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Dynamic Pharmaco-Modality Research Group

Project

Project1:Dynamic structure based drug development utilizing various pharmaco-modalities
Researcher:Koh Takeuchi, Yuji Tokunaga, Masahiko Imashimizu

We will develop strategy to expand the potential of pharmaceuticals by utilizing various pharmaco-modalities. Utilizing solution NMR as the primary research technique, we would develop strategies to non-invasively analyze the high order structures of biomedicines, improve the function of middle size bioactive, and dynamically optimize the small molecular weight lead compounds etc.

Dynamic Pharmaco-Modality Research Group02

Project

Project2:Theoretical platform for dynamic molecular recognition of novel pharmaceutical and medical modalities
Researcher:Yoshifumi Fukunishi

The novel modalities exert their activity not only by their static 3D structures, but also through their dynamics. However, theoretical and computational platform for such dynamic molecular recognition have not been developed. With our open-source software suit for structure-guided drug discovery, myPresto, we will elucidate the dynamic molecular-interaction mechanism of biomolecules that regulate life activity.

Dynamic Pharmaco-Modality Research Group03

Project

Project3:Dynamic bio-profiling and automation of bio-experiments
Researcher:Shungo Adachi, Katsuo Mogi, Fumio Maeda

We will develop three key modalities (1) dynamic bio-profiling technology to understand the state of individuals from the analysis of thousands of biomolecules in blood and cells, using mass spectrometry and proximity extension techniques. The effort will eventually predict the future state of individuals. (2) Experimental automation technologies for long-term cell culture, EWOD droplet manipulation, and cloud robotics, to improve the efficiency of biological research. (3) Novel virus modality to intervene in cells using their unique abilities.

Dynamic Pharmaco-Modality Research Group04

Project

Project4:Analysis platform for epigenetics and proteomics for understanding cell state
Researcher:Shin Kobayashi, Eriko Fukuda

Dynamic cellular events that is beyond genetic encodings, such as epigenetics, post-translation modification, and intermolecular protein interaction, play critical roles in dictating cellular functions. Taking advantage of the technologies such as i) live imaging of epigenetic state, using Momiji system, and ii) molecular interaction analysis using protein arrays that cover 80% of human proteome, we study the dynamics of cell state and promote research that will lead to the understanding of organisms and drug discovery.

Dynamic Pharmaco-Modality Research Group05

Member

Name Position
TAKEUCHI Koh Research Group Leader
FUKUNISHI Yoshifumi Senior Researcher
ADACHI Shungo Senior Researcher
KOBAYASHI Shin Senior Researcher
IMASHIMIZU Masahiko Senior Researcher
TOKUNAGA Yuji Senior Researcher
MOGI Katsuo Senior Researcher
FUKUDA Eriko Researcher
MAEDA Fumio Researcher

