- Profile
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栗田 僚二（Ryoji Kurita）国立研究開発法人産業技術総合研究所 健康医工学研究部門（ウェブサイト）
ナノバイオデバイス研究グループ 研究グループ長長岡技術科学大学 客員教授
ORCiD(0000-0001-5666-9561)
- 略歴
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１９９６年０４月 ＮＴＴアドバンステクノロジ（株）入社 ＮＴＴ厚木研究開発センタ勤務
２００４年０３月 博士（工学）号取得 九州大学
２００４年１０月 産業技術総合研究所 生物機能工学研究部門バイオセンシング技術研究グループ
２０１５年 ４月 同所 バイオメディカル研究部門ナノバイオデバイス研究グループ グループ長
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- 賞罰
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２００９年３月 電気化学会 進歩賞・佐野賞
２００９年９月 Tokyo conference award for best poster
２０１２年１月 Hot Article Awards Analytical Sciences
２０１２年６月 The 4th International Symposium on Microchemistry and Microsystems (ISMM2012) Best Poster Award
２０１４年１月 日本分析化学会関東支部・新世紀賞
２０１５年６月 化学とマイクロ・ナノシステム学会奨励賞
２０１６年１月 電気化学会 化学センサ研究会 清山賞
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- 所属学会
・日本化学会
・日本分析化学会
・電気化学会（代議員2014年度～2015年度） および 化学センサ研究会（役員（編集）2024年度～）
・化学とマイクロ・ナノシステム学会
・Electrochemistry誌 編集委員（2011～2012年度)、編集幹事（2018～2019年度）
- 業績リスト
117. Ryoji Kurita and Ryo Nishihara, Dry chemistry utilizing artificial luciferin for human serum albumin quantification, Sensors & Actuators: B. Chemical 423 (2025) 136700.
116. Tsukuru Minamiki, Ryosuke Esaka and Ryoji Kurita,
Displacement Assay in a Polythiophene Sensor System Based on Supramacromolecuar
Disassembly-Caused Emission Quenching, Sensors, 2024, 24(13), 4245.
115. Osamu Niwa, Saki Ohta, Shunsuke Shiba, Dai Kato and Ryoji
Kurita, Sputter Deposited Nanocarbon Film Electrodes for Electrochemical
Analysis of Biomolecules, Electrochemistry, 92(2), 022004 (2024).
114. Yuma Tanaka, Tsukuru Minamiki, and Ryoji Kurita,
Digital Evaluation of Growth and Lipid Production in Lipomyces starkeyi from
a Single Cell. ACS Food Science & Technology, 2024, 4,
1544-1548.
113. Ryo Nishihara, Hisham M. Dokainish, Yoshiki Kihara,
Hiroki Ashiba, Yuji Sugita, and Ryoji Kurita, Pseudo-Luciferase Activity
of the SARS-CoV-2 Spike Protein for Cypridina Luciferin, ACS Central Science,
2024, 10, 2, 283–290.
112. Yuma Tanaka, Tsukuru Minamiki and Ryoji Kurita,
Arrayed labeling-free cultivation and growth evaluation from a single
microorganism, Analytical Methods, 2023, 15, 3019-3025.
111. Yuto Akahoshi, Hiroka Sugai, Masahiro Mimura, Yoichi
Shinkai, Ryoji Kurita, Kentaro Shiraki, Shunsuke Tomita,
Phase-Separation Propensity of Non-ionic Amino Acids in Peptide-Based Complex
Coacervation Systems, Biomacromolecules, 2023, 24, 2, 704–713.
109. Hiroka Sugai, Shunsuke Tomita, Sayaka Ishihara,
Kentaro Shiraki and Ryoji Kurita, Damage-free evaluation of cultured
cells based on multivariate analysis with a single-polymer probe, Chemical
Communications, 2022, 58, 11021-11086.
108. Benediktus N. Hapsianto, Naoshi Kojima, Ryoji
Kurita, Hitoshi Yamagata, Hiroyuki Fujita, Teruo Fujii, and Soo Hyeon Kim, Direct
capture and amplification of small fragmented DNAs using
nitrogen-mustard-coated microbeads, Analytical Chemistry, 2022, 94,
7594-7600.
107. Shunsuke Tomita, Sayaka Ishihara, Ryoji
Kurita, A polymer-based chemical tongue for the
non-invasive monitoring of osteogenic stem-cell differentiation by pattern
recognition of serum-supplemented spent media, Journal of Materials
Chemistry B, 10, 7581-7590 (2022).
