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栗田　僚二（Ryoji Kurita）
国立研究開発法人産業技術総合研究所　健康医工学研究部門（ウェブサイト）
ナノバイオデバイス研究グループ　研究グループ長

筑波大学　准教授（連携大学院）

長岡技術科学大学　客員教授

ORCiD(0000-0001-5666-9561)

Researchmap, Google scholar

略歴

  • １９９６年０４月　ＮＴＴアドバンステクノロジ（株）入社　ＮＴＴ厚木研究開発センタ勤務

    ２００４年０３月　博士（工学）号取得　九州大学

    ２００４年１０月　産業技術総合研究所　生物機能工学研究部門バイオセンシング技術研究グループ

    ２０１５年　４月　同所　バイオメディカル研究部門ナノバイオデバイス研究グループ　グループ長

賞罰

  • ２００９年３月　電気化学会　進歩賞・佐野賞
    ２００９年９月　Tokyo conference award for best poster
    ２０１２年１月　Hot Article Awards Analytical Sciences
    ２０１２年６月　The 4th International Symposium on Microchemistry and Microsystems (ISMM2012)　Best Poster Award
    ２０１４年１月　日本分析化学会関東支部・新世紀賞
    ２０１５年６月　化学とマイクロ・ナノシステム学会奨励賞
    ２０１６年１月　電気化学会　化学センサ研究会　清山賞

所属学会

・日本化学会
・日本分析化学会 
・電気化学会（代議員2014年度～2015年度）　　および化学センサ研究会
・化学とマイクロ・ナノシステム学会
・Electrochemistry誌　編集委員（2011～2012年度)、編集幹事（2018～2019年度）

業績リスト

112. Yuma Tanaka, Tsukuru Minamiki and Ryoji Kurita, Arrayed labeling-free cultivation and growth evaluation from a single microorganism, Analytical Methods, 2023, 15, 3019-3025.

111. Yuto Akahoshi, Hiroka Sugai, Masahiro Mimura, Yoichi Shinkai, Ryoji Kurita, Kentaro Shiraki, Shunsuke Tomita, Phase-Separation Propensity of Non-ionic Amino Acids in Peptide-Based Complex Coacervation Systems, Biomacromolecules, 2023, 24, 2, 704–713.

110. Ryo Nishihara, Yoshiki Kihara, Kazuki Niwa, Masahiro Mimura, Shunsuke Tomita and Ryoji Kurita, Quantum Yield Enhancement of Firefly Bioluminescence with Biomolecular Condensates, Chemical Communications, 2022, 58, 13317-13320

109. Hiroka Sugai, Shunsuke Tomita, Sayaka Ishihara, Kentaro Shiraki and Ryoji Kurita, Damage-free evaluation of cultured cells based on multivariate analysis with a single-polymer probe, Chemical Communications, 2022, 58, 11021-11086

108. Benediktus N. Hapsianto, Naoshi Kojima, Ryoji Kurita, Hitoshi Yamagata, Hiroyuki Fujita, Teruo Fujii, and Soo Hyeon Kim, Direct capture and amplification of small fragmented DNAs using nitrogen-mustard-coated microbeads, Analytical Chemistry, 2022, 94, 7594-7600

107. Shunsuke Tomita, Sayaka Ishihara, Ryoji Kurita, A polymer-based chemical tongue for the non-invasive monitoring of osteogenic stem-cell differentiation by pattern recognition of serum-supplemented spent media, Journal of Materials Chemistry B, 10, 7581-7590 (2022)

106. Shunsuke Tomita, Hiroyuki Kusada, Naoshi Kojima, Sayaka Ishihara, Koyomi Miyazaki, Hideyuki Tamaki and Ryoji Kurita, Polymer-based chemical-nose systems for optical-pattern recognition of gut microbiota, Chemical Science, 2022, 13, 5830-5837

105. Ryo Nishihara and Ryoji Kurita, Mix-and-read bioluminescent copper detection platform using a caged coelenterazine analogue, Analyst, 2021, 146, 6139

104. Masahiro Mimura, Shunsuke Tomita, Hiroka Sugai, Yoichi Shinkai, Sayaka Ishihara, and Ryoji Kurita, Uncharged components of single-stranded DNA modulate liquid?liquid phase separation with cationic linker histone H1, Frontiers in cell and development Biology, 9, 710729 (2021)

103. Masahiro Mimura, Shunsuke Tomita, Yoichi Shinkai, Takuya Hosokai, Hiroyuki Kumeta, Tomohide Saio, Kentaro Shiraki, Ryoji Kurita, Quadruplex folding promotes the condensation of linker histones and DNAs via liquid-liquid phase separation, Journal of the American Chemical Society, 2021, 143, 9849-9857.

102. Tatsunosuke Tomita, Renu Wadhwa, Sunil Kaul, Ryoji Kurita, Naoshi Kojima and Yoshiaki Onishi, A withanolide derivative modulates the circadian clock via interaction with RORA, Journal of Natural Products, 2021 84 (7), 1882-1888.

