細胞光シグナル研究グループ 業績リスト

論文

(2018)
  1. Tabei Y, Sugino S, Nakajima Y, Horie M,
    Reactive oxygen species independent genotoxicity of indium tin oxide nanoparticles triggered by intracellular degradation.
    Food Chem. Toxicol., in press.
  2. Uno K, Murotomi K, Kazuki Y, Oshimura M, Nakajima Y,
    Bioluminescence-based cytotoxicity assay for simultaneous evaluation of cell viability and membrane damage in human hepatoma HepG2 cells.
    Luminescence, 33, 616-624 (2018).
  3. Sato D, Abe S, Kobayashi K, Nakajima Y, Oshimura M, Kazuki Y,
    Human and mouse artificial chromosome technologies for studies of pharmacokinetics and toxicokinetics.
    Drug Metab. Pharmacokinet., 33, 17-30 (2018).
  4. Abe H, Ishioka M, Fujita Y, Umeno A, Yasunaga M, Sato A, Ohnishi S, Suzuki S, Ishida N, Shichiri M, Yoshida Y, Nakajima Y,
    Yuzu (Citrus junos Tanaka) peel attenuates dextran sulfate sodium-induced murine experimental colitis.
    J. Oleo Sci., 67, 335-344 (2018).
  5. Mie Y, Hirano Y, Kowata K, Nakamura A, Yasunaga M, Nakajima Y, Komatsu Y,
    Function control of anti-microRNA oligonucleotides using interstrand cross-linked duplexes.
    Mol. Ther. Nucleic Acids, 10, 64-74 (2018).
(2017)
  1. Wakuri S, Yamakage K, Kazuki K, Kazuki M, Oshimura M, Abutani S, Yasunaga M, Nakajima Y,
    Correlation between luminescence intensity and cytotoxicity in cell-based cytotoxicity assay using luciferase.
    Anal. Biochem., 522, 18-29 (2017).
  2. Yasunaga M, Fujita Y, Saito R, Oshimura M, Nakajima Y,
    Continuous long-term cytotoxicity monitoring in 3D spheroids of beetle luciferase-expressing hepatocytes by nondestructive bioluminescence measurement.
    BMC Biotechnol., 17, 54 (2017).
  3. Ono D, Honma S, Nakajima Y, Kuroda, S, Enoki R, Honma K,
    Dissociation of Per1 and Bmal1 circadian rhythms in the suprachiasmatic nucleus in parallel with behavioral outputs.
    Proc. Natl. Acad. Sci. USA, 114, E3699-E3708 (2017).
  4. Tabei Y, Murotomi K, Umeno A, Horie M, Tsujino Y, Masutani B, Yoshida Y, Nakajima Y,
    Antioxidant properties of 5-hydroxy-4-phenyl-butenolide via activation of Nrf2/ARE signaling pathway.
    Food Chem. Toxicol., 107, 129-137 (2017).
  5. Tarnow P, Bross S, Wollenberg L, Nakajima Y, Ohmiya Y, Tralau T, Luch A,
    A novel dual-colour luciferase reporter assay for simultaneous detection of estrogen and aryl hydrocarbon receptor activation.
    Chem. Res. Toxicol., 30, 1436-1447 (2017).
  6. Futami M, Nakano T, Yasunaga M, Makihara M, Asama T, Hagihara Y, Nakajima Y, Futami J,
    Enhanced in-cell folding of reversibly cationized transcription factor using amphipathic peptide.
    J. Biosci. Bioeng., 123, 419-424 (2017).
  7. Tabei Y, Sugino S, Eguchi K, Tajika M, Abe H, Nakajima Y, Horie M,
    Effect of calcium carbonate particles shape on phagocytosis and pro-inflammatory response in differentiated THP-1 macrophages.
    Biochem. Biophys. Res. Commun., 490, 499-505 (2017).
  8. Horie M, Miura T, Hirakata S, Hosoyama A, Sugino S, Umeno A, Murotomi K, Yoshida Y, Koike T,
    Comparative analysis of the intestinal flora in type 2 diabetes and nondiabetic mice.
    Exp. Anim., 66, 405-416 (2017).
(2016)
  1. Abe H, Tomimoton K, Fujita Y, Chiba Y, Nakayama K, and Nakajima Y,
    Development of N- and O-linked oligosaccharide engineered S. cerevisiae strain.
    Glycobiology, 26, 1248–1256 (2016).
  2. Murotomi K, Arai S, Uchida S, Endo S, Mitsuzumi H, Tabei Y, Yoshida Y, Nakajima Y, 
    Involvement of splenic iron accumulation in the development of nonalcoholic steatohepatitis in Tsumura Suzuki Obese Diabetes mice.
    Sci. Rep., 6, 22476 (2016).
  3. Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M,
    Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage.
