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研究課題

我々が独自にクローニングした2つのタンパク質、モータリンとCARFは、がん細胞で過剰に発現することから、抗がん剤の新たな標的として注目されています。現在、それらのタンパク質について、以下のような検証を進めています。
(i)ストレス、老化及びがん生物学における役割の解明、
(ii)ストレス及びがん診断への有用性、
(iii)ストレス及びがん介入のための阻害剤としての利用

研究課題

直径200nmのナノニードルやお椀形状磁気微粒子マグカップなど独自のナノ材料技術を駆使して、生命の精密かつ柔軟な動作原理を分子レベルで理解する研究を推進します。具体的には、細胞に極めてダメージの小さいナノニードル技術を用いた生細胞内での分子計測と分子操作、転移に関与する新規がんマーカーの機械的機能の解析とこれを標的とした診断および治療技術の開発、センシング機能搭載マグカップを用いたマーカー分子微量発現がん細胞の高感度検出と解析などの研究を行っています。

研究課題

天然資源等からの新規な機能性物質探索を行うために、バイオアッセイを中心に実験を進めています。バイオアッセイとしては、培養細胞を用いて、毒性評価、免疫応答性、生体リズムについて、生物発光を取り入れた新しい検出方法を開発しています。さらにこの開発した技術を用いて新たな生理活性物質を探索しています。植物などの二次代謝産物から生理活性物質を探索しますが、アッセイには粗精製物も適用可能です。その中から必要に応じて活性物質の単離や同定を行い、活性物質の作用点やメカニズムを明らかにする研究も行っています。

研究課題

微細加工技術を利用して生理学性の高い培養環境を創出し、高次の細胞・臓器機能を発現可能な生体模倣システム（Microphysiological systems、MPS）の開発と産業応用を目指します。

メンバー

業績リスト

• Huifu, H; Shefrin, S; Yang, S; Zhang, Z; Kaul, SC; Sundar, D; Wadhwa, R.
  Cucurbitacin-B inhibits cancer cell migration by targeting mortalin and HDM2: computational and in vitro experimental evidence.
  J BIOMOL STRUCT DYN. 2023 May 2:1-10. doi: 10.1080/07391102.2023.2206914
• Zhang, H; Wang, J; Prakash, J; Zhang, Z; Kaul, SC; Wadhwa, R.
  Three-way Cell-based Screening of Antistress Compounds: Identification, Validation, and Relevance to Old-age Related Pathologies.
  J GERONTOL A BIOL SCI MED SCI. 2023 Apr 15:glad103. doi: 10.1093/gerona/glad103
• Sugiura, S; Yamahira, S; Tamura, M; Shin, K; Shibuta, M; Satoh, T; Matsuzawa, Y; Fujii, G; Yanagawa, F; Mutoh, M; Yanagisawa, M; Kato, R; Matsui, H.
  Automated cell isolation from photodegradable hydrogel based on fluorescence image analysis.
  BIOTECHNOL BIOENG. 2023 Mar 15. doi: 10.1002/bit.28375
• Kumar, V; Sari, AN; Meidinna, HN; Kaul, A; Basu, B; Ishida, Y; Terao, K; Kaul, SC; Vrati, S; Sundar, D; Wadhwa, R.
  Computational and experimental evidence of the anti-COVID-19 potential of honeybee propolis ingredients, caffeic acid phenethyl ester and artepillin c.
  PHYTOTHER RES. 2023 Feb 9. doi: 10.1002/ptr.7717
• Huang, T; Sato, Y; Kuramochi, A; Ohba, Y; Sano, M; Miyagishi, M; Tateno, H; Wadhwa, R; Kawasaki, K; Uchida, T; Ekdahl, KN; Nilsson, B; Chung, UI; Teramura, Y.
  Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells.
  REGEN THER. 2023 Jan 11;22:90-98. doi: 10.1016/j.reth.2022.12.007
• Yu, Y; Zhang, GX; Li, ZP; Wang, J; Liu, Y; Bhardwaj, R; Wadhwa, R; Nagao, Y; Shichiri, M; Gao, R.
  Designed fabrication of active tumor targeting covalent organic framework nanotherapeutics via a simple post-synthetic strategy.