Results

  • Moritsugu, K; Takeuchi, K; Kamiya, N; Higo, J; Yasumatsu, I; Fukunishi, Y; Fukuda, I.
    Flexibility and Cell Permeability of Cyclic Ras-Inhibitor Peptides Revealed by the Coupled Nos├ę-Hoover Equation.
    J CHEM INF MODEL. 2021 Apr 9. doi: 10.1021/acs.jcim.0c01427
  • Hirama, H; Otahara, R; Mogi, K; Hayase, M; Torii, T; Mekaru, H.
    Rapid Prototyping of a Nanoparticle Concentrator Using a Hydrogel Molding Method.
    POLYMERS (Basel). 2021 Mar 29;13(7):1069. doi: 10.3390/polym13071069
  • Lintuluoto, M; Horioka, Y; Hongo, S; Lintuluoto, JM; Fukunishi, Y.
    Molecular Dynamics Simulation Study on Allosteric Regulation of CD44-Hyaluronan Binding as a Force Sensing Mechanism.
    ACS OMEGA. 2021 Mar 16;6(12):8045-8055. doi: 10.1021/acsomega.0c05502. eCollection
  • Higo J, Takashima H, Fukunishi Y, Yoshimori A
    Generalized-ensemble method study: A helix-mimetic compound inhibits protein-protein interaction by long-range and short-range intermolecular interactions.
    J COMPUT CHEM. 2021 Mar 23. doi: 10.1002/jcc.26516
  • Hayami T, Kamiya N, Kasahara K, Kawabata T, Kurita JI, Fukunishi Y, Nishimura Y, Nakamura H, Higo J
    Difference of binding modes among three ligands to a receptor mSin3B corresponding to their inhibitory activities.
    SCI REP. 2021 Mar 17;11(1):6178. doi: 10.1038/s41598-021-85612-9
  • Bekker GJ, Fukuda I, Higo J, Fukunishi Y, Kamiya N
    Cryptic-site binding mechanism of medium-sized Bcl-xL inhibiting compounds elucidated by McMD-based dynamic docking simulations.
    SCI REP. 2021 Mar 3;11(1):5046. doi: 10.1038/s41598-021-84488-z
  • Higo J, Kusaka A, Kasahara K, Kamiya N, Hayato I, Qilin X, Takahashi T, Fukuda I, Mori K, Hata Y, Fukunishi Y
    GA-guided mD-VcMD: A genetic-algorithm-guided method for multi-dimensional virtual-system coupled molecular dynamics
    Biophys Physicobiol. 2020 Dec 26;17:161-176. doi: 10.2142/biophysico.BSJ-2020008
  • Fukuda E, Tanaka H, Yamaguchi K, Takasaka M, Kawamura Y, Okuda H, Isotani A, Ikawa M, Shapiro VS, Tsuchida J, Okada Y, Tsujimura A, Miyagawa Y, Fukuhara S, Kawakami Y, Wada M, Nishimune Y, Goshima N
    Identification and characterization of the antigen recognized by the germ cell mAb TRA98 using a human comprehensive wet protein array
    Genes Cells. 2021 Feb 1. doi: 10.1111/gtc.12832
  • Takeuchi K, Misaki I, Tokunaga Y, Fujisaki M, Kamoshida H, Takizawa T, Hanzawa H, Shimada I
    Conformational plasticity of cyclic Ras-inhibitor peptides defines cell permeabilization activity.
    ANGEW CHEM INT ED ENGL. 2021 Jan 11. doi: 10.1002/anie.202016647
  • Udagawa T, Seki M, Okuyama T, Adachi S, Natsume T, Noguchi T, Matsuzawa A, Inada T
    Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival.
    CELL REP. 2021 Jan 5;34(1):108599. doi: 10.1016/j.celrep.2020.108599
  • Higo J, Kawabata T, Kusaka A, Kasahara K, Kamiya N, Fukuda I, Mori K, Hata Y, Fukunishi Y, Nakamura H
    Molecular Interaction Mechanism of a 14-3-3 Protein with a Phosphorylated Peptide Elucidated by Enhanced Conformational Sampling.
    J. Chem. Inf. Model 60 (10) 4867-4880; (2020) doi: 10.1021/acs.jcim.0c00551 OCT 26
  • Tokunaga Y, Takeuchi K
    Role of NMR in High Ordered Structure Characterization of Monoclonal Antibodies.
