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多細胞システム制御研究グループ
研究概要
我々は独自の細胞工学（幹細胞品質管理、生体模倣・疾患モデル）、先端分析（シングルセル糖鎖/遺伝子seq技術、クライオ電顕技術）、有機合成（糖ペプチド合成技術）を融合することで、創薬・再生医療産業、食品産業、スマートセル産業の推進に貢献する革新的技術を開発します。
研究課題
研究課題1:糖鎖解析技術の開発
研究担当者:小高 陽樹、舘野 浩章
糖鎖は全ての細胞の最も外側を覆い、細胞の種類や状態（分化、がん化）で変化することから「細胞の顔」と呼ばれ、再生医療に用いる細胞の品質管理や、がん等の疾患の創薬標的として期待されています。我々はこれまで組換えレクチンライブラリーを構築し、これらを用いることで糖鎖をプロファイリングする技術の開発に取り組んできました。まず複数のレクチンをスライドグラス上に固定化したレクチンアレイの開発と利用を進めてきました。また最近、シーケンシングによる糖鎖プロファイリング技術を開発し、１細胞ごとの糖鎖発現と遺伝子発現を同時解析する技術(scGR-seq）の確立に展開することに成功しました。さらに微生物叢の糖鎖プロファイリングにも応用しました。本技術の更なる高度化と応用を進めていきます。
研究課題
研究課題2:幹細胞品質管理技術の開発
研究担当者:渡邊 朋子、原本 悦和、回渕 修治、舘野 浩章
ヒト多能性細胞やヒト間葉系幹細胞は再生医療のための細胞源として期待されています。これら細胞をヒトに移植する際、細胞の安全性や品質の確保が極めて重要です。我々はこれまで、移植用細胞に残存する造腫瘍性のヒト多能性幹細胞を非破壊的に検出し、除去する技術を開発し、企業と共同で実用化することに成功しました。今後も新しい品質管理技術の開発を目指します。
研究課題
研究課題3:がん、糖尿病、精神・神経変性疾患診断治療技術の開発
研究担当者:回渕 修治、小高 陽樹、桑原 知子、舘野 浩章
がん、糖尿病、精神・神経疾患の診断技術の開発は、確定診断・治療方針の決定・QOLの向上・早期の社会復帰のために重要です。我々は正常細胞と疾患細胞（前立腺がん、乳がん、膵癌、糖尿病、精神疾患）の細胞機能や遺伝子・糖鎖発現を比較解析することで、新規の診断技術の開発を目指しています。
研究課題
研究課題4:エクソソームの分離精製、活用技術の開発
研究担当者:石井 則行、小高 陽樹、渡邊 朋子、舘野 浩章
エクソソームは真核細胞のエンドソーム区画で産生される細胞膜結合性の細胞外小胞であり、体循環に乗って他の細胞へと運ばれ、発生、生理、病理的プロセスにおいて細胞間コミュニケーションツールとして機能しています。
所内外と連携し、細胞から分泌された直後のインタクトな状態にある膜小胞の調製技術の高度化、活用技術の開発、糖鎖機能解明など、理工学的視点からナノサイズの未開拓領域である謎多きエクソソームの本質の解明に挑戦します。
研究課題
研究課題5:器官形成・組織再生メカニズムの解析
研究担当者:原本 悦和
再生医療に利用できる臓器・組織の作製方法を開発するために、生体内で臓器・組織が形作られるメカニズムの解明を行っています。両生類は脊椎動物の中で非常に高い再生能力を有しており、その再生メカニズムを解析し、得られた知見を医療に応用することを目指しています。
また、自己複製能や多分化能を有する成体幹細胞は、様々な組織において、失われた細胞を補うことで恒常性を維持する上で重要な役割を果たしており、再生医療に有用な幹細胞として期待されています。 成体幹細胞を探索し、成体幹細胞の自己再生と未分化状態の維持に重要な微小環境とシグナルの解明を目指しています。
研究課題
研究課題6:マイクロ波を利用した糖ペプチド合成
研究担当者:清水 弘樹
電子レンジに活用される様に、マイクロ波により物質を効率的に加熱することができる。この特性を利用して、マイクロ波は化学反応の効率加熱手段として多用されている。一方、化学反応におけるマイクロ波の加熱特性以外の特有効果についても多く研究されているが、実験手法上の問題や、また真向からマイクロ波効果を否定する研究者も存在するなど、一般に特有効果については疑問視される傾向にあることは否めない。
我々は、この「まやかし」とも揶揄されるマイクロ波特有の非加熱効果について、実験的にその存在を明確にし、その正体を暴く研究を進めている。具体的には、 LeX３糖体合成において低温維持のままマイクロ波照射することで「不可能を可能」にし、マイクロ波の導電損失作用を利用することで酵素反応の促進させた。その他に、低温でも反応促進させることで、高価で貴重な糖アミノ酸シントンの安定性と反応性両方の向上に成功し、世界に類のない複雑な糖鎖ペプチドの数十mgスケール合成法の確立に成功した。
多種の糖鎖を含む合成した複雑な糖鎖ペプチドは、創薬分野へ2次研究展開されている。
メンバー
| 名前 | 役職 | 主な研究テーマ |
|---|---|---|
| 舘野 浩章 TATENO Hiroaki | グループ長 | ・１細胞糖鎖RNA同時計測技術の開発 ・膵がんの診断・治療技術の開発 ・微生物叢やエクソソーム糖鎖解析技術の開発 |
| 清水 弘樹 SHIMIZU Hiroki | 主任研究員 | ・有機合成化学におけるマイクロ波利用と効果検証研究 ・複雑な糖ペプチドの合成研究 ・細胞を制御する生理活性物質、薬剤候補化合物の合成研究 |
| 石井 則行 ISHII Noriyuki | 主任研究員 | ・細胞外小胞（エクソソーム）の生物物理化学特性の解明 ・生体超分子・タンパク複合体のクライオ電子顕微鏡解析 ・自己組織化、配向制御・階層的秩序形成の生物物理解析 |
| 桑原 知子 KUWABARA Tomoko | 主任研究員 | ・成体神経幹細胞の分化制御機構の解明 ・疾患下の成体神経幹細胞の制御機構の解明 ・運動による神経幹細胞機能の活性化機構の解析 |
| 原本 悦和 HARAMOTO Yoshikazu | 主任研究員 | ・器官形成メカニズムの解析 ・組織再生メカニズムの解析 ・成体幹細胞の探索と制御機構の解析 |
| 回渕 修治 MAWARIBUCHI Shuuji | 主任研究員 | ・細胞の品質管理技術の開発 ・細胞の性質評価系の開発 ・細胞・組織・臓器における性差の解析 |
| 渡邊 朋子 WATANABE Tomoko | 主任研究員 | ・幹細胞の品質管理マーカー探索 ・幹細胞の分化能評価系開発 ・間葉系幹細胞による血管新生機構解明 |
