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分子細胞マルチオミクス研究グループ

研究概要

からだの主成分であるタンパク質は、その多くが糖鎖の修飾を受けて機能分子として働いています。糖鎖も含めた理解があって本来の機能を知ることができますが、ほかの機能分子に比べ、糖鎖は圧倒的に調べにくいことが課題でした。
私たちは、複数の独自糖タンパク質解析・利用技術を開発し、複合的なオミクス解析に組み込むことで、生命の理解を深め医療に貢献する研究を進めています。

分子細胞マルチオミクス研究グループ紹介

研究課題

研究課題1:タンパク質上糖鎖修飾機構の統合的理解を目指したマルチオミクス技術の開発
研究担当者:久野 敦、梶 裕之、岡谷 千晶

主要な翻訳後修飾の一つである糖鎖修飾は、タンパク質の立体構造や細胞内局在、他分子との相互作用等を変化させることで、タンパク質機能を制御することが知られています。
このようなタンパク質上糖鎖の生体機能を理解するためには、疾患や生理状態の変化に伴い、どのような糖鎖修飾機構の変化が生じ、その結果どのようなタンパク質のどの部位にどのような構造の糖鎖修飾がどの程度発現するのかを、特定糖タンパク質、細胞、組織、個体の各レベルで統合的に理解することが重要です。
産総研では、この重要課題に多角的に取り組むため、グライコプロテオミクス、グライコミクス、トランスクリプトミクス、メタボロミクス等のマルチオミクス技術の開発を進めています。また、これらの開発技術により取得したデータを糖鎖科学コミュニティで広く活用できるよう、データベース開発・公開にも積極的に取り組んでいます。

分子細胞マルチオミクス研究グループ2

研究課題

研究課題2:細胞糖鎖機能解析
研究担当者:佐藤 隆、日尾野 隆大

細胞が正常なコントロールから外れて、がんなどの疾患状態になると、糖鎖構造が変化することが知られています。
産総研では、疾患における特定のタンパク質上の糖鎖変化を疾患バイオマーカーや創薬標的として活用する研究開発を行なってきました。しかしながら、変化した糖鎖がどのような機能を持つのかは、ほとんど解明されていません。
当グループでは、正常状態と疾患状態の個体、組織、細胞、分子における糖鎖変化を、糖鎖遺伝子、糖タンパク質、タンパク質、分解物などを対象に、多様な網羅的解析(マルチオミクス)技術を用いて多角的に解析を行います。マルチオミクス解析から得られるデータと、細胞増殖、転移能、分化能、細胞死などの細胞機能解析や、癌、免疫、生殖、老化、ウイルス感染などの疾患に関連する病態表現型解析の結果を統合することにより、糖鎖の構造と機能の関係を統合的に理解することを目指しています。

分子細胞マルチオミクス研究グループ3

メンバー

名前 役職 主な研究テーマ
久野 敦 KUNO Atsushi グループ長 ・糖鎖バイオマーカー・糖鎖標的開発と橋渡し
・グライコプロテオームアトラスの構築
・全自動糖鎖プロファイリングシステムの実用化
梶 裕之 KAJI Hiroyuki 上級主任研究員 ・糖ペプチド同定のための質量分析解析法の開発
・疾患特異的糖タンパク質バイオマーカー・創薬標的の探索
・グライコプロテオーム解析による糖鎖修飾の実態の解明
佐藤 隆 Sato Takashi 主任研究員 ・糖鎖遺伝子改変による糖鎖機能解析
・改変レクチンを用いた疾患関連分子の検出
・糖鎖改変細胞を用いた糖タンパク質生産
岡谷 千晶 OKATANI Chiaki 主任研究員 ・組織糖鎖プロファイリング技術の開発・応用
・グライコプロテオミクス技術の開発・応用
・マーカー・治療標的となる糖タンパク質の探索と橋渡し
日尾野 隆大 HIONO Takahiro 研究員 ・レクチンマイクロアレイ技術の開発
・ウイルス感染症の病態発現における糖鎖の意義解明
・ウイルス粒子上の糖鎖解析技術の開発と応用
安形 清彦 ANGATA Kiyohiko 招聘研究員

