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HOME > Topics List > A novel antithrombogenic coating that overcomes challenges in endovascular treatment: Reducing the risk of thrombosis and the use of antiplatelet drugs

A novel antithrombogenic coating that overcomes challenges in endovascular treatment: Reducing the risk of thrombosis and the use of antiplatelet drugs

A research group led by Chief Senior Researcher, Yuji Teramura, in collaboration with Japan Medical Device Startup Incubation Program (JMPR) and N.B. Medical Co., Ltd. (N.B. Medical), developed a coating technology for stents used for intracranial aneurysm treatment, which had both antithrombogenicity and cell adhesive property. After various candidate molecules were tested for stent coating, 3-aminopropyltriethoxysilane was found to exhibit antithrombogenicity equal to or greater than that of conventional coating with antithrombogenic polymers. The safety of the coating was also assessed through large animal experiments using pigs. This antithrombogenicity reduces the risk of thrombotic complications, which have been a challenge in stent treatment, and the improved cell adhesion property can promote endothelialization of the stent, and accelerate the coverage with cells of blood vessel. Because of the shorter period for the treatment and the reduced dosage of antiplatelet drugs, there will be reduction of the burden on patients, that will contribute to medical cost cut.

Details of this technology are published online in Scientific Reports on July 10, 2024.

*For more details, please see the press release below.

research

Press release

Collaborators

  • Japan Medical Device Startup Incubation Program (JMPR)
  • N.B. Medical Co., Ltd. (N.B. Medical)

    • Publication

    • Title: Stent coating containing a charged silane coupling agent that regulates protein adsorption to confer antithrombotic and cell-adhesion properties
    • Naoki Inuzuka, Yasuhiro Shobayashi, Satoshi Tateshima, Yuya Sato, Yoshio Ohba, Kristina N. Ekdahl, Bo Nilsson, and Yuji Teramura.
    • Journal: Scientific Reports, 10th July, 2024
    • DOI: 10.1038/s41598-024-65832-5

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