多細胞システム制御研究グループ

研究課題

糖鎖は全ての細胞の最も外側を覆い、細胞の種類や状態（分化、がん化）で変化することから「細胞の顔」と呼ばれ、再生医療に用いる細胞の品質管理や、がん等の疾患の創薬標的として期待されています。我々はこれまで組換えレクチンライブラリーを構築し、これらを用いることで糖鎖をプロファイリングする技術の開発に取り組んできました。これまでに、複数のレクチンをスライドグラス上に固定化したレクチンアレイの開発や、１細胞ごとの糖鎖と遺伝子の発現を同時解析する技術(scGR-seq）の開発に成功しています。また、糖鎖合成酵素活性の測定技術開発に取り組んでいます。これらの技術の更なる高度化を進めると共に、糖鎖解析技術を応用したがんや脳疾患、代謝異常症などの診断法や治療法開発に取り組んでいます。

エクソソームは、すべての細胞から細胞外に分泌される脂質二重膜で覆われたナノサイズの小胞であり、細胞間コミュニケーションの重要なツールとして機能しています。さらに、医療、食品、化粧品などの分野で利用可能な新たなバイオ素材として注目されています。所内外の専門家と連携し、糖鎖工学技術や化学ラベル化技術を駆使して、エクソソームの革新的な分離技術や組織特異的なデザイナーエクソソームの開発に取り組んでいます。これにより、薬物送達や再生医療への応用を目指しています。

電子レンジの例で良く知られるマイクロ波加熱は、誘電損失や導電損失によって発生する。すなわち、マイクロ波は分子に直接作用するが、この作用機序の解明を進めることで、化学反応においてこれまで主に効率加熱手段としてのみ利用されているマイクロ波を、多官能基生理活性物質生産、精密有機合成、生化学分野などへ利用展開する研究を進めている。具体的には、１）冷却機能を併せ持たせることで、マイクロ波照射しつつ精密な温度制御や低温中での照射を可能するシステム開発；２）必要試薬量の低減と反応性の向上効果を得て、複雑な糖ペプチドの実践合成研究；３）酵素反応やバイオものづくりへの展開研究；４）エネルギー消費や有害物質の利用など環境負荷の低減につながる出口研究などをすすめている。

生体内の糖鎖は脂質やタンパク質と結合した複合糖質として存在し、細胞間情報伝達やタンパク質の品質管理など、さまざまな生命現象に関与しています。私たちは、有機化学的手法および酵素工学的手法を駆使して、糖鎖、糖ペプチド、糖リン脂質、薬剤候補化合物の精密合成および誘導化技術を開発しています。これら合成分子ツールを用いて、糖鎖が関わる生命現象のメカニズムを解明します。また、研究課題１で示した糖鎖解析技術と組み合わせることで、合成した化合物を診断および治療に応用します。

再生医療の分野において、ヒト多能性幹細胞（hPSC）およびヒト間葉系幹細胞（hMSC）は、細胞源として大きな期待を寄せられています。しかし、臨床応用に向けては、細胞の安全性および品質の確保が極めて重要な課題となります。これまでの研究において、hPSCの培養過程で生じる低品質な不要細胞や、分化誘導後に残存する未分化細胞を検出・除去する技術の開発に成功しています。現在の研究では、糖鎖解析技術などを用いて、これらの幹細胞を1細胞レベルで詳細に解析し、機能性の高い細胞を分離・濃縮する技術の開発を目指しています。このアプローチにより、再生医療における細胞治療の安全性と有効性がさらに向上することが期待されます。

高齢化社会における健康寿命の延伸を目指し、未病と疾患を理解し、評価するためのモデルシステムの構築と解明に取り組みます。神経疾患模倣モデルとして、グリア細胞や血管を含むより生体に近いヒト脳オルガノイドを作成する新たな技術開発取り組み、動物代替モデルとしての利活用や創薬・機能性食品等のスクリーニング法への応用を目指します。また、社会的ストレス評価モデルとして、社会性昆虫であるアリをモデルとした社会的ストレス、および加齢変容応答の生体基盤の理解に取り組み、未病・ストレスの改善に貢献するバイオマーカーの探索と開発を目指します。

業績リスト

• Tateno, H; Mahal, LK; Feizi, T; Kettner, C; Paulson, JC.
