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Stem Cell Biotechnology Research Group


Project1:Research of adipose tissue for regenerative medicine
Researcher:Yasuyuki S. Kida, Nobuhito Mori, Yuzo Takayama

Our goal is establishing global informatic data and usages of adipose tissue. We are also challenging to develop stem cell technologies for regenerative medicine.

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Project2:In vitro reconstruction of inter-organ interactions using neural interface
Researcher:Yuzo Takayama

By connecting the peripheral nervous system (PNS) to organ, we have attempted to apply it to drug discovery assay systems. In addition, we are focusing on the development of induction methods for neurons in the autonomic nervous system.

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Project3:Fabrication of artificial tissues integrated with vascular channels
Researcher:MORI Nobuhito

We investigate a technique for fabricating large vascular channels and capillaries in artificial tissues by a tissue culture device. Our system enables supply of oxygen and nutrients to maintain large tissues and also drugs for toxicity and efficacy test.

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Project4:Development of non-invasive cell fractionation technology by confocal Raman spectroscopy
Researcher:Yuka Akagi

We develop non-invasive and high accurate cell fractionation technology by applying confocal Raman spectroscopy to living-tissue derived cell. This technology can lead the development of new drugs using processed cell.

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Project5:Medical seeds study of stromal shield features and roles related to escape immune surveillance
Researcher:Yasuyuki S. Kida, Yutaro Kumagai, Nobuhito Mori, Yuzo Takayama

we attempt to uncover pivotal mechanisms in the tumor environment and discover medical seeds that break through the important clinical characteristics.

Stem Cell Biotechnology Research Group6


Project6:Research on immunoinformatics
Researcher:Yutaro Kumagai

To reveal mechanism of immune system, which is involved in not only detecting foreign bodies such as pathogens, but also in cancer and metabolic diseases, we integrate experimental, information theoretical, and mathematical methods.

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Project7:Development of pressure driven microphyiological systems
Researcher:Shinji Sugiura, Toshiyuki Kanamori

We aim to develop pressure-driven microphysiological systems (PD-MPS) that can create and maintain high-level cell and organ functions as an alternative to animal experiments and a novel research tool in drug discovery.

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Name Position
KIDA Yasuyuki Research Group Leader
KANAMORI Toshiyuki Chief Senior Researcher
SUGIURA Shinji Chief Senior Researcher
TAKAYAMA Yuzo Senior Researcher
KUMAGAI Yutaro Senior Researcher
MORI Nobuhito Researcher
AKAGI Yuuka Researcher


