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AIST-INDIA 機能性資源連携研究室

研究概要

我々は、細胞培養、生化学・分子生物学、バイオインフォマティクスなどを統合した手法を用い、ストレス、加齢、がんなどの生命現象の理解及びそれらに介入する独自技術の開発に取り組んでいます。
既存技術では不可能だった細胞機能の解析を実現し、ヒト正常細胞で厳密に制御される細胞分裂と増殖が、がん化により破綻するメカニズムに注目し研究を進めています。
このプロジェクトのために、インド国内の様々な研究機関との国際連携を行っており、学生や若手研究者育成のための様々なプログラムを推進しています。
参照 http://web.iitd.ac.in/~sundar/dailab/ AIST-INDIA 機能性資源連携研究室

研究課題

研究課題1:がん標的としてのモータリンとCARFの検証:ストレス及びがん生物学におけるその役割の分子的理解、および介入ツールと技術の開発
研究担当者:ワダワ レヌー

我々が独自にクローニングした2つのタンパク質、モータリンとCARFは、がん細胞で過剰に発現することから、抗がん剤の新たな標的として注目されています。現在、それらのタンパク質について、以下のような検証を進めています。
(i)ストレス、老化及びがん生物学における役割の解明、
(ii)ストレス及びがん診断への有用性、
(iii)ストレス及びがん介入のための阻害剤としての利用

AIST-INDIA機能性資源連携研究室2

研究課題

研究課題2:分子バイオメカニクスに基づく生命現象の動的原理の解明
研究担当者:中村 史、秋葉 龍郎、金 賢徹、山岸 彩奈

直径200nmのナノニードルやお椀形状磁気微粒子マグカップなど独自のナノ材料技術を駆使して、生命の精密かつ柔軟な動作原理を分子レベルで理解する研究を推進します。具体的には、細胞に極めてダメージの小さいナノニードル技術を用いた生細胞内での分子計測と分子操作、転移に関与する新規がんマーカーの機械的機能の解析とこれを標的とした診断および治療技術の開発、センシング機能搭載マグカップを用いたマーカー分子微量発現がん細胞の高感度検出と解析などの研究を行っています。

AIST-INDIA機能性資源連携研究室3

研究課題

研究課題3:細胞を用いた新たな機能性評価系の開発とその応用
研究担当者:冨田 辰之介

天然資源等からの新規な機能性物質探索を行うために、バイオアッセイを中心に実験を進めています。バイオアッセイとしては、培養細胞を用いて、毒性評価、免疫応答性、生体リズムについて、生物発光を取り入れた新しい検出方法を開発しています。さらにこの開発した技術を用いて新たな生理活性物質を探索しています。植物などの二次代謝産物から生理活性物質を探索しますが、アッセイには粗精製物も適用可能です。その中から必要に応じて活性物質の単離や同定を行い、活性物質の作用点やメカニズムを明らかにする研究も行っています。

AIST-INDIA機能性資源連携研究室4

メンバー

名前 役職 主な研究テーマ
ワダワ レヌー WADHWA Renu 連携研究室長 ・がん発生におけるモータリンの分子機構解析
・アシュワガンダによるがんの抑制と治療
・ストレス改善の為のCARFメカニズム解析
中村 史 NAKAMURA Chikashi 副連携研究室長 ・中間径フィラメント捕縛による転写制御機構の解明
・ナノニードルを用いた安全・高効率物質導入技術の開発
・悪性がん細胞の機械的特性に着目した浸潤性制御
秋葉 龍郎 AKIBA Tatsuro 主任研究員 ・水棲生物の速度勾配応答特性の研究
・水棲生物の自動分級装置の開発
・海洋生態系構造観測装置の開発
冨田 辰之介 TOMITA Tatsunosuke 主任研究員 ・生体リズムを指標とした生理活性物質探索
・生理活性物質探索に適したレポータ細胞の設計構築
・細胞の培養方法を工夫した新たなアッセイ方法開発
金 賢徹 KIM Hyonchol 主任研究員 ・AFMを用いたがん組織細胞間相互作用解析
・新規微粒子の開発と1細胞分子計測への応用
・オンチップ計測によるリキッドバイオプシー
山岸 彩奈 YAMAGISHI Ayana 研究員 ・がん細胞の転移に関わる中間径フィラメントの機能解明
・癌細胞の弾性率と転移性の関係解明
・癌転移性評価方法の開発
カウル スニル KAUL Sunil 招聘研究員

