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※ Glycan Lectin Engineering Research Group was reorganized as Cellular Glycome-targeted Technology Research Group as of May 2, 2016.
Glycan Lectin Engineering Research Group

List of titles, authors, and journal information of published papers.



Elimination of Tumorigenic Human Pluripotent Stem Cells by a Recombinant Lectin-Toxin Fusion Protein
Tateno H, Onuma Y, Ito Y, Minoshima F, Saito S, Shimizu M, Aiki Y, Asashima M, Hirabayashi J
Stem Cell Reports. 2015 May 12;4(5):811-20
Engineering of a 3'-sulpho-Galβ1-4GlcNAc-specific probe by a single amino acid substitution of a fungal galectin
Hu D, Huang H, Tateno H, Nakakita S, Sato T, Narimatsu H, Yao X, Hirabayashi J
J Biochem. 2015 Apr;157(4):197-200
A Stable Chimeric Fibroblast Growth Factor (FGF) Can Successfully Replace Basic FGF in Human Pluripotent Stem Cell Culture
Onuma Y, Higuchi K, Aiki Y, Shu Y, Asada M, Asashima M, Suzuki M, Imamura T, Ito Y
PLoS One. 2015 Apr 7;10(4):e0118931
S-nitrosylation of mouse galectin-2 prevents oxidative inactivation by hydrogen peroxide
Tamura M, Saito M, Yamamoto K, Takeuchi T, Ohtake K, Tateno H, Hirabayashi J, Kobayashi J, Arata Y
Biochem Biophys Res Commun. 2015 Feb 20;457(4):712-7
Isolation and Biochemical Characterization of Apios Tuber Lectin
Kenmochi E, Kabir SR, Ogawa T, Naude R, Tateno H, Hirabayashi J, Muramoto K
Molecules. 2015 Jan 9;20(1):987-1002

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A C-type lectin isolated from the skin of Japanese bullhead shark (Heterodontus japonicus) binds a remarkably broad range of sugars and induces blood coagulation
Tsutsui S, Dotsuta Y, Ono A, Suzuki M, Tateno H, Hirabayashi J, Nakamura O
J Biochem. 2015 May;157(5):345-56
Cellular Internalization of Fibroblast Growth Factor-12 Exerts Radioprotective Effects on Intestinal Radiation Damage Independently of FGFR Signaling
Nakayama F, Umeda S, Yasuda T, Fujita M, Asada M, Meineke V, Imamura T, Imai T
Int J Radiat Oncol Biol Phys. 2014 Feb 1;88(2):377-84
Molecular Clock Regulates Daily α1-2-Fucosylation of the Neural Cell Adhesion Molecule (NCAM) within Mouse Secondary Olfactory Neurons
Kondoh D, Tateno H, Hirabayashi J, Yasumoto Y, Nakao R, Oishi K
J Biol Chem. 2014 Dec 26;289(52):36158-65
Two jacalin-related lectins from seeds of the African breadfruit (Treculia africana L.)
Shimokawa M, Nsimba-Lubaki SM, Hayashi N, Minami Y, Yagi F, Hiemori K, Tateno H, Hirabayashi J
Biosci Biotechnol Biochem. 2014 Dec;78(12):2036-44
A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells
Tateno H, Onuma Y, Ito Y, Hiemori K, Aiki Y, Shimizu M, Higuchi K, Fukuda M, Warashina M, Honda S, Asashima M, Hirabayashi J
Sci Rep. 2014 Feb 12;4:4069