| 小高 陽樹 ODAKA Haruki | 研究員 | ・精神疾患の診断・創薬支援技術開発 ・エクソソームの性状解析 ・iPS細胞を使った脳オルガノイドの作製と応用 |
業績リスト
- Odaka, H.
Target-Specific O-linked N-acetylglucosamine Modification with a Dual-Specificity Aptamer Reveals Functions of O-GlcNAcylation in beta-catenin.
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. May 25, 2023; Volume 35(2023) Issue 205. doi: 10.4052/tigg.2309.6E - Watanabe, T, Tateno, H.
Lectin Blotting of Cell Lysates.
CURR PROTOC. 2023 May;3(5):e790. doi: 10.1002/cpz1.790 - Kuroda, Y; Oda, T; Shimomura, O; Louphrasitthiphol, P; Mathis, BJ; Tateno, H, Hatano, K.
Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: (18) F-labeled rBC2LCN lectin.
CANCER SCI. 2023 May 19. doi: 10.1111/cas.15846 - Odaka, H; Tateno, H.
Single-Cell Glycan and RNA Sequencing (scGR-seq).
CURR PROTOC. 2023 May;3(5):e777. doi: 10.1002/cpz1.777 - Ikemoto, MJ; Aihara, Y; Ishii, N; Shigemori, H.
3,4-Dihydroxybenzalacetone Inhibits the Propagation of Hydrogen Peroxide-Induced Oxidative Effect via Secretory Components from SH-SY5Y Cells.
BIOL PHARM BULL. 2023;46(4):599-607. doi: 10.1248/bpb.b22-00727 - Murata, Y; Jitsukawa, T; Iida, M; Furuta, T; Haramoto, Y; Shigeri, Y; Fujisaki, S.
Liquid chromatography-mass spectrometry analyses of polyprenyl phosphates in Escherichia coli cells in which genes for isoprenoid synthesis are amplified.
J BIOSCI BIOENG. 2023 Mar 1:S1389-1723(23)00047-6. doi: 10.1016/j.jbiosc.2023.02.003 - Mawaribuchi, S; Ito, M; Ogata, M; Yoshimura, Y; Miura, I.
Parallel Evolution of Sex-Linked Genes across XX/XY and ZZ/ZW Sex Chromosome Systems in the Frog Glandirana rugosa.
GENES (Basel). 2023 Jan 18;14(2):257. doi: 10.3390/genes14020257 - Sato, Y; Kato, Y; Iizumi, Y; Morimoto, T; Kobashi, K; Sugino, T; Tateno, H; Okazaki, T.
Size distributions of cellulose nanocrystals in dispersions using the centrifugal sedimentation method.
INT J BIOL MACROMOL. 2023 Feb 2:123520. doi: 10.1016/j.ijbiomac.2023.123520 - Mawaribuchi, S; Shimomura, O; Oda, T; Hiemori, K; Shimizu, K; Yamase, K; Date, M; Tateno, H.
rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma.
GLYCOBIOLOGY. 2023 Feb 2:cwad009. doi: 10.1093/glycob/cwad009 - Huang, T; Sato, Y; Kuramochi, A; Ohba, Y; Sano, M; Miyagishi, M; Tateno, H; Wadhwa, R; Kawasaki, K; Uchida, T; Ekdahl, KN; Nilsson, B; Chung, UI; Teramura, Y.
Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells.
REGEN THER. 2023 Jan 11;22:90-98. doi: 10.1016/j.reth.2022.12.007 - Mawaribuchi, S; Haramoto, Y; Ikeda, N; Ito, M.
Evolutionary features of ligands and their receptors via protein-protein interactions and essentiality in primates.
GENES CELLS. 2023 Jan 9. doi: 10.1111/gtc.13006 - Ishii, N.
C-shaped dipper: A novel useful auxiliary tool for preparation of specimen grids for transmission electron microscopy.
