1. ホーム>
  2. 研究成果>
  3. 論文発表 >
  4. 誌上発表(国際誌・査読有)2018年

研究成果 Research Result

誌上発表(国際誌・査読有)2018年

部門研究戦略1:生物機能解明

脳遺伝子研究グループ

  • Saito, R., Shinkai, Y., Doi, M.: Intestinal F-box protein regulates quick avoidance behavior of Caenorhabditis elegans to the pathogenic bacterium Pseudomonas aeruginosa. Genes Cells, (2018).
  • Shinkai, Y., Doi, M.: EOR-1 mediates non-cell autonomous regulation of abts-1 gene expression in HSNs​. microPublication Biology (2018).
  • Shinkai, Y., Kuramochi, M., Doi, M.: A simple method for visualization of locus-specific H4K20me1 modifications in living Caenorhabditis elegans single cells. G3-Genes Genomes Genet., 8(7), 2249-2255 (2018).
  • Nagasaki, A., Kato, Y., Meguro, K., Yamagishi, A., Nakamura, C., Uyeda, T.Q.P.: A genome editing vector that enables easy selection and identification of knockout cells. Plasmid, 98, 37-44 (2018).
  • Shinkai, Y., Kuramochi, M., Doi, M.: Regulation of chromatin states and gene expression during HSN neuronal maturation is mediated by EOR-1/PLZF, MAU-2/cohesin loader, and SWI/SNF complex. Sci Rep., 8, 7942 (2018).
  • Kijima, S.T., Staiger, C., Katoh, K., Nagasaki, A., Ito, K., Uyeda, T.Q.: Arabidopsis vegetative actin isoforms, AtACT2 and AtACT7, generate distinct filament arrays in living plant cells. Sci Rep., 8(1) (2018).
  • Ito, N., Katoh, K., Kushige, K., Saito, Y., Umemoto, T., Matsuzaki, Y., Kiyonari, H., Kobayashi, D., Soga, M., Era, T., Araki, N., Furuta, Y., Suda, T., Kida, Y., Ohta, K.: Ribosome incorporation into somatic cells promotes lineage transdifferentiation towards multipotency. Sci. Rep., 8(1), 1634 (2018).

脳機能調節因子研究グループ

  • Murao, N., Matsubara, S., Matsuda, T., Noguchi, H., Mutoh, T., Mutoh, M., Koseki, H., Namihira, M., Nakashima, K: Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain. Neurosci. Res. (2018).
  • Semi, K., Sanosaka, T., Namihira, M., Nakashima, K.: Nuclear factor I/A coordinates the timing of oligodendrocyte differentiation/maturation via Olig1 promoter methylation. Hayati Journal of Bioscience, 25(2) (2018).

細胞分子機能研究グループ

  • Fukuda, N., Kanazawa, M., Tsuru, K., Tsuchiya, A., Sunarso, Toita, R., Mori, Y., Nakashima, Y., Ishikawa, K.: Synergistic effect of surface phosphorylation and micro-roughness on enhanced osseointegration ability of poly(ether ether ketone) in the rabbit tibia. Sci Rep, 8(1), 16887 (2018).
  • Toita, R., Otani, K., Kawakno, T., Murata, M., Kang, J-H.: Protein kinase A (PKA) inhibition reduces human aortic smooth muscle cell calcification stimulated by inflammatory response and inorganic phosphate. Life Sci., 209, 466-471 (2018).
  • Toita, R., Fujita, S., Kang, J-H.: Macrophage uptake behavior and anti-inflammatory response of bovine brain- or soybean-derived phosphatidylserine liposomes. J. Oleo Sci., 67(9), 1131-1135 (2018).
  • Sunarso, Tsuchiya, A., Fukuda, N., Toita, R., Tsuru, K., Ishikawa, K.: Effect of micro-roughening of poly(ether ether ketone) on bone marrow derived stem cell and macrophage responses, and osseointegration. J. Biomater. Sci.-Polym. Ed., 1-14 (2018).
  • Toita, R., Kawano, T., Fujita, S., Murata, M., Kang, J-H.: Increased hepatic inflammation in a normal-weight mouse after long-term high-fat diet feeding. J. Toxicol. Pathol., 31(1) (2018).