105. Ryo Nishihara and Ryoji Kurita, Mix-and-read
bioluminescent copper detection platform using a caged coelenterazine analogue,
Analyst, 2021, 146, 6139.
103. Masahiro Mimura,
Shunsuke Tomita, Yoichi Shinkai, Takuya Hosokai, Hiroyuki Kumeta, Tomohide Saio,
Kentaro Shiraki, Ryoji Kurita, Quadruplex folding promotes the
condensation of linker histones and DNAs via liquid-liquid phase separation,
Journal of the American Chemical Society, 2021, 143, 9849-9857.
100. Shunsuke
Tomita and Ryoji Kurita, Pattern-recognition-based Identification of
Proteases and Their Complexes by a One-component Array Composed of a
Dansyl-modified Charged Polymer, Sensors and Materials, 33 (2021) 233-240.
99. Ryo
Nishihara, Kazuki Niwa, Tatsunosuke Tomita and Ryoji Kurita, Coelenterazine
Analogue with Human Serum Albumin-Specific Bioluminescence, Bioconjugate
Chemistry, 2020, 31, 2679−2684.
98. Hiroka Sugai,
Shunsuke Tomita, Sayaka Ishihara and Ryoji Kurita, Microfluidic Sensing
System with a Multichannel Surface Plasmon Resonance Chip: Damage-Free
Characterization of Cells by Pattern Recognition, Analytical Chemistry,
2020, 92, 14939–14946.
97. Shunsuke
Tomita, Hiroka Sugai, Sayaka Ishihara and Ryoji Kurita, A biomimetic
sensor array based on a single fluorescent block-copolymer for the pattern
recognition of proteins, Chemistry Letters, 2020, 49, 1447-1451.
96. Mari Okada,
Hiroka Sugai, Shunsuke Tomita and Ryoji Kurita, A Multichannel
Pattern-recognition-based Protein Sensor with a Fluorophore-conjugated
Single-stranded DNA Set, Sensors, 2020, 20(18), 5110
92. Tsukuru
Minamiki, Yuki Ichikawa and Ryoji Kurita, The Power of Assemblies at
Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes, Sensors,
2020, 20(8), 2228.
91. Tsukuru
Minamiki, Yuki Ichikawa and Ryoji Kurita, Systematic Investigation of
Molecular Recognition Ability in FET-based Chemical Sensors Functionalized with
a Mixed Self-Assembled Monolayer System, ACS Applied Materials &
Interfaces, 2020, 12, 13, 15903-15910.
88. Takaaki
Kurinomaru, Naoshi Kojima, Ryoji Kurita, Sequential Assessment of
Multiple Epigenetic Modifications of Cytosine in Whole Genomic DNA by Surface
Plasmon Resonance, Analytical Chemistry, 2019, 91, 13933-13939.
87. Takaaki
Kurinomaru, Naoshi Kojima and Ryoji Kurita, Immobilization of DNA on
Biosensing Devices with Nitrogen Mustard–Modified Linkers, Current protocols in
Nucleic Acid Chemistry, Current Protocols in Nucleic Acid Chemistry,
e85. doi: 10.1002/cpnc.85
86. Tomoyuki
Kamata, Michinori Sumimoto, Shunsuke Shiba, Ryoji Kurita, Osamu Niwa and
Dai Kato, Increased electrode activity during geosmin oxidation provided by Pt
nanoparticle-embedded nanocarbon film, Nanoscale, 2019, 11, 8845 – 8854.
84. Shunsuke
Tomita, Sayaka Ishihara and Ryoji Kurita, Biomimicry Recognition of
Proteins and Cells Using a Small Array of Block-Copolymers Appended with Amino
Acids and Fluorophores, ACS Applied Materials & Interfaces, 2019,
11, 6451-6758.
81. Masahiro
Mimura, Shunsuke Tomita, Ryoji Kurita, and Kentaro Shiraki, Array-based
generation of response fingerprints with common fluorescent dyes for
identification of proteins and cells, Analytical Sciences, 35, 99-102
(2019)
79. Kyoko Yoshioka
and Ryoji Kurita, N6-methylation assessment in E. coli 23S rRNA
utilizing a bulge loop in an RNA-DNA hybrid, Analytical Chemistry, 2018,
90, 7578-7582.