  The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting lectin microarray data.
  GLYCOBIOLOGY. 2025 Feb 19. doi:10.1093/glycob/cwaf006
• Ishii, N; Tateno, H.
  Preparation of Small Extracellular Vesicles Using Sequential Ultrafiltration with Regenerated Cellulose Membranes of Different Molecular Weight Cutoffs: A Study of Morphology and Size by Electron Microscopy.
  MICROSC MICROANAL. 2025 Jan 13. doi:10.1093/mam/ozae133
• Keisham, S; Tateno, H.
  Emerging technologies for single-cell glycomics.
  BBA ADV. 2024 Nov 26. doi:10.1016/j.bbadva.2024.100125
• Hayashi, Y; Tajiri, K; Ozawa, T; Angata, K; Sato, T; Togayachi, A; Nagashima, I; Shimizu, H; Murayama, A; Muraishi, N; Narimatsu, H; Yasuda, I.
  Impact of preS1 Evaluation in the Management of Chronic Hepatitis B Virus Infection.
  MEDICINA (Kaunas). 2024 Aug 16;60(8):1334. doi: 10.3390/medicina60081334
• Satoh, T; Yagi-Utsumi, M; Ishii, N; Mizushima, T; Yagi, H; Kato, R; Tateno, H; Matsuo, I; Kato, K; Suzuki, T; Yoshida, Y.
  Structural basis of sugar recognition by SCFFBS2 ubiquitin ligase involved in NGLY1 deficiency.
  FEBS LETTERS. 2024 Aug 22. doi: 10.1002/1873-3468.15003
• Páez-Watson, T; Tomás-Martínez, S; de, Wit R; Keisham, S; Tateno, H; van, Loosdrecht MCM; Lin, Y.
  Sweet Secrets: Exploring Novel Glycans and Glycoconjugates in the Extracellular Polymeric Substances of “Candidatus Accumulibacter”.
  ACS ES T WATER. 2024 Jul 12;4(8):3391-3399. doi: 10.1021/acsestwater.4c00247
• Yamasaki, K; Tsuzuki, S; Tateno, H.
  Stabilization of the Protein Structure by the Many-Body Cooperative Effect in the NH/π Hydrogen-bonding Tryptophan Triad.
  J PHYS CHEM B. 2024 Jul 17. doi: 10.1021/acs.jpcb.4c02391
• Arai, J; Hayakawa, Y; Tateno, H; Fujiwara, H; Kasuga, M; Fujishiro, M.
  The role of gastric mucins and mucin-related glycans in gastric cancers.
  CANCER SCI. 2024 Jul 19. doi: 10.1111/cas.16282
• Wang, ZG; Yang, ZH; Shishido, M; Daoudi, K; Hidaka, M; Tateno, H; Futai, E; Ogawa, T.
  Microcystis viridis NIES-102 Cyanobacteria Lectin (MVL) Interacts with SARS-CoV-2 Spike Protein Receptor Binding Domains (RBDs) via Protein-Protein Interaction.
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024 Jun 18;25(12):6696. doi: 10.3390/ijms25126696
• Nie, H; Saini, P; Miyamoto, T; Liao, L; Zielinski, RJ; Liu, H; Zhou, W; Wang, C; Murphy, B; Towers, M; Yang, T; Qi, Y; Kannan, T; Kossenkov, A; Tateno, H; Claiborne, DT; Zhang, N; Abdel-Mohsen, M; Zhang, R.
  Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade.