MICROSC RES TECH. 2022 Dec 29. doi: 10.1002/jemt.24283 - Ando, M; Kawasaki, H; Tamura, S; Haramoto, Y; Shigeri, Y.
Recent Advances in Gas Sensing Technology Using Non-Oxide II-VI Semiconductors CdS, CdSe, and CdTe.
CHEMOSENSORS. 2022 10(11)482. doi: 10.3390/chemosensors10110482 - Nagashima, I; Sugiyama, JI; Shimizu, H.
Study of 400 MHz microwave conduction loss effect for a hydrolysis reaction by thermostable β-Glucosidase HT1.
BIOSCI BIOTECHNOL BIOCHEM. 2022 Dec 6:zbac194. doi: 10.1093/bbb/zbac194 - Kuroda, Y; Shimomura, O; Nakahashi, H; Miyazaki, Y; Nakajima, T; Tateno, H; Oda, T.
Lectin-based photoimmunotherapy targeting cell surface glycans for pancreatic cancer.
CANCER RESEARCH 82 (22). 2022 NOV 15. doi: 10.1158/1538-7445.PANCA22-B083 - Kuroda, Y; Oda, T; Shimomura, O; Hashimoto, S; Akashi, Y; Miyazaki, Y; Furuya, K; Furuta, T; Nakahashi, H; Louphrasitthiphol, P; Mathis, BJ; Nakajima,T; Tateno, H.
Lectin-based phototherapy targeting cell surface glycans for pancreatic cancer.
INT J CANCER. 2022 Nov 22. doi: 10.1002/ijc.34362 - Tasaki, M; Tateno, H; Sato, T; Narimatsu, H; Saito, K; Nakagawa, Y; Aoki, T; Kamimura, M; Ushiki, T; Takahashi, K; Tomita, Y.
Hyporesponsiveness against donors ABO antigens of renal grafts after ABO-incompatible kidney transplantation.
CLIN EXP NEPHROL. 2022 Oct 8. doi: 10.1007/s10157-022-02280-3 - Kosaka, T; Yamaguchi, S; Izuta, S; Yamahira, S; Shibasaki, Y; Tateno, H; Okamoto, A.
Bioorthogonal Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications.
AM CHEM SOC. 2022 Sep 20. doi: 10.1021/jacs.2c07321 - Yamasaki, K; Adachi, N; Ngwe Tun, MM; Ikeda, A; Moriya, T; Kawasaki, M; Yamasaki, T; Kubota, T; Nagashima, I; Shimizu, H; Tateno, H; Morita, K.
Core fucose-specific Pholiota squarrosa lectin (PhoSL) as a potent broad-spectrum inhibitor of SARS-CoV-2 infection.
FEBS J. 2022 Aug 25. doi: 10.1111/febs.16599 - Katsumi, T; Shams, F; Yanagi, H; Ohnishi, T; Toda, M; Lin, SM; Mawaribuchi, S; Shimizu, N; Ezaz, T; Miura, I.
Highly rapid and diverse sex chromosome evolution in the Odorrana frog species complex.
DEV GROWTH DIFFER. 2022 Jul 26. doi: 10.1111/dgd.12800 - Numakawa, T; Odaka, H.
The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022 Jul 13;23(14):7726. doi: 10.3390/ijms23147726 - Kokubu, R; Ohno, S; Kuratani, H; Takahashi, Y; Manabe, N; Shimizu, H; Chiba, Y; Denda-Nagai, K; Tsuiji, M; Irimura, T; Yamaguchi, Y.
O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations.
INT J MOL SCI. 2022 Jul 16;23(14):7855. doi: 10.3390/ijms23147855 - Nagae, M; Hirata, T; Tateno, H; Mishra, SK; Manabe, N; Osada, N; Tokoro, Y; Yamaguchi, Y; Doerksen, RJ; Shimizu, T; Kizuka, Y.
Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A).
COMMUN BIOL. 2022 Jul 19;5(1):695. doi: 10.1038/s42003-022-03661-w - Odaka, H.
Genome-wide CRISPR/Cas9 Screening Identifies KDM2B as a Modifier of Heparan Sulfate-Protein Interactions.
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. 2022 Volume 34 Issue 199 Pages E63. doi: 10.4052/tigg.2203.6E - Tsukano, K; Yamamoto, T; Watanabe, T; Michiue, T.
Xenopus Dusp6 modulates FGF signaling to precisely pattern pre-placodal ectoderm.
DEVELOPMENTAL BIOLOGY. 2022 May 16. doi: 10.1016/j.ydbio.2022.05.009 - Oinam, L; Tateno, H.
Glycan Profiling by Sequencing to Uncover Multicellular Communication: Launching Glycobiology in Single Cells and Microbiomes.
FRONT CELL DEV BIOL. 2022 May 27;10:919168. doi: 10.3389/fcell.2022.919168 - Yang, Y; Akashi, Y; Shimomura, O; Tateno, H; Saito, S; Hiemori, K; Miyazaki, Y; Furuta, T; Kitaguchi, D; Kuroda, Y; Pakavarin, L; Oda, T.
Glycan expression profile of signet ring cell gastric cancer cells and potential applicability of rBC2LCN-targeted lectin drug conjugate therapy.
GASTRIC CANCER. 2022 Jun 17. doi: 10.1007/s10120-022-01312-x - Miura, I; Shams, F; Jeffries, DL; Katsura, Y; Mawaribuchi, S; Perrin, N; Ito, M; Ogata, M; Ezaz, T.