77. Shunsuke
Tomita, Ayumi Matsuda, Suguru Nishinami, Ryoji Kurita and Kentaro
Shiraki, One-Step Identification of Antibody Degradation Pathways Using
Fluorescence Signatures Generated by Cross-Reactive DNA-Based Arrays, Analytical
Chemistry, 2017, 89 (15), pp 7818–7822
74. Ryoji Kurita, Hiroyuki Yanagisawa, Tomoyuki Kamata, Dai Kato and
Osamu Niwa, On-Chip Evaluation of DNA Methylation with Electrochemical Combined
Bisulfite Restriction Analysis utilizing a Carbon Film Containing a
Nanocrystalline Structure, Analytical Chemistry, 89 (2017) 5976–5982.
73. Tatsunosuke
Tomita, Ryoji Kurita and Yoshiaki Onisi, Epigenetic regulation of the
circadian clock: Role of 5-aza-2’-deoxycytidine, Bioscience Reports, 37
(2017) BSR20170053.
72. Takaaki
Kurinomaru and Ryoji Kurita, Bisulfite-free approaches for DNA
methylation profiling, Analytical Methods, 9 (2017) 1537–1549.
71. Tsukuru
Minamiki, Tsuyoshi Minami, Yui Sasaki, Shin-ichi Wakida, Ryoji Kurita,
Osamu Niwa, Shizuo Tokito, Label-Free Detection of Human Glycoprotein (CgA)
Using an Extended-Gated Organic Transistor-Based Immunosensor, Sensors,
2016, 16(12) 2033.
70. Wataru Iwasaki,
Ramachandra Rao Sathuluri, Ryoji Kurita, Osamu Niwa and Masaya Miyazaki,
Effects of Electrode Placement and Measurement Time on Electrochemical Signal
of Redox Species Flowing through Porous Material, Sensors and Materials,
28, No. 12 (2016) 1329–1335.
68. Ryoji Kurita and Osamu
Niwa, Microfluidic platforms for DNA methylation analysis, Lab on a chip,
16 (2016) 3631-3644.
67. Shunsuke Tomita, Saki Yokoyama, Ryoji Kurita,
Osamu Niwa, Keitaro Yoshimoto, The use of an enzyme-based sensor array to
fingerprint proteomic signatures of sera from different mammalian species, Analytical
Sciences, 32 (2016) 237-240.
65. Ryoji
Kurita, Hiroyuki Yanagisawa, Kyoko Yoshioka and Osamu Niwa, On-Chip
Sequence-Specific Immunochemical Epigenomic Analysis utilizing Outward Turned
Cytosine in a DNA Bulge with Handheld Surface Plasmon Resonance Equipment, Analytical
Chemistry, 87 (2015) 11581–11586.
64. Hiroyuki Yanagisawa, Ryoji Kurita, Takehito
Yoshida, Tomoyuki Kamata and Osamu Niwa, Electrochemical assessment of local
cytosine methylation in genomic DNA on a nanocarbon film electrode fabricated
by unbalanced magnetron sputtering, Sensors and Actuators B: Chemical,
221 (2015) 816-822
62. Tsukuru Minamiki, Tsuyoshi Minami, Yui Sasaki, Ryoji
Kurita, Osamu Niwa, Shin-ichi Wakida, Kenjiro Fukuda, Daisuke Kumaki and
Shizuo Tokito, An Organic Field-Effect Transistor with an Extended-Gate
Electrode Capable of Detecting Human Immunoglobulin A, Analytical Sciences,
31 (2015) 725-728.
61. Hiroyuki Yanagisawa, Ryoji Kurita, Tomoyuki
Kamata, Kyoko Yoshioka, Dai Kato, Tetsuya Nakazato, Masaki Torimura and Osamu
Niwa, Effect of sp2/sp3 Ratio in a Hybrid Nanocarbon Thin
Film Electrode for Anodic Stripping Voltammetry Fabricated by Unbalanced
Magnetron Sputtering Equipment, Analytical Sciences, 31 (2015) 635-641
60. Ryoji Kurita, Hiroyuki Yanagisawa Kyoko Yoshioka and
Osamu Niwa, Site-specific immunochemical
methylation assessment from genome DNA utilizing a conformational difference
between looped-out target and stacked-in nontarget methylcytosines, Biosensors
and Bioelectronics, 70 (2015) 366-371.