101. Hiroki Okada, Masahiro Mimura, Shunsuke Tomita and Ryoji Kurita, Affinity diversification of a polymer probe for pattern-recognition-based biosensing using chemical additives, Analytical Sciences, 37 (2021) 713-719.

100. Shunsuke Tomita and Ryoji Kurita, Pattern-recognition-based Identification of Proteases and Their Complexes by a One-component Array Composed of a Dansyl-modified Charged Polymer, Sensors and Materials, 33 (2021) 233-240.

99. Ryo Nishihara, Kazuki Niwa, Tatsunosuke Tomita and Ryoji Kurita, Coelenterazine Analogue with Human Serum Albumin-Specific Bioluminescence, Bioconjugate Chemistry, 2020, 31, 2679?2684.

98. Hiroka Sugai, Shunsuke Tomita, Sayaka Ishihara and Ryoji Kurita, Microfluidic Sensing System with a Multichannel Surface Plasmon Resonance Chip: Damage-Free Characterization of Cells by Pattern Recognition, Analytical Chemistry, 2020, 92, 14939?14946.

97. Shunsuke Tomita, Hiroka Sugai, Sayaka Ishihara and Ryoji Kurita, A biomimetic sensor array based on a single fluorescent block-copolymer for the pattern recognition of proteins, Chemistry Letters, 2020, 49, 1447-1451.

96. Mari Okada, Hiroka Sugai, Shunsuke Tomita and Ryoji Kurita, A Multichannel Pattern-recognition-based Protein Sensor with a Fluorophore-conjugated Single-stranded DNA Set, Sensors, 2020, 20(18), 5110

95. Naoshi Kojima, Tomomi Suda, Shinichiro Fujii, Kazumi Hirano, Masakazu Namihira, Ryoji Kurita, Quantitative analysis of global 5-methyl- and 5-hydroxymethylcytosine in TET1 expressed HEK293T cells, Biosensors and Bioelectronics, 167 (2020) 112472

94. Hiroka Sugai, Shunsuke Tomita and Ryoji Kurita, Pattern-recognition-based Sensor Arrays for Cell Characterization: From Materials and Data Analyses to Biomedical Applications, Analytical Sciences, 2020, 36, 923-934.

93. Sima Chaudharid, Tomoyuki Kamata, Naoshi Kojima, Michinori Sumimoto, Kapaettu Satyamoorthy,Ryoji Kurita, Dai Kato, Oxidation potential-dependent selective detection of epigenetic 5-hydroxymethylcytosine using nanocarbon film, Sensors and Actuators B, Chemical, 2020, 314, 128092

92. Tsukuru Minamiki, Yuki Ichikawa and Ryoji Kurita, The Power of Assemblies at Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes, Sensors 2020, 20(8), 2228.

91. Tsukuru Minamiki, Yuki Ichikawa and Ryoji Kurita, Systematic Investigation of Molecular Recognition Ability in FET-based Chemical Sensors Functionalized with a Mixed Self-Assembled Monolayer System,ACS Applied Materials & Interfaces, 2020, 12, 13, 15903-15910.

90. Shunsuke Tomita, Hiroka Sugai, Masahiro Mimura, Sayaka Ishihara, Kentaro Shiraki and Ryoji Kurita, Optical Fingerprints of Proteases and Their Inhibited Complexes Provided by Differential Cross-Reactivity of Fluorophore-Labeled Single-Stranded DNA, ACS Applied Materials & Interfaces, 2019, 11, 50, 47428-47436.

89. Naoshi Kojima, Ajaya R. Shrestha, Takuya Akisawa, Haishun Piao, Hideki Kizawa, Yoshihiro Ohmiya,Ryoji Kurita, Development of Gapmer Antisense Oligonucleotide with Deoxyribonucleic Guanidine (DNG) Modifications, Nucleosides, Nucleotides & Nucleic Acids, doi.org/10.1080/15257770.2019.1668563

88. Takaaki Kurinomaru, Naoshi Kojima, Ryoji Kurita, Sequential Assessment of Multiple Epigenetic Modifications of Cytosine in Whole Genomic DNA by Surface Plasmon Resonance, Analytical Chemistry, 2019, 91, 13933-13939.

87. Takaaki Kurinomaru, Naoshi Kojima and Ryoji Kurita, Immobilization of DNA on Biosensing Devices with Nitrogen Mustard?Modified Linkers, Current protocols in Nucleic Acid Chemistry, Current Protocols in Nucleic Acid Chemistry, e85. doi: 10.1002/cpnc.85

86. Tomoyuki Kamata, Michinori Sumimoto, Shunsuke Shiba, Ryoji Kurita, Osamu Niwa and Dai Kato, Increased electrode activity during geosmin oxidation provided by Pt nanoparticle-embedded nanocarbon film, Nanoscale, 2019, 11, 8845 - 8854

85. Hiroka Sugai, Shunsuke Tomita, Sayaka Ishihara and Ryoji Kurita, One-Component Array Based on a Dansyl-Modified Polylysine: Generation of Differential Fluorescent Signatures for the Discrimination of Human Cells, ACS sensors, 2019, 4, 827-831.

