国際比較INTERNATIONAL COMPARISON

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国際度量衡局物質量諮問委員会(BIPM/CCQM)の下で各ワーキンググループが計画・実行する国際比較は、NMIJをはじめとした各国の国家計量標準機関(NMI)の校正・測定能力(CMC)を実証するための重要な場となっています。

私たちのグループでは、

  • 核酸分析ワーキンググループ(Nucleic Acid Analysis Working Group, NAWG)
  • タンパク質分析ワーキンググループ(Protein Analysis Working Group, PAWG)
  • 有機分析ワーキンググループ(Organic Analysis Working Group, OAWG)
  • 細胞分析ワーキンググループ(Cell Analysis Working Group, CAWG)

の4つのワーキンググループにおいて関連する国際比較に参加しています。
国際比較への参加を通して培った測定技術は、私たちの開発する認証標準物質に精確な値づけ(純度値や濃度値の決定)を行う上での重要な基盤技術となっています。

NAWG

Reference No. Description Coordinating
Laboratory
Start
date
CCQM-P54 DNA primary quantification LGC 2004
CCQM-P54.1 DNA quantification (repeat) LGC 2006
CCQM-P94 Quantitative Analysis of DNA Methylation KRISS 2006
CCQM-P94.1 Quantitative Analysis of DNA Methylation KRISS 2008
CCQM-P94.2 Quantitative Analysis of DNA Methylation KRISS 2012
CCQM-K86.b Relative quantification of Bt63 in GM rice matrix sample NIMC / GLHK 2015
CCQM-K86.c Relative quantification of genomic DNA fragments extracted from high oil matrix (OSR/canola) NRC/IRMM 2016
CCQM-P184 Copy number concentration and fractional abundance of a mutation (SNV or INDEL) mixed with WT DNA NMIA/LGC 2017
CCQM-P199 Copy number concentration of HIV-1 RNA genomic sequences LGC /(NIBSC) 2018
CCQM-P199.b Copy number concentration of SARS-CoV-2 RNA genomic sequences NML(LGC), NIMC, NIBSC, NIST 2020
CCQM-K181/P227 SARS-CoV-2 RNA copy number quantification LGC, NIMC, NIBSC, NIST 2022

PAWG

Reference No. Description Coordinating
Laboratory
Start
date
CCQM-P55 Peptide / protein quantification LGC 2004
CCQM-P58 Fluorescence in ELISA NPL/NIST 2004/2005
CCQM-P55.1 Peptide / protein quantification (repeat) LGC 2008
CCQM-K115 Peptide purity determination - synthetic human C peptide (HCP) BIPM/NIMC 2013
CCQM-K151 Determination of the amount content of a purity-assessed recombinant protein in an aqueous calibration solution KRISS 2017
CCQM-P164 Mass fracton of human growth hormone in serum PTB 2017
CCQM-K115.b Peptide purity - synthetic oxytocin (OXT) BIPM/NIMC 2018
CCQM-K115.c Peptide purity - synthetic glycated hexapeptide of HbA1c (GE) BIPM/NIMC/HSA 2019
CCQM-K115.2018 Peptide purity - synthetic hexapeptide of HbA0 (VE) BIPM/NIMC/HSA 2019
CCQM-P216 Quantification of SARS-CoV-2 monoclonal antibody in solution NIM, NRC and BIPM 2020

OAWG

Reference No. Description Coordinating
Laboratory
Start
date
CCQM-K11.1 Glucose in Serum (subsequent comparison) KRISS 2005
CCQM-P77.a Progesterone in Serum NIST 2006
CCQM-K63.a Non-Peptide Hormones in Serum: Cortisol NIST 2007-2008
CCQM-K63.b Non-Peptide Hormones in Serum: Progesterone NIST 2007-2008
CCQM-K11.2 Glucose in Serum (subsequent comparison) NIST 2012
CCQM-K12.2 Creatinine in Serum (subsequent comparison) NIST 2012
CCQM-K109 Urea and uric acid in serum HSA 2016
CCQM-K159 Mass fraction of leucine, phenylalanine in pooled frozen human plasma LGC 2019

CAWG

Reference No. Description Coordinating
Laboratory
Start
date
CCQM-P217 Quantification of fixed mononuclear cells in suspension NIBSC/NIST 2021
CCQM-P222 Particle number concentration measurement for cellular analysis NMIJ/PTB 2022