MENU
- Group Introduction
- Molecular and Cellular Glycoproteomics Research Group
- Applied Molecular Function Research Group
- Stem Cell Biotechnology Research Group
- Multicellular System Regulation Research Group
- Healthy Food Science Research Group
- Leading-edge Biotechnology Research Group
- Biological Data Science Research Group
- Dynamic Pharmaco-Modality Research Group
- AIST-INDIA Diverse Assets & Applications International Laboratory
Stem Cell Biotechnology Research Group
Project
Project1:Research of adipose tissue for regenerative medicine
Researcher:Yasuyuki S. Kida, Nobuhito Mori, Yuzo Takayama
Our goal is establishing global informatic data and usages of adipose tissue. We are also challenging to develop stem cell technologies for regenerative medicine.

Project
Project2:In vitro reconstruction of inter-organ interactions using neural interface
Researcher:Yuzo Takayama
By connecting the peripheral nervous system (PNS) to organ, we have attempted to apply it to drug discovery assay systems. In addition, we are focusing on the development of induction methods for neurons in the autonomic nervous system.

Project
Project3:Fabrication of artificial tissues integrated with vascular channels
Researcher:MORI Nobuhito
We investigate a technique for fabricating large vascular channels and capillaries in artificial tissues by a tissue culture device. Our system enables supply of oxygen and nutrients to maintain large tissues and also drugs for toxicity and efficacy test.

Project
Project4:Development of non-invasive cell fractionation technology by confocal Raman spectroscopy
Researcher:Yuka Akagi
We develop non-invasive and high accurate cell fractionation technology by applying confocal Raman spectroscopy to living-tissue derived cell. This technology can lead the development of new drugs using processed cell.

Project
Project5:Medical seeds study of stromal shield features and roles related to escape immune surveillance
Researcher:Yasuyuki S. Kida, Yutaro Kumagai, Nobuhito Mori, Yuzo Takayama
we attempt to uncover pivotal mechanisms in the tumor environment and discover medical seeds that break through the important clinical characteristics.

Project
Project6:Research on immunoinformatics
Researcher:Yutaro Kumagai
To reveal mechanism of immune system, which is involved in not only detecting foreign bodies such as pathogens, but also in cancer and metabolic diseases, we integrate experimental, information theoretical, and mathematical methods.

Project
Project7:Development of pressure driven microphyiological systems
Researcher:Shinji Sugiura, Toshiyuki Kanamori
We aim to develop pressure-driven microphysiological systems (PD-MPS) that can create and maintain high-level cell and organ functions as an alternative to animal experiments and a novel research tool in drug discovery.