    J. Biochem., 159, 225-237 (2016).
(2015)
  1. Yasunaga M, Murotomi K, Abe H, Yamazaki T, Nishii S, Ohbayashi T, Oshimura M, Noguchi T, Niwa K, Ohmiya Y, Nakajima Y,
    Highly sensitive luciferase reporter assay using a potent destabilization sequence of calpain 3.
    J. Biotechnol., 194, 115-23 (2015).
  2. Kimura Y, Fujimura C, Ito Y, Takahashi T, Nakajima Y, Ohmiya Y, Aiba S,
    Optimization of the IL-8 Luc assay as an in vitro test for skin sensitization.
    Toxicol. In Vitro, 29, 1816-1830 (2015).
  3. Yoshikawa T, Nakajima Y, Yamada Y, Enoki R, Watanabe K, Yamazaki M, Sakimura K, Honma S, Honma K,
    Spatiotemporal profiles of arginine vasopressin transcription in cultured suprachiasmatic nucleus.
    Eur. J. Neurosci., 42, 2678-2689 (2015).
  4. Murotomi K, Umeno A, Yasunaga M, Shichiri M, Ishida N, Abe H, Yoshida Y, Nakajima Y,
    Switching from singlet-oxygen-mediated oxidation to free-radical-mediated oxidation in the pathogenesis of type 2 diabetes in model mouse.
    Free Radic. Res., 49, 133-138 (2015).
  5. Murotomi K, Umeno A, Yasunaga M, Shichiri M, Ishida N, Koike T, Matsuo T, Abe H, Yoshida Y, Nakajima Y,
    Oleuropein-Rich Diet Attenuates Hyperglycemia and Impaired Glucose Tolerance in Type 2 Diabetes Model Mouse.
    J. Agri. Food Chem., 63, 6715-6722 (2015).
  6. Umeno A, Takashima M, Murotomi K, Nakajima Y, Koike T, Matsuo T, Yoshida Y,
    Radical-scavenging activity and antioxidative effects of olive leaf components oleuropein and hydroxytyrosol in comparison with homovanillic alcohol.
    J. Oleo Sci., 64, 793-800 (2015)
  7. Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M,
    In vitro evaluation of the cellular effect of indium tin oxide nanoparticles using the human lung adenocarcinoma A549 cells.
    Metallomics, 7, 816-827 (2015).
  8. Iwaki T, Ishido T, Hirano K, Lazutin A A, Vasilevskaya V V, Kenmotsu T, Yoshikawa K,
    Marked difference in conformational fluctuation between giant DNA molecules in circular and linear forms.
    J. Chem. Phys., 142, 145101 (2015).
(2014)
  1. Yasunaga M, Nakajima Y, Ohmiya Y,
    Dual-color bioluminescence imaging assay using green- and red-emitting beetle luciferases at subcellular resolution.
    Anal. Bioanal. Chem., 406, 5735-42 (2014).
  2. Suzuki S, Murotomi K, Nakajima Y, Kawai K, Ohta K, Warita K, Miki T, Takeuchi Y,
    Development of an artificial calcium-dependent transcription factor to detect sustained intracellular calcium elevation.
    ACS Synth. Biol., 3, 717-722 (2014).
  3. Okabe T, Kumagai M, Nakajima Y, Shirotake S, Kodaira K, Oyama M, Ueno M, Ikeda M, 
    The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.
    PLoS One,. 9, e109693 (2014).
  4. Murotomi K, Umeno A, Yasunaga M, Shichiri M, Ishida N, Abe H, Yoshida Y, Nakajima Y,
    Type 2 diabetes model TSOD mouse is exposed to oxidative stress at young age.
    J. Clin. Biochem. Nutr., 55, 216-220 (2014).
(2013)
  1. Tomimoto K, Fujita Y, Iwaki T, Chiba Y, Jigami Y, Nakayama K, Nakajima Y, Abe H,
    Protease-deficient Saccharomyces cerevisiae strains for the synthesis of human-compatible glycoproteins. 
    Biosci. Biotechnol. Biochem., 77, 2461-2466 (2013).
  2. Koinuma S, Asakawa T, Nagano M, Furukawa K, Sujino M, Masumoto KH, Nakajima Y, Hashimoto S, Yagita K, Shigeyoshi Y,
    Regional circadian period difference in the suprachiasmatic nucleus of the mammalian circadian center.
    Eur. J. Neurosci,. 38, 2832-2841 (2013).
  3. Yamada Y, Nishide SY, Nakajima Y, Watanabe T, Ohmiya Y, Honma K, Honma S,
    Monitoring circadian time in rat plasma using a secreted Cypridina luciferase reporter.
    Anal. Biochem., 439, 80-87 (2013).
  4. Yang F, Inoue I, Kumagai M, Takahashi S, Nakajima Y, Ikeda M,
    Real-time analysis of the circadian oscillation of the Rev-Erbβ promoter.