部門研究戦略2:生物機能計測

バイオアナリティカル研究グループ

  • Morita, M., Katoh, K., Noda, N.: Direct observation of bacterial growth in giant unilamellar vesicles: A novel tool for bacterial culture. ChemistryOpen, 7(11), 845-849 (2018).
  • Miyamoto, T., Yokota, A., Ota, Y., Tsuruga, M., Aoi, R., Tsuneda, S., Noda, N.: Nitrosomonas europaea MazF specifically recognises the UGG motif and promotes selective RNA degradation. Front. Microbiol.9, 2386 (2018).
  • Sasaki, A., Yamamoto, J., Kinjo, M., Noda, N.: Absolute quantification of RNA molecules using fluorescence correlation spectroscopy with certified reference materials. Anal. Chem., 90(18), 10865-10871 (2018).
  • Tourlousse, D.M., Ohashi, A., Sekiguchi, Y.: Sample tracking in microbiome community profiling assays using synthetic 16S rRNA gene spike-in controls. Sci Rep, 8(1), 9095 (2018).
  • Sato, Y., Endo, M., Morita, M., Takinoue, M., Sugiyama, H., Murata, S., Nomura, S.M., Suzuki, Y.: Environment-dependent self-assembly of DNA origami lattices on phase-separated lipid membranes. Adv. Mater. Interfaces, 5(14), 1-6 (2018).
  • Sugawara, J., Tomota, T., Noda, N., Matsukura, S., Tsukagoshi, K., Hayashi, K., Hieda, M., Maeda, S.: Effects of endothelin-related gene polymorphisms and aerobic exercise habit on age-related arterial stiffening: a 10-yr longitudinal study. J. Appl. Physiol., 124, 312-320 (2018).

細胞・生体医工学研究グループ

  • Nautiyal, K., Kibria, M.G., Akazawa-Ogawa, Y., Hagihara, Y., Kuroda, Y.: Design and assessment of an active anti-epidermal growth factor receptor (EGFR) single chain variable fragment (ScFv) with improved solubility. Biochem. Biophys. Res. Commun., 508(4), 1043-1049 (2018).
  • Suzuki, T., Mochizuki, Y., Kimura, S., Akazawa-Ogawa, Y., Hagihara, Y., Nemoto, N.: Anti-survivin single-domain antibodies derived from an artificial library including three synthetic random regions by in vitro selection using cDNA display. Biochem. Biophys. Res. Commun., 503(3), 2054-2060 (2018).
  • Takata, H., Madung, M., Katoh, K., Fukui, K.: Cdk1-dependent phosphorylation of KIF4A at S1186 triggers lateral chromosome compaction during early mitosis. PLoS One, 13(12), e0209614 (2018).
  • Soeta, Y., Sakamoto, Y.: An exploratory analysis of sound field characteristics using the impulse response in a car cabin. Environments, 5(4), 44 (2018).

次世代メディカルデバイス研究グループ

  • Matsuda, A., Mimura, M., Maruyama, T., Kurinomaru, T., Shiuhei, M., Shiraki, K.: Liquid droplet of protein-polyelectrolyte complex for high-concentration formulations. J. Pharm. Sci., 107(10), 2713-2719 (2018).
  • Yamazoe, H.: Spectroscopic study on the conformation of serum albumin in film state. J. Biosci. Bioeng. (2018).
  • Endo, A., Kurinomaru, T., Shiraki, K.: Hyperactivation of serine proteases by the Hofmeister effect. Mol. Catal., 488(8), 32-37 (2018).
  • Ando, M., Biju, V., Kawasaki, H., Shigeri, Y.: Optical ozone sensing by composite films of noble metals and CdSe/ZnS quantum dots. Proceedings of the 17th International Meeting on Chemical Sensors., 91-92 (2018).
  • Furutani, S., Nishio, K., Naruishi, N., Akazawa-Ogawa, Y., Hagihara, Y., Yoshida, Y., Nagai, H.: Rapid enzyme-linked immunosorbent assays for diagnosis of diabetes in a compact disc-shaped microfluidic device. Anal. Sci., 34(3), 379-382 (2018).