Identification of ancestral sex chromosomes in the frog Glandirana rugosa bearing XX-XY and ZZ-ZW sex-determining systems.
MOL ECOL. 2022 Jun 12. doi: 10.1111/mec.16551 - Odaka, H; Hiemori, K; Shimoda, A; Akiyoshi, K; Tateno, H.
CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma.
BMC GASTROENTEROLOGY. 2022 Mar 28;22(1):153. doi: 10.1186/s12876-022-02228-7 - Hayashi, Y; Yimiti, D; Sanada, Y; Ding, C; Omoto, T; Ogura, T; Nakasa, T; Ishikawa, M; Hiemori, K; Tateno, H; Miyaki, S; Adachi, N.
The therapeutic capacity of bone marrow MSC-derived extracellular vesicles in Achilles tendon healing is passage-dependent and indicated by specific glycans.
FEBS LETTERS. 2022 Apr;596(8):1047-1058. doi: 10.1002/1873-3468.14333 - Tasaki, M; Tateno, H; Sato, T; Tomioka, A; Kaji, H; Narimatsu, H; Saito, K; Nakagawa, Y; Aoki, T; Kamimura, M; Ushiki, T; Okada, M; Miwa, Y; Hotta, K; Yoshida, Y; Takahashi, K; Tomita, Y.
A Novel Method of CD31-Combined ABO Carbohydrate Antigen Microarray Predicts Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.
TRANSPL INT. 2022 Mar 23;35:10248. doi: 10.3389/ti.2022.10248 - Oinam, L; Hayashi, R; Hiemori, K; Kiyoi, K; Sage-Ono, K; Miura, K; Ono, M; Tateno, H.
Quantitative evaluation of glycan-binding specificity of recombinant Concanavalin A produced in lettuce (Lactuca sativa).
BIOTECHNOL BIOENG. 2022 Apr 8. doi: 10.1002/bit.28099 - Ishii, N.
Systematic Investigation of Lanthanoid Transition Heavy Metal Acetates as Electron Staining Reagents for Protein Molecules in Biological Transmission Electron Microscopy.
MICROSC MICROANAL. 2022 Apr 1:1-10. doi: 10.1017/S1431927622000411 - Seo, N; Nakamura, J; Kaneda, T; Tateno, H; Shimoda, A; Ichiki, T; Furukawa, K; Hirabayashi, J; Akiyoshi, K; Shiku, H.
Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method.
J EXTRACELL VESICLES. 2022 Mar;11(3):e12205. doi: 10.1002/jev2.12205 - Odaka, H; Ozaki, H; Tateno, H.
scGR-seq: Integrated analysis of glycan and RNA in single cells.
STAR PROTOC. 2022 Feb 18;3(1):101179. doi: 10.1016/j.xpro.2022.101179. eCollection - Irumagawa, S; Hiemori, K; Saito, S; Tateno, H; Arai, R.
Self-Assembling Lectin Nano-Block Oligomers Enhance Binding Avidity to Glycans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 (2);doi: 10.3390/ijms23020676 JAN - Oinam, L; Tateno, H.
Evaluation of Glycan-Binding Specificity by Glycoconjugate Microarray with an Evanescent-Field Fluorescence Detection System.
METHODS MOL BIOL. 2022;2460:25-32. doi: 10.1007/978-1-0716-2148-6_2 - Kaifu, T; Yabe, R; Maruhashi, T; Chung, SH; Tateno, H; Fujikado, N; Hirabayashi, J; Iwakura, Y.
DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.
J EXP MED. 2021 Dec 6;218(12):e20210435. doi: 10.1084/jem.20210435. Epub 2021 Nov - Shimoda, A; Miura, R; Tateno, H; Seo, N; Shiku, H; Sawada, S; Sasaki, Y; Akiyoshi, K.
Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications.
SMALL METHODS; doi: 10.1002/smtd.202100785 - Tulin, EKC; Nakazawa, C; Nakamura, T; Saito, S; Ohzono, N; Hiemori, K; Nakakita, SI; Tateno, H; Tonozuka, T; Nishikawa, A.
Glycan detecting tools developed from the Clostridium botulinum whole hemagglutinin complex.
SCI REP. 2021 Nov 9;11(1):21973. doi: 10.1038/s41598-021-01501-1 - Kaigawa, H; Tateno, H; Arai, R.
Self-Assembling Functional Complexes of Protein Nanobuilding Blocks with a Trimeric Lectin.
PROTEIN SCIENCE 30 158-159; OCT - Irumagawa, S; Tateno, H; Arai, R.
Self-Assembling Lectin Nano-Building Blocks Enhance Avidity to Glycans through Polyvalent Effect.
PROTEIN SCIENCE 30 173-174; OCT - Hoshi, K; Ito, H; Abe, E; Fuwa, TJ; Kanno, M; Murakami, Y; Abe, M; Murakami, T, Yoshihara, A, Ugawa, Y, Saito, T, Saido, TC, Matsumoto, K, Yamaguchi, Y, Furukawa, K, Arai, H, Kanai, M, Miyajima, M, Arai, H, Ogawa, N, Akatsu, H, Hashizume, Y, Tateno, H, Honda, T, Hashimoto, Y.
Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimers Disease.
METABOLITES. 2021 Sep 10;11(9):616. doi: 10.3390/metabo11090616 - Minoshima, F; Ozaki, H; Odaka, H; Tateno, H.