業績リスト

  • Priyanka, Wadhwa R, Chaudhuri R, Nag TC, Seth P
    Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis
    J Neuroinflammation.;17(1):276. (2020) doi: 10.1186/s12974-020-01912-3
  • Yu Y, Yang X, Reghu S, Kaul SC, Wadhwa R, Miyako E
    Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes
    Nat Commun. 11:4117 (2020) doi: 10.1038/s41467-020-17768-3
  • Wang J, Bhargava P, Yu Y, Sari AN, Zhang H, Ishii N, Yan K, Zhang Z, Ishida Y, Terao K, Kaul SC, Miyako E, Wadhwa R
    Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells
    Cancers (Basel). 12(9):E2370. (2020) doi: 10.3390/cancers12092370
  • Malik V, Garg S, Afzal S, Dhanjal JK, Yun CO, Kaul SC, Sundar D, Wadhwa R
    Bioinformatics and Molecular Insights to Anti-Metastasis Activity of Triethylene Glycol Derivatives
    Int J Mol Sci. 21(15):E5463. (2020) doi: 10.3390/ijms21155463
  • Kalra RS, Tomar D, Meena AS, Kandimalla R
    SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings
    Pathogens. 9: 0 (2020) doi: 10.3390/pathogens9070546
  • Kumar V, Dhanjal JK, Bhargava P, Kaul A, Wang J, Zhang H, Kaul SC, Wadhwa R, Sundar D
    Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells
    J. Biomolecular Structure 21: 0 (2020) doi: 10.1080/07391102.2020.1775704
  • Asano K, Kim HJ, Sakaki K, Nakamura YM, Wang YM, Isobe S, Doi M, Fujita A, Maejima N, Machida A, Watanuki T, Westerwaal RJ, Schreuders H, Dam B
    Metallurgical Synthesis of Mg2FexSi1-x Hydride: Destabilization of Mg2FeH6 Nanostructured in Templated Mg2Si
    Inorganic Chemistry 59: 2758-2764 (2020) doi: 10.1021/acs.inorgchem.9b03117
  • Kumar V, Dhanjal JK, Bhargava P, Kaul A, Wang J, Zhang H, Kaul SC, Wadhwa R, Sundar D.
    Withanone and withaferin-A Are Predicted to Interact with Transmembrane Protease Serine 2 (TMPRSS2) and Block Entry of SARS-CoV-2 Into Cells
    J Biomol Struct Dyn. 1-27 (2020) doi: 10.1080/07391102.2020.1775704
  • Kumar V, Dhanjal JK, Kaul SC, Wadhwa R, Sundar D
    Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (Mpro) of SARS-CoV-2 and inhibit its activity
    J Biomol Struct Dyn 1-13 (2020) doi: 10.1080/07391102.2020.1772108
  • Kim H, Hoshi M, Iijima M, Kuroda S, Nakamura C
    Development of a universal method for the measurement of binding affinities of antibody drugs towards a living cell based on AFM force spectroscopy
    Anal Methods (2020) doi: 10.1039/d0ay00788a
  • Sari AN, Bhargava P, Dhanjal JK, Putri JF, Radhakrishnan N, Shefrin S, Ishida Y, Terao K, Sundar D, Kaul SC, Wadhwa R
    Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action
    Cancers 12(5): E1160 (2020). doi: 10.3390/cancers12051160
  • Omar A, Kalra RS, Putri J, Elwakeel A, Kaul SC, Wadhwa R
    Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells
    Sci Rep. 10: 6323 (2020) doi: 10.1038/s41598-020-62953-5
  • Kalra RS, Chaudhary A, Omar A, Cheung CT, Garg S, Kaul SC, Wadhwa R
    Stress-induced changes in CARF expression determine cell fate to death, survival, or malignant transformation