Member
Name | Position |
---|---|
KIDA Yasuyuki | Research Group Leader |
KANAMORI Toshiyuki | Chief Senior Researcher |
SUGIURA Shinji | Chief Senior Researcher |
TAKAYAMA Yuzo | Senior Researcher |
KUMAGAI Yutaro | Senior Researcher |
MORI Nobuhito | Researcher |
AKAGI Yuuka | Researcher |
Results
- Baba T, Takagi T, Sumaru K, Kanamori T, Dewa T, Nango M
Membrane properties of ether-type phosphatidylcholine bearing partially fluorinated C(18)-monoacetylenic chains and their applicability to membrane protein reconstitution matrices
Colloids Surf B Biointerfaces. 2020 Nov 13:111459. doi: 10.1016/j.colsurfb.2020.111459 - Figarol A, Piantino M, Furihata T, Satoh T, Sugiura S, Kanamori T, Matsusaki M
Interstitial flow regulates in vitro three-dimensional self-organized brain micro-vessels
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533 (3) 600-606; (2020) doi:10.1016/j.bbrc.2020.09.061 DEC 10 - Takayama Y, Akagi Y, Shibuya Y, Kida YS
Exposure to small molecule cocktails allows induction of neural crest lineage cells from human adipose-derived mesenchymal stem cells
PLoS One. ;15(10):e0241125. (2020)doi: 10.1371/journal.pone.0241125 - Miyazaki Y, Oda T, Mori N, Kida YS
Adipose-derived mesenchymal stem cells differentiate into pancreatic cancer-associated fibroblasts in vitro
FEBS Open Bio. 2020 Sep 15. (2020) doi: 10.1002/2211-5463.12976 - Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T
Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device
ROYAL SOCIETY OPEN SCIENCE 7 (7); (2020) doi: 10.1098/rsos.200027 - Mori N, Kida YS
Expression of genes involved in drug metabolism differs between perfusable 3D liver tissue and conventional 2D-cultured hepatocellular carcinoma cells
FEBS Open Bio. 0 (2020) Aug 14. doi: 10.1002/2211-5463.12948 - Maruyama K, Kidoya H, Takemura N, Sugisawa E, Takeuchi O, Kondo T, Eid MMA, Tanaka H, Martino MM, Takakura N, Takayama Y, Akira S, Vandenbon A, Kumagai Y
Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages
Cell Rep. 32: 107906 (2020) doi:10.1016/j.celrep.2020.107906 - Sugisawa E, Takayama Y, Takemura N, Kondo T, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, Maruyama K
RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis
Cell. 8674: 30754-6 (2020) doi:10.1016/j.cell.2020.06.022 - Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T
Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device
Royal Society Open Science 7 7: 0 (2020) doi:10.1098/rsos.200027 - Watanabe U,Sugiura S, Kakehata M, Yanagawa F, Takagi T, Sumaru K, Satoh T, Tamura M, Hosokawa Y, Torizuka K, Kanamori T
Fabrication of Hollow Structures in Photodegradable Hydrogels Using a Multi-Photon Excitation Process for Blood Vessel Tissue Engineering
Micromachines 11: 0 (2020) doi:10.3390/mi11070679 - Takayama Y, Kushige H, Akagi Y, Suzuki Y, Kumagai Y, Kida YS*
Selective induction of Human Autonomic neurons enables precise control of cardiomyocyte Beating
Sci Rep.10: 9464 (2020) doi:10.1038/s41598-020-66303-3 - Mori N, Akagi Y, Imai Y, Takayama Y, Kida YS*
Fabrication of Perfusable Vascular Channels and Capillaries in 3D Liver-like Tissue
Sci Rep. 10: 5646 (2020) doi: 10.1038/s41598-020-62286-3 - Baba T, Takagi T, Sumaru K, Kanamori T
Effect of the fluorination degree of partially fluorinated octyl-phosphocholine surfactants on their interfacial properties and interactions with purple membrane as a membrane protein model
Chemistry And Physics Lipids 227 0: 0 (2020) doi: 10.1016/j.chemphyslip.2020.104870 - Marx U, Akabane T, Andersson TB, Baker E, Beilmann M, Beken S, Brendler-Schwaab S, Cirit M, David R, Dehne EM, Durieux I, Ewart L, Fitzpatrick SC, Frey O, Fuchs F, Griffith LG, Hamilton GA, Hartung T, Hoeng J, Hogberg H, Hughes DJ, Ingber DE, Iskandar A, Kanamori T, Kojima H, Kuehnl J, Leist M, Li B, Loskill P, Mendrick DL, Neumann T, Pallocca G, Rusyn I, Smirnova L, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tsyb S, Trapecar M, Van de Water B, Van den Eijnden-van Raaij J, Vulto P, Watanabe K, Wolf A, Zhou X, Roth A
