Establishment of protocols for purity assessment for high-purity organic compounds
We are conducting research on improving the accuracy of this quantitative technique, aiming to establish it as a primary method that does not require the same reference as the analyte (Fig. As a result of this method, we have been supplying a purity calibration service for high-purity organic compounds. We have been conducting international comparisons and joint tests to advance the preparation, measurement, and analysis methods in purity assessment. Currently, we are working on research aimed at further improving accuracy and reducing uncertainty.
Development of a quantitative NMR for concentration determination of standard solutions
We have been researching and developing analytical methods for direct evaluation of concentrations in standard solutions. We have established a technique for evaluating the concentrations of amino acid and shellfish toxin standard solutions by NMR by reducing the influence of solvents, which had been an obstacle to their practical use, through pretreatment. Furthermore, we have been working on the NMR concentration evaluation method of mixed standard solutions prepared with deuterium solvents to determine the concentration of mixed standard solutions easily.
Development of quantitative NMR method using multinuclear (13C, 19F, 31P, etc.)
We have been researching and developing quantitative analytical methods using multinuclear NMR with the aim of expanding the range of nuclides to be quantified. Since the effects of sensitivity, measurement frequency range, signal width, and other factors are significantly different in multinuclear NMR compared to 1H NMR, we are working to optimize these factors in order to achieve accuracy equivalent to that of 1H NMR, to expand the range of application of quantitative NMR methods, and to realize the analysis of analytes that cannot be evaluated by 1H NMR.