59. Tsukuru Minamiki, Tsuyoshi Minami, Ryoji Kurita,
Osamu Niwa, Shin-ichi Wakida, Kenjiro Fukuda, Daisuke Kumaki and Shizuo Tokito,
Accurate and reproducible detection of proteins in water using an extended-gate
type organic transistor biosensor, Applied Physics Letters, 104, 243703
(2014) .
58. Tsukuru Minamiki, Tsuyoshi Minami , Ryoji Kurita,
Osamu Niwa, Shin-ichi Wakida, Kenjiro Fukuda, Daisuke Kumaki and Shizuo Tokito,
A Label-Free Immunosensor for IgG Based on an Extended-Gate Type Organic Field
Effect Transistor, Materials, 7 (2014) 6843-6852.
57. Hiroyuki Yanagisawa, Ryoji Kurita, Tomoyuki
Kamata, Dai Kato and Osamu Niwa, Anodic Stripping Voltammetric Determination of
Cd and Pb with Nanocarbon Film Electrode Fabricated by Unbalanced Magnetron
Sputtering, Electrochemistry, 82 (2014) 949-953.
56. Ryoji Kurita, Hiroyuki Yanagisawa and Osamu Niwa, Indoor
Allergen Assessment Quantified by a Thin-Layer Electrochemical Cell and
Magnetic Beads, Biosensors and Bioelectronics, 48 (2013) 43-48.
55. Ryoji Kurita and Osamu Niwa, DNA Methylation Analysis
Triggered by Bulge Specific Immuno-Recognition, Analytical Chemistry, 84
(2012) 7533-7538.
54. Ryo Futahashi, Ryoji Kurita, Hiroaki Mano and
Takema Fukatsu, Redox alters yellow dragonflies into red, Proceedings of the
National Academy of Sciences USA, 109 (2012) 12626-12631.
53. Kohei Nakamoto, Ryoji Kurita and Osamu Niwa,
Electrochemical Surface Plasmon Resonance Measurement Based on Gold Nanohole
Array Fabricated by Nanoimprinting Technique, Analytical Chemistry, 84
(2012) 3187-3191.
52. Ryoji Kurita, Kumi Arai, Kohei Nakamoto, Dai Kato and
Osamu Niwa, Determination of DNA Methylation using Electrochemiluminescence
with Surface Accumulable Coreactant, Analytical Chemistry, 84 (2012)
1799-1803.
51. Ryoji Kurita, Kohei Nakamoto, Yuko Sato, Tomoyuki Kamata,
Akio Ueda, Dai Kato, Shigeru Hirono and Osamu Niwa, An sp2 and sp3
Hybrid Nanocrystalline Carbon Film Electrode for Anodic Stripping Voltammetry,
and Its Application for Electrochemical Immunoassay, Analytical Sciences,
28 (2012) 13-20. (Hot article award)
50. Kohei Nakamoto, Ryoji Kurita, Osamu Niwa,
Toshiyuki Fujii, Munehiro Nishida, Development of mass-producible on-chip
plasmonic nanohole array biosensor, Nanoscale, 3 (2011) 5067-5075.
49. Dai Kato, Mayuri Komoriya, Kohei Nakamoto, Ryoji
Kurita, Shigeru Hirono and Osamu Niwa, Electrochemical Determination of
Oxidative Damaged DNA with High Sensitivity and Stability Using a Nanocarbon
Film, Analytical Sciences, 27 (2011) 703-707.
48. Tetsuya Nishimura, Yukari Sato, Mutsuo Tanaka, Ryoji
Kurita, Kohei Nakamoto, and Osamu Niwa, Bifunctional Tri(ethylene glycol)
Alkanethiol Monolayer Modified Gold Electrode for On-Chip Electrochemical
Immunoassay of pg Level Leptin, Analytical Sciences, 27 (2011) 465-469.
47. Akio Ueda, Dai Kato, Ryoji Kurita, Tomoyuki
Kamata, Hiroaki Inokuchi, Shigeru Umemura, Shigeru Hirono and Osamu Niwa,
Efficient Direct Electron Transfer with Enzyme on a Nanostructured Carbon Film
Fabricated with a Maskless Top-Down UV/Ozone Process, Journal of the
American Chemical Society, 133 (2011) 4840-4846.
46. Kohei Nakamoto, Ryoji Kurita and Osamu Niwa,
One-chip Biosensor for Simultaneous Disease Marker / Calibration Substance
Measurement in Human Urine by Electrochemical Surface Plasmon Resonance Method,
Biosensors and Bioelectronics, 26 (2010) 1536-1542.