Integrated analysis of glycan and RNA in single cells.
ISCIENCE. 2021 Jul 17;24(8):102882. doi: 10.1016/j.isci.2021.102882. eCollection - Watanabe, T; Takeda, K; Hiemori, K; Minamisawa, T; Tateno, H.
A glycosaminoglycan microarray identifies the binding of SARS-CoV-2 spike protein to chondroitin sulfate E.
FEBS LETT. 2021 Aug 10. doi: 10.1002/1873-3468.14173 - Haramoto, Y.
First person - Yoshikazu Haramoto.
BIOLOGY OPEN 10 (4);doi: 10.1242/bio.058759 APR - Ogita, Y; Tamura, K; Mawaribuchi, S; Takamatsu, N; Ito, M.
Independent pseudogenizations and losses of sox15 during amniote diversification following asymmetric ohnolog evolution.
BMC ECOL EVOL. 2021 Jun 30;21(1):134. doi: 10.1186/s12862-021-01864-z - Furuta, T; Oda, T; Kiyoi, K; Ozawa, Y; Kimura, S; Kurimori, K; Miyazaki, Y; Yu, Y; Furuya, K; Akashi, Y; Shimomura, O; Tateno, H
Carcinoembryonic antigen as a specific glycoprotein ligand of rBC2LCN lectin on pancreatic ductal adenocarcinoma cells
Cancer Sci. 2021 Jun 11. doi: 10.1111/cas.15023 - Numakawa, T; Odaka, H.
Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimers Disease: Beneficial Effects of Flavonoids for Neuroprotection.
INT J MOL SCI. 2021 May 27;22(11):5719. doi: 10.3390/ijms22115719 - Haramoto, Y; Sakata, M; Kobayashi, S.
Visualization of X chromosome reactivation in mouse primordial germ cells in vivo.
BIOL OPEN. 2021 Apr 15;10(4):bio058602. doi: 10.1242/bio.058602. Epub 2021 Apr 29 - Watanabe, T; Tateno, H.
Elimination of cells deviated from human induced pluripotent stem cells with a photoactivatable IR700-labelled antibody.
BIOCHEM BIOPHYS RES COMMUN. 2021 Mar 25;554:13-18. doi: 10.1016/j.bbrc.2021.03.078 - Furuta T, Tateno H, Kiyoi K, Miyazaki Y, Kimura S, Kurimori K, Shimomura O, Oda T
Glycans on CEA as a targeting ligand of pancreatic ductal adenocarcinoma in novel lectin-drug conjugated therapy.
CANCER SCIENCE 112 718-718; FEB - Odaka H, Numakawa T, Soga M, Kido J, Matsumoto S, Kajihara R, Okumiya T, Tani N, Tanoue Y, Fukuda T, Furuya H, Inoue T, Era T
An iPSC-based neural model of sialidosis uncovers glycolytic impairment-causing presynaptic dysfunction and deregulation of Ca(2+) dynamics
Neurobiol Dis. 2021 Jan 28:105279. doi: 10.1016/j.nbd.2021.105279 - Kimura S, Oda T, Shimomura O, Enomoto T, Hashimoto S, Kuroda Y, Yu Y, Kurimori K, Furuta T, Miyazaki Y, Tateno H
Novel Pancreatic Cancer Therapy Targeting Cell Surface Glycans by Liposomes Modified with rBC2LCN Lectin
Eur Surg Res. 2021 Jan 27:1-10. doi: 10.1159/000513430 - Inagaki H, Haramoto Y, Kubota HY, Shigeri Y
Complete mitochondrial genome sequence of Japanese forest green tree frog (Rhacophorus arboreus.
Mitochondrial DNA B Resour 2020 Sep 16;5(3):3347-3348. doi: 10.1080/23802359.2020.1820396 - Odaka H, Hiemori K, Shimoda A, Akiyoshi K, Tateno H
Platelet-derived extracellular vesicles are increased in sera of Alzheimers disease patients, as revealed by Tim4-based assays.
FEBS OPEN BIO 2020 Dec 20. doi: 10.1002/2211-5463.13068 - Hasehira K, Furuta T, Shimomura O, Asada M, Oda T, Tateno H
Quantitative structural analysis of glycans expressed within tumors derived from pancreatic cancer patient-derived xenograft mouse models
Biochem Biophys Res Commun. 2020 Dec 4:S0006-291X(20)32131-8. doi: 10.1016/j.bbrc.2020.11.087 - Kitaguchi D, Oda T, Enomoto T, Ohara Y, Owada Y, Akashi Y, Furuta T, Yu Y, Kimura S, Kuroda Y, Kurimori K, Miyazaki Y, Furuya K, Shimomura O, Tateno H
Lectin Drug Conjugate Therapy for Colorectal Cancer
Cancer Sci. 2020 Oct 15. (2020) doi: 10.1111/cas.14687 - Inagaki H, Haramoto Y, Kubota HY, Shigeri Y
Complete mitochondrial genome sequence of Japanese forest green tree frog (Rhacophorus arboreus)
MITOCHONDRIAL DNA PART B-RESOURCES 5 (3) 3365-3366; (2020) doi:10.1080/23802359.2020.1820396 - Watanabe T, Kakuta J, Saito S, Hasehira K, Kiyoi K, Imai T, Tateno H
Monoclonal antibodies specific for podocalyxin expressed on human induced pluripotent stem cells.
