Biotechnology Research Institute for Drug Discovery
breadcrumb navigationOrganization > Biotechnology Research Institute for Drug Discovery > Research Groups > Stem Cell Engineering Research Group

Stem Cell Engineering Research Group

Stem Cell Engineering Research Group develops stem cell technology for quality control, stable supply and standardization. In addition, we study reliable differentiation methods using stem cells. Through the R&D of fundamental technology for regenerative medicine and drug discovery, we aim to give back these results to society and to realize healthy and longevity life.

Group's Research Theme

Human iPS/ES marker for quality control
Human iPS/ES marker for quality control


Development of quality control technologies of stem cells

Our aim is to support drug discovery and regenerative medicine through development of quality management technologies of human stem cells, such as iPS cells, ES cells, and mesenchymal stem cells. We are engaged in the establishment of more stable and high quality stem cell supply system, especially in development of biomarkers for evaluation and selection of suitable stem cells and improvement of the culture media or additives. We also investigate the mechanisms of cell differentiation occurring in the body, for applying it for development and validation of a method for manufacturing artificial organs and tissues.


Unexpected differentiation of ES cells in the standard culture   Differentiation test using mesenchymal stem cell (MSC)
Unexpected differentiation of ES cells in the standard culture.
(Upper left) Bright field, (Upper right) Cell nucleus, (Lower left) Stem cell marker, (Lower right) Differentiation marker
 
Differentiation test using mesenchymal stem cell (MSC). Adipocyte (Upper right), chondrocyte (Lower right) and osteocyte (Lower left) derived from MSC (Upper left)

Application of three dimensional culture technique to drug discovery and tissue engineering

(Upper left) Xenopus laevis, (Upper right) Silurana tropicalis
(Lower left) Cynops pyrrhogaster, (Lower right) Pleurodeles waltl

Elucidation of mechanisms for organ development and tissue regeneration

To develop the methodology to generate organs and tissues applicable in regenerative medicine, we study in vivo differentiation mechanisms of organs and tissues. Amphibians are known for high regenerative capability among the Vertebrata. We analyze their regenerative mechanism and aim to apply the obtained insights to medicine.

Page top

Research Achievements

Page top

Staff Members

Position & Name Email Address
Group Leader
Yuzuru ITO
Email AddressEmail Address
Senior Researcher
Yasuko ONUMA
Email AddressEmail Address
Senior Researcher
Yoshikazu HARAMOTO
Email AddressEmail Address
Researcher
Shuuji MAWARIBUCHI
Email AddressEmail Address
Researcher
Tomoko WATANABE
Email AddressEmail Address

Page top