    Int. J. Mol. Sci. 2021, 22(1), 46; doi: 10.3390/ijms22010046
  • Shimamoto N, Imashimizu M
    RNA Polymerase and Transcription Mechanisms: The Forefront of Physicochemical Studies of Chemical Reactions.
    BIOMOLECULES. 2020 Dec 29;11(1):E32. doi: 10.3390/biom11010032
  • Toyosaki M, Homma K, Suzuki S, Muraoka N, Hashimoto H, Goshima N, Ieda M, Sasaki J
    Dermal fibroblast-like cells reprogrammed directly from adipocytes in mouse.
    SCI REP.10(1):21467 (2020) doi: 10.1038/s41598-020-78523-8
  • Suzuki T, Adachi S, Kikuguchi C, Shibata S, Nishijima S, Kawamoto Y, Iizuka Y, Koseki H, Okano H, Natsume T, Yamamoto T
    Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development
    Int J Mol Sci.;21(23):9319 (2020) doi: 10.3390/ijms21239319
  • Imashimizu M, Tanaka M, Hoshina H
    Gre factors prevent thermal and mechanical stresses induced by terahertz irradiation during transcription
    Genes Cells. 2020 Nov 28. doi: 10.1111/gtc.12822
  • Iida S, Nakamura HK, Mashimo T, Fukunishi Y
    Structural Fluctuations of Aromatic Residues in an Apo-Form Reveal Cryptic Binding Sites: Implications for Fragment-Based Drug Design
    J Phys Chem B. 2020 Nov 3. (2020)doi: 10.1021/acs.jpcb.0c04963
  • Motohashi T, Kawamura N, Watanabe N, Kitagawa D, Goshima N, Kunisada T
    Sox10 functions as an inducer of the direct conversion of keratinocytes into neural crest cells
    Stem Cells Dev. 2020 Oct 12. (2020)doi: 10.1089/scd.2020.0106
  • Mizukoshi Y, Takeuchi K, Tokunaga Y, Matsuo H, Imai M, Fujisaki M, Kamoshida H, Takizawa T, Hanzawa H, Shimada I
    Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium
    Sci Adv. 6(40):eabd0480. (2020) doi: 10.1126/sciadv.abd0480
  • Kato A, Adachi S, Kawano S, Takeshima K, Watanabe M, Kitazume S, Sato R, Kusano H, Koyanagi N, Maruzuru Y, Arii J, Hatta T, Natsume T, Kawaguchi Y
    Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
    Nat Commun. 11(1):4894. (2020) doi: 10.1038/s41467-020-18718-9
  • Imashimizu M, Tokunaga Y, Afek A, Takahashi H, Shimamoto N, Lukatsky DB
    Control of Transcription Initiation by Biased Thermal Fluctuations on Repetitive Genomic Sequences
    Biomolecules. 10(9):E1299. (2020) doi: 10.3390/biom10091299
  • Maruyama Y, Koroku S, Imai M, Takeuchi K, Mitsutake A
    Mutation-induced change in chignolin stability from pi-turn to alpha-turn
    Rsc Advances 10 10: 22797-22808 (2020) doi: 10.1039/d0ra01148g
  • Dubey A, Takeuchi K, Reibarkh M, Arthanari H
    The role of NMR in leveraging dynamics and entropy in drug design
    J. Biomolecular Nmr 66: 0 (2020) doi: 10.1007/s10858-020-00335-9
  • Kitakaze T, Yoshikawa M, Kobayashi Y, Kimura N, Goshima N, Ishikawa T, Ogata Y, Yamashita Y, Ashida H, Harada N, Yamaji R
    Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56
    Biochim Biophys Acta Mol Cell Res. 1867:118563 (2020) doi:10.1016/j.bbamcr.2019.118563
  • Tokunaga Y, Takeuchi K*, Okude J, Ori K, Torizawa T, Shimada I*
    Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via (15)N Direct Detection Nuclear Magnetic Resonance
    J Med Chem. 12: 0 (2020) doi: 10.1021/acs.jmedchem.0c00231