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
Altex. 12: 0 (2020) doi: 10.14573/altex.2001241 - Arakawa H, Sugiura S, Kawanishi T, Shin K, Toyoda H, Satoh T, Sakai Y, Kanamori T, Kato Y
Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system
Lab Chip. 3: 25 (2020) doi: 10.1039/c9lc00884e - Komatsu H, Sakai K, Baba T, Takagi T, Kanamori T
Aggregation behavior of short-chained archaeal phospholipid analogs: Contribution methyl branches to lipid hydrophobicity and membrane formability
Colloid And Interface Science Communications 129: 3827-3832 (2019) doi: 10.1016/j.colcom.2019.100200 - Hirama H, Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Kanamori T, Inoue T
Glass-based organ-on-a-chip device for restricting small molecular absorption
J Biosci Bioeng. 127: 641-646 (2019) doi: 10.1016/j.jbiosc.2018.10.019 - Shimoaka T, Sonoyama M, Amii H, Takagi T, Kanamori T, Hasegawa T
Raman Optical Activity on a Solid Sample: Identification of Atropisomers of Perfluoroalkyl Chains Having a Helical Conformation and No Chiral Center
J. Physical Chemistry A 123: 3985-3991 (2019) doi: 10.1021/acs.jpca.8b11613 - Ishida S, Kanamori T
Microphysiological system as a promising technology for drug assay
Nihon Yakurigaku Zasshi. 154: 345-351 (2019) doi: 10.1254/fpj.154.345 - Kise R, Fukumi A, Shioya N, Shimoaka T, Sonoyama M, Amii H, , Takagi T, Kanamori T, Eda K, Hasegawa T
Fluorous Property of a Short Perfluoroalkyl-Containing Compound Realized by Self-Assembled Monolayer Technique on a Silicon Substrate
Bulletin The Chemical Society Japan 92: 785-789 (2019) doi: 10.1246/bcsj.20180356 - Tsukamoto T, Sogo T, Ueyama T, Nakao S, Harada Y, Ihara D, Akagi, Y, Kida YS, Hasegawa K, Nagamune T, Kawahara M*, Kawamura T*
Chimeric G-CSF Receptor-Mediated STAT3 Activation Contributes to Efficient Induction of Cardiomyocytes from Mouse Induced Pluripotent Stem Cells
Biotechnology J. 93: 10 (2019) doi: 10.1002/biot.201900052 - Takahashi H, Yoshino M, Morita K, Takagi T, Yokoyama Y, Kikukawa T, Amii H, Kanamori T, Sonoyama M
Stability of the two-dimensional lattice of bacteriorhodopsin reconstituted in partially fluorinated phosphatidylcholine bilayers
Biochim Biophys Acta Biomembr. 1861: 631-642 (2019) doi: 10.1016/j.bbamem.2018.12.015 - Hayashi Y, Matsumoto J, Kumagai S, Morishita K, Xiang L, Kobori Y, Hori S, Suzuki M, Kanamori T, Hotta K, Sumaru K
Automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer
Commun Biol. 1: 218 (2018) doi: 10.1038/s42003-018-0222-4 - Shibuta M, Tamura M, Kanie K, Yanagisawa M, Matsui H, Satoh T, , Takagi T, Kanamori T, Sugiura S, Kato R
Imaging cell picker: A morphology-based automated cell separation system on a photodegradable hydrogel culture platform
J. Bioscience And Bioengineering 126: 653-660 (2018) doi: 10.1016/j.jbiosc.2018.05.004 - Mori N, Morimoto Y, Takeuchi S*
Perfusable and stretchable 3D culture system for skin-equivalent
Biofabrication. 11: 011001 (2018) doi: 10.1088/1758-5090/aaed12 - Vandenbon A#, Kumagai Y#, Lin M, Suzuki Y, Nakai K*
Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation
Genome Biol. 19: 138 (2018) doi: 10.1186/s13059-018-1524-z - Tashiro S, Le MNT, Kusama Y, Nakatani E, Suga M, Furue MK, Satoh T, Sugiura S, Kanamori T, Ohnuma K
High cell density suppresses BMP4-induced differentiation of human pluripotent stem cells to produce macroscopic spatial patterning in a unidirectional perfusion culture chamber
J Biosci Bioeng. 126: 379-388 (2018) doi: 10.1016/j.jbiosc.2018.03.007 - Maruyama K*, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M*
The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception
iScience. 0: 0 (2018) doi: 10.1016/j.isci.2018.08.007 - Wagatsuma A*, Takayama Y, Hoshino T, Shiozuka M, Yamada S, Matsuda R, Mabuchi K
