Biotechnology Research Institute for Drug Discovery
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Research Laboratory for Human Cell Engineering

Normal human tissue cells are invaluable resources for regenerative medicine and for gene therapy. On the other hand, the cells obtained from human body without invasive process are limited. Moreover, as the human cells are quite different from other animal species (e.g., mice), we need to focus on human cells. We are conducting investigation of human cells for future medical application, such as technology for human cell reprogramming and standardization of human tissue cells.

Group's Research Theme

Development of novel gene delivery and expression system based on RNA platform

Gene delivery and expression in human cells is the fundamental technology in gene therapy and regenerative medicine. However, most of these technologies have been developed in 1980's and in 1990's, and do not satisfy the requirement by modern medical applications. Recently, we succeed to develop a novel gene delivery / expression system named as "Stealth RNA Vector (SRV)". SRV is an only platform capable stable gene expression from cytoplasmic RNA genome, and will become valuable tool for gene therapy, for regenerative medicine and for biopharmaceutical production.

Development of clinical grade human induced pluripotent stem (iPS) cells
 

Development of clinical grade human induced pluripotent stem (iPS) cells

One of the exciting applications of Stealth RNA Vector is generation of clinical grade human induced pluripotent stem (iPS) cells with highest quality. Traditionally, human iPS cells have been generated with "Yamanaka's Factors" (OCT3/4, SOX2, KLF4 and c-MYC). However, these iPS cells have a number of mutations caused by double strand breaks of genome DNA. We are investigating novel technology for generating clinical grade human iPS cells without undesired mutations using SRV.

Other research projects

Quality control of human stem cells; Investigation of mechanism of stem cell regulation (Stem Cell Engineering Research Group); Application of fat-derived mesenchymal stem cells in regenerative medicine (Stem Cell Biotechnology Research Group); Lectin-based technologies for regenerative medicine and for drug discovery (Cellular Glycome-targeted Technology Research Group); Standardization of human cells and their production process (Biomaterials Research Group, Health Research Institute); Clinical application of mesenchymal stem cells (Medical and Biological Engineering Research Group, Biomedical Research Institute).


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Research Achievements

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Staff Members

Position & Name Email Address & Web SiteWeb Site
Laboratory Director
Mahito NAKANISHI
Email AddressEmail Address
Deputy Director, BRD
Masashi SUZUKI
Email AddressEmail Address
Prime Senior Researcher
Jun HIRABAYASHI
Email AddressEmail Address
Group Leader
Yuzuru ITO
Email AddressEmail Address
Chief Senior Researcher
Yuzuru IKEHARA
Email AddressEmail Address
Web Sitehttps://staff.aist.go.jp/yuzuru-ikehara/
Senior Researcher
Masahiro ASADA
Email AddressEmail Address
Senior Researcher/Group Leader
Hiroaki TATENO
Email AddressEmail Address
Web Sitehttps://staff.aist.go.jp/h-tateno/
Senior Researcher
Yasuko ONUMA
Email AddressEmail Address
Senior Researcher
Masayuki SANO
Email AddressEmail Address
Group Leader
Yasuyuki KIDA
Email AddressEmail Address
Web Sitehttps://staff.aist.go.jp/y-kida/
Senior Researcher
Yoshikazu HARAMOTO
Email AddressEmail Address
Researcher
Yuzo TAKAYAMA
Email AddressEmail Address
Web Sitehttps://sites.google.com/site/yuzotaka0124/engpage
Senior Researcher
Shunsuke YUBA
(Medical and Biological Engineering Research Group, Biomedical Research Institute)
Email AddressEmail Address
Senior Researcher
Motohiro HIROSE
(Biomaterials Research Group, Health Research Institute)
Email AddressEmail Address

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