部門研究戦略3:生物機能応用

分子細胞デザイン研究グループ

  • Yageta, S., Imamura, H., Shibuya, R., Honda, S.: C H 2 domain orientation of human immunoglobulin G in solution: Structural comparison of glycosylated and aglycosylated Fc regions using small-angle X-ray scattering. mAbs (2018)
  • Odahara, T., Odahara, K.: Various salts employed as precipitant in combination with polyethylene glycol in protein/detergent particle association. Heliyon, 4(12), e01073 (2018).
  • Shibakami, M., Sohma, M.: Thermal, crystalline, and pressure-sensitive adhesive properties of paramylon monoesters derived from an euglenoid polysaccharide. Carbohydr. Polym. 200, 239-247 (2018).
  • Senga, Y., Honda, S.: Suppression of aggregation of therapeutic monoclonal antibodies during storage by removal of aggregation precursors using a specific adsorbent of non-native IgG conformers. Bioconjugate Chem., 29(10), 3250-3261 (2018).
  • Hattan, J., Shindo, K., Sasaki, T., Ohno, F., Tokuda, H., Ishikawa, K., Misawa, N.: Identification of novel sesquiterpene synthase genes that mediate the biosynthesis of valerianol, which was an unknown ingredient of tea. Sci Rep, 8, 12474 (2018).
  • Yamashita, M., Sueyoshi, N., Yamada, H., Katayama, S., Senga, Y., Takenaka, Y., Ishida, A., Kameshita, I., Shigeri, Y.: Characterization of CoPK02, a Ca2+/calmodulin-dependent protein kinase in mushroom Coprinopsis cinerea. Biosci. Biotechnol. Biochem., 82(8), 1335-1343 (2018).
  • Shibakami, M., Nemoto, T., Sohma, M.: Dependence of dissolution, dispersion, and aggregation characteristics of cationic polysaccharides made from euglenoid β-1,3-glucan on degree of substitution. Cellulose, 25(4), 2217-2234 (2018).

構造創薬研究グループ

  • Takagi, Y., Nosato, H., Doi, M., Furukawa, K., Sakanashi, H.: Development of a motion-based cell-counting system for Trypanosoma parasite using a pattern recognition approach. Biotechniques, 66(3) (2018).
  • Tani, O., Akutsu, Y., Ito, S., Suzuki, T., Tateishi, Y., Yamaguchi, T., Niimi, T., Namatame, I., Chiba, Y., Sakashita, H., Kubota, T., Yanagi, T., Mizukami, S., Hirayama, K., Furukawa, K., Yamasaki, K.: NMR biochemical assay for oxidosqualene cyclase: Evaluation of inhibitor activities on trypanosoma cruzi and human enzymes. J. Med. Chem., 61, 5047-5053 (2018).
  • Yamasaki, K., Yamasaki, T., Tateno, H.: The trimeric solution structure and fucose-binding mechanism of the core fucosylation-specific lectin PhoSL. Sci Rep., 8(7740), 1-12 (2018).
  • Ishitobi, H., Sanada, Y., Kato, Y., Ikuta, Y., Shibata, S., Yamasaki, S., Lotz, M.K., Matsubara, K., Miyaki, S., Adachi, N.: Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes. Eur. J. Pharmacol., 830, 1-8 (2018).
  • Kubota, T., Tani, O., Yamaguchi, T., Namatame, I., Sakashita, H., Furukawa, K., Yamasaki, K.: Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase from Trypanosoma brucei. FEBS Open Bio (2018).

生体分子創製研究グループ

  • Fukuda, N., Honda, S.: Artificial mating-type conversion and repetitive mating for polyploid generation. ACS Synth. Biol., 7(5), 1413-1423 (2018).
  • Nakamura, T., Koma, D., Oshima, M., Hoshino, H., Ohmoto, T., Uegaki, K.: Application of chromosomal gene insertion into Escherichia coli for expression of recombinant proteins. J. Biosci. Bioeng., 126(2), 266-272 (2018).
  • Sashiwa, H., Fukuda, R., Okura, T., Sato, S., Nakayama, A.: Microbial degradation behavior in seawater of polyester blends containing poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx). Mar. Drugs, 16(34) (2018).

先端ゲノムデザイン研究グループ

  • Iwasaki, M., Miyake, M., Maseda, H., Qi, G., Pan, Z., Ihara, I., Umetsu, K.: Thermophilic anaerobic digestion is an effective treatment for reducing cefazolin-resistant bacteria and ESBL-producers in dairy manure. J. Mater. Cycles Waste Manag., 1-7 (2018).
  • Oishi, I., Yoshii, K., Miyahara, D., Tagumi, T.: Efficient production of human interferon beta in the white of eggs from ovalbumin gene–targeted hens. Sci Rep, 8, 10203 (2018).
  • Tonoyama, Y., Shinya, M., Toyoda, A., Kitano, T., Oga, A., Nishimaki, T., Katsumura, T., Oota, H., Wan, M.T., Yip, B.W.P., Helen, M.O.L., Chisada, S., Deguchi, T., Au, D.W.T., Naruse, K., Kamei, Y., Taniguchi, Y.: Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. (2018).

総括研究主幹・部門付き

先進バイオ計測研究グループ

  • Waite, D.W., Dsouza, M., Sekiguchi, Y., Hugenholtz, P., Taylor, M.W.: Network-guided genomic and metagenomic analysis of the faecal microbiota of the critically endangered kakapo. Sci. Rep., 8, 8128 (2018).