    J. Atheroscler. Thromb., 20, 267-276 (2013).
  5. Morigaki K, Mizutani K, Saito M, Okazaki T, Nakajima Y, Tatsu Y, Imanishi H,
    Surface functionalization of a polymeric lipid bilayer for coupling a model biological membrane with molecules, cells, and microstructures.
    Langmuir, 29, 2722-2730 (2013).
  6. Hirano K, Ishido T, Yamamoto Y S, Murase N, Baba Y, Itoh T,
    Plasmonic imaging of Brownian motion of single DNA molecules spontaneously binding to Ag nanoparticles.
    Nano Lett., 13, 1877-1882 (2013).
  7. Yamamoto Y S, Hirano K, Ishido T, Yasui T, Murase N, Baba Y, Itoh T,
    Plasmonic staining of DNA molecules with photo-induced Ag nanopraticles monitored using dark-field microscopy.
    Phys Chem. Chem. Phys., 15, 10316-10320 (2013).
  8. Frusawa H, Manabe T, Kagiyama E, Hirano K, Kameta N, Masuda M, Shimizu T,
    Electric moulding of dispersed lipid nanotubes into a nanofluidic device.
    Sci. Rep., 3, 2165 (2013).
(2012)
  1. Noguchi T, Ikeda M, Ohmiya Y, Nakajima Y,
    A dual-color luciferase assay system reveals circadian resetting of cultured fibroblasts by co-cultured adrenal glands.
    PLoS One, 7, e37093 (2012).
  2. Myung J, Hong S, Hatanaka F, Nakajima Y, De Schutter E, Takumi T,
    Period coding of Bmal1 oscillators in the suprachiasmatic nucleus.
    J.Neurosci., 32, 8900-8918 (2012).
  3. Tahara Y, Kuroda H, Saito K, Nakajima Y, Kubo Y, Ohnishi N, Seo Y, Otsuka M, Fuse Y, Ohura Y, Komatsu T, Moriya Y, Okada S, Furutani N, Hirao A, Horikawa K, Kudo T, Shibata S, 
    In Vivo monitoring of peripheral circadian clocks in the mouse.
    Curr. Biol., 22:1029-1034 (2012).
  4. Miyako E, Deguchi T, Nakajima Y, Yudasaka M, Hagihara Y, Horie M, Shichiri M, Higuchi Y, Yamashita F, Hashida M, Shigeri Y, Yoshida Y, Iijima S,
    Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns. 
    Proc. Natl.Acad. Sci. USA, 109, 7523-7528 (2012).
  5. Hayashi K, Yano S, Abe H, Fujita Y, Kishida M,
    Improvement of the growth defect in salt- and ethanol-tolerant yeast mutagenized with error-prone DNA polymerization by using backcross cell fusion.
    J. Biosci. Bioeng., 114, 476-478 (2012).
  6. Syamala KM, Abe H, Fujita Y, Tomimoto K, Biju V, Ishikawa M, Ozaki Y, Itoh T,
    Inhibition assay of yeast cell walls by plasmon resonance Rayleigh scattering and surface-enhanced Raman scattering imaging.
    Langmuir. 28, 8592-8958 (2012).
  7. Hirano K, Ichikawa M, Ishido T, Ishikawa M, Baba Y, Yoshikawa K,
    How Environmental Solution Conditions Determine the Compaction Velocity of Single DNA Molecules.
    Nucleic Acids Res., 40, 284-289 (2012).
  8. Myobatake Y, Takeuchi T, Kuramochi K, Kuriyama I, Ishido T, Hirano K, Sugawara F, Yoshida H, Mizushina Y,
    Pinophilins A and B, inhibitors of mammalian A-, B- and Y-families of DNA polymerases and human cancer cell proliferation.
    J. Nat. Prod., 75, 135-141 (2012).
  9. Murotomi K, Takagi N, Muroyama A, Kaji N, Takeo S, Tanonaka K, 
    Transient focal cerebral ischemia differentially decreases Homer1a and 1b/c contents in the postsynaptic density.
    Neurosci. Lett., 515, 92-96 (2012).
(2011)
  1. Takahashi T, Kimura Y, Saito R, Nakajima Y, Ohmiya Y, Yamasaki K, Aiba S, 
    An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8.
    Toxicol. Sci. 124, 359-369 (2011).
  2. Yatsushiro S, Akamine R, Yamamura S, Hino M, Kajimoto K, Abe K, Abe H, Kido J, Tanaka M, Shinohara Y, Baba Y, Ooie T, Kataoka M,
    Quantitative analysis of serum procollagen type I C-terminal propeptide by immunoassay on microchip.
    PLoS One,13, e18807 (2011).
  3. Yamaguchi Y, Yatsushiro S, Yamamura S, Abe H, Abe K, Watanabe M, Kajimoto K, Shinohara Y, Baba Y, Kataoka M,
    Ribonuclease protection assay on microchip electrophoresis.
    Analyst, 136, 2247-2251 (2011).