    Cell Stress Chaperones 25(3): 481-494 (2020). doi: 10.1007/s12192-020-01088-y
  • Kurinomaru T, Inagaki A, Hoshi M, Nakamura C, Yamazoe H
    Protein microswimmers capable of delivering cells for tissue engineering applications
    Materials Horizons 7 7: 877-884 (2020) doi: 10.1039/c9mh01799b
  • Afzal S, Garg S, Adiga D, Ishida Y, Terao K, Kaul SC, Wadhwa R
    Anti-stress, Glial- and Neuro-differentiation Potential of Resveratrol: Characterization by Cellular, Biochemical and Imaging Assays
    Nutrients 12(3): 671 (2020). doi: 10.3390/nu12030671
  • Kim H, Ishibashi K, Okada T, Nakamura C
    Adhesion strengths between cancer cells with different malignancies and endothelial cells measured using atomic force microscopy
    Jpn J Appl Phys 59: SDDE01 (2020) doi: 10.7567/1347-4065/ab51ad
  • Garg S, Huifu H, Kumari A, Sundar D, Kaul SC, Wadhwa R
    Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential
    J Gerontol A Biol Sci Med Sci. 75(6):1031-1041 (2020). doi: 10.1093/gerona/glz077
  • Putri JF, Bhargava P, Dhanjal JK, Yaguchi T, Sundar D, Kaul SC, Wadhwa R
    Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
    J Exp Clin Cancer Res. 38(1): 499 (2019). doi: 10.1186/s13046-019-1500-9
  • Tomita T, Mori T, Onishi Y
    beta-Arrestin 1 (ARRB1) serves as a molecular marker of the peripheral circadian rhythm
    Int J Oral Sci. 11: 32 (2019) doi: 10.1038/s41368-019-0065-y
  • Chaudhary A, Kalra RS, Malik V, Katiyar SP, Sundar D, Kaul SC, Wadhwa R
    2, 3-Dihydro-3beta-methoxy Withaferin-A Lacks Anti-Metastasis Potency: Bioinformatics and Experimental Evidences
    Sci Rep. 9(1):17344 (2019). doi: 10.1038/s41598-019-53568-6
  • Garg S, Wu C, Ohmiya Y, Kaul SC, Wadhwa R
    Express ELISA for detection of mortalin
    Biotechniques. 67(4):166-171 (2019). doi: 10.2144/btn-2018-0158
  • Kim H, Ishibashi K, Okada T, Nakamura C
    Mechanical Property Changes in Breast Cancer Cells Induced by Stimulation with Macrophage Secretions in Vitro
    Micromachines 10: 738 (2019) doi: 10.3390/mi10110738
  • Konar A, Gupta R, Shukla RK, Maloney B, Khanna VK, Wadhwa R, , Lahiri DK, Thakur MK
    M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera
    Sci Rep. 9(1):13990 (2019). doi: 10.1038/s41598-019-48238-6
  • Kim H, Ishibashi K, Matsuo K, Kira A, Okada T, Watanabe K, Inada, M, Nakamura C
    Quantitative Measurements of Intercellular Adhesion Strengths between Cancer Cells with Different Malignancies Using Atomic Force Microscopy
    Anal Chem 91: 10557-10563 (2019) doi: 10.1021/acs.analchem.9b01569
  • Yu Y, Wang J, Kaul SC, Wadhwa R, Miyako E
    Folic Acid Receptor-Mediated Targeting Enhances the Cytotoxicity, Efficacy, and Selectivity of Withania somnifera Leaf Extract: In vitro and in vivo Evidence
    Front Oncol. 9: 602 (2019). doi: 10.3389/fonc.2019.00602
  • Garg S, Afzal S, Elwakeel A, Sharma D, Radhakrishnan N, Dhanjal JK, Sundar D, Kaul SC, Wadhwa R
    Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence
    Mar Drugs. 17(6): 338 (2019). doi: 10.3390/md17060338