  • Fukuda T, Hamaguchi M, Osaka T, Hashimoto Y, Ushigome E, Asano M, Yamazaki M, Fukuda E, Yamaguchi K, Ogawa K, Goshima N, Fukui M
    A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes
    Molecules. 25: 0 (2020) doi: 10.3390/molecules25071667
  • Murano K, Iwasaki YW, Ishizu H, Mashiko A, Shibuya A, Kondo S, Adachi S, Suzuki S, Saito K, Natsume T, Siomi MC, Siomi H
    Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing
    EMBO JOURNAL 0: 0 (2020) doi: 10.15252/embj.2019102870
  • Otsuka H, Fukao A, Tomohiro T, Adachi S, Suzuki T, Takahashi A, Funakami Y, Natsume T, Yamamoto T, Duncan KE, Fujiwara T
    ARE-binding protein ZFP36L1 interacts with CNOT1 to directly repress translation via a deadenylation-independent mechanism
    Biochimie. 9084: 30080-8 (2020) doi: 10.1016/j.biochi.2020.04.010
  • Goldshtein M, Mellul M, Deutch G, Imashimizu M, Takeuchi K, Meshorer E, Ram O, Lukatsky DB
    Transcription Factor Binding in Embryonic Stem Cells Is Constrained by DNA Sequence Repeat Symmetry
    Biophysical J. 118 118: 2015-2026 (2020) doi: 10.1016/j.bpj.2020.02.009
  • Tatebayashi K, Yamamoto K, Tomida T, Nishimura A, Takayama T, Oyama M, Kozuka-Hata H, Adachi-Akahane S, Tokunaga Y Saito H
    Osmostress enhances activating phosphorylation of Hog1 MAP kinase by mono-phosphorylated Pbs2 MAP2K
    EMBO JOURNAL 39 39: 0 (2020) doi: 10.15252/embj.2019103444
  • Yoshida M, Saito M, Ito S, Ogawa K, Goshima N, Nagata K, Doi T
    Structure-Activity Relationship Study on Col-003, a Protein-Protein Interaction Inhibitor between Collagen and Hsp47
    Chem Pharm Bull 68: 220-226 (2020) doi: 10.1248/cpb.c19-00634
  • Tokunaga Y, Viennet T, Arthanari H, Takeuchi K*
    Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR
    INTERNATIONAL J. Molecular Sciences 21 21: 0 (2020) doi: 10.3390/ijms21051829
  • Kitazawa M, Hatta T, Sasaki Y, Fukui K, Ogawa K, Fukuda E, Goshima N, Okita N, Yamada Y, Nakagama H, Natsume T, Horimoto K
    Promotion of the Warburg effect is associated with poor benefit from adjuvant chemotherapy in colorectal cancer
    Cancer Sci. 111: 658-666 (2020) doi: 10.1111/cas.14275
  • Ninomiya K, Adachi S, Natsume T, Iwakiri J, Terai G, Asai K, Hirose T
    LncRNA-dependent nuclear stress bodies promote intron retention through SR protein phosphorylation
    EMBO JOURNAL 39 39: 0 (2020) doi: 10.15252/embj.2019102729
  • Asano T, Noda Y, Tanaka KI, Yamakawa N, Wada M, Mashimo T, Fukunishi Y, Mizushima T, Takenaga M
    A2B adenosine receptor inhibition by the dihydropyridine calcium channel blocker nifedipine involves colonic fluid secretion
    Sci Rep. 10: 3555 (2020) doi: 10.1038/s41598-020-60147-7
  • Taniue K, Hayashi T, Kamoshida Y, Kurimoto A, Takeda Y, Negishi L, Iwasaki K, Kawamura Y, Goshima N, Akiyama T
    UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells
    Oncogene 39 39: 1018-1030 (2020) doi: 10.1038/s41388-019-1032-y
  • Yasuda R, Adachi S, Okonogi A, Anzai Y, Kamiyama T, Katano K, Hoshi N, Mogi K, Natsume T
    Cell Stress Reduction by a Novel Perfusion-Culture System Using Commercial Culture Dish
    Applied Sciences-Basel 10 10: 0 (2020) doi: 10.3390/app10010095
  • Hia F, Yang SF, Shichino Y, Yoshinaga M, Murakawa Y, Vandenbon A, Fukao A, Fujiwara T, Landthaler M, Natsume T, Adachi S, Iwasaki S, Takeuchi O