業績リスト

  • Yokose T, Kabe Y, Matsuda A, Kitago M, Matsuda S, Hirai M, Nakagawa T, Masugi Y, Hishiki T, Nakamura Y, Shinoda M, Yagi H, Abe Y, Oshima G, Hori S, Nakano Y, Honda K, Kashiro A, Morizane C, Nara S, Kikuchi S, Shibahara T, Itonaga M, Ono M, Minegishi N, Koshiba S, Yamamoto M, Kuno A, Handa H, Sakamoto M, Suematsu M, Kitagawa Y
    O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer
    Cancers (Basel) 12(9):E2469. (2020) doi: 10.3390/cancers12092469
  • Angata K, Sawaki H, Tsujikawa S, Ocho M, Togayachi A, Narimatsu H
    Glycogene Expression Profiling of Hepatic Cells by RNA-Seq Analysis for Glyco-Biomarker Identification.
    FRONTIERS IN ONCOLOGY 10 57-77; (2020) doi: 10.3389/fonc.2020.01224
  • Ito K, Angata K, Kuno A, Okumura A, Sakamoto K, Inoue R, Morita N, Watashi K, Wakita T, Tanaka Y, Sugiyama M, Mizokami M, Yoneda M, Narimatsu H
    Screening siRNAs against host glycosylation pathways to develop novel antiviral agents against hepatitis B virus
    HEPATOLOGY RESEARCH ; (2020) doi: 10.1111/hepr.13552
  • Hiono T, Kuno A
    C-Terminally tagged NA in replication-competent influenza A viruses reveals differences in glycan profiles between NA and HA
    Analyst. 145(17): 5845-5853. (2020) doi: 10.1039/d0an00770f
  • Angata K, Sawaki H, Tsujikawa S, Ocho M, Togayachi A, Narimatsu H.
    Glycogene expression profiling of hepatic cells by RNA-Seq analysis for glyco-biomarker identification.
    Frontiers In Oncology. 10:1224 (2020). doi: 10.3389/fonc.2020.01224
  • Hiono T and Kuno A.
    C-terminally tagged NA in replication competent influenza A viruses reveals differences in glycan profiles between NA and HA.
    Analyst. Accepted(2020). doi:10.1039/D0AN00770F
  • Silsirivanit A Matsuda A, Kuno A, Tsuruno C, Uenoyama Y, Seubwai W, Angata K, Teeravirote K, Wongkham C, Araki N, Takahama Y, Wongkham S, Narimatsu H.
    Multi-serum glycobiomarkers improves the diagnosis and prognostic prediction of cholangiocarcinoma.
    Clin Chim Acta. 510:142-149 (2020). doi: 10.1016/j.cca.2020.07.017
  • Yamada I, Shiota M, Shinmachi D, Ono T, Tsuchiya S, Hosoda M, Fujita A, Aoki NP, Watanabe Y, Fujita N, Angata K, Kaji H, Narimatsu H, Okuda S, Aoki-Kinoshita KF.
    The GlyCosmos Portal: a unified and comprehensive web resource for the glycosciences.
    Nat Methods.17: 649-650 (2020). doi: 10.1038/s41592-020-0879-8
  • Matsuda A, Kuno A#*, Yoshida M, Wagatsuma T, Sato T, Miyagishi M, Suematsu M, Kabe Y, Narimatsu H
    Comparative glycomic analysis of exosome subpopulations derived from pancreatic cancer cell lines.
    J Proteom Res 19: 2516-2524 (2020). doi.org:10.1021/acs.jproteome.0c00200
  • Ulaankhuu A, Bazarragchaa E, Okamatsu M, Hiono T, Bodisaikhan K, Amartuvshin T, Tserenjav J, Urangoo T, Buyantogtokh K, Matsuno K, Hattori T, Kondoh T, Sato M, Takadate Y, Torii S, Isono M, Okuya K, Saito T, Kasajima N, Kida Y, Maruyama J, Igarashi M, Takada A, Kida H, Batchuluun D, Sakoda Y.
    Genetic and Antigenic Characterization of H5 and H7 Avian Influenza Viruses Isolated From Migratory Waterfowl in Mongolia From 2017 to 2019
    Virus Genes. 19: 1-8 (2020). doi: 10.1007/s11262-020-01764-2
  • Xu Z, Ku X, Tomioka A, Xie W, Liang T, Zou X, Cui Y, Sato T, Kaji H, Narimatsu H, Yan W, Zhang Y