45. Ryoji Kurita, Kumi Arai, Kohei Nakamoto, Dai Kato and
Osamu Niwa, Development of electrogenerated chemiluminescence-based enzyme
linked immunosorbent assay for sub-pM detection, Analytical Chemistry,
82 (2010) 1692-1697.
44. Ryoji Kurita, Kohei Nakamoto, Dai Kato and Osamu Niwa,
Surface accumulable coreactant for bright electrogenerated chemiluminescence at
trace level concentrations, Chemistry Letters, 38 (2009) 804-805.
43. Akio Ueda, Dai Kato, Naoyuki Sekioka, Tomoyuki Kamata, Ryoji
Kurita, Hiroshi Uetsuka, Yoshiki Hattori, Shigeru Hirono, Shigeru Umemura
and Osamu Niwa, Fabrication of electrochemically stable fluorinated nano-carbon
film compared with other fluorinated carbon materials, Carbon, 47 (2009)
1943-1952.
42. Ryoji Kurita, Kohei Nakamoto, Akio Ueda and Osamu Niwa,
Comparison of Electrochemical and Surface Plasmon Resonance Immunosensor
Responses on Single Thin Film, Electroanalysis, 20 (2008) 2241-2246.
41. Naoyuki, Sekioka, Dai Kato, Akio Ueda, Tomoyuki Kamata, Ryoji
Kurita, Shigeru Umemura, Sigeru Hirono, Osamu Niwa, Controllable electrode
activities of nano-carbon films while maintaining surface flatness by
electrochemical pretreatment, Carbon, 45 (2008) 1918-1926.
40. Fumio Mizutani, Dai Kato, Ryoji Kurita, Yasuhiro
Mie and Osamu Niwa, Highly-sensitive biosensors with chemically-amplified
responses, Electrochemistry, 8 (2008) 515-521.
39. Dai Kato, Naoyuki Sekioka, Akio Ueda, Ryoji Kurita,
Shigeru Hirono, Koji Suzuki and Osamu Niwa, Nano-hybrid carbon film for
electrochemical SNP detection without hybridization or labeling,, Angewandte
Chemie -International Edition, 47 (2008) 6681-6684.
38. Kohei Nakamoto, Ryoji Kurita, Naoyuki Sekioka,
Osamu Niwa, Simultaneous On-chip Surface Plasmon Resonance Measurement of
Disease Marker Protein and Small Metabolite Combined with Immuno and Enzymatic
Reactions, Chemistry Letters, 37 (2008) 698-699.
37. Dai Kato, Naoyuki Sekioka, Akio Ueda, Ryoji Kurita,
Shigeru Hirono, Koji Suzuki, Osamu Niwa, A Nano-Carbon Film Electrode as a
Platform for Exploring DNA Methylation, Journal of American Chemical Society,
130 (2008) 3716-3717.
36. Ryoji Kurita, Yoshiki Hirata, Soichi Yabuki, Yoshimi
Yokota, Dai Kato, Yukari Sato, Fumio Mizutani and Osamu Niwa, Surface
Modification of Thin Polyion Complex Film for Surface Plasmon Resonance
Immunosensor, Sensors and Actuators B, 130 (2008) 320-325
35. Ryoji Kurita, Yoshimi Yokota, Akio Ueda and Osamu Niwa,
Electrochemical surface plasmon resonance measurement in a microliter volume
flow cell for evaluating the affinity and catalytic activity of biomolecules, Analytical
Chemistry, 79 (2007) 9572-9576
34. Naoyuki Sekioka, Dai Kato, Ryoji Kurita, Shigeru
Hirono and Osamu Niwa, Improved detection limit for an electrochemical
γ-aminobutyric acid sensor based on stable NADPH detection using an electron
cyclotron resonance sputtered carbon film electrode, Sensors and Actuators
B, 129 (2008) 442-449
33. Chiming Wei, Takeharu Nagai, Wenchi Wei, Tomomi Nemoto, Muhammad
Awais, Osamu Niwa, Ryoji Kurita and Yashinobu Baba, New
Advances in Nanomedicine: Diagnosis and Preventive Medicine, Medical Clinics
of North America, 91 (2007) 871-879
32. Dai Kato, Guobao Xu, Yuzuru Iwasaki, Yoshiki Hirata, Ryoji
Kurita, Osamu Niwa, Heavy Phosphate Adsorption on Amorphous ITO Film
Electrodes, Langmuir, 23 (2007) 8400-8405
31. Osamu Niwa, Dai Kato, Ryoji Kurita, Tianyan You,
Yuzuru Iwasaki, Shigeru Hirono, Electrocatalytic detection of hydrogen peroxide
using palladium-nanoparticle dispersed carbon film electrodes, Sensors and
materials, 19 (2007) 225-233
30. Jianbo Jia, Dai Kato, Ryoji Kurita, Kenichi
Maruyama, Koji Suzuki, Shigeru Hirono, Toshiro Ando and Osamu Niwa, Structure
and electrochemical properties of carbon films prepared by a electron cyclotron
resonance sputtering method, Analytical Chemistry, 79 (2007) 98-105.
