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Structural finger print of therapeutic antibodies by a novel fully-non-invasive NMR strategy

In collaboration with the University of Tokyo and Chugai Pharmaceutical Co., Ltd., the research group of Yuji Tokunaga and Koh Takeuchi (Dynamic Pharmaco-modality Research Group) developed, a novel fully-non-invasive NMR strategy, N-CRINPT. N-CRINEPT presents a structural finger print of a therapeutic antibody at low storage temperature under various prescription solution conditions. The strategy can be utilized in various stages in the development of therapeutic antibodies. N-CRINEPT also pushes the limitation of NMR in applying to high molecular weight (> 100K) proteins, especially to those can only be expressed in mammalian or insect cell systems. The details are discussed in Journal of Medicinal Chemistry (doi: 10.1021/acs.jmedchem.0c00231), which is published in May, 2020.

Structural finger print of a therapeutic antibody was obtained in various prescription conditions at storage temperature by a novel fully-non-invasive NMR strategy.

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