using Non-Oxide II-VI Semiconductors CdS, CdSe, and CdTe.
  CHEMOSENSORS. 2022 10(11)482. doi: 10.3390/chemosensors10110482
• Nagashima, I; Sugiyama, JI; Shimizu, H.
  Study of 400 MHz microwave conduction loss effect for a hydrolysis reaction by thermostable β-Glucosidase HT1.
  BIOSCI BIOTECHNOL BIOCHEM. 2022 Dec 6:zbac194. doi: 10.1093/bbb/zbac194
• Kuroda, Y; Shimomura, O; Nakahashi, H; Miyazaki, Y; Nakajima, T; Tateno, H; Oda, T.
  Lectin-based photoimmunotherapy targeting cell surface glycans for pancreatic cancer.
  CANCER RESEARCH 82 (22). 2022 NOV 15. doi: 10.1158/1538-7445.PANCA22-B083
• Kuroda, Y; Oda, T; Shimomura, O; Hashimoto, S; Akashi, Y; Miyazaki, Y; Furuya, K; Furuta, T; Nakahashi, H; Louphrasitthiphol, P; Mathis, BJ; Nakajima,T; Tateno, H.
  Lectin-based phototherapy targeting cell surface glycans for pancreatic cancer.
  INT J CANCER. 2022 Nov 22. doi: 10.1002/ijc.34362
• Tasaki, M; Tateno, H; Sato, T; Narimatsu, H; Saito, K; Nakagawa, Y; Aoki, T; Kamimura, M; Ushiki, T; Takahashi, K; Tomita, Y.
  Hyporesponsiveness against donors ABO antigens of renal grafts after ABO-incompatible kidney transplantation.
  CLIN EXP NEPHROL. 2022 Oct 8. doi: 10.1007/s10157-022-02280-3
• Kosaka, T; Yamaguchi, S; Izuta, S; Yamahira, S; Shibasaki, Y; Tateno, H; Okamoto, A.
  Bioorthogonal Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications.
  AM CHEM SOC. 2022 Sep 20. doi: 10.1021/jacs.2c07321
• Yamasaki, K; Adachi, N; Ngwe Tun, MM; Ikeda, A; Moriya, T; Kawasaki, M; Yamasaki, T; Kubota, T; Nagashima, I; Shimizu, H; Tateno, H; Morita, K.
  Core fucose-specific Pholiota squarrosa lectin (PhoSL) as a potent broad-spectrum inhibitor of SARS-CoV-2 infection.
  FEBS J. 2022 Aug 25. doi: 10.1111/febs.16599
• Katsumi, T; Shams, F; Yanagi, H; Ohnishi, T; Toda, M; Lin, SM; Mawaribuchi, S; Shimizu, N; Ezaz, T; Miura, I.
  Highly rapid and diverse sex chromosome evolution in the Odorrana frog species complex.
  DEV GROWTH DIFFER. 2022 Jul 26. doi: 10.1111/dgd.12800
• Numakawa, T; Odaka, H.
  The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases.
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022 Jul 13;23(14):7726. doi: 10.3390/ijms23147726
• Kokubu, R; Ohno, S; Kuratani, H; Takahashi, Y; Manabe, N; Shimizu, H; Chiba, Y; Denda-Nagai, K; Tsuiji, M; Irimura, T; Yamaguchi, Y.
  O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations.
  INT J MOL SCI. 2022 Jul 16;23(14):7855. doi: 10.3390/ijms23147855
• Nagae, M; Hirata, T; Tateno, H; Mishra, SK; Manabe, N; Osada, N; Tokoro, Y; Yamaguchi, Y; Doerksen, RJ; Shimizu, T; Kizuka, Y.
  Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A).
  COMMUN BIOL. 2022 Jul 19;5(1):695. doi: 10.1038/s42003-022-03661-w
• Odaka, H.
  Genome-wide CRISPR/Cas9 Screening Identifies KDM2B as a Modifier of Heparan Sulfate-Protein Interactions.
  TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. 2022 Volume 34 Issue 199 Pages E63. doi: 10.4052/tigg.2203.6E
• Tsukano, K; Yamamoto, T; Watanabe, T; Michiue, T.
  Xenopus Dusp6 modulates FGF signaling to precisely pattern pre-placodal ectoderm.
  DEVELOPMENTAL BIOLOGY. 2022 May 16. doi: 10.1016/j.ydbio.2022.05.009
• Oinam, L; Tateno, H.
  Glycan Profiling by Sequencing to Uncover Multicellular Communication: Launching Glycobiology in Single Cells and Microbiomes.
  FRONT CELL DEV BIOL. 2022 May 27;10:919168. doi: 10.3389/fcell.2022.919168
• Yang, Y; Akashi, Y; Shimomura, O; Tateno, H; Saito, S; Hiemori, K; Miyazaki, Y; Furuta, T; Kitaguchi, D; Kuroda, Y; Pakavarin, L; Oda, T.
  Glycan expression profile of signet ring cell gastric cancer cells and potential applicability of rBC2LCN-targeted lectin drug conjugate therapy.
  GASTRIC CANCER. 2022 Jun 17. doi: 10.1007/s10120-022-01312-x
• Miura, I; Shams, F; Jeffries, DL; Katsura, Y; Mawaribuchi, S; Perrin, N; Ito, M; Ogata, M; Ezaz, T.
  Identification of ancestral sex chromosomes in the frog Glandirana rugosa bearing XX-XY and ZZ-ZW sex-determining systems.
  MOL ECOL. 2022 Jun 12. doi: 10.1111/mec.16551
• Odaka, H; Hiemori, K; Shimoda, A; Akiyoshi, K; Tateno, H.
  CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma.