  NANO RESEARCH. 03 January 2023. doi: 10.1007/s12274-022-5265-7
• Limjanthong, N; Tohbaru, Y; Okamoto, T; Okajima, R; Kusama, Y; Kojima, H; Fujimura, A; Miyazaki, T; Kanamori, T; Sugiura, S; Ohnuma, K.
  Gravity-driven microfluidic device placed on a slow-tilting table enables constant unidirectional perfusion culture of human induced pluripotent stem cells.
  J BIOSCI BIOENG. 2022 Dec 29:S1389-1723(22)00346-2. doi: 10.1016/j.jbiosc.2022.11.007
• Sugiura, S; Shin, K; Kanamori, T.
  Perfusion culture of endothelial cells under shear stress on microporous membrane in a pressure-driven microphysiological system.
  J BIOSCI BIOENG. 2022 Oct 14:S1389-1723(22)00258-4. doi: 10.1016/j.jbiosc.2022.09.005
• Shefrin, S; Sari, AN; Kumar, V; Zhang, H; Meidinna, HN; Kaul, SC; Wadhwa, R; Sundar, D.
  Comparative computational and experimental analyses of some natural small molecules to restore transcriptional activation function of p53 in cancer cells harbouring wild type and p53(Ser46) mutant.
  CURR RES STRUCT BIOL. 2022 Sep 13;4:320-331. doi: 10.1016/j.crstbi.2022.09.002
• Meidinna, HN; Shefrin, S; Sari, AN; Zhang, H; Dhanjal, JK; Kaul, SC; Sundar, D; Wadhwa, R.
  Identification of a new member of Mortaparib class of inhibitors that target mortalin and PARP1.
  FRONT CELL DEV BIOL. 2022 Sep 12;10:918970. doi: 10.3389/fcell.2022.918970
• Sugiura, S; Satoh, T; Shin, K; Onuki-Nagasaki, R; Kanamori, T.
  Perfusion culture of multi-layered HepG2 hepatocellular carcinoma cells in a pressure-driven microphysiological system.
  J BIOSCI BIOENG. 2022 Aug 11:S1389-1723(22)00189-X. doi: 10.1016/j.jbiosc.2022.07.001
• Tomita, T; Kawano, Y; Kassai, M; Onda, H; Nakajima, Y; Miyazaki, K.
  Hydroxy-β-sanshool isolated from Zanthoxylum piperitum (Japanese pepper) shortens the period of the circadian clock.
  FOOD FUNCT. 2022 Aug 12. doi: 10.1039/d2fo01036d
• Yamagishi, A; Mizusawa, M; Uchida, K; Iijima, M; Kuroda, S; Fukazawa, K; Ishihara, K; Nakamura, C.
  Mechanical detection of interactions between proteins related to intermediate filament and transcriptional regulation in living cells.
  BIOSENS BIOELECTRON. 2022 Aug 6;216:114603. doi: 10.1016/j.bios.2022.114603
• Yoon, AR; Wadhwa, R; Kaul, SC; Yun, CO.
  Why is Mortalin a Potential Therapeutic Target for Cancer.
  FRONT CELL DEV BIOL. 2022 Jun 29;10:914540. doi: 10.3389/fcell.2022.914540
• Viswan, A; Yamagishi, A; Hoshi, M; Furuhata, Y; Kato, Y; Makimoto, N; Takeshita, T; Kobayashi, T; Iwata, F; Kimura, M; Yoshizumi, T; Nakamura, C.
  Microneedle Array-Assisted, Direct Delivery of Genome-Editing Proteins Into Plant Tissue.
  FRONT PLANT SCI. 2022 Jun 24;13:878059. doi: 10.3389/fpls.2022.878059
• Nagasaki, A; Katoh, K; Hoshi, M; Doi, M; Nakamura, C; Uyeda, TQP.
  Characterization of phalloidin-negative nuclear actin filaments in U2OS cells expressing cytoplasmic actin-EGFP.
  GENES TO CELLS. 2022 Feb 23. doi: 10.1111/gtc.12930
• Radhakrishnan, N; Kaul, SC; Wadhwa, R; Sundar, D.
  Phosphatidylserine Exposed Lipid Bilayer Models for Understanding Cancer Cell Selectivity of Natural Compounds: A Molecular Dynamics Simulation Study.
  MEMBRANES 12 (1);doi: 10.3390/membranes12010064 JAN
• Malik, V; Radhakrishnan, N; Kaul, SC; Wadhwa, R; Sundar, D.