84. Shunsuke Tomita, Sayaka Ishihara and Ryoji Kurita, Biomimicry Recognition of Proteins and Cells Using a Small Array of Block-Copolymers Appended with Amino Acids and Fluorophores, ACS Applied Materials & Interfaces, 2019, 11, 6451-6758.

83. Tsukuru Minamiki and Ryoji Kurita, Potentiometric detection of biogenic amines utilizing affinity on a 4-mercaptobenzoic acid monolayer. Analytical Methods, 2019, 11, 1155-1158.

82. Hiroka Sugai, Shunsuke Tomita, Sayaka Ishihara and Ryoji Kurita, Fingerprint-based Protein Identification in Cell Culture Medium Using Environment-sensitive Turn-on Fluorescent Polymer,Sensors and Materials, 31, 1-11 (2019).

81. Masahiro Mimura, Shunsuke Tomita, Ryoji Kurita, and Kentaro Shiraki, Array-based generation of response fingerprints with common fluorescent dyes for identification of proteins and cells, Analytical Sciences, 35, 99-102 (2019)

80. Naoshi Kojima, Tomomi Suda, Takaaki Kurinomaru and Ryoji Kurita, Immobilization of DNA with nitrogen mustard?biotin conjugate for global epigenetic analysis, Analytica Chimica Acta, 2018, 1043, 107-114

79. Kyoko Yoshioka and Ryoji Kurita, N6-methylation assessment in E. coli 23S rRNA utilizing a bulge loop in an RNA-DNA hybrid, Analytical Chemistry, 2018, 90, 7578-7582

78. Shunsuke Tomita, Sayaka Ishihara and Ryoji Kurita, A multi-fluorescent DNA/graphene oxide conjugate sensor for signature-based protein discrimination, Sensors, 2017, 17(10), 2194

77. Shunsuke Tomita, Ayumi Matsuda, Suguru Nishinami, Ryoji Kurita and Kentaro Shiraki, One-Step Identification of Antibody Degradation Pathways Using Fluorescence Signatures Generated by Cross-Reactive DNA-Based Arrays, Analytical Chemistry, 2017, 89 (15), pp 7818?7822

76. Takaaki Kurinomaru, Naoshi Kojima and Ryoji Kurita, An Alkylating immobilization linker for immunochemical epigenetic assessment, Chemical Communications, 2017, 53, 8308 - 8311

75. Shunsuke Tomita, Sayaka Ishihara and Ryoji Kurita, An environment-sensitive “turn-on” fluorescent polyamino acid: Fingerprinting protein populations with post-translational modifications, ACS Applied Materials & Interfaces, 2017, 9 (27), pp 22970?22976.

74. Ryoji Kurita, Hiroyuki Yanagisawa, Tomoyuki Kamata, Dai Kato and Osamu Niwa, On-Chip Evaluation of DNA Methylation with Electrochemical Combined Bisulfite Restriction Analysis utilizing a Carbon Film Containing a Nanocrystalline Structure, Analytical Chemistry, 89 (2017) 5976?5982.

73. Tatsunosuke Tomita, Ryoji Kurita and Yoshiaki Onisi, Epigenetic regulation of the circadian clock: Role of 5-aza-2’-deoxycytidine, Bioscience Reports, 37 (2017) BSR20170053.

72. Takaaki Kurinomaru and Ryoji Kurita, Bisulfite-free approaches for DNA methylation profiling,Analytical Methods, 9 (2017) 1537?1549.

71. Tsukuru Minamiki, Tsuyoshi Minami, Yui Sasaki, Shin-ichi Wakida, Ryoji Kurita, Osamu Niwa, Shizuo Tokito, Label-Free Detection of Human Glycoprotein (CgA) Using an Extended-Gated Organic Transistor-Based Immunosensor, Sensors, 2016, 16(12) 2033.

70. Wataru Iwasaki, Ramachandra Rao Sathuluri, Ryoji Kurita, Osamu Niwa and Masaya Miyazaki, Effects of Electrode Placement and Measurement Time on Electrochemical Signal of Redox Species Flowing through Porous Material, Sensors and Materials, 28, No. 12 (2016) 1329?1335.

69. Shunsuke Tomita, Osamu Niwa and Ryoji Kurita, Artificial modification of an enzyme for construction of cross-reactive polyion complexes to fingerprint signatures of proteins and mammalian cells,Analytical Chemistry, 88 (2016) 9079?9086.

68. Ryoji Kurita and Osamu Niwa, Microfluidic platforms for DNA methylation analysis, Lab on a chip, 16 (2016) 3631-3644.

67. Shunsuke Tomita, Saki Yokoyama, Ryoji Kurita, Osamu Niwa, Keitaro Yoshimoto, The use of an enzyme-based sensor array to fingerprint proteomic signatures of sera from different mammalian species, Analytical Sciences, 32 (2016) 237-240.

