Group Introductions

Functional Biomolecular Research Group

Research Outline

●Based on findings in differences between various bioluminescence systems and molecular/cellular mechanisms of biological systems, we develop novel technologies for disease/disorder/function examinations such as in vivo imaging of cancer cells, BRET-based auto-illuminated fluorescence proteins (BAF), the de novo syntheses of luciferin, and so on, by engineering various luciferase-based luminescence- and fluorescence-probes and novel optical measurement systems.

 

●Based on crystalline/NMR structure analyses of the functional motifs of metabolic enzymes, receptor proteins, transcription factors, and their binding to ligands or partners, we develop novel functional proteins and fragment designs for healthcare or ecological technologies, and so on.

 

●Development of transgenic “Medaka” for sensing chemical risks such as environmental chemicals, agricultural chemicals and food additives and for disease models.

 

●Development of artificial nose sensors for detecting and identifying early stages of diseases, accumulated stresses, or dangerous objects as a platform for developing novel instruments using olfactory information.

 

●Modeling for behaviors and other biological systems by using computer simulation.


Key words: hyperthermophilic enzymes, chitinases, celluloses, biomass, receptors, protein crystallizations, X-ray structure analysis, NMR structure analysis, structure and function analysis, transcription factors, differentiation-inducing factors, large-scale protein expression, luciferase, optical probes for biological functions, luminescence imaging, real-time imaging, gene expression regulation factors, BRET-based auto-illuminated fluorescence proteins (BAF), nano-biolight, the de novo syntheses of luciferin, far-red probes of tumor-specific membrane antigens, visualization of neural pathway, chemical senses, odorant receptors, artificial nose sensor, cell-based assay, olfactory center, algorithm, image analysis, functional imaging, molecular dynamics modeling.

 

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