  Computational Identification of BCR-ABL Oncogenic Signaling as a Candidate Target of Withaferin A and Withanone.
  BIOMOLECULES 12 (2);doi: 10.3390/biom12020212 FEB
• Sari, AN; Dhanjal, JK; Elwakeel, A; Kumar, V; Meidinna, HN; Zhang, H; Ishida, Y; Terao, K; Sundar, D; Kaul, SC; Wadhwa, R.
  A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms.
  CANCERS (Basel). 2022 Feb 3;14(3):787. doi: 10.3390/cancers14030787
• Penedo, M; Miyazawa, K; Okano, N; Furusho, H; Ichikawa, T; Alam, MS; Miyata, K; Nakamura, C; Fukuma, T.
  Visualizing intracellular nanostructures of living cells by nanoendoscopy-AFM.
  SCI ADV. 2021 Dec 24;7(52):eabj4990. doi: 10.1126/sciadv.abj4990. Epub 2021 Dec 22
• Malik, V; Kumar, V; Kaul, SC; Wadhwa, R; Sundar, D.
  Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl ester as ATP-competitive inhibitors of BRAF: A bioinformatics study.
  CURR RES STRUCT BIOL. 2021 Nov 18;3:301-311. doi: 10.1016/j.crstbi.2021.11.004
• Kaul, A; Kuthethur, R; Ishida, Y; Terao, K; Wadhwa, R; Kaul, SC.
  Molecular Insights into the Antistress Potentials of Brazilian Green Propolis Extract and Its Constituent Artepillin C.
  MOLECULES. 2021 Dec 23;27(1):80. doi: 10.3390/molecules27010080
• Hori, K; Yoshimoto, S; Yoshino, T; Zako, T; Hirao, G; Fujita, S; Nakamura, C; Yamagishi, A; Kamiya, N.
  Recent advances in research on biointerfaces: From cell surfaces to artificial interfaces.
  J BIOSCI BIOENG. 2022 Jan 5:S1389-1723(21)00331-5. doi: 10.1016/j.jbiosc.2021.12.004
• Radhakrishnan, N; Dhanjal, JK; Sari, AN; Ishida, Y; Terao, K; Kaul, SC; Sundar, D; Wadhwa, R.
  Caffeic acid phenethyl ester (CAPE) confers wild type p53 function in p53(Y220C) mutant: bioinformatics and experimental evidence.
  DISCOVER ONCOLOGY 12 (1);doi: 10.1007/s12672-021-00461-2 DEC 20
• Wang, J; Zhang, H; Kaul, A; Li, K; Priyandoko, D; Kaul, SC; Wadhwa, R.
  Effect of Ashwagandha Withanolides on Muscle Cell Differentiation.
  BIOMOLECULES. 2021 Oct 4;11(10):1454. doi: 10.3390/biom11101454
• Kumar, V; Sari, AN; Meidinna, HN; Dhanjal, JK; Subramani, C; Basu, B; Kaul, SC; Vrati, S; Sundar, D; Wadhwa, R.
  Computational and in vitro experimental analyses of the anti-COVID-19 potential of Mortaparib and MortaparibPlus.
  BIOSCI REP. 2021 Oct 29;41(10):BSR20212156. doi: 10.1042/BSR20212156
• Bhargava, P; Mahanta, D; Kaul, A; Ishida, Y; Terao, K; Wadhwa, R; Kaul, SC.
  Experimental Evidence for Therapeutic Potentials of Propolis.
  NUTRIENTS. 2021 Jul 24;13(8):2528. doi: 10.3390/nu13082528
• Kumar, A; Konar, A; Garg, S; Kaul, SC; Wadhwa, R.
  Experimental evidence and mechanism of action of some popular neuro-nutraceutical herbs.
  NEUROCHEMISTRY INTERNATIONAL 149; doi: 10.1016/j.neuint.2021.105124
• Kaul, Z; Cheung, CTY; Bhargava, P; Sari, AN ; Yu, Y; He, HF; Bid, H; Henson, JD; Groden, J; Reddel, RR; Kaul, SC; Wadhwa, R.
  Functional characterization of miR-708 microRNA in telomerase positive and negative human cancer cells.
  SCI REP. 2021 Aug 23;11(1):17052. doi: 10.1038/s41598-021-96096-y
• Elwakeel, A; Sari, AN; Dhanjal, JK; Meidinna, HN; Sundar, D; Kaul, SC; Wadhwa, R.