66. Tsuyoshi Minami, Yui Sasaki, Tsukuru Minamiki, Shin-ichi Wakida, Ryoji Kurita, Osamu Niwa, and Shizuo Tokito, Selective nitrate detection by an enzymatic sensor based on an extended-gate type organic field-effect transistor, Biosensors and Bioelectronics, 81 (2016) 87-91.

65. Ryoji Kurita, Hiroyuki Yanagisawa, Kyoko Yoshioka and Osamu Niwa, On-Chip Sequence-Specific Immunochemical Epigenomic Analysis utilizing Outward Turned Cytosine in a DNA Bulge with Handheld Surface Plasmon Resonance Equipment, Analytical Chemistry, 87 (2015) 11581?11586.

64. Hiroyuki Yanagisawa, Ryoji Kurita, Takehito Yoshida, Tomoyuki Kamata and Osamu Niwa, Electrochemical assessment of local cytosine methylation in genomic DNA on a nanocarbon film electrode fabricated by unbalanced magnetron sputtering, Sensors and Actuators B: Chemical, 221 (2015) 816-822

63. Shunsuke Tomita, Miho Sakao, Ryoji Kurita, Osamu Niwa and Keitaro Yoshimoto, A Polyion Complex Sensor Array for Markerless and Noninvasive Identification of Differentiated Mesenchymal Stem Cells from Human Adipose Tissue, Chemical Science, 6 (2015) 5831-5836.

62. Tsukuru Minamiki, Tsuyoshi Minami, Yui Sasaki, Ryoji Kurita, Osamu Niwa, Shin-ichi Wakida, Kenjiro Fukuda, Daisuke Kumaki and Shizuo Tokito, An Organic Field-Effect Transistor with an Extended-Gate Electrode Capable of Detecting Human Immunoglobulin A, Analytical Sciences, 31 (2015) 725-728.

61. Hiroyuki Yanagisawa, Ryoji Kurita, Tomoyuki Kamata, Kyoko Yoshioka, Dai Kato, Tetsuya Nakazato, Masaki Torimura and Osamu Niwa, Effect of sp2/sp3 Ratio in a Hybrid Nanocarbon Thin Film Electrode for Anodic Stripping Voltammetry Fabricated by Unbalanced Magnetron Sputtering Equipment,Analytical Sciences, 31 (2015) 635-641

60. Ryoji Kurita, Hiroyuki Yanagisawa Kyoko Yoshioka and Osamu Niwa, Site-specific immunochemical methylation assessment from genome DNA utilizing a conformational difference between looped-out target and stacked-in nontarget methylcytosines, Biosensors and Bioelectronics, 70 (2015) 366-371.

59. Tsukuru Minamiki, Tsuyoshi Minami, Ryoji Kurita, Osamu Niwa, Shin-ichi Wakida, Kenjiro Fukuda, Daisuke Kumaki and Shizuo Tokito, Accurate and reproducible detection of proteins in water using an extended-gate type organic transistor biosensor, Applied Physics Letters, 104, 243703 (2014) .

58. Tsukuru Minamiki, Tsuyoshi Minami , Ryoji Kurita, Osamu Niwa, Shin-ichi Wakida, Kenjiro Fukuda, Daisuke Kumaki and Shizuo Tokito, A Label-Free Immunosensor for IgG Based on an Extended-Gate Type Organic Field Effect Transistor, Materials, 7 (2014) 6843-6852.

57. Hiroyuki Yanagisawa, Ryoji Kurita, Tomoyuki Kamata, Dai Kato and Osamu Niwa, Anodic Stripping Voltammetric Determination of Cd and Pb with Nanocarbon Film Electrode Fabricated by Unbalanced Magnetron Sputtering, Electrochemistry, 82 (2014) 949-953.

56. Ryoji Kurita, Hiroyuki Yanagisawa and Osamu Niwa, Indoor Allergen Assessment Quantified by a Thin-Layer Electrochemical Cell and Magnetic Beads, Biosensors and Bioelectronics, 48 (2013) 43-48.

55. Ryoji Kurita and Osamu Niwa, DNA Methylation Analysis Triggered by Bulge Specific Immuno-Recognition, Analytical Chemistry, 84 (2012) 7533-7538.

54. Ryo Futahashi, Ryoji Kurita, Hiroaki Mano and Takema Fukatsu, Redox alters yellow dragonflies into red, Proceedings of the National Academy of Sciences USA, 109 (2012) 12626-12631.

53. Kohei Nakamoto, Ryoji Kurita and Osamu Niwa, Electrochemical Surface Plasmon Resonance Measurement Based on Gold Nanohole Array Fabricated by Nanoimprinting Technique, Analytical Chemistry, 84 (2012) 3187-3191.

52. Ryoji Kurita, Kumi Arai, Kohei Nakamoto, Dai Kato and Osamu Niwa, Determination of DNA Methylation using Electrochemiluminescence with Surface Accumulable Coreactant, Analytical Chemistry, 84 (2012) 1799-1803.

