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ヒト細胞医工学研究ラボ [ 所在地:つくばセンター(中央) ] 

中西 真人 研究ラボ長がこれまでに発表した、原著論文の発行年月、タイトル、著者、掲載誌等および、特許の一覧です。

2017


A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation
Nishimura K, Aizawa S, Nugroho FL, Shiomitsu E, Tran YT, Bui PL, Borisova E, Sakuragi Y, Takada H, Kurisaki A, Hayashi Y, Fukuda A, Nakanishi M, Hisatake K
Stem Cell Reports. 2017 Mar 14;8(3):787-801


2016


An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors
Yamashita-Sugahara Y, Matsumoto M, Ohtaka M, Nishimura K, Nakanishi M, Mitani K, Okazaki Y
Sci Rep. 2016 Oct 27;6:35908
Novel Strategy to Control Transgene Expression Mediated by a Sendai Virus-Based Vector Using a Nonstructural C Protein and Endogenous MicroRNAs
Sano M, Iijima M, Ohtaka M, Nakanishi M
PLoS One. 2016 Oct 20;11(10):e0164720
Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency
Muñoz-López A, Romero-Moya D, Prieto C, Ramos-Mejía V, Agraz-Doblas A, Varela I, Buschbeck M, Palau A, Carvajal-Vergara X, Giorgetti A, Ford A, Lako M, Granada I, Ruiz-Xivillé N, Rodríguez-Perales S, Torres-Ruíz R, Stam RW, Fuster JL, Fraga MF, Nakanishi M, Cazzaniga G, Bardini M, Cobo I, Bayon GF, Fernandez AF, Bueno C, Menendez P
Stem Cell Reports. 2016 Oct 11;7(4):602-18
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Dafinca R, Scaber J, Ababneh N, Lalic T, Weir G, Christian H, Vowles J, Douglas AG, Fletcher-Jones A, Browne C, Nakanishi M, Turner MR, Wade-Martins R, Cowley SA, Talbot K
Stem Cells. 2016 Aug;34(8):2063-78
Distinctive features of single nucleotide alterations in induced pluripotent stem cells with different types of DNA repair deficiency disorders
Okamura K, Sakaguchi H, Sakamoto-Abutani R, Nakanishi M, Nishimura K, Yamazaki-Inoue M, Ohtaka M, Periasamy VS, Alshatwi AA, Higuchi A, Hanaoka K, Nakabayashi K, Takada S, Hata K, Toyoda M, Umezawa A
Sci Rep. 2016 May 20;6:26342
Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities
Banno K, Omori S, Hirata K, Nawa N, Nakagawa N, Nishimura K, Ohtaka M, Nakanishi M, Sakuma T, Yamamoto T, Toki T, Ito E, Yamamoto T, Kokubu C, Takeda J, Taniguchi H, Arahori H, Wada K, Kitabatake Y, Ozono K
Cell Rep. 2016 May 10;15(6):1228-41
Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling
Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H
Stem Cell Reports. 2016 Mar 8;6(3):422-35
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics
Handel AE, Chintawar S, Lalic T, Whiteley E, Vowles J, Giustacchini A, Argoud K, Sopp P, Nakanishi M, Bowden R, Cowley S, Newey S, Akerman C, Ponting CP, Cader MZ
Hum Mol Genet. 2016 Mar 1;25(5):989-1000
Cellular Ontogeny and Hierarchy Influence the Reprogramming Efficiency of Human B Cells into Induced Pluripotent Stem Cells
Muñoz-López Á, van Roon EH, Romero-Moya D, López-Millan B, Stam RW, Colomer D, Nakanishi M, Bueno C, Menendez P
Stem Cells. 2016 Mar;34(3):581-7
Reprogramming human B cells into induced pluripotent stem cells and its enhancement by C/EBPα
Bueno C, Sardina JL, Di Stefano B, Romero-Moya D, Muñoz-López A, Ariza L, Chillón MC, Balanzategui A, Castaño J, Herreros A, Fraga MF, Fernández A, Granada I, Quintana-Bustamante O, Segovia JC, Nishimura K, Ohtaka M, Nakanishi M, Graf T, Menendez P
Leukemia. 2016 Mar;30(3):674-82
Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells
Kitayama S, Zhang R, Liu TY, Ueda N, Iriguchi S, Yasui Y, Kawai Y, Tatsumi M, Hirai N, Mizoro Y, Iwama T, Watanabe A, Nakanishi M, Kuzushima K, Uemura Y, Kaneko S
Stem Cell Reports. 2016 Feb 9;6(2):213-27
Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential
Kyttälä A, Moraghebi R, Valensisi C, Kettunen J, Andrus C, Pasumarthy KK, Nakanishi M, Nishimura K, Ohtaka M, Weltner J, Handel BV, Parkkonen O, Sinisalo J, Jalanko A, Hawkins RD, Woods NB, Otonkoski T, Trokovic R
Stem Cell Reports. 2016 Feb 9;6(2):200-12
Generation of cleidocranial dysplasia-specific human induced pluripotent stem cells in completely serum-, feeder-, and integration-free culture
Yamasaki S, Hamada A, Akagi E, Nakatao H, Ohtaka M, Nishimura K, Nakanishi M, Toratani S, Okamoto T
In Vitro Cell Dev Biol Anim. 2016;52:252-64