    O-linked N-acetylgalactosamine modification is present on the tumor suppressor p53
    Biochim Biophys Acta Gen Subj. 1864: 129635 (2020) doi: 10.1016/j.bbagen.2020.129635
  • Fuseya S, Suzuki R, Okada R, Hagiwara K, Sato T, Narimatsu H, Yokoi H, Kasahara M, Usui T, Morito N, Yamagata K, Kudo T, Takahashi S.
    Mice lacking core 1-derived O-glycan in podocytes develop transient proteinuria, resulting in focal segmental glomerulosclerosis.
    Biochem Biophys Res Commun. 523:1007-1013 (2020) doi: 10.1016/j.bbrc.2020.01.033
  • Kikutani Y, Masatoshi, Shoko, Takase-Yoden S, Hiono T, de Vries RP, Ryan, Keita, Hiroshi, Yoshihiro
    E190V substitution of H6 hemagglutinin is one of key factors for binding to sulfated sialylated glycan receptor and infection to chickens
    Microbiol. Immunol. 73: 171-174 (2020) doi: 10.1111/1348-0421.12773
  • Otani K, Tokudome T, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A, Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, Kangawa K.
    Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart
    Circulation. 141: 571-588 (2020). doi: 10.1161/CIRCULATIONAHA.119.039761
  • Shimazaki H, Ono A, Tsuruga M, Ueki A, Koseki-Kuno S, Toyoda T, Saito K, Sawakami K, Kariya M, Segawa O, Nakamura K, Koizuka M, Kuno A*
    GlycoBIST: A System for Automatic Glycan Profiling of a Target Protein Using Milli-Bead Array in a Tip
    Curr Protoc Protein Sci. 99: e103 (2020) doi: 10.1002/cpps.103
  • Wagatsuma T, Nagai-Okatani C#, Matsuda A, Masugi Y, Imaoka M, Yamazaki K, Sakamoto M, Kuno A*
    Discovery of Pancreatic Ductal Adenocarcinoma-Related Aberrant Glycosylations: A Multilateral Approach of Lectin Microarray-Based Tissue Glycomic Profiling With Public Transcriptomic Datasets
    Frontiers In Oncology 10: 338 (2020) doi: 10.3389/fonc.2020.00338
  • Zou X, Yao F, Yang F, Zhang F, Xu ZJ, Shi JJ, Kuno A, Zhao H, Zhang Y
    Glycomic Signatures of Plasma IgG Improve Preoperative Prediction of the Invasiveness of Small Lung Nodules
    Molecules 25: 28 (2020) doi: 10.3390/molecules25010028
  • Holdener BC, Percival CJ, Grady RC, Cameron DC, Berardinelli SJ, Zhang A, Neupane S, Takeuchi M, Jimenez-Vega JC, Uddin SMZ, Komatsu DE, Honkanen R, Dubail J, Apte SS, Sato T, Narimatsu H, McClain SA, Haltiwanger RS.
    ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome.
    Hum Mol Genet. 28: 4053-4066 (2019) doi: 10.1093/hmg/ddz225
  • Kurata I, Matsumoto I, Ohyama A, Osada A, Ebe H, Kawaguchi H, Kaneko S, Kondo Y, Tsuboi H, Tomioka A, Kaji H, Sumida T
    Potential involvement of OX40 in the regulation of autoantibody sialylation in arthritis
    Ann Rheum Dis. 78: 1488-1496 (2019) doi: 10.1136/annrheumdis-2019-215195
  • Nagai-Okatani C#*, Nishigori M, Sato T, Minamino N, Kaji H, Kuno A*
    Wisteria floribunda agglutinin staining for the quantitative assessment of cardiac fibrogenic activity in a mouse model of dilated cardiomyopathy
    Lab Invest. 99: 1749-1765 (2019) doi: 10.1038/s41374-019-0279-9
  • Shimazaki H, Saito K, Matsuda A, Sawakami K, Kariya M, Segawa O, , Miyashita Y, Ueda T, Koizuka M, Nakamura K, Kaji H, Tajima H, , Kuno A*
    Lectin Bead Array in a Single Tip Facilitates Fully Automatic Glycoprotein Profiling
    Anal Chem. 91: 11162-11169 (2019) doi: 10.1021/acs.analchem.9b01876
  • Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, , Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H
    Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation
    J. Allergy Clin Immunol. 144: 698-709 (2019) doi: 10.1016/j.jaci.2019.05.010
  • Takahama H, Nishikimi T, Takashio S, Hayashi T, Nagai-Okatani C, Asada T, Fujiwara A, Nakagawa Y, Amano M, Hamatani Y, Okada A, Amaki M, Hasegawa T, Kanzaki H, Nishimura K, Yasuda S, Kangawa K, Anzai T, Minamino N, Izumi C.
    Change in the NT-proBNP/Mature BNP Molar Ratio Precedes Worsening Renal Function in Patients With Acute Heart Failure: A Novel Predictor Candidate for Cardiorenal Syndrome
    J Am Heart Assoc. 8: e011468 (2019). doi: 10.1161/JAHA.118.011468
  • Nagai-Okatani C#, Aoki-Kinoshita KF, Kakuda S, Nagai M, Hagiwara K, Kiyohara K, Fujita N, Suzuki Y, Sato T, Angata K, Kuno A*
    LM-GlycomeAtlas Ver. 1.0: A Novel Visualization Tool for Lectin Microarray-Based Glycomic Profiles of Mouse Tissue Sections
    Molecules. 24: 2962 (2019) doi: 10.3390/molecules24162962
  • Takashio S, Takahama H, Nishikimi T, Hayashi T, Nagai-Okatani C, Matsuo A, Nakagawa Y, Amano M, Hamatani Y, Okada A, Amaki M, Hasegawa T, Kanzaki H, Yasuda S, Kangawa K, Anzai T, Minamino N, Izumi C.
    Superiority of Proatrial Natriuretic Peptide in the Prognostic Power in Patients With Acute Decompensated Heart Failure on Hospital Admission: Comparison With B-type Natriuretic Peptide and Other Natriuretic Peptide Forms
    Open Geart. 6: e001072 (2019). doi: 10.1136/openhrt-2019-001072
  • Nakane T, Angata K, Sato T, Kaji H, Narimatsu H
    Identification of mammalian glycoproteins with type-I LacdiNAc structures synthesized by the glycosyltransferase B3GALNT2
    J Biol Chem. 294: 7433-7444 (2019) doi: 10.1074/jbc.RA118.006892
  • Shan A, Lu J, Xu Z, Li X, Xu Y, Li W, Liu F, Yang F, Sato T, Narimatsu H, Zhang Y.
    Polypeptide N-acetylgalactosaminyltransferase 18 non-catalytically regulates the ER homeostasis and O-glycosylation.
    Biochim Biophys Acta Gen Subj. 1863: 870-882 (2019). doi: 10.1016/j.bbagen.2019.01.009
  • Nagai-Okatani C#, Nagai M, Sato T, Kuno A*
    An Improved Method for Cell Type-Selective Glycomic Analysis of Tissue Sections Assisted by Fluorescence Laser Microdissection
    Int J Mol Sci. 20: 700 (2019) doi: 10.3390/ijms20030700
  • Shirabe K, Bekki Y, Gantumur D, Araki K, Ishii N, Kuno A, Narimatsu H, Mizokami M
    Response to the letter by Dr. Naoya Yamada, and Dr. Koichi Mizuta regarding our manuscript
    J Gastroenterol. 54: 206-207 (2019) doi: 10.1007/s00535-018-1524-5
  • Matsumoto S, Ohara A, Nagai-Okatani C, Zhou YJ, Fujinaga D, Seike H, Nagata S
    Antagonistic Effect of Short Neuropeptide F on Allatotropin-Inhibited Feeding Motivation of the Silkworm Larva, Bombyx mori
    Zoolog Sci. 36: 58-67 (2019) doi: 10.2108/zs180119
  • Hiono T#*, Matsuda A, Wagatsuma T, Okamatsu M, Sakoda Y, Kuno A*
    Lectin microarray analyses reveal host cell-specific glycan profiles of the hemagglutinins of influenza A viruses
    Virology. 38: 103 (2019) doi: 10.1016/j.virol.2018.11.010
  • Matsuo A, Nagai-Okatani C, Nishigori M, Kangawa K, Minamino N
    Natriuretic peptides in human heart: Novel insight into their molecular forms, functions, and diagnostic use