51. Ryoji Kurita, Kohei Nakamoto, Yuko Sato, Tomoyuki Kamata, Akio Ueda, Dai Kato, Shigeru Hirono and Osamu Niwa, An sp2 and sp3 Hybrid Nanocrystalline Carbon Film Electrode for Anodic Stripping Voltammetry, and Its Application for Electrochemical Immunoassay, Analytical Sciences, 28 (2012) 13-20. (Hot article award)

50. Kohei Nakamoto, Ryoji Kurita, Osamu Niwa, Toshiyuki Fujii, Munehiro Nishida, Development of mass-producible on-chip plasmonic nanohole array biosensor, Nanoscale, 3 (2011) 5067-5075.

49. Dai Kato, Mayuri Komoriya, Kohei Nakamoto, Ryoji Kurita, Shigeru Hirono and Osamu Niwa, Electrochemical Determination of Oxidative Damaged DNA with High Sensitivity and Stability Using a Nanocarbon Film, Analytical Sciences, 27 (2011) 703-707.

48. Tetsuya Nishimura, Yukari Sato, Mutsuo Tanaka, Ryoji Kurita, Kohei Nakamoto, and Osamu Niwa, Bifunctional Tri(ethylene glycol) Alkanethiol Monolayer Modified Gold Electrode for On-Chip Electrochemical Immunoassay of pg Level Leptin, Analytical Sciences, 27 (2011) 465-469.

47. Akio Ueda, Dai Kato, Ryoji Kurita, Tomoyuki Kamata, Hiroaki Inokuchi, Shigeru Umemura, Shigeru Hirono and Osamu Niwa, Efficient Direct Electron Transfer with Enzyme on a Nanostructured Carbon Film Fabricated with a Maskless Top-Down UV/Ozone Process, Journal of the American Chemical Society, 133 (2011) 4840-4846.

46. Kohei Nakamoto, Ryoji Kurita and Osamu Niwa, One-chip Biosensor for Simultaneous Disease Marker / Calibration Substance Measurement in Human Urine by Electrochemical Surface Plasmon Resonance Method, Biosensors and Bioelectronics, 26 (2010) 1536-1542.

45. Ryoji Kurita, Kumi Arai, Kohei Nakamoto, Dai Kato and Osamu Niwa, Development of electrogenerated chemiluminescence-based enzyme linked immunosorbent assay for sub-pM detection, Analytical Chemistry, 82 (2010) 1692-1697.

44. Ryoji Kurita, Kohei Nakamoto, Dai Kato and Osamu Niwa, Surface accumulable coreactant for bright electrogenerated chemiluminescence at trace level concentrations, Chemistry Letters, 38 (2009) 804-805.

43. Akio Ueda, Dai Kato, Naoyuki Sekioka, Tomoyuki Kamata, Ryoji Kurita, Hiroshi Uetsuka, Yoshiki Hattori, Shigeru Hirono, Shigeru Umemura and Osamu Niwa, Fabrication of electrochemically stable fluorinated nano-carbon film compared with other fluorinated carbon materials, Carbon, 47 (2009) 1943-1952.

42. Ryoji Kurita, Kohei Nakamoto, Akio Ueda and Osamu Niwa, Comparison of Electrochemical and Surface Plasmon Resonance Immunosensor Responses on Single Thin Film, Electroanalysis, 20 (2008) 2241-2246.

41. Naoyuki, Sekioka, Dai Kato, Akio Ueda, Tomoyuki Kamata, Ryoji Kurita, Shigeru Umemura, Sigeru Hirono, Osamu Niwa, Controllable electrode activities of nano-carbon films while maintaining surface flatness by electrochemical pretreatment, Carbon, 45 (2008) 1918-1926.

40. Fumio Mizutani, Dai Kato, Ryoji Kurita, Yasuhiro Mie and Osamu Niwa, Highly-sensitive biosensors with chemically-amplified responses, Electrochemistry, 8 (2008) 515-521.

39. Dai Kato, Naoyuki Sekioka, Akio Ueda, Ryoji Kurita, Shigeru Hirono, Koji Suzuki and Osamu Niwa, Nano-hybrid carbon film for electrochemical SNP detection without hybridization or labeling,,Angewandte Chemie -International Edition, 47 (2008) 6681-6684.

38. Kohei Nakamoto, Ryoji Kurita, Naoyuki Sekioka, Osamu Niwa, Simultaneous On-chip Surface Plasmon Resonance Measurement of Disease Marker Protein and Small Metabolite Combined with Immuno and Enzymatic Reactions, Chemistry Letters, 37 (2008) 698-699.

37. Dai Kato, Naoyuki Sekioka, Akio Ueda, Ryoji Kurita, Shigeru Hirono, Koji Suzuki, Osamu Niwa, A Nano-Carbon Film Electrode as a Platform for Exploring DNA Methylation, Journal of American Chemical Society, 130 (2008) 3716-3717.

