Artificial Organ Research Group
Our group has been developing centrifugal blood pumps with hydrodynamic bearing for extracorporeal circulation to save severe heart failure patients (Fig.1).
We optimize the clearance gap at the bearing to produce an extracorporeal circulation pump for long time use. Blood flow analysis and thrombosis in the pump are also important. We design the flow path of the impeller to avoid high shear stress in silico (Fig.2), and obtain the relationship between shear stress and thrombosis in vitro (Fig.3).
Recently, optical real-time monitoring system for thrombosis in the pump is receiving a lot of attention for safety extracorporeal circulation (Fig.4).
Hyperspectral imaging (HSI) is applied to the detection of the thrombi, this new method reach to avoid the complication for thrombosis. Moreover, we are also elucidating structural analysis and mechanical properties based on regenerative medicine (Fig.5).