Pharmacological targeting of HSP90 with 17-AAG induces apoptosis of myogenic cells through activation of the intrinsic pathway
Mol Cell Biochem. 163: 170-182 (2018) doi: 10.1007/s11010-017-3250-3 - Sumaru K, Takagi T, Morishita K, Satoh T, Kanamori T
Fabrication of pocket-like hydrogel microstructures through photolithography
St Matter 14: 5710-5714 (2018) doi: 10.1039/c8sm00865e - Sumaru K, Takagi T, Morishita K, Kanamori T
Photoresponsive Aqueous Dissolution of Poly( N-Isopropylacrylamide) Functionalized with o-Nitrobenzaldehyde through Phase Transition
Biomacromolecules. 19: 2913-2922 (2018) doi: 10.1021/acs.biomac.8b00470 - Hayashi Y, Matsumoto J, Kumagai S, Morishita K, Xiang L, Kobori Y, Hori S, Suzuki M, Kanamori T, Hotta K, Sumaru K
Automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer
Commun Biol. 0: 0 (2018) doi: 10.1038/s42003-018-0222-4 - Kanamori T, Sugiura S, Sakai Y
Technical aspects of microphysiological systems (MPS) as a promising wet human-in-vivo simulator
Drug Metab Pharmacokinet. 33: 40-42 (2018) doi: 10.1016/j.dmpk.2017.11.006 - Sumaru K, Takagi T, Satoh T, Kanamori T
Photo- and Thermoresponsive Dehydration of Spiropyran-Functionalized Polymer Regulated by Molecular Recognition
Macromol Rapid Commun. 39: 0 (2018) doi: 10.1002/marc.201700234 - Ito N, Katoh K, Kushige H, Saito Y, Umemoto T, Matsuzaki Y, Kiyonari H, Kobayashi D, Soga M, Era T, Araki N, Furuta Y, Suda T, Kida Y, Ohta K*
Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency
Sci Rep. 8: 1634 (2018) doi: 10.1038/s41598-018-20057-1 - Ueyama T, Nakao S, Tsukamoto T, Ihara D, Harada Y, Akagi Y, Nakagawa S, Kida YS, Sogo T and Kawamura T*
PTEN/Akt Axis is Involved in Somatic Cell Reprogramming to Mouse iPS Cells
Biomed J Sci & Tech. Res. 11: 5 (2018) DOI: 10.26717/BJSTR.2018.11.002162 - Shimoaka T, Sonoyama M, Amii H, Takagi T, Kanamori T, Hasegawa T
Study of Perfluoroalkyl Chain-Specific Band Shift in Infrared Spectra on the Chain Length
J. Physical Chemistry A 121: 8425-8431 (2017) doi: 10.1021/acs.jpca.7b08940 - Kondo Y, Hattori K, Tashiro S, Nakatani E, Yoshimitsu R, Satoh T, Sugiura S, Kanamori T, Ohnuma K
Compartmentalized microfluidic perfusion system to culture human induced pluripotent stem cell aggregates
J Biosci Bioeng. 124: 234-241 (2017) doi: 10.1016/j.jbiosc.2017.03.014 - Sumaru K, Morishita K, Takagi T, Satoh T, Kanamori T
Sectioning of cultured cell monolayer using photo-acid-generating substrate and micro-patterned light projection
European Polymer J. 121: 16964-16969 (2017) doi: 10.1016/j.eurpolymj.2017.02.021 - Watanabe Y, Miyasaka KY, Kubo A, Kida YS, Nakagawa O, Hirate Y, Sasaki H, Ogura T*
Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm
Sci Rep. 0: 0 (2017) doi: 10.1038/srep46135 - Kondo Y, Yada Y, Haga T, Takayama Y, Isomura T, Jimbo Y, Fukayama O, Hoshino T*, Mabuchi K
Temporal relation between neural activity and neurite pruning on a numerical model and a microchannel device with micro electrode array
Biochem Biophys Res Commun. 486: 539-544 (2017) doi: 10.1016/j.bbrc.2017.03.082 - Tamura M, Sugiura S, Takagi T, Satoh T, Sumaru K, Kanamori T, Okada T, Matsui H
Morphology-based optical separation of subpopulations from a heterogeneous murine breast cancer cell line
PloS One. 12: 0 (2017) doi: 10.1371/journal.pone.0179372 - Takayama Y#, Wakabayashi T#, Kushige H, Saito Y, Shibuya Y, Shibata S, Akamatsu W, Okano H, Kida YS*
Brief Exposure to Small Molecules Allows Induction of Mouse Embryonic Fibroblasts Into Neural Crest-Like Precursors
FEBS Lett. 591: 590-602 (2017) doi: 10.1002/1873-3468.12572 - Satoh T#, Sugiura S#*, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T
A Multi-Throughput Multi-Organ-On-A-Chip System on a Plate Formatted Pneumatic Pressure-Driven Medium Circulation Platform
Lab Chip. 18:115-125 (2017) doi: 10.1039/c7lc00952f