  4. Ishido T, Yamazaki N, Ishikawa M, Hirano K,
    Characterization of DNA polymerase β from Danio rerio by overexpression in E. coli using the in vivo/in vitro compatible pIVEX plasmid.
    Microb. Cell Fact., 10, 84 (2011).
  5. Kitahama Y, Itoh T, Ishido T, Hirano K, Ishikawa M,
    Surface-enhanced Raman Scattering from Photo-reduced Ag Nanoaggregates on an Optically-trapped Single Bacterium.
    Bull. Chem. Soc. Jpn., 84, 976-978 (2011).
  6. Murotomi K, Takagi N, Takeo S, Tanonaka K,
    NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient focal cerebral ischemia and reperfusion.
    Mol. Cell. Neurosci., 46, 681-688 (2011).
(2010)
  1. Noguchi T, Michihata T, Nakamura W, Takumi T, Shimizu R, Yamamoto M, Ikeda M, Ohmiya Y, Nakajima Y,
    Dual-color luciferase mouse directly demonstrates coupled expression of two clock genes.
    Biochemistry, 49, 8053-8061 (2010).
  2. Nakajima Y, Yamazaki T, Nishii S, Noguchi T, Hoshino H, Niwa K, Viviani VR, Ohmiya Y,
    Enhanced beetle luciferase for highresolution bioluminescence imaging.
    PLoS One, 5, e10011 (2010).
  3. Lee Y, Lee J, Kwon I, Nakajima Y, Ohmiya Y, Son GH, Lee KH, Kim K,
    Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock.
    J.Cell Sci., 123, 3547-3557 (2010).
  4. Niwa K, Ichino Y, Kumata S, Nakajima Y, Hiraishi Y, Kato D, Viviani VR, Ohmiya Y,
    Quantum yields and kinetics of the firefly bioluminescence reaction of beetle luciferase.
    Photochem. Photobiol., 86, 1046-1049 (2010).
  5. Kwon H, Enomoto T, Shimogawara M, Yasuda K, Nakajima Y, Ohmiya Y,
    Bioluminescence imaging of dual gene expression at single-cell level.
    BioTechniques, 10, 460-462 (2010).
  6. Niwa K, Nakajima Y, Ohmiya Y, 
    Bioluminescence assays for L-cysteine and luciferase.
    Anal. Biochem., 396, 316-318 (2010).
  7. Li X, Nakajima Y, Niwa K, Viviani VR,. Ohymiya Y,
    Enhanced red-emitting railroad worm luciferase for bioassays and bioimaging.
    Protein Sci., 19, 26-33 (2010).
  8. Takahashi S, Inoue I, Nakajima Y, Seo M, Nakano T, Kumagai M, Yang F, Kodama T, Awata T, Ikeda M, Katayama S,
    A promoter in the novel exon of hPPARγ directs the circadian expression of PPARγ.
    J. Atheroscler. Thromb., 17, 73-83 (2010).
  9. Hirano K, Yoshida Y, Ishido T, Wada Y, Moriya N, Yamazaki N, Mizushina Y, Baba Y, Ishikawa M,
    Consecutive incorporation of fluorochrome-labeled nucleotides by mammalian DNA polymerase beta.
    Anal. Biochem., 405, 160-167 (2010).
  10. Ishido T, Ishikawa M, Hirano K,
    Analysis of supercoiled DNA by agarose gel electrophoresis using low-conducting sodium threonine medium.
    Anal. Biochem., 400, 148-150 (2010).
  11. Kamiya K, Hamabe W, Tokuyama S, Hirano K, Satake T, Kumamoto-Yonezawa Y, Yoshida H, Mizushina Y,
    Inhibitory effect of anthraquinones isolated from the Noni (Morinda citrifolia) root on animal A, B and Y families of DNA polymerases and human cancer cell proliferation.
    Food Chem., 118, 725-730 (2010).
  12. Murotomi K, Takagi N, Mizutani R, Honda TA, Ono M, Takeo S, Tanonaka K,
    mGluR1 antagonist decreases NADPH oxidase activity and superoxide production after transient focal cerebral ischemia.
    J. Neurochem., 114, 1711-1719 (2010).
(2009)
  1. Yang F, Nakajima Y, Kumagai M, Ohmiya Y, Ikeda M,
    The molecular mechanism regulating the autonomous circadian expression of Topoisomerase I in NIH3T3 cells.
    Biochem. Biophys. Res. Commun., 380, 22-27 (2009).
  2. Abe H, Fujita Y, Takaoka Y, Kurita E, Yano S, Tanaka N, Nakayama K,
    Ethanol-tolerant Saccharomyces cerevisiae strains isolated under selective conditions by over-expression of a proofreading-deficient DNA polymerase delta.
    J. Biosci. Bioeng.,108, 199-204 (2009).
  3. Abe H, Fujita Y, Chiba Y, Jigami Y, Nakayama K,
    Upregulation of genes involved in gluconeogenesis and the glyoxylate cycle suppressed the drug sensitivity of an N-glycan-deficient Saccharomyces cerevisiae mutant.