    Peptides. 11: 453-462 (2019) doi: 10.1016/j.peptides.2018.08.006
  • Torii S, Matsuno K, Qiu Y, Mori-Kajihara A, Kajihara M, Nakao R, Nao N, Okazaki K, Sashika M, Hiono T, Okamatsu M, Sakoda Y, Ebihara H, Takada A, Sawa H.
    Infection of newly identified phleboviruses in ticks and wild animals in Hokkaido, Japan indicating tick-borne life cycles.
    Ticks Tick Borne Dis. 10: 328-335 (2019). doi: 10.1016/j.ttbdis.2018.11.012
  • Solovieva E, Shikanai T, Fujita N, Narimatsu H
    GGDonto ontology as a knowledge-base for genetic diseases and disorders of glycan metabolism and their causative genes.
    J Biomed Semantics.9: 14 (2018). doi:10.1186/s13326-018-0182-0
  • Narimatsu H, Kaji H, Vakhrushev SY, Clausen H, Zhang H, Noro E, Togayachi A, Nagai-Okatani C, Kuno A, Zou X, Cheng L, Tao SC, Sun Y
    Current Technologies for Complex Glycoproteomics and Their Applications to Biology/Disease-Driven Glycoproteomics
    J Proteome Res. 17: 4097-4112 (2018) doi: 10.1021/acs.jproteome.8b00515
  • Nagai-Okatani C#, Nagata S, Nagasawa H
    Tissue distribution and biochemical characteristics of receptors for sinus gland peptide VII as a crustacean hyperglycemic hormone and vitellogenesis-inhibiting hormone of the kuruma prawn, Marsupenaeus japonicus
    Gen Comp Endocrinol. 266: 157-165 (2018) doi: 10.1016/j.ygcen.2018.05.010
  • Wagatsuma T, Kuno A, Angata K, Tajiri K, Takahashi J, Korenaga M, Mizokami M, Narimatsu H
    Highly Sensitive Glycan Profiling of Hepatitis B Viral Particles and a Simple Method for Dane Particle Enrichment
    Anal Chem. 90: 10196-10203 (2018) doi: 10.1021/acs.analchem.8b01030
  • Takahama H, Takashio S, Nishikimi T, Hayashi T, Nagai-Okatani C, Nakagawa Y, Amaki M, Ohara T, Hasegawa T, Sugano Y, Kanzaki H, Yasuda S, Kangawa K, Minamino N, Anzai T.
    Ratio of pro-B-type Natriuretic Peptide (BNP) to Total BNP Is Decreased in Mild, but Not Severe, Acute Decompensated Heart Failure Patients: A Novel Compensatory Mechanism for Acute Heart Failure.
    Int J Cardiol. 258: 165-171 (2018). doi: 10.1016/j.ijcard.2017.12.047
  • Matsuura R, Kaji H, Tomioka A, Sato T, Narimatsu H, Moriwaki Y, Misawa H, Imai K, Tsuji S
    Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1
    Sci Rep. 8: 14251 (2018) doi: 10.1038/s41598-018-32534-8
  • Shirabe K, Bekki Y, Gantumur D, Araki K, Ishii N, Kuno A, Narimatsu H, Mizokami M
    Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis
    J Gastroenterol. 53: 819-826 (2018) doi: 10.1007/s00535-017-1425-z
  • Wang ZJ, Kikutani Y, Nguyen LT, Hiono T, Matsuno K, Okamatsu M, Krauss S, Webby R, Lee YJ, Kida H, Sakoda Y.
    H13 influenza viruses in wild birds have undergone genetic and antigenic diversification in nature.
    Virus Genes. 54: 543-549 (2018). doi: 10.1007/s11262-018-1573-0
  • Togayachi A, Tomioka A, Fujita M, Sukegawa M, Noro E, Takakura D, Miyazaki M, Shikanai T, Narimatsu H, Kaji H
    Identification of Poly-N-Acetyllactosamine-Carrying Glycoproteins from HL-60 Human Promyelocytic Leukemia Cells Using a Site-Specific Glycome Analysis Method, Glyco-RIDGE
    J Am Soc Mass Spectrom. 29: 1138-1152 (2018) doi: 10.1007/s13361-018-1938-6
  • Narimatsu H, Sato T
