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Di(2-ethylhexyl)phthalate
Risk Assessment Document
ABSTRACT
In Japan, di(2-ethylhexyl)phthalate (DEHP) is annually manufactured
in amount of about 200,000 ton and is predominantly used as
a plasticizer in flexible polyvinyl chloride (PVC) products.
In this study, risks to human health and aquatic organisms
caused by exposure to DEHP in Japan were evaluated. In the
exposure analysis phase, emissions from PVC products in-use
was quantified by analyzing life cycle of DEHP in various
products, in addition to emission of DEHP from manufacturing
and processing facilities.
Mathematical models were used to identify significant pathways
and contributions quantitatively from various sources to human
and aquatic organisms.
Furthermore, probabilistic approaches using available
monitoring data on DEHP in the environment and foodstuffs
were applied to evaluate current risk levels for human health
and aquatic organisms.
The results of human health risk assessment show that
the intake of DEHP for human is mainly due to orally ingestion
of foodstuffs containing DEHP. Infant and children are identified
as the high exposed subpopulation, but their risk levels to
testis and reproductive toxicities are not of concern.
The model simulation suggests that the major source contributing
human intake of DEHP are facilities producing PVC products
and agricultural PVC film for protection of vegetations against
cold and rain.
Results of ecological risk assessment show that risk levels
of DEHP to aquatic organisms including benthos are also not
of concern. The major source to the aquatic environment is
identified to be PVC products used in outdoor.
KEYWORDS
Di(2-ethylhexyl)phthalate, human risk, ecological risk
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Full text in English
[zip file, 6MB, 355pages long] 7.April.2008 |
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Executive summary
[PDF file, 650KB] 1.April.2005 |
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Di(2-ethylhexyl)phthalate (DEHP) Risk Assessment Document was produced
within the Comprehensive Chemical Substance Assessment and Management
Program funded by NEDO, the New Energy and Industrial Technology
Development Organization. The executive summary was translated from
Japanese by Japan Plasticizer Industry Association.
The full text of DEHP Risk Assessment Document (in Japanese only)
was published by MARUZEN Co., LTD. in 2005 January.
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