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Ashwagandha and propolis are expected be the mother nature’s COVID-19 warriors

Renu WADHWA (Prime Senior Scientist) and Sunil KAUL (Senior Scientist) in collaboration with Durai SUNDAR (Professor), Indian Institute of Technology (IIT)-Delhi (under DAICENTER project supported by Department of Biotechnology (DBT), Govt. of India and AIST, Japan) tested the capability of natural compounds from Ashwagandha and propolis to inhibit viral replication and infection by molecular docking tools. They found that CAPE from propolis, and Withanone (but not Withaferin A) from Ashwagandha, an Ayurvedic herb may inhibit the SARS-CoV-2 main protease. Withanone is also predicted to block human cell surface receptor TMPRSS2, required for virus infection. The team described that Withanone is particularly enriched in Ashwagandha stem. Therefore, Ashwagandha and propolis although easily available and affordable globally, one needs to be conscious about the content of active ingredients for further testing in laboratory or clinic.

Natural compounds Withanone from Ashwagandha-an Ayurvedic herb, and CAPE from New Zealand propolis may inhibit viral main protease Mpro that is required for viral replication in host cells.

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