Biotechnology Research Institute for Drug Discovery
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Cellular Glycome-targeted Technology Research Group

We develop advanced technologies to analyze the cellular glycome of stem cells and cancer cells in a comprehensive manner, identify cell surface markers, and study the functions of the cellular glycome. We engineer lectins/proteins/peptides to target and regulate cellular functions using our protein engineering and molecular evolutionary approaches toward development of high-sensitive systems for detection and selection of target cells. Our goal is to contribute to various fields of life science such as drug discovery and regenerative medicine and to translate to the industry.

Group's Research Theme

Development and industrial application of lectin-based technologies for regenerative medicine and drug discovery
 




Development and industrial application of lectin-based technologies for regenerative medicine and drug discovery

Our goal is to develop novel technologies for stem cell qualification, drug discovery, and homeostasis qualification using our glycan-lectin engineering technologies (high-density lectin microarray, glycoconjugate microarray, frontal affinity chromatography, recombinant lectin library, lectin engineering technologies, etc.) and transfer to industry to realize practical use. Our strategy allowed us to discover a human pluripotent stem cell-specific lectin (rBC2LCN/AiLecS1) and successfully develop the technologies to detect and eliminate tumorigenic human pluripotent stem cells for safe stem cell therapy through collaboration with a company.

Development and application of advanced technologies for glycoconjugate analysis
 


Development and application of advanced technologies for glycoconjugate analysis

Mucins are a family of heavily glycosylated high molecular mass proteins. They are known as constituents of saliva and tear fluid and are produced by mucosal epithelial cells. Mucins have long been implicated in tumor progression and infection. We have developed a new type of membrane electrophoresis "Supported molecular matrix electrophoresis (SMME)" that can simply separate and characterize mucins, and applied this technique to disease biomarker discovery. Moreover, we study novel, robust, and quantitative evaluation of glycosylation heterogeneity on biopharmaceuticals, and aim to contribute to advanced manufacturing of biopharmaceuticals.

Analysis and application of functional mechanisms of sugar chains on bioactive growth factors
 

Analysis and application of functional mechanisms of sugar chains on bioactive growth factors

Growth factors are multi-functional proteins controlling cell growth, differentiation, and other phenomena. We are interested in the functional mechanisms of sugar chains to modulate the bioactivity of several growth factors. The goal of our research is to make an innovative contribution to the pharmaceutical and medical field utilizing the sugar chain functions integrated in the bioactive proteins.

Development of peptide therapeutics discovery technology targeting cellular surface proteins
 


Development of peptide therapeutics discovery technology targeting cellular surface proteins

Ion channels and transporters on the cellular membrane play important roles in biological functions and are promising as target molecules in drug development. Functional modifications of ion channels by sugar chains in various diseases are well-know and one example is such modification induces extreme pain in diabetic neuropathy patients. If drugs targeting these ion channels can be developed, they will be considered to become good analgesics. We aim to create next generation peptide therapeutics via combination of the intra periplasm secretion and selection (PERISS) method and the electrophysiological method.

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Research Achievements

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Staff Members

Photo Position & Name Email Address &Web Site
Chief Senior Researcher
Hiroaki TATENO
Email AddressEmail Address
Web Sitehttps://staff.aist.go.jp/h-tateno/
no photo
Principal Research Manager
Masashi SUZUKI
Email AddressEmail Address
no photo
Prime Senior Researcher
Jun HIRABAYASHI
Email AddressEmail Address
no photo
Chief Senior Researcher
Akihiko KAMEYAMA
Email AddressEmail Address
no photo
Senior Researcher
Masahiro ASADA *
Email AddressEmail Address
no photo
Senior Researcher
Tadashi KIMURA
Email AddressEmail Address
  * Research and Innovation Promotion Headquarters Large-Scale Collaboration Office

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