    Biosci. Biotechnol. Biochem., 73, 1398-1403 (2009).
  4. Abe H, Takaoka Y, Chiba Y, Sato N, Ohgiya S, Itadani A, Hirashima M, Shimoda C, Jigami Y, Nakayama K,
    Development of valuable yeast strains using a novel mutagenesis technique for the effective production of therapeutic glycoproteins.
    Glycobiology, 19, 428-436 (2009).
  5. Hirano K, Ishido T, Ishikawa M,
    Rapid sequencing gel electrophoresis by using glycerol-tolerant sodium taurine medium.
    Anal. Biochem., 390, 100-101 (2009).
  6. Hirano K. Aoyagi M, Ishido T, Ooie T, Frusawa H, Asakawa M, Shimizu T, Ishikawa M,
    Measuring the length distribution of self-assembled lipid nanotubes by orientation control with a high frequency electric field in aqueous solutions.
    Anal. Chem., 81, 1459-1464 (2009).
  7. Mizushina Y, Motoshima H, Yamaguchi Y, Takeuchi T, Hirano K, Sugawara F, Yoshida H,
    3-O-Methylfunicone, a Selective Inhibitor of Mammalian Y-Family DNA Polymerases from a Fungal Strain from Australian Sea Salt.
    Mar. Drugs, 7, 624-639 (2009).
  8. Miyako E, Nagata H, Funahashi R, Hirano K, Hirotsu T,
    Light-Driven Thermoelectric Conversion Based on a Carbon Nanotube-Ionic Liquid Gel Composite.
    ChemSusChem, 2, 740-742 (2009).
  9. Miyako E, Nagata H, Hirano K, Hirotsu T,
    Micropatterned Carbon Nanotube-Gel Composite as Photothermal Material.
    Adv. Mater., 21, 2819-2823 (2009).
  10. Miyako E, Nagata H, Funahashi R, Hirano K, Hirotsu T,
    Light-Triggered Thermoelectric Conversion Based on a Carbon Nanotube-Polymer Hybrid Gel.
    ChemSusChem, 2, 419-422 (2009).
  11. Miyako E, Nagata H, Hirano K, Hirotsu T,
    Laser-triggered Carbon Nanotube Microdevice for Remote Control.
    Lab Chip, 9, 788-794 (2009).
  12. Takenaga Y, Takagi N, Murotomi K, Tanonaka K, Takeo S,
    Inhibition of Src activity decreases tyrosine phosphorylation of occludin in brain capillaries and attenuates increase in permeability of the blood–brain barrier after transient focal cerebral ischemia.
    J. Cereb. Blood Flow Metab., 29, 1099-1108 (2009).
(2008)
  1. Noguchi T, Ikeda M, Ohmiya Y, Nakajima Y,
    Simultaneous monitoring of independent gene expression patterns in two types of cocultured fibroblasts with different color-emitting luciferases. 
    BMC Biotechnol., 8, 40 (2008).
  2. Miyamoto N, Izumi H, Noguchi T, Nakajima Y, Ohmiya Y, Shiota M, Kidani A, Tawara A, Kohno K,
    Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance. 
    J. Biol. Chem., 283, 18218-18226 (2008).
  3. Sujith A, Itoh T, Abe H, Yoshida K, Anas AA, Biju VP, Ishikawa M, 
    Surface enhanced Raman scattering analyses of individual silver nanoaggregates on living single yeast cell wall.
    Appl. Phys. Lett., 92:103901-103903 (2008).
  4. Hirano K, Nagata H, Ishido T, Tanaka Y, Baba Y, Ishikawa M,
    Sizing of single globular DNA molecules by using a circular acceleration technique with laser trapping.
    Anal. Chem., 80, 5197-5202 (2008).
  5. Miyako E, Nagata H, Hirano K, Hirotsu T,
    Photodynamic thermoresponsive nanocarbon-polymer gel hybrids.
    Small, 4, 1711-1715 (2008).
  6. Miyako E, Nagata H, Hirano K, Makita Y, Nakayama K, Hirotsu T,
    Photoinduced antiviral carbon nanohorns.
    Nanotechnology, 19, 075106-075111 (2008).
  7. Miyako E, Nagata H, Hirano K, Makita Y, Hirotsu T,
    Photodynamic release of fullerenes from within carbon nanohorn.
    Chem. Phys. Lett., 456, 220-222 (2008).
  8. Miyako E, Nagata H, Hirano K, Hirotsu T,
    Carbon nanotube-polymer composite for light-driven microthermal control.
    Angew. Chem. Int. Ed., 47, 3610-3613 (2008).
  9. Nagata H, Ishikawa M, Yoshida Y, Tanaka Y, Hirano K,
    Use of a heterogeneous buffer combination in microchip electrophoresis for high-resolution separation by on-line concentration of DNA samples.