36. Ryoji Kurita, Yoshiki Hirata, Soichi Yabuki, Yoshimi Yokota, Dai Kato, Yukari Sato, Fumio Mizutani and Osamu Niwa, Surface Modification of Thin Polyion Complex Film for Surface Plasmon Resonance Immunosensor, Sensors and Actuators B, 130 (2008) 320-325

35. Ryoji Kurita, Yoshimi Yokota, Akio Ueda and Osamu Niwa, Electrochemical surface plasmon resonance measurement in a microliter volume flow cell for evaluating the affinity and catalytic activity of biomolecules, Analytical Chemistry, 79 (2007) 9572-9576

34. Naoyuki Sekioka, Dai Kato, Ryoji Kurita, Shigeru Hirono and Osamu Niwa, Improved detection limit for an electrochemical γ-aminobutyric acid sensor based on stable NADPH detection using an electron cyclotron resonance sputtered carbon film electrode, Sensors and Actuators B, 129 (2008) 442-449

33. Chiming Wei, Takeharu Nagai, Wenchi Wei, Tomomi Nemoto, Muhammad Awais, Osamu Niwa, Ryoji Kurita and Yashinobu Baba, New Advances in Nanomedicine: Diagnosis and Preventive Medicine,Medical Clinics of North America, 91 (2007) 871-879

32. Dai Kato, Guobao Xu, Yuzuru Iwasaki, Yoshiki Hirata, Ryoji Kurita, Osamu Niwa, Heavy Phosphate Adsorption on Amorphous ITO Film Electrodes, Langmuir, 23 (2007) 8400-8405

31. Osamu Niwa, Dai Kato, Ryoji Kurita, Tianyan You, Yuzuru Iwasaki, Shigeru Hirono, Electrocatalytic detection of hydrogen peroxide using palladium-nanoparticle dispersed carbon film electrodes,Sensors and materials, 19 (2007) 225-233

30. Jianbo Jia, Dai Kato, Ryoji Kurita, Kenichi Maruyama, Koji Suzuki, Shigeru Hirono, Toshiro Ando and Osamu Niwa, Structure and electrochemical properties of carbon films prepared by a electron cyclotron resonance sputtering method, Analytical Chemistry, 79 (2007) 98-105.

29. Dai Kato, Seiichiro Iijima, Ryoji Kurita, Yukari Sato, Jianbo Jia, Soichi Yabuki, Fumio Mizutani and Osamu Niwa, Electrochemically amplified detection for lipopolysaccharide using ferrocenylboronic acid,Biosensors and Bioelectronics, 22 (2007) 1527-1531

28. Ryoji Kurita, Yoshimi Yokota, Yukari Sato, Fumio Mizutani and Osamu Niwa, On-Chip Enzyme Immunoassay of a Cardiac Marker Using a Microfluidic Device Combined with a Portable Surface Plasmon Resonance System, Analytical Chemistry, 78 (2006) 5525-5531.

27. Osamu Niwa, Jianbo Jia, Yukari Sato, Dai Kato, Ryoji Kurita, Kenichi Maruyama, Koji Suzuki and Shigeru Hirono, Electrochemical Performance of Angstrom Level Flat Sputtered Carbon Film Consisting of sp2 and sp3 Mixed Bonds, Journal of the American Chemical Society, 128 (2006) 7144-7145.

26. Ryoji Kurita, Yoshiki Hirata, Soichi Yabuki, Dai Kato, Yukari Sato, Fumio Mizutani and Osamu Niwa, Surface modification of thin polyion complex film with a high specific binding affinity and prevention of non-specific adsorption in surface plasmon resonance immunoassay, Electrochemistry, 74 (2006) 121-124

25. Ryoji Kurita, Norikuni Yabumoto, Osamu Niwa, Miniaturized One-chip Electrochemical Sensing Device Integrated with a Dialysis Membrane and Double Thin-layer Flow Channels for Measuring Blood Samples, Biosensors and Bioelectronics, 21 (2006) 1649-1653

24. Katsuyoshi Hayashi, Yuzuru Iwasaki, Ryoji Kurita, Kenji Sunagawa, Osamu Niwa, Akiyuki Tate The highly sensitive detection of catecholamines using a microfluidic device integrated with an enzyme-modified pre-reactor for interferent elimination and an interdigitated array electrode, Journal of Electroanalytical Chemistry, 579 (2005) 215-222

23. Zilin Chen, Katsuyoshi Hayashi, Yuzuru Iwasaki, Ryoji Kurita, Osamu Niwa, Kenji Sunagawa, On-Line Monolithic Enzyme Reactor Fabricated by Sol-Gel Process for Elimination of Ascorbic Acid While Monitoring Dopamine, Electroanalysis, 17 (2005) 231 ? 238

22. Ryoji Kurita, Hisao Tabei, Yuzuru Iwasaki, Katsuyoshi, Hayashi, Kenji Sunagawa, Osamu Niwa, Biocompatible glucose sensor prepared by modifying protein and vinylferrocene monomer composite membrane, Biosensors and Bioelectronics, 20 (2004) 518-523

21. Tianyan You, Osamu Niwa, Ryoji Kurita, Yuzuru Iwasaki, Katsuyoshi Hayashi, Koji Suzuki and Shigeru Hirono, Reductive H2O2 detection at nanoparticle iridium/carbon film electrode and its application as L-glutamate enzyme sensor, Electroanalysis, 16 (2004) 54-59.