  Mutant p53(L194F) Harboring Luminal-A Breast Cancer Cells Are Refractory to Apoptosis and Cell Cycle Arrest in Response to Mortaparib(Plus), a Multimodal Small Molecule Inhibitor.
  CANCERS (Basel). 2021 Jun 18;13(12):3043. doi: 10.3390/cancers13123043
• Yamagishi, A; Ito, F; Nakamura, C.
  Study on Cancer Cell Invasiveness via Application of Mechanical Force to Induce Chloride Ion Efflux.
  ANAL CHEM. 2021 Jun 21. doi: 10.1021/acs.analchem.1c01589
• Tomita, T; Wadhwa, R; Kaul, SC; Kurita, R; Kojima, N; Onishi, Y.
  Withanolide Derivative 2,3-Dihydro-3β-methoxy Withaferin-A Modulates the Circadian Clock via Interaction with RAR-Related Orphan Receptor α (RORa.
  J NAT PROD. 2021 Jun 21. doi: 10.1021/acs.jnatprod.0c01276
• Dhanjal, JK; Kumar, V; Garg, S; Subramani, C; Agarwal, S; Wang, J; Zhang, H; Kaul, A; Kalra, RS; Kaul, SC; Vrati, S; Sundar, D; Wadhwa, R
  Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides
  Int J Biol Macromol. 2021 Jun 9:S0141-8130(21)01215-0. doi: 10.1016/j.ijbiomac.2021.06.015
• Li, X; Wang, J; Zhang, H; Xiao, L; Lei, Z; Kaul, SC; Wadhwa, R; Zhang, Z.
  Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties.
  J FUNGI (Basel). 2021 Apr 28;7(5):342. doi: 10.3390/jof7050342
• Penedo, M; Shirokawa, T; Alam, MS; Miyazawa, K; Ichikawa, T; Okano, N; Furusho, H; Nakamura, C; Fukuma, T.
  Cell penetration efficiency analysis of different atomic force microscopy nanoneedles into living cells.
  SCI REP. 2021 Apr 8;11(1):7756. doi: 10.1038/s41598-021-87319-3
• Kalra, RS; Kumar, V; Dhanjal, JK; Garg, S; Li, X; Kaul, SC; Sundar, D; Wadhwa, R.
  COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays.
  J BIOMOL STRUCT DYN. 2021 Apr 2:1-14. doi: 10.1080/07391102.2021.1902858
• Sari AN, Elwakeel A, Dhanjal JK,Kumar V, Sundar D, Kaul SC, Wadhwa R
  Identification and Characterization of Mortaparib(Plus)-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms.
  CANCERS (Basel). 2021 Feb 17;13(4):835. doi: 10.3390/cancers13040835
• Malik V, Kumar V, Kaul SC, Wadhwa R, Sundar D
  Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers.
  BIOMOLECULES. 2021 Jan 26;11(2):160. doi: 10.3390/biom11020160
• Maejima A, Ishibashi K, Kim H, Kumagai I, Asano R
  Evaluation of intercellular cross-linking abilities correlated with cytotoxicities of bispecific antibodies with domain rearrangements using AFM force-sensing.
  BIOSENS BIOELECTRON. 2021 Jan 27;178:113037. doi: 10.1016/j.bios.2021.113037
• Wadhwa R, Yadav NS, Katiyar SP, Yaguchi T, Lee C, Ahn H, Yun CO, Kaul SC, Sundar D
  Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane.