    Electrophoresis, 29, 3744-3751 (2008).
  10. Tanaka Y, Kawada H, Hirano K, Ishikawa M, Kitajima H,
    Automated manipulation of non-spherical micro-objects using optical tweezers combined with image processing techniques.
    Opt. Exp., 16, 15117-15122 (2008).
  11. Murotomi K, Takagi N, Takayanagi G, Ono M, Takeo S, Tanonaka K,
    mGluR1 antagonist decreases tyrosine phosphorylation of NMDA receptor and attenuates infarct size after transient focal cerebral ischemia.
    J. Neurochem., 105, 1625-1634 (2008).
  12. Akita H, Takagi N, Ishihara N, Takagi K, Murotomi K, Funakoshi H, Matsumoto K, Nakamura T, Takeo S,
    Hepatocyte growth factor improves synaptic localization of the NMDA receptor and intracellular signaling after excitotoxic injury in cultured hippocampal neurons.
    Exp. Neurol., 210, 83-94 (2008).
(2007)
  1. Hoshino H, Nakajima Y, Ohmiya Y,
    Single-cell imaging with fluorescent protein excited by luciferin-luciferase reaction.
    Nature Methods, 8, 637-639 (2007).
  2. Tsuboi Y, Abe H, Nakagawa R, Oomizu S, Watanabe K, Nishi N, Nakamura T, Yamauchi A and Hirashima M,
    Galectin-9 protects mice from the Swaartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes.
    Clinical Immunol., 124:221-233 (2007).
  3. Miyanishi N, Nishi N, Abe H, Kashio Y, Shinonaga R, Nakakita S, Sumiyoshi W, Yamauchi A, Nakamura T, Hirashima M, Hirabayashi J,
    Carbohydrate-recognition domains of galectin-9 are involved in intermolecular interaction with galectin-9 itself and other members of the galectin family.
    Glycobiology, 17, 423-32 (2007).
  4. Miyako E, Nagata H, Hirano K, Makita Y, Nakayama K, Hirotsu T,
    Near-infrared laser-triggered carbon nanohorns for selective elimination of microbes.
    Nanotechnology, 18, 475103-475110 (2007).
  5. Tanaka Y, Hirano K, Nagata H, Ishikawa M,
    Real-time three-dimensional orientation control of non-spherical micro-objects using laser trapping.
    Electron. Lett., 43, 412-413 (2007).
(2006)
  1. Nishide S, Honma S, Nakajima Y, Ikeda M, Baba K, Ohmiya Y, Honma K,
    New reporter system for Per1 and Bmal1 expressions revealed self-sustained circadian rhythms in peripheral tissues.
    Genes Cells, 11, 1173-1182 (2006).
  2. Maeda E, Hirano K, Baba Y, Nagata H, Tabuchi M,
    Conformational separation of monosaccharides of glycoproteins labeled with 2-aminoacrydone using microchip electrophoresis.
    Electrophoresis, 27, 2002-2010 (2006).
(2005)
  1. Nakajima Y, Kimura T, Sugata K, Enomoto T, Asakawa A, Kubota H, Ikeda M , Ohmiya Y,
    A multicolor luciferase assay system, one-step monitoring of multiple gene expressions with a single substrate.
    BioTechniques, 38:891-894 (2005).
  2. Suzuki C, Nakajima Y, Akimoto H, Wu C, Ohmiya Y,
    A new additional reporter enzyme, dinoflagellate luciferase, for monitoring of gene expression in mammalian cells.
    Gene, 344, 61-66 (2005).
  3. Nagata H, Tabuchi M, Hirano K, Baba Y,
    Microchip electrophoretic protein separation using electroosmotic flow induced by dynamic SDS-coating of uncoated plastic chips.
    Electrophoresis, 26, 2247-2253 (2005).
  4. Nagata H, Tabuchi M, Hirano K, Nobumasa H, Higasa M, Murakami Y, Yamazaki Y, Baba Y,
    High speed separation of proteins by microchip electrophoresis using a PEG-coated plastic chip with an SDS-linear polyacrylamide solution.
    Electrophoresis, 26, 2687-2691 (2005).
  5. Nagata H, Tabuchi M, Hirano K, Baba Y,
    Automatic protein separation by microchip electrophoresis using quartz chip.
    Chromatography, 26, 23-28 (2005).
(2004)
  1. Nakajima Y, Ikeda M, Kimura T, Honma S, Ohmiya Y, Honma K,
    Bidirectional role of orphan nuclear receptor RORα in clock gene transcriptions demonstrated by a novel reporter assay system.
    FEBS Lett., 565, 122-126 (2004).
  2. Nakajima Y, Kimura T, Suzuki C, Ohmiya Y,
    Improved expression of novel red- and green-emitting luciferases of Phrixothrix railroad worms in mammalian cells.