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Sulfated Glycosaminoglycan-Assisted Receptor Specificity of Human Fibroblast Growth Factor (FGF) 19 Signaling in a Mouse System Is Different from That in a Human System
Nakamura M, Uehara Y, Asada M, Suzuki M, Imamura T
J Biomol Screen. 2013 Mar;18(3):321-30
Structural Stability of Human Fibroblast Growth Factor-1 Is Essential for Protective Effects Against Radiation-Induced Intestinal Damage
Nakayama F, Umeda S, Yasuda T, Asada M, Motomura K, Suzuki M, Zakrzewska M, Imamura T, Imai T
Int J Radiat Oncol Biol Phys. 2013 Feb 1;85(2):477-83
Serum protein fractionation using supported molecular matrix electrophoresis
Dong W, Matsuno YK, Kameyama A
Electrophoresis. 2013 Aug;34(16):2432-9
Identification of mucins by using a method involving a combination of on-membrane chemical deglycosylation and immunostaining
Matsuno YK, Dong W, Yokoyama S, Yonezawa S, Narimatsu H, Kameyama A
J Immunol Methods. 2013 Aug 30;394(1-2):125-30
Terminal N-Acetylgalactosamine-Specific Leguminous Lectin from Wisteria japonica as a Probe for Human Lung Squamous Cell Carcinoma
Soga K, Teruya F, Tateno H, Hirabayashi J, Yamamoto K
PLoS One. 2013 Dec 13;8(12):e83886
Conformational change of a unique sequence in a fungal galectin from Agrocybe cylindracea controls glycan ligand-binding specificity
Kuwabara N, Hu D, Tateno H, Makyio H, Hirabayashi J, Kato R
FEBS Lett. 2013 Nov 15;587(22):3620-5
Tailoring GalNAcα1-3Galβ-specific lectins from a multi-specific fungal galectin: dramatic change of carbohydrate specificity by a single amino-acid substitution
Hu D, Tateno H, Sato T, Narimatsu H, Hirabayashi J
Biochem J. 2013 Jul 15;453(2):261-70
Glycoproteomics-based cancer marker discovery adopting dual enrichment with Wisteria floribunda agglutinin for high specific glyco-diagnosis of cholangiocarcinoma
Matsuda A, Kuno A, Matsuzaki H, Kawamoto T, Shikanai T, Nakanuma Y, Yamamoto M, Ohkohchi N, Ikehara Y, Shoda J, Hirabayashi J, Narimatsu H
J Proteomics. 2013 Jun 24;85:1-11
NMR structure and dynamics of the C-terminal domain of R-type lectin from the earthworm Lumbricus terrestris
Hemmi H, Kuno A, Hirabayashi J
FEBS J. 2013 Jan;280(1):70-82
Podocalyxin Is a Glycoprotein Ligand of the Human Pluripotent Stem Cell-Specific Probe rBC2LCN
Tateno H, Matsushima A, Hiemori K, Onuma Y, Ito Y, Hasehira K, Nishimura K, Ohtaka M, Takayasu S, Nakanishi M, Ikehara Y, Nakanishi M, Ohnuma K, Chan T, Toyoda M, Akutsu H, Umezawa A, Asashima M, Hirabayashi J
Stem Cells Transl Med. 2013 Apr;2(4):265-73
A Lectin-Based Glycomic Approach to Identify Characteristic Features of Xenopus Embryogenesis
Onuma Y, Tateno H, Tsuji S, Hirabayashi J, Ito Y, Asashima M
PLoS One. 2013 Feb 14;8(2):e56581
rBC2LCN, a new probe for live cell imaging of human pluripotent stem cells
Onuma Y, Tateno H, Hirabayashi J, Ito Y, Asashima M
Biochem Biophys Res Commun. 2013 Feb 15;431(3):524-9

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Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling
Kimura-Ueki M, Oda Y, Oki J, Komi-Kuramochi A, Honda E, Asada M, Suzuki M, Imamura T
J Invest Dermatol. 2012 May;132(5):1338-45
A Procedure for Alcian Blue Staining of Mucins on Polyvinylidene Difluoride Membranes
Dong W, Matsuno YK, Kameyama A
Anal Chem. 2012 Oct 16;84(20):8461-6
Structural and Quantitative Evidence for Dynamic Glycome Shift on Production of Induced Pluripotent Stem Cells
Hasehira K, Tateno H, Onuma Y, Ito Y, Asashima M, Hirabayashi J
Mol Cell Proteomics. 2012 Dec;11(12):1913-23
Malectin Forms a Complex with Ribophorin I for Enhanced Association with Misfolded Glycoproteins
Qin SY, Hu D, Matsumoto K, Takeda K, Matsumoto N, Yamaguchi Y, Yamamoto K
J Biol Chem. 2012 Nov 2;287(45):38080-9
Generation of monoclonal antibodies against the Galβ1-4Gal epitope: A key tool in studies of species-specific glycans expressed in fish, amphibians and birds
Suzuki N, Nawa D, Tateno H, Yasuda T, Oda S, Mitani H, Nishimaki T, Katsumura T, Oota H, Hanihara T, Oga A, Hirabayashi J, Yamamoto K
Glycobiology. 2013 Jan;23(1):91-105
Domain composition of rhamnose-binding lectin from shishamo smelt eggs and its carbohydrate-binding profiles
Hosono M, Sugawara S, Tatsuta T, Hikita T, Kominami J, Nakamura-Tsuruta S, Hirabayashi J, Kawsar SM, Ozeki Y, Hakomori SI, Nitta K
Fish Physiol Biochem. 2013 Dec;39(6):1619-30
A Novel Core Fucose-specific Lectin from the Mushroom Pholiota squarrosa
Kobayashi Y, Tateno H, Dohra H, Moriwaki K, Miyoshi E, Hirabayashi J, Kawagishi H
J Biol Chem. 2012 Oct 5;287(41):33973-82
Characterization and cloning of GNA-like lectin from the mushroom Marasmius oreades
Shimokawa M, Fukudome A, Yamashita R, Minami Y, Yagi F, Tateno H, Hirabayashi J
Glycoconj J. 2012 Oct;29(7):457-65
Directed Evolution of Lectins with Sugar-binding Specificity for 6-Sulfo-galactose
Hu D, Tateno H, Kuno A, Yabe R, Hirabayashi J
J Biol Chem. 2012 Jun 8;287(24):20313-20
Difference in Fine Specificity to Polysaccharides of Candida albicans Mannoprotein between Mouse SIGNR1 and Human DC-SIGN
Takahara K, Arita T, Tokieda S, Shibata N, Okawa Y, Tateno H, Hirabayashi J, Inaba K
Infect Immun. 2012 May;80(5):1699-706
Purification, Characterization, and Molecular Cloning of Lectin from Winter Buds of Lysichiton camtschatcensis (L.) Schott
Nakagawa Y, Sakamoto H, Tateno H, Hirabayashi J, Oguri S
Biosci Biotechnol Biochem. 2012;76(1):25-33
Mannose-specific lectin from the mushroom Hygrophorus russula
Suzuki T, Sugiyama K, Hirai H, Ito H, Morita T, Dohra H, Murata T, Usui T, Tateno H, Hirabayashi J, Kobayashi Y, Kawagishi H
Glycobiology. 2012 May;22(5):616-29
Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system
Tateno H, Yabe R, Sato T, Shibazaki A, Shikanai T, Gonoi T, Narimatsu H, Hirabayashi J
Glycobiology. 2012 Feb;22(2):210-20

