In order to ensure the accurate determination of purity or concentration of various biological reference substances, we are developing analytical methods those are traceable to the the International System of Units (SI).
To improve the sensitivity and selectivity of analytical methods and create a high level of accurate and robust analytical methods, we are keeping in mind some points; trying to develop the methods based on the instrumental analysis such as LC/MS and GC/MS, and to use various pretreatment operations such as simple purification and derivatization, etc.
Research topics
Small molecule
- Development of pretreatment technology
- Qualitative analysis of impurities using precision mass
- Development of D-amino acid analysis technology
Nucleic acid
- Development of reference material for nucleic acid
- Development of high-efficiency spray technology
- Development of nucleic acid analysis / quantification method by HPLC and LC / MS
- Development of accurate nucleic acid quantification method based on PCR
Peptide and Protein
- Post-translational modification analysis by mass spectrometry
- Development of high-precision quantification method for proteins
- Development of higher-order structural analysis for proteins and protein complexes using mass spectrometry
- Structural analysis of peptides and proteins in the gas phase by computational chemistry