20. Ryoji Kurita, Katsuyoshi Hayashi, Keiichi Torimitsu and Osamu Niwa, Continuous measurement of glutamate and hydrogen peroxide using a microfabricated biosensor for studying the neurotoxicity of tributyltin, Analytical Sciences,19 (2003) 1581-1585.

19. Katsuyoshi Hayashi, Yuzuru Iwasaki, Ryoji Kurita, Kenji Sunagawa, Osamu Niwa, On-line microfluidic sensor integrated with a micro array electrode and enzyme-modified pre-reactor for the real-time monitoring of blood catecholamine, Electrochemistry communications, 5 (2003) 1037-1042.

18. Katsuyoshi Hayashi, Ryoji Kurita, Tsutomu Horiuchi, Osamu Niwa, Selective detection of L-glutamate using a microfluidic device integrated with an enzyme-modified pre-reactor and an electrochemical detector, Biosensors & Bioelectronics, 18 (2003) 1249-1255.

17. Katsuyoshi Hayashi, Ryoji Kurita, Tsutomu Horiuchi, Osamu Niwa, Microfabricated on-line electrochemical flow cell integrated with small volume pre-reactor for highly selective detection of biomolecules, Electroanalysis, 14 (2002) 333-338.

16. Ryoji Kurita, Katsuyoshi Hayashi, Xu Fan, Katsunobu Yamamoto, Takeshi Kato and Osamu Niwa, Microfluidic device integrated with pre-reactor and dual enzyme modified microelectrodes for monitoring in vivo glucose and lactate, Sensors and Actuators B, 87 (2002) 296-303.

15. Shoko Iwaki, Masahito Ogasawara, Ryoji Kurita, Osamu Niwa, Katsuyuki Tanizawa, Yuichi Ohashi, Kazutaka Maeyama, Real-time monitoring of histamine released from rat basophilic leukemia (RBL-2H3) cells with a histamine microsensor using recombinant histamine oxidase, Analytical Biochemistry, 304 (2002) 236-243.

14. Ryoji Kurita, Katsuyoshi Hayashi, Tsutomu Horiuchi, Osamu Niwa, Kazutaka Maeyama and Katsuyuki Tanizawa, Differential measurement with a microfluidic device for the highly selective continuous measurement of histamine released from rat basophilic leukemia cells (RBL-2H3), Lab on a chip, 2 (2002) 34-38.

13. Ryoji Kurita, Katsuyoshi Hayashi, Osamu Niwa, Keiichi Torimitsu, Katsunobu Yamamoto and Takeshi Kato, Microfabricated devices for real-time measurement of in vivo and in vitro biomolecules,Analytical Sciences, 17 (2001) i437-i439.

12. Ryoji Kurita, Hisao Tabei, Katsuyoshi Hayashi, Tsutomu Horiuchi, Keiichi Torimitsu and Osamu Niwa, Improvement in signal reliability when measuring L-glutamate released from cultured cells using multi-channel microfabricated sensors, Analytica Chimica Acta, 441 (2001) 165-174.

11. Katsuyoshi Hayashi, Tsutomu Horiuchi, Ryoji Kurita, Keiichi Torimitsu, Osamu Niwa, Real-time electrochemical imaging using an individually addressable multi-channel electrode, Biosensors & Bioelectronics, 15 (2000) 523-529.

10. Ryoji Kurita, Hisao Tabei, Zhiming Liu, Tsutomu Horiuchi and Osamu Niwa, Fabrication and electroproperties of an interdigitated array electrode in a microfabricated wall-jet cell, Sensors and Actuators B, 71, 82-89 (2000).

9. Zhiming Liu, Osamu Niwa, Ryoji Kurita and Tsutomu Horiuchi, Miniaturized thin-layer radial flow cell with interdigitated ring-shaped microarray electrode used as amperometric detector for capillary electrophoresis, Journal of Chromatography A, 891, 149-156 (2000).

8. Osamu Niwa, Ryoji Kurita, Katsuyoshi Hayashi, Tsutomu Horiuchi, Keiichi Torimitsu, Kazutaka Maeyama and Katsuyuki Tanizawa, Continuous measurement of histamine from rat basophilic leukemia cells (RBL-2H3) with an on-line sensor using histamine oxidase, Sensors and Actuators B, 67, 43-51 (2000).

7. Zhiming Liu, Osamu Niwa, Ryoji Kurita and Tsutomu Horiuchi, Carbon film based interdigitated array microelectrode used in capillary electrophoresis with electrochemical detection, Analytical Chemistry, 72, 1315-1321 (2000).