  SCI REP. 2021 Jan 27;11(1):2352. doi: 10.1038/s41598-021-81729-z
• Landeira JM, Liu BB, Omura T, Akiba T, Tanaka Y
  Salinity effects on the first larval stage of the invasive crab Hemigrapsus takanoi: Survival and swimming patterns
  ESTUARINE COASTAL AND SHELF SCIENCE 245; (2020) doi: 10.1016/j.ecss.2020.106976
• Konar A, Kalra RS, Chaudhary A, Nayak A, Guruprasa KP, Satyamoorthy K, Ishida Y, Terao K, Kaul SC, Wadhwa R
  Identification of Caffeic Acid Phenethyl Ester (CAPE) as a Potent Neurodifferentiating Natural Compound That Improves Cognitive and Physiological Functions in Animal Models of Neurodegenerative Diseases
  Front Aging Neurosci. 2020 Nov 10;12:561925. doi: 10.3389/fnagi.2020.561925
• Nishihara R, Niwa K, Tomita T, Kurita R
  Coelenterazine Analogue with Human Serum Albumin-Specific Bioluminescence
  Bioconjug Chem. 2020 Nov 25. doi: 10.1021/acs.bioconjchem.0c00536
• Kim H, Ishibashi K, Iijima M, Kuroda S, Nakamura C
  Influence of Nivolumab for Intercellular Adhesion Force between a T Cell and a Cancer Cell Evaluated by AFM Force Spectroscopy
  Sensors (Basel) 20(19):E5723. (2020)doi: 10.3390/s20195723
• Priyanka, Wadhwa R, Chaudhuri R, Nag TC, Seth P
  Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis
  J Neuroinflammation.;17(1):276. (2020) doi: 10.1186/s12974-020-01912-3
• Yu Y, Yang X, Reghu S, Kaul SC, Wadhwa R, Miyako E
  Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes
  Nat Commun. 11:4117 (2020) doi: 10.1038/s41467-020-17768-3
• Wang J, Bhargava P, Yu Y, Sari AN, Zhang H, Ishii N, Yan K, Zhang Z, Ishida Y, Terao K, Kaul SC, Miyako E, Wadhwa R
  Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells
  Cancers (Basel). 12(9):E2370. (2020) doi: 10.3390/cancers12092370
• Malik V, Garg S, Afzal S, Dhanjal JK, Yun CO, Kaul SC, Sundar D, Wadhwa R
  Bioinformatics and Molecular Insights to Anti-Metastasis Activity of Triethylene Glycol Derivatives
  Int J Mol Sci. 21(15):E5463. (2020) doi: 10.3390/ijms21155463
• Kalra RS, Tomar D, Meena AS, Kandimalla R
  SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings
  Pathogens. 9: 0 (2020) doi: 10.3390/pathogens9070546
• Kumar V, Dhanjal JK, Bhargava P, Kaul A, Wang J, Zhang H, Kaul SC, Wadhwa R, Sundar D
  Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells
  J. Biomolecular Structure 21: 0 (2020) doi: 10.1080/07391102.2020.1775704
• Asano K, Kim HJ, Sakaki K, Nakamura YM, Wang YM, Isobe S, Doi M, Fujita A, Maejima N, Machida A, Watanuki T, Westerwaal RJ, Schreuders H, Dam B
  Metallurgical Synthesis of Mg2FexSi1-x Hydride: Destabilization of Mg2FeH6 Nanostructured in Templated Mg2Si
  Inorganic Chemistry 59: 2758-2764 (2020) doi: 10.1021/acs.inorgchem.9b03117
• Kumar V, Dhanjal JK, Bhargava P, Kaul A, Wang J, Zhang H, Kaul SC, Wadhwa R, Sundar D.
  Withanone and withaferin-A Are Predicted to Interact with Transmembrane Protease Serine 2 (TMPRSS2) and Block Entry of SARS-CoV-2 Into Cells
  J Biomol Struct Dyn. 1-27 (2020) doi: 10.1080/07391102.2020.1775704
• Kumar V, Dhanjal JK, Kaul SC, Wadhwa R, Sundar D
  Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (Mpro) of SARS-CoV-2 and inhibit its activity
  J Biomol Struct Dyn 1-13 (2020) doi: 10.1080/07391102.2020.1772108
• Kim H, Hoshi M, Iijima M, Kuroda S, Nakamura C
  Development of a universal method for the measurement of binding affinities of antibody drugs towards a living cell based on AFM force spectroscopy
  Anal Methods (2020) doi: 10.1039/d0ay00788a
• Sari AN, Bhargava P, Dhanjal JK, Putri JF, Radhakrishnan N, Shefrin S, Ishida Y, Terao K, Sundar D, Kaul SC, Wadhwa R
  Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action
  Cancers 12(5): E1160 (2020). doi: 10.3390/cancers12051160
