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  4. 誌上発表(国際誌・査読有)2017年

研究成果

誌上発表(国際誌・査読有)2017年

重点課題1:

分子細胞育種研究グループ

  • Torisu, T., Maruno, T., Yoneda, S., Hamaji, Y., Honda, S., Ohkubo, T., Uchiyama, S.: Friability testing as a new stress-stability assay for biopharmaceuticals. J. Pharm. Sci. (2017).
  • Fukuda, N., Kaishima, M., Ishii, J., Honda, S.: Positive detection of GPCR antagonists using a system for inverted expression of a fluorescent reporter gene. ACS Synth. Biol. (2017).
  • Yageta, S., Shibuya, R., Imamura, H., Honda, S.: Conformational and colloidal stabilities of human immunoglobulin G Fc and its cyclized variant: Independent and compensatory participation of domains in aggregation of multi-domain proteins. Mol. Pharm. (2017).
  • Imamura, H., Honda, S.: Calibration-free concentration analysis for an analyte prone to self-association. Anal. Biochem., 516, 61-64 (2017).
  • Shibakami, M., Sohma, M.: Synthesis and thermal properties of paramylon mixed esters and optical, mechanical, and crystal properties of their hot-pressed films. Carbohydr. Polym., 155, 416-424 (2017).

蛋白質デザイン研究グループ

  • Muraki, M., Hirota, K.: Site-specific chemical conjugation of human Fas ligand extracellular domain using trans-cyclooctene – methyltetrazine reactions. BMC Biotechnol., 17, 56 (2017).
  • Kudo, S., Caaveiro, J.M., Nagatoishi, S., Miyafusa, T., Matsuura, T., Sudou, Y., Tsumoto, K.: Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin. Sci. Rep., 7:39518 (2017).

構造生理研究グループ

  • Kato, M., Hanyu, Y.: Single-step colony assay for screening antibody libraries. J. Biotechnol., 255, 1-8 (2017).
  • Kato, M., Hanyu, Y.: Enzymatic assembly for scFv library construction. Synthetic Antibodies, (1575), 31-44 (2017).
  • Okada, T., Ogura, T.: High-resolution imaging of living mammalian cells bound by nanobeads-connected antibodies in a medium using scanning electron-assisted dielectric microscopy. Sci. Rep., 7, 43025 (2017).
  • Kinoshita, T., Sato, C., Fuwa, TJ., Nishihara, S.: Short stop mediates axonal compartmentalization of mucin-type core 1 glycans. Sci Rep, 7, 41455 (2017).
  • Takeda, S., Himeno, T., Kakizoe, K., Okazaki, H., Okada, T., Watanabe, K., Aramaki, H.: Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness. J Nat Med, 71(1), 286-291 (2017).
  • Okada, T., Kurabayashi, A., Akimitsu, N., Furihata, M.: Expression of cadherin-17 promotes metastasis in a highly bone marrow metastatic murine breast cancer model. Biomed Res. Int., 2017, 8494286 (2017).

先端ゲノムデザイン研究グループ

生体分子創製研究グループ

  • Yamano, N., Kawasaki, N., Ida, S., Nakayama, Y., Nakayama, A.: Biodegradation of polyamide 4 in vivo. Polym. Degrad. Stabil., 137, 281-288 (2017).

分子細胞病態研究特別チーム

  • Mizui, T., Ohira, K., Kojma, M.: BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing. Neural Regen. Res., 12(7), 1024-1027 (2017).
  • Uegaki, K., Kumanogoh, H., Mizui, T., Hirokawa, T., Ishikawa, Y., Kojima, M.: BDNF binds its pro-peptide with high affinity and the common Val66Met polymorphism attenuates the interaction. Int. J. Mol. Sci., 18, 1042 (2017).