  • Wadhwa R, Li L, Singh R, Wang J, Gao R, Nigam N, Forestier S, Ando N, Kaul SC
    Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin
    Evid Based Complement Alternat Med. 10: 800-805 (2019) doi: 10.1155/2019/9848969
  • Yamagishi A, Susaki M, Takano Y, Mizusawa M, Mishima M, Iijima M, Kuroda S, Okada T, Nakamura C
    The Structural Function of Nestin in Cell Body Softening is Correlated with Cancer Cell Metastasis
    INTERNATIONAL J. Biological Sciences 15: 1546-1556 (2019) doi: 10.7150/ijbs.33423
  • Irie H, Ito K, Fujioka Y, Oguchi K, Fujioka A, Hashimoto A, , Ohsawa H, Tanaka K, Funabashi K, Araki H, Kawai Y, Shimamura T, , Wadhwa R, Ohkubo S, Matsuo K
    TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models
    Mol Cancer Ther. 18: 733-742 (2019) doi: 10.1158/1535-7163. MCT-18-1085
  • Kalra RS, Bapat SA
    Proteomics to Predict Loss of RXR-gamma During Progression of Epithelial Ovarian Cancer
    Methods Mol Biol. 19: 0 (2019) doi: 10.1007/978-1-4939-9585-1_1
  • Yamagishi A, Matsumoto D, Kato Y, Honda Y, Morikawa M, Iwata F, , Kobayashi T, Nakamura C
    Direct Delivery of Cas9-sgRNA Ribonucleoproteins into Cells Using a Nanoneedle Array
    Applied Sciences-Basel 9: 10 (2019) doi: 10.3390/app9050965
  • Afzal S, Garg S, Ishida Y, Terao K, Kaul SC, Wadhwa R
    Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin
    Mar Drugs. 17(3):189 (2019). doi: 10.3390/md17030189
  • Furuhata Y, Sakai A, Murakami T, Morikawa M,Nakamura C,Yoshizumi, T, Fujikura U, Nishida K, Kato Y
    A method using electroporation for the protein delivery of Cre recombinase into cultured Arabidopsis cells with an intact cell wall
    Scientific Reports 509: 943-948 (2019) doi: 10.1038/s41598-018-38119-9
  • Odaka M, Kim H, Nakamura Y, Hattori A, Matsuura K, Iwamura M, Miyagi Y, Yasuda K
    Size Distribution Analysis with On-Chip Multi-Imaging Cell Sorter for Unlabeled Identification of Circulating Tumor Cells in Blood
    Micromachines10:154 (2019) doi: 10.3390/mi10020154
  • Sundar D, Yu Y, Katiyar SP, Putri JF, Dhanjal JK, Wang J, Sari AN, Kolettas E, Kaul SC, Wadhwa R
    Wild type p53 function in p53(Y220C) mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence
    J Exp Clin Cancer Res. 38(1): 103 (2019). doi: 10.1186/s13046-019-1099-x
  • Bhargava P, Malik V, Liu Y, Ryu J, Kaul SC, Sundar D, Wadhwa R
    Molecular Insights into Withaferin-A-Induced Senescence: Bioinformatics and Experimental Evidence to the Role of NFkappaB and CARF
    J Gerontol A Biol Sci Med Sci. 74: 183-191 (2019) doi: 10.1093/gerona/gly107
  • Garg S, Kaul SC, Wadhwa R
    Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence
    Ann Neurosci. 25: 201-209 (2018) doi: 10.1159/000490693
  • Ishida Y, Gao R, Shah N, Bhargava P, Furune T, Kaul SC, Terao K, Wadhwa R
    Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With gamma-Cyclodextrin
    Integr Cancer Ther. 17: 867-873 (2018) doi: 10.1177/1534735417753545
  • Bhargava P, Kumari A, Putri JF, Ishida Y, Terao K, Kaul SC, Sundar D, Wadhwa R