  NAT COMMUN. 2024 Apr 2;15(1):2853. doi: 10.1038/s41467-024-47069-y
• Arai, J; Hayakawa, Y; Tateno, H; Murakami, K; Hayashi, T; Hata, M; Matsushita, Y; Kinoshita, H; Abe, S; Kurokawa, K; Oya, Y; Tsuboi, M; Ihara, S; Niikura, R; Suzuki, N; Iwata, Y; Shiokawa, T; Shiomi, C; Uekura, C; Yamamoto, K; Fujiwara, H; Kawamura, S; Nakagawa, H; Mizuno, S; Kudo, T; Takahashi, S; Ushiku, T; Hirata, Y; Fujii, C; Nakayama, J; Shibata, S; Woods, S; Worthley, DL; Hatakeyama, M; Wang, TC; Fujishiro, M.
  Impaired glycosylation of gastric mucins drives gastric tumorigenesis and serves as a novel therapeutic target.
  GASTROENTEROLOGY. 2024 Apr 5:S0016-5085(24)00363-9. doi: 10.1053/j.gastro.2024.03.037
• Nakahashi, H; Oda, T; Shimomura, O; Akashi, Y; Takahashi, K; Miyazaki, Y; Furuta, T; Kuroda, Y; Louphrasitthiphol, P; Mathis, BJ; Tateno, H.
  Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations.
  J ONCOL. 2024 Mar 18;2024:1529449. doi: 10.1155/2024/1529449
• Nagashima, I; Shimizu, H.
  Preparation of Mucin Glycopeptides by Organic Synthesis.
  METHODS MOL BIOL. 2024;2763:187-199. doi: 10.1007/978-1-0716-3670-1_16
• Chen, LM; Keisham, S; Tateno, H; van, Ede J; Pronk, M; van, Loosdrecht MCM; Lin, Y.
  Alterations of Glycan Composition in Aerobic Granular Sludge during the Adaptation to Seawater Conditions.
  ACS ES T WATER. 2023 Dec 27;4(1):279-286. doi: 10.1021/acsestwater.3c00625
• Keisham, S; Saito, S; Kowashi, S; Tateno, H.
  Droplet-Based Glycan and RNA Sequencing for Profiling the Distinct Cellular Glyco-States in Single Cells.
  SMALL METHODS. 2024 Jan 2:e2301338. doi: 10.1002/smtd.202301338
• Yonezawa, A; Mizushima, K; Hirai, Y; Tateno, H; Muto, A; Igarashi, K; Takag, T; Naito, Y; Higashimura, Y.
  Involvement of transcription repressor Bach1 in function of intestinal goblet cells.
  ANNALS OF NUTRITION AND METABOLISM. 2023;79 (suppl 1) 1170-1170; AUG. doi: 10.1159/000530786
• Odaka, H.
  Target-Specific O-linked N-acetylglucosamine Modification with a Dual-Specificity Aptamer Reveals Functions of O-GlcNAcylation in beta-catenin.
  TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. May 25, 2023; Volume 35(2023) Issue 205. doi: 10.4052/tigg.2309.6E
• Watanabe, T, Tateno, H.
  Lectin Blotting of Cell Lysates.
  CURR PROTOC. 2023 May;3(5):e790. doi: 10.1002/cpz1.790
• Kuroda, Y; Oda, T; Shimomura, O; Louphrasitthiphol, P; Mathis, BJ; Tateno, H, Hatano, K.
  Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: (18) F-labeled rBC2LCN lectin.
  CANCER SCI. 2023 May 19. doi: 10.1111/cas.15846
• Odaka, H; Tateno, H.
  Single-Cell Glycan and RNA Sequencing (scGR-seq).
  CURR PROTOC. 2023 May;3(5):e777. doi: 10.1002/cpz1.777
• Sato, Y; Kato, Y; Iizumi, Y; Morimoto, T; Kobashi, K; Sugino, T; Tateno, H; Okazaki, T.
  Size distributions of cellulose nanocrystals in dispersions using the centrifugal sedimentation method.
  INT J BIOL MACROMOL. 2023 Feb 2:123520. doi: 10.1016/j.ijbiomac.2023.123520
• Mawaribuchi, S; Shimomura, O; Oda, T; Hiemori, K; Shimizu, K; Yamase, K; Date, M; Tateno, H.
  rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma.
