Regulation of Cancer's Immune Evasion Capabilities with Glycans
A research group led by Mr. Anh Dinh, a graduate student at the University of Tsukuba, and Dr. Hiroaki Tateno, in collaboration with Professor Tatsuya Oda and colleagues from the University of Tsukuba's Faculty of Medicine and Medical Sciences, has developed a novel method called the “GlycoChat method” to comprehensively explore glycan-lectin interactions within cancerous tumor tissues. Using this method, they elucidated at the glycan level the interaction between macrophages, which suppress the immune response to cancer cells, and pancreatic cancer cells.
Development of a Novel Screening Technology for Glycan-Based Immune Checkpoint Molecules
AIST press release
https://www.aist.go.jp/aist_j/press_release/pr2026/pr20260113/pr20260113.html
Publication
Title: GlycoChat Uncovers Glycan-Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
Authors: : Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno
Journal:Advanced Science