    Codon bias confers stability to human mRNAs
    EMBO Rep. 20: 0 (2019) doi: 10.15252/embr.201948220
  • Fukuda E*, Mori M, Shiku H, Miyahara Y, Kawamura Y, Ogawa K, Ogura T, Goshima N
    Development of INSOL-tag for proteome-wide protein handling and its application in protein array analysis
    Genes Cells. 0: 0 (2019) doi: 10.1111/gtc.12735
  • Takeuchi K, Imai M, Shimada I
    Conformational equilibrium defines the variable induction of the multidrug-binding transcriptional repressor QacR
    Proc Natl Acad Sci U S A. 116: 19963-19972 (2019) doi: 10.1073/pnas.1906129116
  • Arthanari H#*, Takeuchi K#*, Dubey A, Wagner G #
    Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins
    Current Opinion In Structural Biology 58 294-304 65: 455-458 (2019) doi: 10.1016/j.sbi.2019.06.005
  • Fukunishi Y, Mashimo T, Kurosawa T, Wakabayashi Y, Nakamura HK, Takeuchi K
    Prediction of Passive Membrane Permeability by Semi-Empirical Method Considering Viscous and Inertial Resistances and Different Rates of Conformational Change and Diffusion
    Mol Inform. 15: 0 (2019) doi: 10.1002/minf.201900071
  • Sekine S, Kiyono T, Ryo E, Ogawa R, Wakai S, Ichikawa H, Suzuki, K, Arai S, Tsuta K, Ishida M, Sasajima Y, Goshima N, Yamazaki N, , Mori T
    Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma
    J. Clinical Investigation 129: 3827-3832 (2019) doi: 10.1172/JCI126185
  • Naffouje R, Grover P, Yu H, Sendilnathan A, Wolfe K, Majd N, Smith EP, Takeuchi K, Senda T, Kofuji S, Sasaki AT
    Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story
    Cancers 11: 0 (2019) doi: 10.3390/cancers11091346
  • Takeuchi K, Baskaran K, Arthanari H
    Structure determination using solution NMR: Is it worth the effort
    J. Magnetic Resonance 189: 233-248 (2019) doi: 10.1016/j.jmr.2019.07.045
  • Ito S, Saito M, Yoshida M, Takeuchi K, Doi T, Nagata K
    A BRET-based assay reveals collagen-Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction
    J Biol Chem. 0: 0 (2019) doi: 10.1074/jbc.RA119.010567
  • Yamashita Y, Tanaka K, Yamakawa N, Asano T, Kanda Y, Takafuji A, , Kawahara M, Takenaga M, Fukunishi Y, Mizushima T
    Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity
    Bioorganic 27: 3339-3346 (2019) doi: 10.1016/j.bmc.2019.06.016
  • Sato T, Higashioka K, Sakurai H, Yamamoto T, Goshima N, Ueno M, Sotozono C
    Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells
    Stem Cell Reports. 13: 352-365 (2019) doi: 10.1016/j.stemcr.2019.06.006
  • Aly MK, Ninomiya K, Adachi S, Natsume T, Hirose T
    Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure
    Biochem.... And Biophysical Res. Communications 516: 419-423 (2019) doi: 10.1016/j.bbrc.2019.06.061
  • Ghani FI, Dendo K, Watanabe R, Yamada K, Yoshimatsu Y, Yugawa T, , Nakahara T, Tanaka K, Yoshida H, Yoshida M, Ishikawa M, Goshima N, , Kato T, Kiyono T
    An Ex-Vivo Culture System of Ovarian Cancer Faithfully Recapitulating the Pathological Features of Primary Tumors
    Cells 8: 10 (2019) doi: 10.3390/cells8070644
  • Higo J, Kasahara K, Wada M, Dasgupta B, Kamiya N, Hayami T, Fukuda I, Fukunishi Y, Nakamura H