    Biosci. Biotechniol. Biochem., 68, 948-951 (2004).
  3. Nakajima Y, Kobayashi K, Yamagishi K, Enomoto T, Ohmiya Y,
    cDNA cloning and characterization of a secreted luciferase from the luminous Japanese ostracod, Cypridina noctiluca.
    Biosci. Biotechnol. Biochem., 68, 565-570 (2004).
  4. Abe H, Ohba H, Shimma H and Jigami Y, 
    Yeast cells harboring human α-1, 3 -fucosyltransferase at the cell surface engineered using Pir, a cell wall-anchored protein.
    FEMS Yeast Res., 4, 417-425 (2004).
  5. Nakamura T, Abe H, Shimoda C, 
    ADAM family protein Mde10 is essential for development of spore envelopes in the fission yeast Schizosaccharomyces pombe.
    Eukaryotic Cell, 3, 27-39 (2004).

解説・総説、著書

  1. 丹羽一樹、中島芳浩、近江谷克裕 
    発光甲虫プローブを用いた細胞機能解析 
    生化学、87, 675-685 (2015).
  2. Yoshida Y, Umeno A, Akazawa Y, Shichiri M, Murotomi K, Horie M,
    Chemistry of lipid peroxidation products and its use as early detection of diseases as biomarkers.
    J. Oleo Sci., 64, 347-356 (2015).
  3. 吉田康一、七里元督、赤澤陽子、梅野彩、室冨和俊 
    ビタミンE類の抗酸化作用と中枢神経疾患抑制の可能性 
    ビタミン, vol.88, no.2, pp.63-71 (2014).
  4. 平野 研:1分子蛍光検出によるDNAシークエンサー、現代化学、p. 34-35、東京化学同人 (2011)
  5. 安部博子
    新規育種技術を利用したヒト型糖タンパク質生産に適した酵母株の開発
    バイオ医薬品開発における糖鎖技術(早川堯夫・掛樋一晃・平林淳 編)、p129-149、シーエムシー出版 (2011)
  6. Nakajima Y, Ohmiya Y,
    Bioluminescence Assays -Multicolor luciferase assay, Secreted luciferase assay, and Imaging luciferase assay-. Expert Opin. Drug Discover., 5, 835-849 (2010)
  7. 近江谷克裕、星野英人、中島芳浩
    生物発光で細胞活動を長時間計測する
    バイオサイエンスとインダストリー66、199-201 (2008)
  8. 中島芳浩
    発光レポーター
    時間生物学事典(石田真理雄、本間研一 編)、朝倉書店、p.94-95 (2008)
  9. 中島芳浩
    アカパンカビ
    時間生物学事典(石田真理雄、本間研一 編)、朝倉書店、120-121 (2008)
  10. 中島芳浩、野口貴子、近江谷克裕
    ルシフェラーゼプローブによる細胞機能の解析
    蛍光・発光試薬の選び方と使い方(羊土社)(2007)
  11. 中島芳浩、野口貴子、池田正明、近江谷克裕
    概日リズム研究におけるルシフェラーゼとその応用
    時間生物学13, 1, 37-47 (2007)
  12. 中島芳浩、近江谷克裕
    遺伝子発現リアルタイム解析への発光イメージングの応用
    バイオテクノロジージャーナル6、230-232 (2006)
  13. 平野研、馬場嘉信:1分子からのDNAシークエンスを目指せ、化学、vol. 59, p. 62-63、化学同人 (2004)
  14. 安部 博子、地神 芳文
    酵母宿主による活性タンパク質の生産
    バイオテクノロジーのための基礎分子生物学(大島泰治、北本勝ひこ、原島 俊、宮川都吉 編)、化学同人、p.167-169 (2004)
  15. 平野研、馬場嘉信:ナノデバイスの創成と単一DNA分子操作・解析への展開、 化学と工業、vol. 56, p. 975-978 (2003)
  16. 横尾 岳彦、安部 博子、地神 芳文
    酵母の糖鎖合成に関与する遺伝子
    蛋白質 核酸 酵素、p.1002-1009、共立出版 (2003)

特許出願・登録、工業標準化等

<国内特許、登録>