    Caffeic acid phenethyl ester (CAPE) possesses pro-hypoxia and anti-stress activities: bioinformatics and experimental evidences
    Cell Stress Chaperones. 23: 1055-1068 (2018) doi: 10.1007/s12192-018-0915-0
  • Hasako S, Terasaka M, Abe N, Uno T, Ohsawa H, Hashimoto A, Fujita R, Tanaka K, Okayama T, Wadhwa R, Miyadera K, Aoyagi Y, Yonekura K, Matsuo K
    TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations
    Mol Cancer Ther. 17: 1648-1658 (2018) doi: 10.1158/1535-7163.MCT-17-1206
  • Garg S, Huifu H, Kaul SC, Wadhwa R
    Integration of conventional cell viability assays for reliable and reproducible read-outs: experimental evidence
    BMC Res Notes. 11: 403 (2018) doi: 10.1186/s13104-018-3512-5
  • Nagasaki A, Kato Y, Meguro K, Yamagishi A, Nakamura C, Uyeda TQP
    A genome editing vector that enables easy selection and identification of knockout cells
    Plasmid. 9: 3829 (2018) doi: 10.1016/j.plasmid.2018.08.005
  • Yu Y, Nishikawa M, Liu M, Tei T, Kaul SC, Wadhawa R, Zhang MF, Takahashi J, Miyako E
    Self-assembled nanodiamond supraparticles for anticancer chemotherapy
    Nanoscale 10: 8969-8978 (2018) doi: 10.1039/c8nr00641e
  • Kalra RS, Chaudhary A, Yoon AR, Bhargava P, Omar A, Garg S, Yun, CO, Kaul SC, Wadhwa R
    CARF enrichment promotes epithelial-mesenchymal transition via Wnt/beta-catenin signaling: its clinical relevance and potential as a therapeutic target
    Oncogenesis. 7(5): 39 (2018). doi: 10.1038/s41389-018-0048-4
  • Kaur A, Singh B, Ohri P, Wang J, Wadhwa R, Kaul SC, Pati PK, Kaur A
    Organic cultivation of Ashwagandha with improved biomass and high content of active Withanolides: Use of Vermicompost
    PLoS One. 13(4): e0194314 (2018). doi: 10.1371/journal.pone.0194314
  • Nishio M, Yamagishi A, Tsukakoshi K, Kato Y, Nakamura C, Ikebukuro, K
    Selection and Characterization of DNA Aptamers Against FokI Nuclease Domain
    Zinc Finger Proteins 509: 943-948 (2018) doi: 10.1007/978-1-4939-8799-3_12
  • Oh E, Garg S, Liu Y, Afzal S, Gao R, Yun CO, Kaul SC, Wadhwa R
    Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
    Front Oncol. 8: 552 (2018). doi: 10.3389/fonc.2018.00552
  • Bhargava P, Grover A, Nigam N, Kaul A, Doi M, Ishida Y, Kakuta H, Kaul SC, Terao K, Wadhwa R
    Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action
    Int J Oncol. 52: 925-932 (2018) doi: 10.3892/ijo.2018.4249
  • Garg S, Kaul SC, Wadhwa R
    Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review
    Int J Oncol. 52: 19-37 (2018) doi: 10.3892/ijo.2017.4203.
  • Li L, Gao R, Yu Y, Kaul Z, Wang J, Kalra RS, Zhang Z, Kaul SC, Wadhwa R
    Tumor suppressor activity of miR-451: Identification of CARF as a new target
    Sci Rep. 8: 375 (2018) doi: 10.1038/s41598-017-18559-5
  • Kim H, Ishibashi K, Matsuo K, Kira A, Onomura Y, Okada T, Nakamura C
    Adhesion strength of a living cell to various substrates measured using a cup-attached AFM chip
    Jpn J Appl Phys 57: 03EB01 (2018) doi: 10.7567/JJAP.57.03EB01
  • Ryu, S, Matsumoto Y, Matsumoto T, Ueno T, Silberberg YR, Nakamura C