Biochem Biophys Res Commun. 2020 Sep 7:S0006-291X(20)31692-2. (2020) doi:10.1016/j.bbrc.2020.08.092 - Giron LB, Colomb F, Papasavvas E, Azzoni L, Yin X, Fair M, Anzurez A, Damra M, Mounzer K, Kostman JR, Tebas P, ODoherty U, Tateno H, Liu Q, Betts MR, Montaner LJ, Abdel-Mohsen M
Interferon-α alters host glycosylation machinery during treated HIV infection
EBioMedicine. 59:102945. (2020) doi: 10.1016/j.ebiom.2020.102945 - Wang J, Bhargava P, Yu Y, Sari AN, Zhang H, Ishii N, Yan K, Zhang Z, Ishida Y, Terao K, Kaul SC, Miyako E, Wadhwa R
Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells
Cancers (Basel). 12(9):E2370. (2020) doi: 10.3390/cancers12092370 - Watanabe T, Saito S, Hiemori K, Kiyoi K, Mawaribuchi S, Haramoto Y, Tateno H
SSEA-1-positive fibronectin is secreted by cells deviated from the undifferentiated state of human induced pluripotent stem cells
Biochem Biophys Res Commun. 529 (3) 575-581;(2020) doi:10.1016/j.bbrc.2020.06.074 - Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M
Sialyl-Lewis(X) Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy
Cell Rep. Aug 4;32(5):107991. (2020) doi: 10.1016/j.celrep.2020.107991 - Oinam L, Changarathil G, Raja E, Ngo YX, Tateno H, Sada A, Yanagisawa H
Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging
Aging Cell. 35: 0 (2020) doi:10.1111/acel.13190 - Haramoto Y＃, Onuma Y＃, Mawaribuchi S, Nakajima Y, Aiki Y, Higuchi K, Shimizu M, Tateno H, Hirabayashi J, Ito Y.
A technique for removing tumourigenic pluripotent stem cells using rBC2LCN lectin.
Regen Ther. 14: 306-314 (2020) doi: 10.1016/j.reth.2020.03.017 - Tateno H*
Expression and Purification of a Human Pluripotent Stem Cell-Specific Lectin Probe, rBC2LCN
Methods Mol Biol. 9084: 30080-8 (2020) doi: 10.1007/978-1-0716-0430-4_44 - Mawaribuchi S, Haramoto Y, Tateno H, Onuma Y, Aiki Y, Ito Y
rBC2LCN lectin as a potential probe of early-stage HER2-positive breast carcinoma
FEBS Open Bio 10: 1056-1064 (2020) doi: 10.1002/2211-5463.12852 - Giron LB, Tanes CE, Schleimann MH, Engen PA, Mattei LM, Anzurez A, Damra M, Zhang HJ, Bittinger K, Bushman F, Kossenkov A, Denton PW, Tateno H, Keshavarzian A, Landay AL, Abdel-Mohsen M
Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection
Mucosal Immunology 129: 215-222 (2020) doi: 10.1038/s41385-020-0279-5 - Giron LB, Papasavvas E, Azzoni L, Yin XF, Anzurez A, Damra M, Mounzer K, Kostman JR, Sanne I, Firnhaber CS, Tateno H, Liu Q, Montaner LJ, Abdel-Mohsen M
Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint
Aids 34 34: 681-686 (2020) doi: 10.1097/QAD.0000000000002476 - Tateno H*, Hiemori K, Minoshima F, Kiyoi K, Matoba K, Katayama J, Kumada Y
Oriented immobilization of rBC2LCN lectin for highly sensitive detection of human pluripotent stem cells using cell culture supernatants
J Biosci Bioeng. 129: 215-222 (2020) doi: 10.1016/j.jbiosc.2019.08.003 - Ogita Y＃, Mawaribuchi S＃, Nakasako K, Tamura K, Matsuda M, Katsumura T, Oota H, Watanabe G, Yoneda S, Takamatsu N, Ito M
Parallel Evolution of Two dmrt1-Derived Genes, dmy and dm-W, for Vertebrate Sex Determination
iScience 23: 100757 (2020) doi: 10.1016/j.isci.2019.100757 - Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A
Clec10a regulates mite-induced dermatitis
Science Immunology 4 4: 0 (2019) doi: 10.1126/sciimmunol.aax6908 - Ogawa T, Sato R, Naganuma T, Liu K, Lakudzala AE, Muramoto K, Osada M, Yoshimi K, Hiemori K, Hirabayashi J, Tateno H
Glycan Binding Profiling of Jacalin-Related Lectins from the Pteria Penguin Pearl Shell
Int J Mol Sci. 20: 0 (2019) doi: 10.3390/ijms20184629 - Mawaribuchi S*, Ito Y, Ito M＊
Independent evolution for sex determination and differentiation in the DMRT family in animals
Biology Open 8: 10 (2019) doi: 10.1242/bio.041962 - Mawaribuchi S, Aiki Y, Ikeda N, Ito Y
mRNA and miRNA expression profiles in an ectoderm-biased substate of human pluripotent stem cells
Scientific Reports 189: 233-248 (2019) doi: 10.1038/s41598-019-48447-z - Yamasaki K, Kubota T, Yamasaki T, Nagashima I, Shimizu H, Terada RI, Nishigami H, Kang J, Tateno M, Tateno H