• Omar A, Kalra RS, Putri J, Elwakeel A, Kaul SC, Wadhwa R
  Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells
  Sci Rep. 10: 6323 (2020) doi: 10.1038/s41598-020-62953-5
• Kalra RS, Chaudhary A, Omar A, Cheung CT, Garg S, Kaul SC, Wadhwa R
  Stress-induced changes in CARF expression determine cell fate to death, survival, or malignant transformation
  Cell Stress Chaperones 25(3): 481-494 (2020). doi: 10.1007/s12192-020-01088-y
• Kurinomaru T, Inagaki A, Hoshi M, Nakamura C, Yamazoe H
  Protein microswimmers capable of delivering cells for tissue engineering applications
  Materials Horizons 7 7: 877-884 (2020) doi: 10.1039/c9mh01799b
• Afzal S, Garg S, Adiga D, Ishida Y, Terao K, Kaul SC, Wadhwa R
  Anti-stress, Glial- and Neuro-differentiation Potential of Resveratrol: Characterization by Cellular, Biochemical and Imaging Assays
  Nutrients 12(3): 671 (2020). doi: 10.3390/nu12030671
• Kim H, Ishibashi K, Okada T, Nakamura C
  Adhesion strengths between cancer cells with different malignancies and endothelial cells measured using atomic force microscopy
  Jpn J Appl Phys 59: SDDE01 (2020) doi: 10.7567/1347-4065/ab51ad
• Garg S, Huifu H, Kumari A, Sundar D, Kaul SC, Wadhwa R
  Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential
  J Gerontol A Biol Sci Med Sci. 75(6):1031-1041 (2020). doi: 10.1093/gerona/glz077
• Putri JF, Bhargava P, Dhanjal JK, Yaguchi T, Sundar D, Kaul SC, Wadhwa R
  Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
  J Exp Clin Cancer Res. 38(1): 499 (2019). doi: 10.1186/s13046-019-1500-9
• Tomita T, Mori T, Onishi Y
  beta-Arrestin 1 (ARRB1) serves as a molecular marker of the peripheral circadian rhythm
  Int J Oral Sci. 11: 32 (2019) doi: 10.1038/s41368-019-0065-y
• Chaudhary A, Kalra RS, Malik V, Katiyar SP, Sundar D, Kaul SC, Wadhwa R
  2, 3-Dihydro-3beta-methoxy Withaferin-A Lacks Anti-Metastasis Potency: Bioinformatics and Experimental Evidences
  Sci Rep. 9(1):17344 (2019). doi: 10.1038/s41598-019-53568-6
• Garg S, Wu C, Ohmiya Y, Kaul SC, Wadhwa R
  Express ELISA for detection of mortalin
  Biotechniques. 67(4):166-171 (2019). doi: 10.2144/btn-2018-0158
• Kim H, Ishibashi K, Okada T, Nakamura C
  Mechanical Property Changes in Breast Cancer Cells Induced by Stimulation with Macrophage Secretions in Vitro
  Micromachines 10: 738 (2019) doi: 10.3390/mi10110738
• Konar A, Gupta R, Shukla RK, Maloney B, Khanna VK, Wadhwa R, , Lahiri DK, Thakur MK
  M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera
  Sci Rep. 9(1):13990 (2019). doi: 10.1038/s41598-019-48238-6
• Kim H, Ishibashi K, Matsuo K, Kira A, Okada T, Watanabe K, Inada, M, Nakamura C
  Quantitative Measurements of Intercellular Adhesion Strengths between Cancer Cells with Different Malignancies Using Atomic Force Microscopy
  Anal Chem 91: 10557-10563 (2019) doi: 10.1021/acs.analchem.9b01569
• Yu Y, Wang J, Kaul SC, Wadhwa R, Miyako E
  Folic Acid Receptor-Mediated Targeting Enhances the Cytotoxicity, Efficacy, and Selectivity of Withania somnifera Leaf Extract: In vitro and in vivo Evidence
  Front Oncol. 9: 602 (2019). doi: 10.3389/fonc.2019.00602
• Garg S, Afzal S, Elwakeel A, Sharma D, Radhakrishnan N, Dhanjal JK, Sundar D, Kaul SC, Wadhwa R
  Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence
  Mar Drugs. 17(6): 338 (2019). doi: 10.3390/md17060338
• Wadhwa R, Li L, Singh R, Wang J, Gao R, Nigam N, Forestier S, Ando N, Kaul SC
  Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin
  Evid Based Complement Alternat Med. 10: 800-805 (2019) doi: 10.1155/2019/9848969
• Yamagishi A, Susaki M, Takano Y, Mizusawa M, Mishima M, Iijima M, Kuroda S, Okada T, Nakamura C
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