6. Osamu Niwa, Ryoji Kurita, Zhiming Liu, Tsutomu Horiuchi and Keiichi Torimitsu, Subnanoliter volume wall-jet cells combined with interdigitated microarray electrode and enzyme modified planar microelectrode, Analytical Chemistry, 72, 949-955 (2000).

5. Zhiming Liu, Osamu Niwa, Tsutomu Horiuchi, Ryoji Kurita and Keiichi Torimitsu, NADH and glutamate on-line sensors using Os-gel-HRP/GC electrodes modified with NADH oxidase and glutamate dehydrogenase, Biosensors & Bioelectronics, 14, 631-638 (1999).

4. Osamu Niwa, Ryoji Kurita, Tsutomu Horiuchi and Keiichi Torimitsu, Continuous monitoring of l-glutamate released form cultured rat nerve cells with a microfabricated on-line sensor at a slow flow rate, Electroanalysis, 11, 356-361 (1999).

3. Osamu Niwa, Tsutomu Horiuchi, Ryoji Kurita, Hisao Tabei and Keiichi Torimitsu, Microfabricated on-line sensor for continuous monitoring of l-glutamate, Analytical Sciences, 14, 947-953 (1998).

2. Osamu Niwa, Tsutomu Horiuchi, Ryoji Kurita and Keiichi Torimitsu, On-line electrochemical sensor for selective continuous measurement of acetylcholine in cultured brain tissue, Analytical Chemistry, 70, 1126-1132 (1998).

1. Osamu Niwa, Ryoji Kurita, Tsutomu Horiuchi and Keiichi Torimitsu, Small volume on-line sensor for continuous measurement of γ-aminobutyric acid, Analytical Chemistry, 70, 89-93 (1998).


  		•

    主な著書・解説記事など

     

    • “先進化学センサ”、第１章、第５節　免疫センサチップ　（株）ティー・アイ・シィー
    • “マイクロマシン”、第１１章第２節　細胞間伝達物質、生体内分子のマイクロチップによる計測、江刺正喜監修、（株）産業技術サービスセンター
    • “バイオ電気化学の実際－バイオセンサ・バイオ電池の実用展開－”、第９章　超微小電極とバイオセンサ、池田篤治監修、（株）シーエムシー出版
    • 栗田僚二、産総研Ｔｏｄａｙ２００７年２月号、心疾患マーカー検出用マイクロセンシングチップ
    • 栗田僚二、丹羽修、化学とマイクロ・ナノシステム研究会誌、? ２００７年、6 巻? 1 号? 23 頁～? 27 頁、心疾患マーカーの迅速検出を目的とした、携帯型表面プラズモン共鳴装置用小型免疫センサチップの開発
    • 栗田僚二、丹羽修、ペプチドホルモンセンサー：血中の心疾患マーカー分子を指先サイズのチップで検出する、化学と教育、2007年、５５巻、９号、４５０－４５１
    • 栗田僚二、加藤大、丹羽修、“ワンチップ分析装置が実現するオーダーメイド医療”、2010年、精密工学会誌
    • 分析化学便覧（改訂六版）　5.4.7 バイオマーカー，2011年9月
    • バイオセンサの先端科学技術と新製品への応用開発、発　刊 ： ２０１４年４月３０日、技術情報協会
    • 次世代ヘルスケア機器の新製品開発、発刊　：　２０１４年５月３０日、技術情報協会

    特許（成立済みのもののみ掲載）

     

     
    • 微少量オンラインバイオセンサー及びその製造方法、特許第３４６１６９６号
    • オンラインバイオセンサー、特許第３４８０８８４号
    • 微少量フローセル及びその製造方法、特許第３４１９６９１号
    • 微少量オンラインバイオセンサー及びその製造方法、特許3515908号
    • 電気化学検出器、特許第３４６２４０１号
    • ヒスタミン計測用微小電極およびヒスタミン計測用センサ、特許第３４９９７６７号
    • ヒスタミンセンサ、特許3751480号
    • キャピラリー電気泳動用電気化学検出器及びその製造方法、特許3509064号
    • 電気化学オンライン型バイオセンサ、特許4015561号
    • オンラインカテコールアミンセンシングデバイス、特許第3902156号
    • 電気化学バイオセンサおよびその製造方法、特許4185423号
    • エンドトキシンの濃度測定方法およびエンドトキシンの濃度測定キット、特許4465452号
    • 表面プラズモン共鳴法による免疫測定、特許4487049号
    • 免疫センサ用デバイス、特許4517081号
    • 酵素免疫測定方法及びそのための酵素免疫センサ、特許4581128号
    • 過酸化水素の濃度測定法、特許4654411号
    • メチル化DNAの電気化学的定量方法、特許4817331号
    • ＤＮＡ及びＲＮＡ中の核酸塩基の電気化学的検出方法、特許4831429号
    • 電気化学発光を利用した免疫測定法及び該免疫測定法に使用される電気化学発光量測定用キット、特許4873492号
    • 非特異性吸着抑制材料、特許4911415
    • 免疫センサ、特許5311406号


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