  1. 抗酸化剤及び抗酸化用組成物、中島芳浩、田部井陽介、室冨和俊、梅野彩、吉田康一、桝谷文武、辻野義雄、特許第6157041号
  2. 多色発光細胞を用いた免疫毒性評価システム、相場節也、齋藤るみ子、近江谷克裕、中島芳浩、西井重明、山崎友実、安田真琴、 特許第5999644号
  3. 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法、安部博子、冨本和也、藤田康子、岩城知子、千葉靖典、中島芳浩、仲山賢一、片岡正俊、八代聖基、山村 昌平、特許第5885191号
  4. 精製転写因子の調製法と細胞導入技術、中島芳浩、上垣浩一、萩原義久、特許第5637354号
  5. 安定化赤色発光ルシフェラーゼ変異体、近江谷克裕、李学燕、中島芳浩、西井重明、山崎友美、特許第5644993号
  6. バイオイメージングに特化した変異型赤色発光ルシフェラーゼ、近江谷克裕、李学燕、中島芳浩、西井重明、山崎友美、特許第5644994号
  7. 発光性渦鞭毛藻由来青色発光酵素を用いた細胞内遺伝子転写活性測定法、近江谷克裕、中島芳浩、鈴木智恵、龍福正行、特許第5564640号
  8. ポリマー脂質二分子膜を用いた機能性基板、森垣憲一、岡崎敬、達吉郎、中島芳浩、特許第5532229号
  9. タンパク質短寿命化ペプチドをコードする遺伝子及びその使用方法、近江谷克裕、李学燕、中島芳浩、西井重明、山崎友美、特許第5278942号
  10. 細胞内発光イメージングのために最適化されたルシフェラーゼ遺伝子,近江谷克裕、中島芳浩、Viviani Vadim、西井重明、浅井友実,特許第5164085号、特許第5083750号
  11. マルチ遺伝子転写活性測定システム,近江谷克裕、中島芳浩、特許第4385135号
  12. ラクトシルセラミドを有効成分とする医薬, 安部博子、仲山賢一、平島光臣、特許第 5158535号
  13. 酵母の製造方法、酵母、及び糖タンパク質又はβ−グルカンの製造方法, 安部博子、仲山賢一、地神芳文、千葉靖典、板谷有希子、高岡友紀、特許第 5119466号
  14. 微粒子アレイの作成方法および装置、田中芳夫、川田博之、平野 研、石川 満、北島博之、特許第5116928号
  15. カーボンナノチューブの分散方法、都英次郎、長田英也、平野 研、廣津孝弘、特許第5339379号
  16. DNAポリメラーゼβを用いた核酸合成方法及び1分子シーケンス法、平野 研、馬場嘉信、石川 満、水品善之、西本尚弘、特許第5220596号
  17. カーボンナノホーンの分散方法、都英次郎、長田英也、平野 研、廣津孝弘、特許第5212954号
  18. 極小線状柔軟物の切断方法および切断装置、田中芳夫、平野 研、特許第5126804号
  19. 異種緩衝液を使用する電気泳動法、長田英也、平野 研、石川 満、特許第5057451号
  20. カーボンナノチューブ均一分散有機溶媒の製造方法及びカーボンナノチューブ均一分散ポリマー樹脂の製造方法、都英次郎、長田英也、平野 研、廣津孝弘、特許第5012707号
  21. カーボンナノホーン複合体、該複合体を含む抗菌剤および微生物殺滅方法、都英次郎、長田英也、平野 研、廣津孝弘、特許第5007446号
  22. 熱電モジュール及び該熱電モジュールを用いた発電方法、都英次郎、長田英也、平野 研、廣津孝弘、特許第4840944号
  23. 微粒子回収装置、平野 研、馬場嘉信、吉田敏雄、間口挙秀、特許第4816906号
  24. 微粒子の分別回収方法および回収装置、平野 研、馬場嘉信、特許第4512686号
  25. 核酸分子を伸張させて固定する方法と装置、平野 研、馬場嘉信、西本尚弘、特許第4449666号
  26. 試料分離フィルタおよび電気泳動デバイス、津田順、多田有希、橋口原、平野 研、加地範匡、馬場嘉信、特許第4012111号
  27. 電気泳動デバイス、津田順、多田有希、橋口原、平野 研、加持範匡、馬場嘉信、特許第3984557号
<国内特許、出願中>
  1. 活動量の低下及び/又は不安の改善用組成物、室冨和俊、中島芳浩、吉田康一、小池泰介、松尾俊輝、特願2015-010545
  2. 人工染色体ベクター及び形質転換哺乳類細胞、中島芳浩、室冨和俊、安永茉由、大林徹也、押村光雄、特願2013-263910
<国外特許、登録>
  1. マルチ遺伝子転写活性測定システム,近江谷克裕、中島芳浩、US7572629、DE602004030104.3-08、FR 1621634、GB1621634、CN1784496
  2. 細胞内発光イメージングのために最適化されたルシフェラーゼ遺伝子, 近江谷克裕、中島芳浩、Viviani Vadim、西井重明、浅井友実、US8383797
  3. 酵母の製造方法、酵母、及び糖タンパク質の製造方法、安部博子、仲山賢一、千葉靖典、地神芳文、板谷有希子、US7803605
  4. 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法、安部博子、冨本和也、藤田康子、岩城知子、千葉靖典、中島芳浩、仲山賢一、片岡正俊、八代聖基、山村 昌平、US20130171692A1
  5. 微粒子の分別回収方法および回収装置、平野 研、馬場嘉信、US 7428971 B2

ページトップへ

研究グループ紹介