  • Miyazaki Y, Oda T, Mori N, Kida YS
    Adipose-derived mesenchymal stem cells differentiate into pancreatic cancer-associated fibroblasts in vitro
    FEBS Open Bio. 2020 Sep 15. (2020) doi: 10.1002/2211-5463.12976
  • Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T
    Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device
    ROYAL SOCIETY OPEN SCIENCE 7 (7); (2020) doi: 10.1098/rsos.200027
  • Mori N, Kida YS
    Expression of genes involved in drug metabolism differs between perfusable 3D liver tissue and conventional 2D-cultured hepatocellular carcinoma cells
    FEBS Open Bio. 0 (2020) Aug 14. doi: 10.1002/2211-5463.12948
  • Maruyama K, Kidoya H, Takemura N, Sugisawa E, Takeuchi O, Kondo T, Eid MMA, Tanaka H, Martino MM, Takakura N, Takayama Y, Akira S, Vandenbon A, Kumagai Y
    Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages
    Cell Rep. 32: 107906 (2020) doi:10.1016/j.celrep.2020.107906
  • Sugisawa E, Takayama Y, Takemura N, Kondo T, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, Maruyama K
    RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis
    Cell. 8674: 30754-6 (2020) doi:10.1016/j.cell.2020.06.022
  • Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T
    Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device
    Royal Society Open Science 7 7: 0 (2020) doi:10.1098/rsos.200027
  • Watanabe U,Sugiura S, Kakehata M, Yanagawa F, Takagi T, Sumaru K, Satoh T, Tamura M, Hosokawa Y, Torizuka K, Kanamori T
    Fabrication of Hollow Structures in Photodegradable Hydrogels Using a Multi-Photon Excitation Process for Blood Vessel Tissue Engineering
    Micromachines 11: 0 (2020) doi:10.3390/mi11070679
  • Takayama Y, Kushige H, Akagi Y, Suzuki Y, Kumagai Y, Kida YS*
    Selective induction of Human Autonomic neurons enables precise control of cardiomyocyte Beating
    Sci Rep.10: 9464 (2020) doi:10.1038/s41598-020-66303-3
  • Mori N, Akagi Y, Imai Y, Takayama Y, Kida YS*
    Fabrication of Perfusable Vascular Channels and Capillaries in 3D Liver-like Tissue
    Sci Rep. 10: 5646 (2020) doi: 10.1038/s41598-020-62286-3
  • Baba T, Takagi T, Sumaru K, Kanamori T
    Effect of the fluorination degree of partially fluorinated octyl-phosphocholine surfactants on their interfacial properties and interactions with purple membrane as a membrane protein model
    Chemistry And Physics Lipids 227 0: 0 (2020) doi: 10.1016/j.chemphyslip.2020.104870
  • Marx U, Akabane T, Andersson TB, Baker E, Beilmann M, Beken S, Brendler-Schwaab S, Cirit M, David R, Dehne EM, Durieux I, Ewart L, Fitzpatrick SC, Frey O, Fuchs F, Griffith LG, Hamilton GA, Hartung T, Hoeng J, Hogberg H, Hughes DJ, Ingber DE, Iskandar A, Kanamori T, Kojima H, Kuehnl J, Leist M, Li B, Loskill P, Mendrick DL, Neumann T, Pallocca G, Rusyn I, Smirnova L, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tsyb S, Trapecar M, Van de Water B, Van den Eijnden-van Raaij J, Vulto P, Watanabe K, Wolf A, Zhou X, Roth A
    Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
    Altex. 12: 0 (2020) doi: 10.14573/altex.2001241
  • Arakawa H, Sugiura S, Kawanishi T, Shin K, Toyoda H, Satoh T, Sakai Y, Kanamori T, Kato Y
    Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system
    Lab Chip. 3: 25 (2020) doi: 10.1039/c9lc00884e
  • Komatsu H, Sakai K, Baba T, Takagi T, Kanamori T
    Aggregation behavior of short-chained archaeal phospholipid analogs: Contribution methyl branches to lipid hydrophobicity and membrane formability
    Colloid And Interface Science Communications 129: 3827-3832 (2019) doi: 10.1016/j.colcom.2019.100200
  • Hirama H, Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Kanamori T, Inoue T