  GLYCOBIOLOGY. 2023 Feb 2:cwad009. doi: 10.1093/glycob/cwad009
• Huang, T; Sato, Y; Kuramochi, A; Ohba, Y; Sano, M; Miyagishi, M; Tateno, H; Wadhwa, R; Kawasaki, K; Uchida, T; Ekdahl, KN; Nilsson, B; Chung, UI; Teramura, Y.
  Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells.
  REGEN THER. 2023 Jan 11;22:90-98. doi: 10.1016/j.reth.2022.12.007
• Nagashima, I; Sugiyama, JI; Shimizu, H.
  Study of 400 MHz microwave conduction loss effect for a hydrolysis reaction by thermostable β-Glucosidase HT1.
  BIOSCI BIOTECHNOL BIOCHEM. 2022 Dec 6:zbac194. doi: 10.1093/bbb/zbac194
• Kuroda, Y; Shimomura, O; Nakahashi, H; Miyazaki, Y; Nakajima, T; Tateno, H; Oda, T.
  Lectin-based photoimmunotherapy targeting cell surface glycans for pancreatic cancer.
  CANCER RESEARCH 82 (22). 2022 NOV 15. doi: 10.1158/1538-7445.PANCA22-B083
• Kuroda, Y; Oda, T; Shimomura, O; Hashimoto, S; Akashi, Y; Miyazaki, Y; Furuya, K; Furuta, T; Nakahashi, H; Louphrasitthiphol, P; Mathis, BJ; Nakajima,T; Tateno, H.
  Lectin-based phototherapy targeting cell surface glycans for pancreatic cancer.
  INT J CANCER. 2022 Nov 22. doi: 10.1002/ijc.34362
• Tasaki, M; Tateno, H; Sato, T; Narimatsu, H; Saito, K; Nakagawa, Y; Aoki, T; Kamimura, M; Ushiki, T; Takahashi, K; Tomita, Y.
  Hyporesponsiveness against donors ABO antigens of renal grafts after ABO-incompatible kidney transplantation.
  CLIN EXP NEPHROL. 2022 Oct 8. doi: 10.1007/s10157-022-02280-3
• Kosaka, T; Yamaguchi, S; Izuta, S; Yamahira, S; Shibasaki, Y; Tateno, H; Okamoto, A.
  Bioorthogonal Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications.
  AM CHEM SOC. 2022 Sep 20. doi: 10.1021/jacs.2c07321
• Yamasaki, K; Adachi, N; Ngwe Tun, MM; Ikeda, A; Moriya, T; Kawasaki, M; Yamasaki, T; Kubota, T; Nagashima, I; Shimizu, H; Tateno, H; Morita, K.
  Core fucose-specific Pholiota squarrosa lectin (PhoSL) as a potent broad-spectrum inhibitor of SARS-CoV-2 infection.
  FEBS J. 2022 Aug 25. doi: 10.1111/febs.16599
• Numakawa, T; Odaka, H.
  The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases.
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022 Jul 13;23(14):7726. doi: 10.3390/ijms23147726
• Kokubu, R; Ohno, S; Kuratani, H; Takahashi, Y; Manabe, N; Shimizu, H; Chiba, Y; Denda-Nagai, K; Tsuiji, M; Irimura, T; Yamaguchi, Y.
  O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations.
  INT J MOL SCI. 2022 Jul 16;23(14):7855. doi: 10.3390/ijms23147855
• Nagae, M; Hirata, T; Tateno, H; Mishra, SK; Manabe, N; Osada, N; Tokoro, Y; Yamaguchi, Y; Doerksen, RJ; Shimizu, T; Kizuka, Y.
  Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A).
  COMMUN BIOL. 2022 Jul 19;5(1):695. doi: 10.1038/s42003-022-03661-w
• Odaka, H.
  Genome-wide CRISPR/Cas9 Screening Identifies KDM2B as a Modifier of Heparan Sulfate-Protein Interactions.
  TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. 2022 Volume 34 Issue 199 Pages E63. doi: 10.4052/tigg.2203.6E
• Tsukano, K; Yamamoto, T; Watanabe, T; Michiue, T.
