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Discovery of a peptide that inhibits infection with new coronavirus

We have discovered a peptide that is capable of inhibiting infection with conventional and omicron strains of a novel coronavirus. The peptide recognizes and binds to N-glycans on the spike protein, causing them to aggregate and thereby inhibit infection. It is known that the sites on the spike protein where the glycans are attached are not easily mutated, indicating that this peptide is also highly resistant to mutation. Using this peptide as a starting point, we will contribute to the creation of inhibitors that can respond to new mutations that may occur in the future. Details of this technology were published in The FEBS Journal on August 25, 2022.


research

Press release

Publication

  • Title: Core fucose-specific Pholiota squarrosa lectin (PhoSL) as a potent broad-spectrum inhibitor of SARS-CoV-2 infection.
  • Authors: Yamasaki K, Adachi N, Ngwe Tun MM, Ikeda A, Moriya T, Kawasaki M, Yamasaki T, Kubota T, Nagashima I, Shimizu H, Tateno H, Morita K.
  • Journal: FEBS J. 2022 Aug 25.
  • DOI: 10.1111/febs.16599

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