    Glass-based organ-on-a-chip device for restricting small molecular absorption
    J Biosci Bioeng. 127: 641-646 (2019) doi: 10.1016/j.jbiosc.2018.10.019
  • Shimoaka T, Sonoyama M, Amii H, Takagi T, Kanamori T, Hasegawa T
    Raman Optical Activity on a Solid Sample: Identification of Atropisomers of Perfluoroalkyl Chains Having a Helical Conformation and No Chiral Center
    J. Physical Chemistry A 123: 3985-3991 (2019) doi: 10.1021/acs.jpca.8b11613
  • Ishida S, Kanamori T
    Microphysiological system as a promising technology for drug assay
    Nihon Yakurigaku Zasshi. 154: 345-351 (2019) doi: 10.1254/fpj.154.345
  • Kise R, Fukumi A, Shioya N, Shimoaka T, Sonoyama M, Amii H, , Takagi T, Kanamori T, Eda K, Hasegawa T
    Fluorous Property of a Short Perfluoroalkyl-Containing Compound Realized by Self-Assembled Monolayer Technique on a Silicon Substrate
    Bulletin The Chemical Society Japan 92: 785-789 (2019) doi: 10.1246/bcsj.20180356
  • Tsukamoto T, Sogo T, Ueyama T, Nakao S, Harada Y, Ihara D, Akagi, Y, Kida YS, Hasegawa K, Nagamune T, Kawahara M*, Kawamura T*
    Chimeric G-CSF Receptor-Mediated STAT3 Activation Contributes to Efficient Induction of Cardiomyocytes from Mouse Induced Pluripotent Stem Cells
    Biotechnology J. 93: 10 (2019) doi: 10.1002/biot.201900052
  • Takahashi H, Yoshino M, Morita K, Takagi T, Yokoyama Y, Kikukawa T, Amii H, Kanamori T, Sonoyama M
    Stability of the two-dimensional lattice of bacteriorhodopsin reconstituted in partially fluorinated phosphatidylcholine bilayers
    Biochim Biophys Acta Biomembr. 1861: 631-642 (2019) doi: 10.1016/j.bbamem.2018.12.015
  • Hayashi Y, Matsumoto J, Kumagai S, Morishita K, Xiang L, Kobori Y, Hori S, Suzuki M, Kanamori T, Hotta K, Sumaru K
    Automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer
    Commun Biol. 1: 218 (2018) doi: 10.1038/s42003-018-0222-4
  • Shibuta M, Tamura M, Kanie K, Yanagisawa M, Matsui H, Satoh T, , Takagi T, Kanamori T, Sugiura S, Kato R
    Imaging cell picker: A morphology-based automated cell separation system on a photodegradable hydrogel culture platform
    J. Bioscience And Bioengineering 126: 653-660 (2018) doi: 10.1016/j.jbiosc.2018.05.004
  • Mori N, Morimoto Y, Takeuchi S*
    Perfusable and stretchable 3D culture system for skin-equivalent
    Biofabrication. 11: 011001 (2018) doi: 10.1088/1758-5090/aaed12
  • Vandenbon A#, Kumagai Y#, Lin M, Suzuki Y, Nakai K*
    Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation
    Genome Biol. 19: 138 (2018) doi: 10.1186/s13059-018-1524-z
  • Tashiro S, Le MNT, Kusama Y, Nakatani E, Suga M, Furue MK, Satoh T, Sugiura S, Kanamori T, Ohnuma K
    High cell density suppresses BMP4-induced differentiation of human pluripotent stem cells to produce macroscopic spatial patterning in a unidirectional perfusion culture chamber
    J Biosci Bioeng. 126: 379-388 (2018) doi: 10.1016/j.jbiosc.2018.03.007
  • Maruyama K*, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M*
    The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception
    iScience. 0: 0 (2018) doi: 10.1016/j.isci.2018.08.007
  • Wagatsuma A*, Takayama Y, Hoshino T, Shiozuka M, Yamada S, Matsuda R, Mabuchi K
    Pharmacological targeting of HSP90 with 17-AAG induces apoptosis of myogenic cells through activation of the intrinsic pathway
    Mol Cell Biochem. 163: 170-182 (2018) doi: 10.1007/s11010-017-3250-3
  • Sumaru K, Takagi T, Morishita K, Satoh T, Kanamori T
    Fabrication of pocket-like hydrogel microstructures through photolithography
    St Matter 14: 5710-5714 (2018) doi: 10.1039/c8sm00865e