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2015


An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils
Lin HT, Masaki H, Yamaguchi T, Wada T, Yachie A, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H, Otsu M
Mol Ther Methods Clin Dev. 2015 Dec 9;2:15046
Vascular Smooth Muscle Cells From Hypertensive Patient-Derived Induced Pluripotent Stem Cells to Advance Hypertension Pharmacogenomics
Biel NM, Santostefano KE, DiVita BB, El Rouby N, Carrasquilla SD, Simmons C, Nakanishi M, Cooper-DeHoff RM, Johnson JA, Terada N
Stem Cells Transl Med. 2015 Dec;4(12):1380-90
A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy
Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H
Stem Cell Reports. 2015 Oct 13;5(4):597-608
Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells
Masaki H, Kato-Itoh M, Umino A, Sato H, Hamanaka S, Kobayashi T, Yamaguchi T, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H
Development. 2015 Sep 15;142(18):3222-30


2014


Advanced Feeder-Free Generation of Induced Pluripotent Stem Cells Directly From Blood Cells
Trokovic R, Weltner J, Nishimura K, Ohtaka M, Nakanishi M, Salomaa V, Jalanko A, Otonkoski T, Kyttälä A
Stem Cells Transl Med. 2014 Dec;3(12):1402-9
Biosynthesis of Ribosomal RNA in Nucleoli Regulates Pluripotency and Differentiation Ability of Pluripotent Stem Cells
Watanabe-Susaki K, Takada H, Enomoto K, Miwata K, Ishimine H, Intoh A, Ohtaka M, Nakanishi M, Sugino H, Asashima M, Kurisaki A
Stem Cells. 2014 Dec;32(12):3099-111
Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes
Takayama K, Morisaki Y, Kuno S, Nagamoto Y, Harada K, Furukawa N, Ohtaka M, Nishimura K, Imagawa K, Sakurai F, Tachibana M, Sumazaki R, Noguchi E, Nakanishi M, Hirata K, Kawabata K, Mizuguchi H
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16772-7
Manipulation of KLF4 Expression Generates iPSCs Paused at Successive Stages of Reprogramming
Nishimura K, Kato T, Chen C, Oinam L, Shiomitsu E, Ayakawa D, Ohtaka M, Fukuda A, Nakanishi M, Hisatake K
Stem Cell Reports. 2014 Nov 11;3(5):915-29
Morphological features of iPS cells generated from Fabry disease skin fibroblasts using Sendai virus vector (SeVdp)
Kawagoe S, Higuchi T, Otaka M, Shimada Y, Kobayashi H, Ida H, Ohashi T, Okano HJ, Nakanishi M, Eto Y
Mol Genet Metab. 2013 Aug;109(4):386-9
GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells
Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Katsumata A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T
RNA. 2013 Jun;19(6):803-10


