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Development of a new method for decoding the viral genes.

Summary: In collaboration with the University of Tokyo, the research group of Shungo Adachi and Tohru Natsume developed a new technique to comprehensively identify viral proteins using mass spectrometry and successfully identified nine novel proteins from herpes simplex virus (HSV) in infected human cells. We also found that one of the newly discovered HSV proteins is a pathogenic factor that controls the onset of viral encephalitis among the pathological conditions caused by HSV. Deciphering the viral gene products, this new technique is applicable to various other virus researches, including those for new coronaviruses, such as covid-19. The details of this research were published online in the Nature Communications" on September 29, 2020(DOI number: 10.1038 / s41467-020-18718-9).

Development of a new method for decoding the viral genes.

Reference

Title:Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

Authors:Akihisa Kato*, Shungo Adachi*, Shuichi Kawano, Kousuke Takeshima, Mizuki Watanabe, Shinobu Kitazume, Ryota Sato, Hideo Kusano, Naoto Koyanagi, Yuhei Maruzuru, Jun Arii, Tomohisa Hatta, Tohru Natsume† & Yasushi Kawaguchi† (*: equal contribution, †: corresponding authors)

Journal: Nature Communications volume 11, Article number: 4894 (2020)

Doi: 10.1038/s41467-020-18718-9

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