29. Dai Kato, Seiichiro Iijima, Ryoji Kurita, Yukari
Sato, Jianbo Jia, Soichi Yabuki, Fumio Mizutani and Osamu Niwa,
Electrochemically amplified detection for lipopolysaccharide using
ferrocenylboronic acid, Biosensors and Bioelectronics, 22 (2007)
1527-1531
28. Ryoji Kurita, Yoshimi Yokota, Yukari Sato, Fumio Mizutani
and Osamu Niwa, On-Chip Enzyme Immunoassay of a Cardiac Marker Using a
Microfluidic Device Combined with a Portable Surface Plasmon Resonance System, Analytical
Chemistry, 78 (2006) 5525-5531.
27. Osamu Niwa, Jianbo Jia, Yukari Sato, Dai Kato, Ryoji
Kurita, Kenichi Maruyama, Koji Suzuki and Shigeru Hirono, Electrochemical
Performance of Angstrom Level Flat Sputtered Carbon Film Consisting of sp2
and sp3 Mixed Bonds, Journal of the American Chemical Society,
128 (2006) 7144-7145.
26. Ryoji Kurita, Yoshiki Hirata, Soichi Yabuki, Dai Kato,
Yukari Sato, Fumio Mizutani and Osamu Niwa, Surface modification of thin
polyion complex film with a high specific binding affinity and prevention of
non-specific adsorption in surface plasmon resonance immunoassay, Electrochemistry,
74 (2006) 121-124
25. Ryoji Kurita, Norikuni Yabumoto, Osamu Niwa, Miniaturized
One-chip Electrochemical Sensing Device Integrated with a Dialysis Membrane and
Double Thin-layer Flow Channels for Measuring Blood Samples, Biosensors and
Bioelectronics, 21 (2006) 1649-1653
24. Katsuyoshi Hayashi, Yuzuru Iwasaki, Ryoji Kurita,
Kenji Sunagawa, Osamu Niwa, Akiyuki Tate The highly sensitive detection of
catecholamines using a microfluidic device integrated with an enzyme-modified
pre-reactor for interferent elimination and an interdigitated array electrode, Journal
of Electroanalytical Chemistry, 579 (2005) 215-222
23. Zilin Chen, Katsuyoshi Hayashi, Yuzuru Iwasaki, Ryoji
Kurita, Osamu Niwa, Kenji Sunagawa, On-Line Monolithic Enzyme Reactor
Fabricated by Sol-Gel Process for Elimination of Ascorbic Acid While Monitoring
Dopamine, Electroanalysis, 17 (2005) 231 – 238
22. Ryoji Kurita, Hisao Tabei, Yuzuru Iwasaki, Katsuyoshi,
Hayashi, Kenji Sunagawa, Osamu Niwa, Biocompatible glucose sensor prepared by
modifying protein and vinylferrocene monomer composite membrane, Biosensors
and Bioelectronics, 20 (2004) 518-523
21. Tianyan You, Osamu Niwa, Ryoji Kurita, Yuzuru
Iwasaki, Katsuyoshi Hayashi, Koji Suzuki and Shigeru Hirono, Reductive H2O2
detection at nanoparticle iridium/carbon film electrode and its application as
L-glutamate enzyme sensor, Electroanalysis, 16 (2004) 54-59.
20. Ryoji Kurita, Katsuyoshi Hayashi, Keiichi Torimitsu and
Osamu Niwa, Continuous measurement of glutamate and hydrogen peroxide using a
microfabricated biosensor for studying the neurotoxicity of tributyltin, Analytical
Sciences,19 (2003) 1581-1585.