    Free-energy landscape of molecular interactions between endothelin 1 and human endothelin type B receptor: fly-casting mechanism
    Protein Engineering Design 32: 297-308 (2019) doi: 10.1093/protein/gzz029
  • Mogi K*, Adachi S, Takada N, Inoue T, Natsume T
    Electrowetting on Dielectric (EWOD) Device with Dimple Structures for Highly Accurate Droplet Manipulation
    Applied Sciences-Basel 9: 10 (2019) doi: 10.3390/app9122406
  • Imashimizu M, Kireeva ML, Lubkowska L, Kashlev M, Shimamoto N
    The Role of Pyrophosphorolysis in the Initiation-to-Elongation Transition by E. coli RNA Polymerase
    J. Molecular Biology 431: 2528-2542 (2019) doi: 10.1016/j.jmb.2019.04.020
  • Boeszoermenyi A, Chhabra S, Dubey A, Radeva DL, Burdzhiev NT, Chanev CD, Petrov OI, Gelev VM, Zhang M, Anklin C, Kovacs H, Wagner G, Kuprov I, Takeuchi K*, Arthanari H*
    Aromatic (19)F-(13)C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics
    Nat Methods. 16: 333-340 (2019) doi: 10.1038/s41592-019-0334-x
  • Takeuchi F, Ikeda S, Tsukamoto Y, Iwasawa Y, Qihao C, Otakaki Y, Ryota O, Yao WL, Narita R, Makoto H, Watashi K, Wakita T, Takeuchi K, Chayama K, Kogure A, Kato H, Fujita T
    Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor
    PloS One. 14: 0 (2019) doi: 10.1371/journal.pone.0212233
  • Yasuda R, Adachi S, Okonogi A, Anzai Y, Kamiyama T, Katano K, , Hoshi N, Natsume T, Mogi K*
    Fabrication of a Novel Culture Dish Adapter with a Small Recess Structure for Flow Control in a Closed Environment
    Applied Sciences-Basel 9: 10 (2019) doi: 10.3390/app9020269
  • Adachi S, Anzai Y, Nishimura F, Yasuda R, Okonogi A, Kamiyamna T, Kotera H, Natsume T
    Development of an ANSI/SBS Standard Size Culture Medium Auto-Exchanger
    JSDE, 54: 391-398 (2018) doi: 10.14953/jjsde.2018.2829
  • Inoko A, Yano T, Miyamoto T, Matsuura S, Kiyono T, Goshima N, Inagaki M, Hayashi Y
    Albatross/FBF1 contributes to both centriole duplication and centrosome separation
    Genes Cells. 23: 1023-1042 (2018) doi: 10.1111/gtc.12648
  • Ohsawa K, Yoshida M, Izumikawa M, Takagi M, Shin-Ya K, Goshima N, Hirokawa T, Natsume T, Doi T
    Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer
    Bioorg Med Chem. 10 185 (2018) doi: 10.1016/j.bmc.2018.11.001
  • Nagai T, Mukoyama S, Kagiwada H, Goshima N, Mizuno K
    Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation
    J Cell Sci. 131: 0 (2018) doi: 10.1242/jcs.219527
  • Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE
    Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
    Nat Commun. 9: 4563 (2018) doi: 10.1038/s41467-018-07012-4
  • Zhai L, Wang S, Nara M, Takeuchi K, Shimada I, Otani Y, Ohwada T
    Application of C-Terminal 7-Azabicyclo[2.2.1]heptane to Stabilize beta-Strand-like Extended Conformation of a Neighboring alpha-Amino Acid
    J Org Chem. 83: 13063-13079 (2018) doi: 10.1021/acs.joc.8b01756
  • Hosoi Y, Soma M, Shiura H, Sado T, Hasuwa H, Abe K, Kohda T, Ishino F, Kobayashi S*
    Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
    Nat Commun. 9: 3829 (2018) doi: 10.1038/s41467-018-06327-6
  • Kurita JI, Hirao Y, Nakano H, Fukunishi Y, Nishimura Y
    Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities
    Sci Rep. 8: 13763 (2018) doi: 10.1038/s41598-018-31852-1
  • Sadahiro T, Isomi M, Muraoka N, Kojima H, Haginiwa S, Kurotsu S, Tamura F, Tani H, Tohyama S, Fujita J, Miyoshi H, Kawamura Y, Goshima N, Iwasaki YW, Murano K, Saito K, Oda M, Andersen P, Kwon C, Uosaki H, Nishizono H, Fukuda K, Ieda M
    Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification
    Cell Stem Cell. 23: 382-395 (2018) doi: 10.1016/j.stem.2018.07.001
  • Fukunishi Y, Yamashita Y, Mashimo T, Nakamura H
    Prediction of Protein-compound Binding Energies from Known Activity Data: Docking-score-based Method and its Applications
    Mol Inform. 28: 741-753 (2018) doi: 10.1002/minf.201700120
  • Sugiki T, Egawa D, Kumagai K, Kojima C, Fujiwara T, Takeuchi K, Shimada I, Hanada K, Takahashi H
    Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif
    J Biol Chem. 293: 11206-11217 (2018) doi: 10.1074/jbc.RA118.002465
  • Yanagita K, Nagashio R, Jiang SX, Kuchitsu Y, Hachimura K, Ichinoe M, Igawa S, Fukuda E, Goshima N, Satoh Y, Murakumo Y, Saegusa M, Sato Y
    Cytoskeleton-Associated Protein 4 Is a Novel Serodiagnostic Marker for Lung Cancer
    Am J Pathol. 188: 1328-1333 (2018) doi: 10.1016/j.ajpath.2018.03.007
  • Mogi K*, Hayashida K, Yamamoto T
    Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel
    Anal Sci. 34: 875-880 (2018) doi: 10.2116/analsci.17P462
  • Noguchi A, Adachi S, Yokota N, Hatta T, Natsume T, Kawahara H
    ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest
    Biology Open 7: 10 (2018) doi: 10.1242/bio.031575
  • Kobayashi S*
    Live Imaging of X-Chromosome Inactivation and Reactivation Kinetics
    Methods Mol Biol. 35: 301-305 (2018) doi: 10.1007/978-1-4939-8766-5_7
  • Takahashi S, Kobayashi S*, Hiratani I*
    Epigenetic differences between naive and primed pluripotent stem cells
    Cell Mol Life Sci. 75: 1191-1203 (2018) doi: 10.1007/s00018-017-2703-x
  • Tanaka KI, Yamakawa N, Yamashita Y, Asano T, Kanda Y, Takafuji A, Kawahara M, Takenaga M, Fukunishi Y, Mizushima T
    Identification of Mepenzolate Derivatives With Long-Acting Bronchodilatory Activity
    Front Pharmacol. 0: 0 (2018) doi: 10.3389/fphar.2018.00344
  • Mogi K*
    A Visualization Technique of a Unique pH Distribution around an Ion Depletion Zone in a Microchannel by Using a Dual-Excitation Ratiometric Method
    Micromachines 9: 0 (2018) doi: 10.3390/mi9040167
  • Yamaguchi T, Suzuki T, Sato T, Takahashi A, Watanabe H, Kadowaki A, Natsui M, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, Natsume T, Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y, Kuba K
    The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function
    Sci Signal. 11: 0 (2018) doi: 10.1126/scisignal.aan3638
  • Dendo K, Yugawa T, Nakahara T, Ohno SI, Goshima N, Arakawa H, Kiyono T
    Induction of non-apoptotic programmed cell death by oncogenic RAS in human epithelial cells and its suppression by MYC overexpression
    Carcinogenesis. 39: 202-213 (2018) doi: 10.1093/carcin/bgx124
  • Kasahara K, Aoki H, Kiyono T, Wang S, Kagiwada H, Yuge M, Tanaka T, Nishimura Y, Mizoguchi A, Goshima N, Inagaki M
    EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
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