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2013


Expansion of Functional Human Mucosal-Associated Invariant T Cells via Reprogramming to Pluripotency and Redifferentiation
Wakao H, Yoshikiyo K, Koshimizu U, Furukawa T, Enomoto K, Matsunaga T, Tanaka T, Yasutomi Y, Yamada T, Minakami H, Tanaka J, Oda A, Sasaki T, Wakao R, Lantz O, Udagawa T, Sekiya Y, Higuchi K, Harada N, Nishimura K, Ohtaka M, Nakanishi M, Fujita H
Cell Stem Cell. 2013 May 2;12(5):546-58
Podocalyxin Is a Glycoprotein Ligand of the Human Pluripotent Stem Cell-Specific Probe rBC2LCN
Tateno H, Matsushima A, Hiemori K, Onuma Y, Ito Y, Hasehira K, Nishimura K, Ohtaka M, Takayasu S, Nakanishi M, Ikehara Y, Nakanishi M, Ohnuma K, Chan T, Toyoda M, Akutsu H, Umezawa A, Asashima M, Hirabayashi J
Stem Cells Transl Med. 2013 Apr;2(4):265-73
Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation
Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H
Cell Stem Cell. 2013 Jan 3;12(1):114-26


2012


Development of Sendai Virus Vectors and their Potential Applications in Gene Therapy and Regenerative Medicine
Nakanishi M, Otsu M
Curr Gene Ther. 2012 Oct;12(5):410-6


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特許


PCT/JP2016/051336
ステルス性を有するRNAを使った遺伝子発現系および当該RNAを含む遺伝子導入・発現ベクター
中西真人、飯島 実((国)産業技術総合研究所、ときわバイオ株式会社)
2016.1.18 出願、公開番号 WO2016/114405
特願2015-007288
ステルス性を有するRNAを使った遺伝子発現系および当該RNAを含む遺伝子導入・発現ベクター
中西真人、飯島 実((独)産業技術総合研究所)
2015.1.16 出願
特許第5963309号
末梢血単球由来多能性幹細胞作製方法
中西真人、西村 健、佐野将之((独)産業技術総合研究所)、大高真奈美((社)バイオ産業情報化コンソーシアム)
2010.11.9 出願、2016.7.26 登録
US 9365866 B2
Vectors for Generating Pluripotent Stem Cells and Methods of Producing Pluripotent Stem Cells Using the Same
中西真人、西村 健、大高真奈美、佐野将之((独)産業技術総合研究所)
2010.11.9 出願、2016.6.14 登録
PCT/JP2011/075715
末梢血単球由来多能性幹細胞作製方法
中西真人、西村 健、佐野将之((独)産業技術総合研究所)、大高真奈美((社)バイオ産業情報化コンソーシアム)
2010.11.9 出願、公開番号 WO2012/063817
US 8496941 B2
Vectors for Generating Pluripotent Stem Cells and Methods of Producing Pluripotent Stem Cells Using the Same
中西真人、西村 健、大高真奈美、佐野将之((独)産業技術総合研究所)
2010.6.2 出願、2013.7.30 登録
特許第5633075号
多能性幹細胞作成用ベクター材料及びこれを用いた多能性幹細胞作成方法
中西真人、西村 健、大高真奈美、佐野将之((独)産業技術総合研究所)
2010.5.18 出願、2014.10.24 登録
PCT/JP2010/58368
多能性幹細胞作成用ベクター材料及びこれを用いた多能性幹細胞作成方法
中西真人、西村 健、大高真奈美、佐野将之((独)産業技術総合研究所)
2010.5.18 出願
US 9145564 B2
Persistenty Infective Sendai Virus Vector
西村 健、瀬川宏知、中西真人((独)産業技術総合研究所)
2008.4.11 出願、2015.9.29 登録
特許第4936482号
改良された持続感染型センダイウイルスベクター
西村 健、瀬川宏知、中西真人((独)産業技術総合研究所)
2008.4.11 出願、2012.3.2 登録
特許第4478788号
センダイウイルス温度感受性株由来のウイルスベクター
西村 健、瀬川宏知、中西真人((独)産業技術総合研究所)
2005.5.27 出願、2010.3.26 登録
特許第4441626号
抗テロメア配列結合蛋白質TRF1抗体および本抗体を産生するハイブリドーマ
羽生義郎、中西真人、岡部 潤、古川功治、古川安津子((独)産業技術総合研究所)
2004.4.23 出願、2010.1.22 登録


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