    Improved efficiency of nanoneedle insertion by modification with a cell-puncturing protein
    Jpn J Appl Phys 57: 03EB02 (2018) doi.org/ 10.7567/JJAP.57.03EB02
  • Kawamura R, Miyazaki M, Shimizu K, Matsumoto Y, Silberberg YR, Sathuluri RR, Iijima M, Ruroda S, Iwata F, Kobayashi T, Nakamura C
    A New Cell Separation Method Based on Antibody-Immobilized Nanoneedle Arrays for the Detection of Intracellular Markers
    Nano Lett. 17: 7117-7124 (2017) doi: 10.1021/acs.nanolett.7b03918
  • Chaudhary A, Kalra RS, Huang C, Prakash J, Kaul SC, Wadhwa R
    2,3-Dihydro-3beta-methoxy Withaferin-A Protects Normal Cells against Stress: Molecular Evidence of Its Potent Cytoprotective Activity
    J Nat Prod. 80: 2756-2760 (2017) doi: 10.1021/acs.jnatprod.7b00573
  • Lee WJ, Ahn HM, Na Y, Wadhwa R, Hong J, Yun CO
    Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids
    Sci Rep. 7(1):12957(2017) doi: 10.1038/s41598-017-13485-y
  • Putri JF, Widodo N, Sakamoto K, Kaul SC, Wadhwa R
    Induction of senescence in cancer cells by 5-Aza-2-deoxycytidine: Bioinformatics and experimental insights to its targets
    Comput Biol Chem. 125: 168-174 (2017) doi: 10.1016/j.compbiolchem.2017.08.003
  • Wadhwa R, Kalra RS, Kaul SC
    CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis
    Mech Ageing Dev. 14: 3025-3035 (2017) doi: 10.1016/j.mad.2017.07.008
  • Kim H, Yamagishi A, Imaizumi M, Onomura Y, Nagasaki A, Miyagi Y, Okada T, Nakamura C
    Quantitative measurements of intercellular adhesion between a macrophage and cancer cells using a cup-attached AFM chip
    Colloids Surf B Biointerfaces 37: 366-372 (2017) doi: 10.1016/j.colsurfb.2017.04.039
  • Girault M, Kim H,, Arakawa H, Matsuura K, Odaka M, Hattori A, Terazono H, Yasuda K
    An on-chip imaging droplet-sorting system: a real-time shape recognition method to screen target cells in droplets with single cell resolution
    Sci Rep 7: 40072 (2017) doi: 10.1038/srep40072
  • Nishio M, Matsumoto D, Kato Y, Abe K, Lee J, Tsukakoshi K, Yamagishi A, Nakamura C,, Ikebukuro K
    DNA aptamers against FokI nuclease domain for genome editing applications
    Biosens. Bioelectron. 93: 26-31 (2017) doi: 10.1016/j.bios.2016.11.042
  • Tomita T, Kurita R, Onishi Y
    Epigenetic regulation of the circadian clock: role of 5-aza-2-deoxycytidine
    Biosci Rep. 37: 0 (2017) doi: 10.1042/BSR20170053
  • Nagasaki A, T Kijima S, Yumoto T, Imaizumi M, Yamagishi A, Kim H, Nakamura C, Q P Uyeda T
    The Position of the GFP Tag on Actin Affects the Filament Formation in Mammalian Cells
    Cell Struct Funct. 42: 131-140 (2017) doi: 10.1247/csf.17016
  • Singh P, Guleri R, Angurala A, Kaur K, Kaur K, Kaul SC, Wadhwa R, Pati PK
    Addressing Challenges to Enhance the Bioactives of Withania somnifera through Organ, Tissue, and Cell Culture Based Approaches
    Biomed Res Int. 486: 539-544 (2017) doi: 10.1155/2017/3278494
  • Yu Y, Katiyar SP, Sundar D, Kaul Z, Miyako E, Zhang Z, Kaul SC, Reddel RR, Wadhwa R
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