Structural basis for specific recognition of core fucosylation in N-glycans by Pholiota squarrosa lectin (PhoSL
Glycobiology. 29: 576-587 (2019) doi: 10.1093/glycob/cwz025 - Oguma K, Sato T, Kawahara T, Haramoto Y, Yamanishi Y
Identification of Aquatic Organisms Using a Magneto-Optical Element
Sensors 19: 3254 (2019) doi: 10.3390/s19153254 - Khummuang S, Chuensirikulchai K, Pata S, Laopajon W, Chruewkamlow N, Mahasongkram K, Sugiura N, Watanabe H, Tateno H, Kamuthachad L, Wongratanacheewin S, Takheaw N, Kasinrerk W
Characterization and functional analysis of novel circulating NK cell sub-populations
Int Immunol. 31: 515-530 (2019) doi: 10.1093/intimm/dxz027 - Tateno H*
Human Stem Cell Glycome: From Structural Elucidation to Social Implementation
Trends In Glycoscience And Glycotechnology 31: 0 (2019) doi: 10.4052/tigg.1939.2SE - Mawaribuchi S, Onuma Y, Aiki Y, Kuriyama Y, Mutoh M, Fujii G, Ito, Y
The rBC2LCN-positive subpopulation of PC-3 cells exhibits cancer stem-like properties
Biochem Biophys Res Commun. 515: 176-182 (2019) doi: 10.1016/j.bbrc.2019.05.108 - Matsunami M, Suzuki M, Haramoto Y, Fukui A, Inoue T, Yamaguchi K, Uchiyama I, Mori K, Tashiro K, Ito Y, Takeuchi T, Suzuki KT, Agata K, Shigenobu S, Hayashi T
A comprehensive reference transcriptome resource for the Iberian ribbed newt Pleurodeles waltl, an emerging model for developmental and regeneration biology
DNA Res. 26: 217-229 (2019) doi: 10.1093/dnares/dsz003 - Dion J, Minoshima F, Saito S, Kiyoi K, Hasehira K, Tateno H*
Photoactivable Elimination of Tumorigenic Human Induced Pluripotent Stem Cells by Using a Lectin-Doxorubicin Prodrug Conjugate
Chembiochem. 20: 1606-1611 (2019) doi: 10.1002/cbic.201900086 - Yamazaki T, Inui M, Hiemori K, Tomono S, Itoh M, Ichimonji I, Nakashima A, Takagi H, Biswas M, Izawa K, Kitaura J, Imai T, Sugiura N, Tateno H, Akashi-Takamura S
Receptor-destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis
J Biol Chem. 294: 6659-6669 (2019) doi: 10.1074/jbc.RA118.006375 - Kondo M, Matsuo M, Igarashi K, Haramoto Y, Yamamoto T, Yasuoka Y, Taira M
De novo transcription of multiple Hox cluster genes takes place simultaneously in early Xenopus tropicalis embryos
Biology Open 8: bio038422 (2019) doi: 10.1242/bio.038422 - Yokoyama H, Moreno-Andres D, Astrinidis SA, Hao Y, Weberruss M, Schellhaus AK, Lue H, Haramoto Y, Gruss OJ, Antonin W
Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome
Life Sci Alliance. 2: e201800120 (2019) doi: 10.26508/lsa.201800120 - Sakai K, Hiemori K, Tateno H, Hirabayashi J, Gonoi T
Fucose-specific lectin of Aspergillus fumigatus: binding properties and effects on immune response stimulation
Med Mycol. 57: 71-83 (2019) doi: 10.1093/mmy/myx163 - Omata Y, Aoki R, Aoki-Yoshida A, Hiemori K, Toyoda A, Tateno H, Suzuki C, Takayama Y
Reduced fucosylation in the distal intestinal epithelium of mice subjected to chronic social defeat stress
Sci Rep. 8: 13199 (2018) doi: 10.1038/s41598-018-31403-8 - Unno H, Nakamura A, Mori S, Goda S, Yamaguchi K, Hiemori K, Tateno H, Hatakeyama T
Identification, Characterization, and X-ray Crystallographic Analysis of a Novel Type of Lectin AJLec from the Sea Anemone Anthopleura japonica
Sci Rep. 8: 11516 (2018) doi: 10.1038/s41598-018-29498-0 - Hirabayashi J, Hu D, Tateno H, Kuwabara N, Kato R, Yagi F
Carbohydrate Recognition Mechanism of the Mushroom Galectin ACG
Trends In Glycoscience And Glycotechnology 30: 0 (2018) doi: 10.4052/tigg.1736.1SE - Yamasaki K, Yamasaki T, Tateno H
The trimeric solution structure and fucose-binding mechanism of the core fucosylation-specific lectin PhoSL
Sci Rep. 8: 7740 (2018) doi: 10.1038/s41598-018-25630-2 - Nakagawa Y, Tateno H, Ebara M
Investigation of Selective Recognition of Sugars Using Lectin-inspired Temperature-responsive Polymers
Chemistry Letters 47: 134-137 (2018) doi: 10.1246/cl.170967 - Saito S, Hiemori K, Kiyoi K, Tateno H*
Glycome analysis of extracellular vesicles derived from human induced pluripotent stem cells using lectin microarray
Sci Rep. 8: 3997 (2018) doi: 10.1038/s41598-018-22450-2 - Shimomura O, Oda T, Tateno H, Ozawa Y, Kimura S, Sakashita S, Noguchi M, Hirabayashi J, Asashima M, Ohkohchi N