  • Sumaru K, Takagi T, Morishita K, Kanamori T
    Photoresponsive Aqueous Dissolution of Poly( N-Isopropylacrylamide) Functionalized with o-Nitrobenzaldehyde through Phase Transition
    Biomacromolecules. 19: 2913-2922 (2018) doi: 10.1021/acs.biomac.8b00470
  • Hayashi Y, Matsumoto J, Kumagai S, Morishita K, Xiang L, Kobori Y, Hori S, Suzuki M, Kanamori T, Hotta K, Sumaru K
    Automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer
    Commun Biol. 0: 0 (2018) doi: 10.1038/s42003-018-0222-4
  • Kanamori T, Sugiura S, Sakai Y
    Technical aspects of microphysiological systems (MPS) as a promising wet human-in-vivo simulator
    Drug Metab Pharmacokinet. 33: 40-42 (2018) doi: 10.1016/j.dmpk.2017.11.006
  • Sumaru K, Takagi T, Satoh T, Kanamori T
    Photo- and Thermoresponsive Dehydration of Spiropyran-Functionalized Polymer Regulated by Molecular Recognition
    Macromol Rapid Commun. 39: 0 (2018) doi: 10.1002/marc.201700234
  • Ito N, Katoh K, Kushige H, Saito Y, Umemoto T, Matsuzaki Y, Kiyonari H, Kobayashi D, Soga M, Era T, Araki N, Furuta Y, Suda T, Kida Y, Ohta K*
    Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency
    Sci Rep. 8: 1634 (2018) doi: 10.1038/s41598-018-20057-1
  • Ueyama T, Nakao S, Tsukamoto T, Ihara D, Harada Y, Akagi Y, Nakagawa S, Kida YS, Sogo T and Kawamura T*
    PTEN/Akt Axis is Involved in Somatic Cell Reprogramming to Mouse iPS Cells
    Biomed J Sci & Tech. Res. 11: 5 (2018) DOI: 10.26717/BJSTR.2018.11.002162
  • Shimoaka T, Sonoyama M, Amii H, Takagi T, Kanamori T, Hasegawa T
    Study of Perfluoroalkyl Chain-Specific Band Shift in Infrared Spectra on the Chain Length
    J. Physical Chemistry A 121: 8425-8431 (2017) doi: 10.1021/acs.jpca.7b08940
  • Kondo Y, Hattori K, Tashiro S, Nakatani E, Yoshimitsu R, Satoh T, Sugiura S, Kanamori T, Ohnuma K
    Compartmentalized microfluidic perfusion system to culture human induced pluripotent stem cell aggregates
    J Biosci Bioeng. 124: 234-241 (2017) doi: 10.1016/j.jbiosc.2017.03.014
  • Sumaru K, Morishita K, Takagi T, Satoh T, Kanamori T
    Sectioning of cultured cell monolayer using photo-acid-generating substrate and micro-patterned light projection
    European Polymer J. 121: 16964-16969 (2017) doi: 10.1016/j.eurpolymj.2017.02.021
  • Watanabe Y, Miyasaka KY, Kubo A, Kida YS, Nakagawa O, Hirate Y, Sasaki H, Ogura T*
    Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm
    Sci Rep. 0: 0 (2017) doi: 10.1038/srep46135
  • Kondo Y, Yada Y, Haga T, Takayama Y, Isomura T, Jimbo Y, Fukayama O, Hoshino T*, Mabuchi K
    Temporal relation between neural activity and neurite pruning on a numerical model and a microchannel device with micro electrode array
    Biochem Biophys Res Commun. 486: 539-544 (2017) doi: 10.1016/j.bbrc.2017.03.082
  • Tamura M, Sugiura S, Takagi T, Satoh T, Sumaru K, Kanamori T, Okada T, Matsui H
    Morphology-based optical separation of subpopulations from a heterogeneous murine breast cancer cell line
    PloS One. 12: 0 (2017) doi: 10.1371/journal.pone.0179372
  • Takayama Y#, Wakabayashi T#, Kushige H, Saito Y, Shibuya Y, Shibata S, Akamatsu W, Okano H, Kida YS*
    Brief Exposure to Small Molecules Allows Induction of Mouse Embryonic Fibroblasts Into Neural Crest-Like Precursors
    FEBS Lett. 591: 590-602 (2017) doi: 10.1002/1873-3468.12572
  • Satoh T#, Sugiura S#*, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T
    A Multi-Throughput Multi-Organ-On-A-Chip System on a Plate Formatted Pneumatic Pressure-Driven Medium Circulation Platform
    Lab Chip. 18:115-125 (2017) doi: 10.1039/c7lc00952f
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