    Wisteria floribunda agglutinin positive glycobiomarkers: a unique lectin as a serum biomarker probe in various diseases
    Expert Rev Proteomics. 15: 183-190 (2018) doi: 10.1080/14789450.2018.1419066
  • Wakui H, Fuseya S, Suzuki R, Shimbo M, Okada R, Hamada M, Kuno A, , Hagiwara K, Sato T, Narimatsu H, Kudo T, Takahashi S
    Incomplete clearance of apoptotic cells by core 1-derived O-glycan-deficient resident peritoneal macrophages
    Biochem Biophys Res Commun. 495: 2017-2023 (2018) doi: 10.1016/j.bbrc.2017.12.066
  • Suzuki R, Fujimoto Z, Kaneko S, Hasegawa T, and Kuno A*.
    Enhanced azidolysis by the formation of stable Ser-His catalytic dyad in a glycoside hydrolase family 10 xylanase mutant.
    J Appl Glycosci 65: 1-8 (2018). doi.org/10.5458/jag.jag.JAG-2017_011
  • Suzuki M, Okamatsu M, Hiono T, Matsuno K, Sakoda Y.
    Potency of an inactivated influenza vaccine prepared from A/duck/Hokkaido/162/2013 (H2N1) against a challenge with A/swine/Missouri/2124514/2006 (H2N3) in mice.
    J Vet Med Sci. 79: 1815-1821 (2017). doi: 10.1292/jvms.17-0312
  • Nguyen LT, Nishi T, Shichinohe S, Chu DH, Hiono T, Matsuno K, Okamatsu M, Kida H, Sakoda Y.
    Selection of antigenic variants of an H5N1 highly pathogenic avian influenza virus in vaccinated chickens.
    Virology. 510: 252-261 (2017. doi: 10.1016/j.virol.2017.07.030
  • Kanai Y, Yasoda A, Mori KP, Watanabe-Takano H, Nagai-Okatani C, , Yamashita Y, Hirota K, Ueda Y, Yamauchi I, Kondo E, Yamanaka S, , Sakane Y, Nakao K, Fujii T, Yokoi H, Minamino N, Mukoyama M, , Mochizuki N, Inagaki N
    Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance
    J. Clin Invest. 127: 4136-4147 (2017) doi: 10.1172/JCI94912
  • Hiono T#, Okamatsu M, Matsuno K, Haga A, Iwata R, Nguyen LT, Suzuki M, Kikutani Y, Kida H, Onuma M, Sakoda Y.
    Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild and captive birds in the winter season of 2016-2017 in Northern Japan.
    Microbiol Immunol. 61: 387-397 (2017). doi: 10.1111/1348-0421.12506
  • Matsuda A, Higashi M, Nakagawa T, Yokoyama S, Kuno A*, Yonezawa S, Narimatsu H
    Assessment of tumor characteristics based on glycoform analysis of membrane-tethered MUC1
    Lab Invest. 97: 1103-1113 (2017) doi: 10.1038/labinvest.2017.53
  • Nguyen LT, Nakaishi K, Motojima K, Ohkawara A, Minato E, Maruyama J, Hiono T, Matsuno K, Okamatsu M, Kimura T, Takada A, Kida H, Sakoda Y.
    Rapid and broad detection of H5 hemagglutinin by an immunochromatographic kit using novel monoclonal antibody against highly pathogenic avian influenza virus belonging to the genetic clade 2.3.4.4.
    PLoS One. 12: e0182228 (2017). doi: 10.1371/journal.pone.0182228
  • Togayachi A, Iwaki J, Kaji H, Matsuzaki H, Kuno A, Hirao Y, Nomura M, Noguchi M, Ikehara Y, Narimatsu H.
    Glycobiomarker, Fucosylated Short-Form Secretogranin III Levels Are Increased in Serum of Patients with Small Cell Lung Carcinoma.
    J Proteome Res. 16: 4495-4505 (2017). doi: 10.1021/acs.jproteome.7b00484
  • Enkhbold B, Shatar M, Wakamori S, Tamura T, Hiono T, Matsuno K, Okamatsu M, Umemura T, Damdinjav B, Sakoda Y.
    Genetic and virulence characterization of classical swine fever viruses isolated in Mongolia from 2007 to 2015.
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