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Review & others

Development and Applications of the Lectin Microarray
Hirabayashi J, Kuno A, Tateno H
SialoGlyco Chemistry and Biology Ⅱ, Top Curr Chem. 2015 Aug 7;367:105-24
Succinylation-Alcian Blue Staining of Mucins on Polyvinylidene Difluoride Membranes
Kameyama A, Dong W, Matsuno Y
Detection of Blotted Proteins, Methods Mol Biol. 2015 Jul 14;1314:325-31
Supported Molecular Matrix Electrophoresis
Matsuno YK, Kameyama A
Detection of Blotted Proteins, Methods Mol Biol. 2015 Jul 14;1314:303-11
The Lectin Frontier Database (LfDB), and Data Generation Based on Frontal Affinity Chromatography
Hirabayashi J, Tateno H, Shikanai T, Aoki-Kinoshita KF, Narimatsu H
Molecules. 2015 Jan 8;20(1):951-73
Evaluation of Galectin Binding by Frontal Affinity Chromatography (FAC)
Iwaki J, Hirabayashi J
Galectins, Methods Mol Biol. 2014 Oct 8;1207:63-74
Supported Molecular Matrix Electrophoresis: A New Membrane Electrophoresis for Characterizing Glycoproteins
Matsuno YK, Kameyama A
Lectins, Methods Mol Biol. 2014 Aug 22;1200:327-33
Lectin Structures: Classification Based on the 3-D Structures
Fujimoto Z, Tateno H, Hirabayashi J
Lectins, Methods Mol Biol. 2014 Aug 22;1200:579-606
Comprehensive List of Lectins: Origins, Natures, and Carbohydrate Specificities
Kobayashi Y, Tateno H, Ogawa H, Yamamoto K, Hirabayashi J
Lectins, Methods Mol Biol. 2014 Aug 22;1200:555-77
Directed Evolution of Lectins by an Improved Error-Prone PCR and Ribosome Display Method
Hu D, Tateno H, Hirabayashi J
Lectins, Methods Mol Biol. 2014 Aug 22;1200:527-38
Evaluation of Glycan-Binding Specificity by Glycoconjugate Microarray with an Evanescent-Field Fluorescence Detection System
Tateno H
Lectins, Methods Mol Biol. 2014 Aug 22;1200:353-9
Live-Cell Imaging of Human Pluripotent Stem Cells by a Novel Lectin Probe rBC2LCN
Tateno H, Onuma Y, Ito Y
Lectins, Methods Mol Biol. 2014 Aug 22;1200:313-8
Application of Lectin Microarray to Bacteria Including Lactobacillus casei/paracasei Strains
Yasuda E, Sako T, Tateno H, Hirabayashi J
Lectins, Methods Mol Biol. 2014 Aug 22;1200:295-311
Differential Glycan Analysis of an Endogenous Glycoprotein: Toward Clinical Implementation-From Sample Pretreatment to Data Standardization
Kuno A, Matsuda A, Unno S, Tan B, Hirabayashi J, Narimatsu H
Lectins, Methods Mol Biol. 2014 Aug 22;1200:265-85
Lectin-Based Glycomics: How and When Was the Technology Born?
Hirabayashi J
Lectins, Methods Mol Biol. 2014 Aug 22;1200:225-42
Lectin microarrays: concept, principle and applications
Hirabayashi J, Yamada M, Kuno A, Tateno H
Chem Soc Rev. 2013 May 21;42(10):4443-58
Recent Advances in Electrophoresis of Mucins
Kameyama A, Matsuno YK
Trends Glycosci Glycotechnol. 2012 Jul;24(138):137-51

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