  Xenopus Dusp6 modulates FGF signaling to precisely pattern pre-placodal ectoderm.
  DEVELOPMENTAL BIOLOGY. 2022 May 16. doi: 10.1016/j.ydbio.2022.05.009
• Oinam, L; Tateno, H.
  Glycan Profiling by Sequencing to Uncover Multicellular Communication: Launching Glycobiology in Single Cells and Microbiomes.
  FRONT CELL DEV BIOL. 2022 May 27;10:919168. doi: 10.3389/fcell.2022.919168
• Yang, Y; Akashi, Y; Shimomura, O; Tateno, H; Saito, S; Hiemori, K; Miyazaki, Y; Furuta, T; Kitaguchi, D; Kuroda, Y; Pakavarin, L; Oda, T.
  Glycan expression profile of signet ring cell gastric cancer cells and potential applicability of rBC2LCN-targeted lectin drug conjugate therapy.
  GASTRIC CANCER. 2022 Jun 17. doi: 10.1007/s10120-022-01312-x
• Odaka, H; Hiemori, K; Shimoda, A; Akiyoshi, K; Tateno, H.
  CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma.
  BMC GASTROENTEROLOGY. 2022 Mar 28;22(1):153. doi: 10.1186/s12876-022-02228-7
• Hayashi, Y; Yimiti, D; Sanada, Y; Ding, C; Omoto, T; Ogura, T; Nakasa, T; Ishikawa, M; Hiemori, K; Tateno, H; Miyaki, S; Adachi, N.
  The therapeutic capacity of bone marrow MSC-derived extracellular vesicles in Achilles tendon healing is passage-dependent and indicated by specific glycans.
  FEBS LETTERS. 2022 Apr;596(8):1047-1058. doi: 10.1002/1873-3468.14333
• Tasaki, M; Tateno, H; Sato, T; Tomioka, A; Kaji, H; Narimatsu, H; Saito, K; Nakagawa, Y; Aoki, T; Kamimura, M; Ushiki, T; Okada, M; Miwa, Y; Hotta, K; Yoshida, Y; Takahashi, K; Tomita, Y.
  A Novel Method of CD31-Combined ABO Carbohydrate Antigen Microarray Predicts Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.
  TRANSPL INT. 2022 Mar 23;35:10248. doi: 10.3389/ti.2022.10248
• Oinam, L; Hayashi, R; Hiemori, K; Kiyoi, K; Sage-Ono, K; Miura, K; Ono, M; Tateno, H.
  Quantitative evaluation of glycan-binding specificity of recombinant Concanavalin A produced in lettuce (Lactuca sativa).
  BIOTECHNOL BIOENG. 2022 Apr 8. doi: 10.1002/bit.28099
• Seo, N; Nakamura, J; Kaneda, T; Tateno, H; Shimoda, A; Ichiki, T; Furukawa, K; Hirabayashi, J; Akiyoshi, K; Shiku, H.
  Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method.
  J EXTRACELL VESICLES. 2022 Mar;11(3):e12205. doi: 10.1002/jev2.12205
• Odaka, H; Ozaki, H; Tateno, H.
  scGR-seq: Integrated analysis of glycan and RNA in single cells.
  STAR PROTOC. 2022 Feb 18;3(1):101179. doi: 10.1016/j.xpro.2022.101179. eCollection
• Irumagawa, S; Hiemori, K; Saito, S; Tateno, H; Arai, R.
  Self-Assembling Lectin Nano-Block Oligomers Enhance Binding Avidity to Glycans.
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (2);doi: 10.3390/ijms23020676 JAN
• Oinam, L; Tateno, H.
  Evaluation of Glycan-Binding Specificity by Glycoconjugate Microarray with an Evanescent-Field Fluorescence Detection System.
  METHODS MOL BIOL. 2022;2460:25-32. doi: 10.1007/978-1-0716-2148-6_2
• Kaifu, T; Yabe, R; Maruhashi, T; Chung, SH; Tateno, H; Fujikado, N; Hirabayashi, J; Iwakura, Y.
  DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.
  J EXP MED. 2021 Dec 6;218(12):e20210435. doi: 10.1084/jem.20210435. Epub 2021 Nov
• Shimoda, A; Miura, R; Tateno, H; Seo, N; Shiku, H; Sawada, S; Sasaki, Y; Akiyoshi, K.
  Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications.
  SMALL METHODS; doi: 10.1002/smtd.202100785
• Tulin, EKC; Nakazawa, C; Nakamura, T; Saito, S; Ohzono, N; Hiemori, K; Nakakita, SI; Tateno, H; Tonozuka, T; Nishikawa, A.
  Glycan detecting tools developed from the Clostridium botulinum whole hemagglutinin complex.
  SCI REP. 2021 Nov 9;11(1):21973. doi: 10.1038/s41598-021-01501-1
• Kaigawa, H; Tateno, H; Arai, R.
  Self-Assembling Functional Complexes of Protein Nanobuilding Blocks with a Trimeric Lectin.
  PROTEIN SCIENCE 30 158-159; OCT
• Irumagawa, S; Tateno, H; Arai, R.
  Self-Assembling Lectin Nano-Building Blocks Enhance Avidity to Glycans through Polyvalent Effect.
  PROTEIN SCIENCE 30 173-174; OCT
• Hoshi, K; Ito, H; Abe, E; Fuwa, TJ; Kanno, M; Murakami, Y; Abe, M; Murakami, T, Yoshihara, A, Ugawa, Y, Saito, T, Saido, TC, Matsumoto, K, Yamaguchi, Y, Furukawa, K, Arai, H, Kanai, M, Miyajima, M, Arai, H, Ogawa, N, Akatsu, H, Hashizume, Y, Tateno, H, Honda, T, Hashimoto, Y.
  Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimers Disease.
  METABOLITES. 2021 Sep 10;11(9):616. doi: 10.3390/metabo11090616
• Angata, K; Wagatsuma, T; Togayachi, A; Sato, T; Sogabe, M; Tajiri, K; Ozawa, T; Nagashima, I; Shimizu, H; Iijima, S; Korenaga, M; Kuno, A; Kaji, H; Mizokami, M; Narimatsu, H.
  O-glycosylated HBsAg peptide can induce specific antibody neutralizing HBV infection.
  BIOCHIM BIOPHYS ACTA GEN SUBJ. 2021 Sep 25:130020. doi: 10.1016/j.bbagen.2021.130020
• Minoshima, F; Ozaki, H; Odaka, H; Tateno, H.
  Integrated analysis of glycan and RNA in single cells.
  ISCIENCE. 2021 Jul 17;24(8):102882. doi: 10.1016/j.isci.2021.102882. eCollection
• Watanabe, T; Takeda, K; Hiemori, K; Minamisawa, T; Tateno, H.
  A glycosaminoglycan microarray identifies the binding of SARS-CoV-2 spike protein to chondroitin sulfate E.
  FEBS LETT. 2021 Aug 10. doi: 10.1002/1873-3468.14173
• Furuta, T; Oda, T; Kiyoi, K; Ozawa, Y; Kimura, S; Kurimori, K; Miyazaki, Y; Yu, Y; Furuya, K; Akashi, Y; Shimomura, O; Tateno, H
  Carcinoembryonic antigen as a specific glycoprotein ligand of rBC2LCN lectin on pancreatic ductal adenocarcinoma cells
  Cancer Sci. 2021 Jun 11. doi: 10.1111/cas.15023
• Numakawa, T; Odaka, H.
  Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimers Disease: Beneficial Effects of Flavonoids for Neuroprotection.
  INT J MOL SCI. 2021 May 27;22(11):5719. doi: 10.3390/ijms22115719
• Watanabe, T; Tateno, H.
  Elimination of cells deviated from human induced pluripotent stem cells with a photoactivatable IR700-labelled antibody.
  BIOCHEM BIOPHYS RES COMMUN. 2021 Mar 25;554:13-18. doi: 10.1016/j.bbrc.2021.03.078