19. Katsuyoshi Hayashi, Yuzuru Iwasaki, Ryoji Kurita,
Kenji Sunagawa, Osamu Niwa, On-line microfluidic sensor integrated with a micro
array electrode and enzyme-modified pre-reactor for the real-time monitoring of
blood catecholamine, Electrochemistry communications, 5 (2003)
1037-1042.
18. Katsuyoshi Hayashi, Ryoji Kurita, Tsutomu
Horiuchi, Osamu Niwa, Selective detection of L-glutamate using a microfluidic
device integrated with an enzyme-modified pre-reactor and an electrochemical
detector, Biosensors & Bioelectronics, 18 (2003) 1249-1255.
17. Katsuyoshi Hayashi, Ryoji Kurita, Tsutomu
Horiuchi, Osamu Niwa, Microfabricated on-line electrochemical flow cell
integrated with small volume pre-reactor for highly selective detection of
biomolecules, Electroanalysis, 14 (2002) 333-338.
16. Ryoji Kurita, Katsuyoshi Hayashi, Xu Fan, Katsunobu
Yamamoto, Takeshi Kato and Osamu Niwa, Microfluidic device integrated with
pre-reactor and dual enzyme modified microelectrodes for monitoring in vivo
glucose and lactate, Sensors and Actuators B, 87 (2002) 296-303.
15. Shoko Iwaki, Masahito Ogasawara, Ryoji Kurita,
Osamu Niwa, Katsuyuki Tanizawa, Yuichi Ohashi, Kazutaka Maeyama, Real-time
monitoring of histamine released from rat basophilic leukemia (RBL-2H3) cells
with a histamine microsensor using recombinant histamine oxidase, Analytical
Biochemistry, 304 (2002) 236-243.
14. Ryoji Kurita, Katsuyoshi Hayashi, Tsutomu Horiuchi, Osamu
Niwa, Kazutaka Maeyama and Katsuyuki Tanizawa, Differential measurement with a
microfluidic device for the highly selective continuous measurement of
histamine released from rat basophilic leukemia cells (RBL-2H3), Lab on a
chip, 2 (2002) 34-38.
13. Ryoji Kurita, Katsuyoshi Hayashi, Osamu Niwa, Keiichi
Torimitsu, Katsunobu Yamamoto and Takeshi Kato, Microfabricated devices for
real-time measurement of in vivo and in vitro biomolecules, Analytical
Sciences, 17 (2001) i437-i439.
12. Ryoji Kurita, Hisao Tabei, Katsuyoshi Hayashi, Tsutomu
Horiuchi, Keiichi Torimitsu and Osamu Niwa, Improvement in signal reliability
when measuring L-glutamate released from cultured cells using multi-channel
microfabricated sensors, Analytica Chimica Acta, 441 (2001) 165-174.
11. Katsuyoshi Hayashi, Tsutomu Horiuchi, Ryoji Kurita,
Keiichi Torimitsu, Osamu Niwa, Real-time electrochemical imaging using an
individually addressable multi-channel electrode, Biosensors &
Bioelectronics, 15 (2000) 523-529.
10. Ryoji Kurita, Hisao Tabei, Zhiming Liu, Tsutomu Horiuchi
and Osamu Niwa, Fabrication and electroproperties of an interdigitated array
electrode in a microfabricated wall-jet cell, Sensors and Actuators B,
71, 82-89 (2000).
9. Zhiming Liu, Osamu Niwa, Ryoji Kurita and Tsutomu
Horiuchi, Miniaturized thin-layer radial flow cell with interdigitated
ring-shaped microarray electrode used as amperometric detector for capillary
electrophoresis, Journal of Chromatography A, 891, 149-156 (2000).
8. Osamu Niwa, Ryoji Kurita, Katsuyoshi Hayashi,
Tsutomu Horiuchi, Keiichi Torimitsu, Kazutaka Maeyama and Katsuyuki Tanizawa,
Continuous measurement of histamine from rat basophilic leukemia cells
(RBL-2H3) with an on-line sensor using histamine oxidase, Sensors and
Actuators B, 67, 43-51 (2000).
7. Zhiming Liu, Osamu Niwa, Ryoji Kurita and Tsutomu
Horiuchi, Carbon film based interdigitated array microelectrode used in
capillary electrophoresis with electrochemical detection, Analytical
Chemistry, 72, 1315-1321 (2000).