A Novel Therapeutic Strategy for Pancreatic Cancer: Targeting Cell Surface Glycan Using rBC2LC-N Lectin-Drug Conjugate (LDC
Mol Cancer Ther. 17: 183-195 (2018) doi: 10.1158/1535-7163.MCT-17-0232 - Ishii N
Folding and Binding Properties of Human Complement Receptor Type 1 Extracellular Domain
Peripheral Membrane Proteins 1: 105-122, (2018) doi:10.5772/intechopen.75120 - Hasehira K, Hirabayashi J, Tateno H*
Structural and quantitative evidence of alpha2-6-sialylated N-glycans as markers of the differentiation potential of human mesenchymal stem cells
Glycoconj J. 34: 797-806 (2017) doi: 10.1007/s10719-016-9699-6 - Nagae M, Mishra SK, Hanashima S, Tateno H, Yamaguchi Y
Distinct roles for each N-glycan branch interacting with mannose-binding type Jacalin-related lectins Orysata and Calsepa
Glycobiology. 27: 1120-1133 (2017) doi: 10.1093/glycob/cwx081 - Dion J, Advedissian T, Storozhylova N, Dahbi S, Lambert A, Deshayes F, Viguier M, Tellier C, Poirier F, Teletchea S, Dussouy C, Tateno H, Hirabayashi J, Grandjean C
Development of a Sensitive Microarray Platform for the Ranking of Galectin Inhibitors: Identification of a Selective Galectin-3 Inhibitor
Chembiochem. 18: 2428-2440 (2017) doi: 10.1002/cbic.201700544 - Fujimaki S, Kuwabara T
Diabetes-Induced Dysfunction of Mitochondria and Stem Cells in Skeletal Muscle and the Nervous System
Int J Mol Sci. 18: 0 (2017) doi: 10.3390/ijms18102147 - Fujimaki S, Kuwabara T
Diabetes-Induced Dysfunction of Mitochondria and Stem Cells in Skeletal Muscle and the Nervous System
INTERNATIONAL J. Molecular Sciences 18: 10 (2017) doi: 10.3390/ijms18102147 - Yagi H, Tateno H, Hayashi K, Hayashi T, Takahashi K, Hirabayashi J, Kato K, Tsuboi M
Lectin microarray analysis of isolated polysaccharides from Sasa veitchii
Biosci Biotechnol Biochem. 81: 1687-1689 (2017) doi: 10.1080/09168451.2017.1340089 - Hatakeyama T, Ichise A, Unno H, Goda S, Oda T, Tateno H, , Hirabayashi J, Sakai H, Nakagawa H
Carbohydrate recognition by the rhamnose-binding lectin SUL-I with a novel three-domain structure isolated from the venom of globiferous pedicellariae of the flower sea urchin Toxopneustes pileolus
Protein Science 26: 1574-1583 (2017) doi: 10.1002/pro.3185 - Tateno H*, Saito S
Engineering of a Potent Recombinant Lectin-Toxin Fusion Protein to Eliminate Human Pluripotent Stem Cells
Molecules. 22: 0 (2017) doi: 10.3390/molecules22071151 - Haramoto Y, Saijyo T, Tanaka T, Furuno N, Suzuki A, Ito Y, Kondo M, Taira M, Takahashi S
Identification and comparative analyses of Siamois cluster genes in Xenopus laevis and tropicalis
Dev Biol. 426: 374-383 (2017) doi: 10.1016/j.ydbio.2016.07.015 - Itakura Y, Nakamura-Tsuruta S, Kominami J, Tateno H, Hirabayashi J
Sugar-Binding Profiles of Chitin-Binding Lectins from the Hevein Family: A Comprehensive Study
INTERNATIONAL J. Molecular Sciences 18: 10 (2017) doi: 10.3390/ijms18061160 - Sato T, Tateno H, Kaji H, Chiba Y, Kubota T, Hirabayashi J, Narimatsu H
Engineering of recombinant Wisteria floribunda agglutinin specifically binding to GalNAcbeta1,4GlcNAc (LacdiNAc
Glycobiology. 0: 0 (2017) doi: 10.1093/glycob/cwx038 - Nakata H, Lin CY, Abolhassani M, Ogawa T, Tateno H, Hirabayashi J, Muramoto K
Isolation of Rice Bran Lectins and Characterization of Their Unique Behavior in Caco-2 Cells
Int J Mol Sci. 18: 0 (2017) doi: 10.3390/ijms18051052 - Ishii N
Electron microscopic and physicobiochemical studies of chaperonin GroEL and GroES complexes.
Microscopy and imaging science: practical approaches to applied research and education 7: 112-119 (2017)
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GroEL and the GroEL-GroES Complex
Macromolecular Protein Complexes: Structure And Function 83: 483 (2017) doi: 10.1007/978-3-319-46503-6_17 - Ishii N
GroEL and the GroEL-GroES Complex
Subcell Biochem. 7: 11563 (2017) doi: 10.1007/978-3-319-46503-6_17 - Yamamoto YY, Uno Y, Sha E, Ikegami K, Ishii N, Dohmae N, Sekiguchi H, Sasaki YC, Yohda M
Asymmetry in the function and dynamics of the cytosolic group II chaperonin CCT/TRiC
PloS One. 12: 0 (2017) doi: 10.1371/journal.pone.0176054