重点課題2:

生物時計研究グループ

  • Nakao R., Okauchi, H., Hashimoto, C., Wada, N., Oishi, K.: Determination of reference genes that are independent of feeding rhythms for circadian studies of mouse metabolic tissues. Mol. Genet. Metab., 121(2), 190-197 (2017).
  • Akimoto, H., Oshima, S., Ohara, K., Negishi, A., Hiroyama, H., Nemoto, T., Kobayashi, D.: High-resolution magic-angle spinning-1H-NMR spectroscopy-based metabolic profiling of hippocampal tissue in rats with depression-like symptoms. Biol. Pharm. Bull., 40(6), 789-796 (2017).
  • Horikawa, K., Hashimoto, C., Kikuchi, Y., Makita, M., Fukudome, SI., Okita, K., Wada, N., Oishi, K.: Wheat alkylresorcinols reduce micellar solubility of cholesterol in vitro and increase cholesterol excretion in mice. Nat. Prod. Res., 31(5), 578-582 (2017).
  • Akitomo, S., Egi, Y., Nakamura, Y., Suetsugu, Y., Oishi, K., Sakamoto, K.: Genome-wide microarray screening for Bombyx mori genes related to transmitting the determination outcome of whether to produce diapause or nondiapause eggs. Insect Sci., 24(2), 187-193 (2017).
  • Oishi, K., Yamamoto, S., Oike, H., Ohkura, N., Taniguchi: Cinnamic acid shortens the period of the circadian clock in mice. Biochemistry and Biophysics Reports, 9, 232-237 (2017).
  • Oishi, K., Ohkura, N., Yasumoto, Y., Yamamoto, S.: Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice. Chronobiol. Int., 34(2), 254-259 (2017).
  • Gonzalez, G., Sasaki, M.,Burkitt-Gray, L., Kamiya, T., Tsuji, N.M., Hirofumi, S., Kimihito, I.: An optimistic protein assembly from sequence reads salvaged an uncharacterized segment of mouse picobirnavirus. Sci Rep. 7, 40447 (2017).
  • Oishi, K., Yasumoto, Y., Higo-Yamamoto, S., Yamamoto, S., Ohkura, N.: Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects. Biochem. Biophys. Res. Commun., 483(1), 165-170 (2017).

健康維持機能物質開発研究グループ

  • Minakawa, E.N., Miyazaki, K., Maruo, K., Yagihara, H., Fujita, H., Wada, K., Nagai, Y.: Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer’s disease model mice. Neurosci. Lett., 653, 362-369 (2017).
  • Tomita, T., Kurita, R., Onishi, Y.: Epigenetic regulation of the circadian clock: role of 5-aza-2′-deoxycytidine. Biosci. Rep., 37(3) (2017).
  • Shimizu, T., Watanabe, K., Anayama, N., Miyazaki, K.: Effect of lipopolysaccharide on circadian clock genes Per2 and Bmal1 in mouse ovary. J. Physioil. Sci. (2017).

DAILAB

  • Yu, Y., Katiyar, S.P., Sundar, D., Kaul, Z., Miyako, E., Zhang, Z., Kaul, S.C., Reddel, R.R., Wadhwa, R.: Withaferin-A kills cancer cells with and without telomerase: Chemical, computational and experimental evidences. Cell Death Dis., e2755 (2017).
  • Kaushik, M.K., Kaul, S.C., Wadhwa, R., Yanagisawa, M., Urade, Y.: Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. PLoS One, 12(2), e0172508 (2017).
  • Singh, P., Guleri, R., Angurala, A., Kaur, K., Kaur, K., Kaul, S.C., Wadhwa, R., Pati, P.K.: Addressing challenges to enhance the bioactives of Withania somnifera through organ, tissue, and cell culture based approaches. Biomed Res. Int., 3278494 (2017).
  • Yun, C-O., Bhargava, P., Na, Y., Lee, J-S., Ryu, J., Kaul, S.C., Wadhwa, R.: Relevance of mortalin to cancer cell stemness and cancer therapy. Dci. Rep., 7, 42016 (2017).
  • Nagpal, N., Goyal, S., Dhanjal, J.K., Ye, L., Kaul, S., Wadhwa, R., Chaturvedi, R., Grover, A.: Molecular dynamics-based identification of novel natural mortalin-p53 abrogators as anticancer agents. J. Recept. Signal Transduct., 37(1), 8-16 (2017).