6. Osamu Niwa, Ryoji Kurita, Zhiming Liu, Tsutomu
Horiuchi and Keiichi Torimitsu, Subnanoliter volume wall-jet cells combined
with interdigitated microarray electrode and enzyme modified planar
microelectrode, Analytical Chemistry, 72, 949-955 (2000).
5. Zhiming Liu, Osamu Niwa, Tsutomu Horiuchi, Ryoji
Kurita and Keiichi Torimitsu, NADH and glutamate on-line sensors using
Os-gel-HRP/GC electrodes modified with NADH oxidase and glutamate
dehydrogenase, Biosensors & Bioelectronics, 14, 631-638 (1999).
4. Osamu Niwa, Ryoji Kurita, Tsutomu Horiuchi and
Keiichi Torimitsu, Continuous monitoring of l-glutamate released form cultured
rat nerve cells with a microfabricated on-line sensor at a slow flow rate, Electroanalysis,
11, 356-361 (1999).
3. Osamu Niwa, Tsutomu Horiuchi, Ryoji Kurita, Hisao
Tabei and Keiichi Torimitsu, Microfabricated on-line sensor for continuous
monitoring of l-glutamate, Analytical Sciences, 14, 947-953 (1998).
2. Osamu Niwa, Tsutomu Horiuchi, Ryoji Kurita and
Keiichi Torimitsu, On-line electrochemical sensor for selective continuous
measurement of acetylcholine in cultured brain tissue, Analytical Chemistry,
70, 1126-1132 (1998).
1. Osamu Niwa, Ryoji Kurita, Tsutomu Horiuchi and
Keiichi Torimitsu, Small volume on-line sensor for continuous measurement of
γ-aminobutyric acid, Analytical Chemistry, 70, 89-93 (1998).
-
主な著書・解説記事など
- “先進化学センサ”、第１章、第５節 免疫センサチップ （株）ティー・アイ・シィー
- “マイクロマシン”、第１１章第２節 細胞間伝達物質、生体内分子のマイクロチップによる計測、江刺正喜監修、（株）産業技術サービスセンター
- “バイオ電気化学の実際－バイオセンサ・バイオ電池の実用展開－”、第９章 超微小電極とバイオセンサ、池田篤治監修、（株）シーエムシー出版
- 栗田僚二、産総研Ｔｏｄａｙ２００７年２月号、心疾患マーカー検出用マイクロセンシングチップ
- 栗田僚二、丹羽修、化学とマイクロ・ナノシステム研究会誌、? ２００７年、6 巻?
1 号?
23 頁～?
27 頁、心疾患マーカーの迅速検出を目的とした、携帯型表面プラズモン共鳴装置用小型免疫センサチップの開発
- 栗田僚二、丹羽修、ペプチドホルモンセンサー：血中の心疾患マーカー分子を指先サイズのチップで検出する、化学と教育、2007年、５５巻、９号、４５０－４５１
- 栗田僚二、加藤大、丹羽修、“ワンチップ分析装置が実現するオーダーメイド医療”、2010年、精密工学会誌
- 分析化学便覧（改訂六版） 5.4.7 バイオマーカー，2011年9月
- バイオセンサの先端科学技術と新製品への応用開発、発 刊 ： ２０１４年４月３０日、技術情報協会
- 次世代ヘルスケア機器の新製品開発、発刊 ： ２０１４年５月３０日、技術情報協会
特許（成立済みのもののみ掲載）
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- 微少量オンラインバイオセンサー及びその製造方法、特許3515908号
- 電気化学検出器、特許第３４６２４０１号
- ヒスタミン計測用微小電極およびヒスタミン計測用センサ、特許第３４９９７６７号
- ヒスタミンセンサ、特許3751480号
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- 表面プラズモン共鳴法による免疫測定、特許4487049号
- 免疫センサ用デバイス、特許4517081号
- 酵素免疫測定方法及びそのための酵素免疫センサ、特許4581128号
- 過酸化水素の濃度測定法、特許4654411号
- メチル化DNAの電気化学的定量方法、特許4817331号
- ＤＮＡ及びＲＮＡ中の核酸塩基の電気化学的検出方法、特許4831429号
- 電気化学発光を利用した免疫測定法及び該免疫測定法に使用される電気化学発光量測定用キット、特許4873492号
- 非特異性吸着抑制材料、特許4911415
- 免疫センサ、特許5311406号
- “先進化学センサ”、第１章、第５節 免疫センサチップ （株）ティー・アイ・シィー