  BMC GASTROENTEROLOGY. 2022 Mar 28;22(1):153. doi: 10.1186/s12876-022-02228-7
• Hayashi, Y; Yimiti, D; Sanada, Y; Ding, C; Omoto, T; Ogura, T; Nakasa, T; Ishikawa, M; Hiemori, K; Tateno, H; Miyaki, S; Adachi, N.
  The therapeutic capacity of bone marrow MSC-derived extracellular vesicles in Achilles tendon healing is passage-dependent and indicated by specific glycans.
  FEBS LETTERS. 2022 Apr;596(8):1047-1058. doi: 10.1002/1873-3468.14333
• Tasaki, M; Tateno, H; Sato, T; Tomioka, A; Kaji, H; Narimatsu, H; Saito, K; Nakagawa, Y; Aoki, T; Kamimura, M; Ushiki, T; Okada, M; Miwa, Y; Hotta, K; Yoshida, Y; Takahashi, K; Tomita, Y.
  A Novel Method of CD31-Combined ABO Carbohydrate Antigen Microarray Predicts Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.
  TRANSPL INT. 2022 Mar 23;35:10248. doi: 10.3389/ti.2022.10248
• Oinam, L; Hayashi, R; Hiemori, K; Kiyoi, K; Sage-Ono, K; Miura, K; Ono, M; Tateno, H.
  Quantitative evaluation of glycan-binding specificity of recombinant Concanavalin A produced in lettuce (Lactuca sativa).
  BIOTECHNOL BIOENG. 2022 Apr 8. doi: 10.1002/bit.28099
• Ishii, N.
  Systematic Investigation of Lanthanoid Transition Heavy Metal Acetates as Electron Staining Reagents for Protein Molecules in Biological Transmission Electron Microscopy.
  MICROSC MICROANAL. 2022 Apr 1:1-10. doi: 10.1017/S1431927622000411
• Seo, N; Nakamura, J; Kaneda, T; Tateno, H; Shimoda, A; Ichiki, T; Furukawa, K; Hirabayashi, J; Akiyoshi, K; Shiku, H.
  Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method.
  J EXTRACELL VESICLES. 2022 Mar;11(3):e12205. doi: 10.1002/jev2.12205
• Odaka, H; Ozaki, H; Tateno, H.
  scGR-seq: Integrated analysis of glycan and RNA in single cells.
  STAR PROTOC. 2022 Feb 18;3(1):101179. doi: 10.1016/j.xpro.2022.101179. eCollection
• Irumagawa, S; Hiemori, K; Saito, S; Tateno, H; Arai, R.
  Self-Assembling Lectin Nano-Block Oligomers Enhance Binding Avidity to Glycans.
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (2);doi: 10.3390/ijms23020676 JAN
• Oinam, L; Tateno, H.
  Evaluation of Glycan-Binding Specificity by Glycoconjugate Microarray with an Evanescent-Field Fluorescence Detection System.
  METHODS MOL BIOL. 2022;2460:25-32. doi: 10.1007/978-1-0716-2148-6_2
• Kaifu, T; Yabe, R; Maruhashi, T; Chung, SH; Tateno, H; Fujikado, N; Hirabayashi, J; Iwakura, Y.
  DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.
  J EXP MED. 2021 Dec 6;218(12):e20210435. doi: 10.1084/jem.20210435. Epub 2021 Nov
• Shimoda, A; Miura, R; Tateno, H; Seo, N; Shiku, H; Sawada, S; Sasaki, Y; Akiyoshi, K.
  Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications.
  SMALL METHODS; doi: 10.1002/smtd.202100785
• Tulin, EKC; Nakazawa, C; Nakamura, T; Saito, S; Ohzono, N; Hiemori, K; Nakakita, SI; Tateno, H; Tonozuka, T; Nishikawa, A.
  Glycan detecting tools developed from the Clostridium botulinum whole hemagglutinin complex.
  SCI REP. 2021 Nov 9;11(1):21973. doi: 10.1038/s41598-021-01501-1
• Kaigawa, H; Tateno, H; Arai, R.
  Self-Assembling Functional Complexes of Protein Nanobuilding Blocks with a Trimeric Lectin.
  PROTEIN SCIENCE 30 158-159; OCT
• Irumagawa, S; Tateno, H; Arai, R.
  Self-Assembling Lectin Nano-Building Blocks Enhance Avidity to Glycans through Polyvalent Effect.
  PROTEIN SCIENCE 30 173-174; OCT
• Hoshi, K; Ito, H; Abe, E; Fuwa, TJ; Kanno, M; Murakami, Y; Abe, M; Murakami, T, Yoshihara, A, Ugawa, Y, Saito, T, Saido, TC, Matsumoto, K, Yamaguchi, Y, Furukawa, K, Arai, H, Kanai, M, Miyajima, M, Arai, H, Ogawa, N, Akatsu, H, Hashizume, Y, Tateno, H, Honda, T, Hashimoto, Y.
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  Investigation of Selective Recognition of Sugars Using Lectin-inspired Temperature-responsive Polymers
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  Carbohydrate recognition by the rhamnose-binding lectin SUL-I with a novel three-domain structure isolated from the venom of globiferous pedicellariae of the flower sea urchin Toxopneustes pileolus
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  Sugar-Binding Profiles of Chitin-Binding Lectins from the Hevein Family: A Comprehensive Study
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  Engineering of recombinant Wisteria floribunda agglutinin specifically binding to GalNAcbeta1,4GlcNAc (LacdiNAc
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  Isolation of Rice Bran Lectins and Characterization of Their Unique Behavior in Caco-2 Cells
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  Electron microscopic and physicobiochemical studies of chaperonin GroEL and GroES complexes.
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