氏名：川崎　一　KAWASAKI Hajime （医学博士）

研究概要：

１．化学物質の有害性発現メカニズムの解析
２．動物試験データからヒト健康影響を推定する際の不確実性の解析
３．代替試験法の有用性に関する研究

キーワード：

有害性評価，免疫毒性，代替試験法

研究業績リスト：

1. Effect of rodent diets on the sexual development of the rat. J. Odum, H. Tinwell, K. Jones, J.P. Van Miller, R.L. Joiner, G. Tobin, H. Kawasaki, R. Deghenghi, and J. Ashby, Toxicological Sciences 61: 115 – 127 (2001)

2. High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosoamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele. K. Ozaki, T. Sukata, S. Yamamoto, S. Uwagawa, T. Seki, H, Kawasaki, A. Yoshitake, H. Wanibuchi, A. Koide, and S. Fukushima, Cancer Research 58: 3806 - 3811 (1998)

3. Immunotoxicological Insignificance of Fenitrothion in Mice and Rats. T. Kunimatsu, Y. Kamita, N. Isobe, and H. Kawasaki, Fundamental and Applied Toxicology 33: 246 - 253 (1996)

4. Mechanism of prolongation of pentobarbital-induced sleeping time by empenthrin in mice. R. Tsuji, N. Isobe and H. Kawasaki, Toxicology 108: 185 - 190 (1996)

5. Lack of induction of epithelial cell proliferation by sodium saccharin and sodium L-ascorbate in the urinary bladder of NCI-Black-Reiter (NBR) rats. S. Uwagawa, K. Saito, Y. Okuno, H. Kawasaki, A.Yoshitake, H.Yamada, and S.Fukushima, Toxicology and Applied Pharmacology 127, 182 - 186 (1994)

6. Risk assessment of houshold insecticides in man. J. Miyamoto and H. Kawasaki, (International Pesticides Conference, Pesticides in Perspective, 28-29 April 1992, Kuala Lumpur, Malaysia)

7. Analysis of endotoxin fever in rabbits by using a monoclonal anti-body to tumor necrosis factor (Cachectin). H. Kawasaki, M. Moriyama, Y. Ohtani, M. Naitoh, A. Tanaka and H. Nariuchi Infection and Immunity 57: 3131 - 3135 (1989)