次世代メディカルデバイス研究グループ

  • Furutani, S., Hagihara, Y., Nagai, H.: On-site identification of meat species in processed foods by a rapid real-time polymerase chain reaction system. Meat Sci., 131, 56-59 (2017).
  • Ando, M., Kamimura, T., Uegaki, K., Biju, V., Damasco Ty, J.T., Shigeri, Y.: Reversible photoluminescence sensing of gaseous alkylamines using CdSe-based quantum dots. Sens. Actuator B-Chem., 246, 1074-1079 (2017).
  • Dong, JH., Shichiri, M., Chung, CI., Shibata, T., Uchida, K., Hagihara, Y., Yoshida, Y., Ueda, H.: An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid. Analyst, 142(5), 787-793 (2017).
  • Homma, T., Akihara, R., Okano, S., Shichiri, M., Yoshida, Y., Yamada, K., Miyata, S., Nakajima, O., Fujii, J.: Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a). Behav. Brain Res., 319, 219-224 (2017).
  • Kitamura, K., Murai, K., Wakida, S., Mitomo, N., Fukushi, K.: A ship navigator’s mental workload using salivary NO3− concentration for simulator-based experiment. Intell. Autom. Soft Comput., 23(1), 161-166 (2017).

重点課題3:

脳遺伝子研究グループ

  • Kuramochi, M., Doi, M.: A computational model based on multi-regional calcium imaging represents the spatio-temporal dynamics in a Caenorhabditis elegans sensory neuron., PLOS ONE, 12(1), e0168415 (2017).
  • Nozumi, M., Nakatsu, F., Katoh, K., Igarashi, M.: Coordinated movement of vesicles and actin bundles during nerve growth revealed by superresolution microscopy. Cell Reports, 18, 2203-2216 (2017).

脳機能調節因子研究グループ

分子複合医薬グループ

  • Ikemoto, M., Murasawa, Y., Wang, PC.: Pentylenetetrazol Modulates Redox System by Inducing Addicsin Translocation from Endoplasmic Reticulum to Plasma Membrane in NG108-15 cells. Biochemistry and Biophysics Reports, 11, 72-78 (2017).
  • Yamamoto, Y., Uno, Y., Sha, E., Ikegami, K., Ishii, N., Dohmae, N., Sekiguchi, H., Sasaki, YC., Yohda, M.: Asymmetry in the function and dynamics of the cytosolic group II chaperonin CCT/TRiC. PLoS One, 12(5), e0176054 (2017).
  • Murakami, K., Zhao, J., Yamasaki, K., Miyagishi, M.: Biochemical and structural features of extracellular vesicle-binding RNA aptamers. Biomedical Reports, 6(6), 615-626 (2017).
  • Zhang, J., Kasim, V., Xie, Y-D., Huang, C., Sisjayawan, J., Ariyanti, A.D., Yan, X-S., Wu, X-Y., Liu, C-P., Yang, L., Miyagishi, M., Wu, S-R.: Inhibition of PHD3 by salidroside promotes neovascularization through cell–cell communications mediated by muscle-secreted angiogenic factors. Sci Rep., 7, 43935 (2017).
  • Ishii, N.: Electron microscopic and physicobiochemical studies of chaperonin GroEL and GroES complexes. Microscopy and imaging science: practical approaches to applied research and education, 7(1), 112-119 (2017).

構造創薬研究グループ

  • Yamashita, S., Takagi, Y., Nagaike, T., Tomita, K.: Crystal structures of U6 snRNA-specific terminal uridylyltransferase. Nat. Commun., 8, 15788 (2017).

細胞分子機能研究グループ

  • Mine, S., Watanabe, M., Kamachi, S., Abe, Y., Ueda, T.: The structure of an archaeal ß-gulucosaminidase provides insight into glycoside hydrolase evolution. J. Biol. Chem., 292, 4996-5006 (2017).

重点課題4:

先進バイオ計測研究グループ

  • Tourlousee DM., Yoshiike, S., Ohashi, A., Matsukura, S., Noda, N., Sekiguchi, Y.: Synthetic spike-in standards for high-throughput 16S rRNA gene amplicon sequencing. Nucleic Acids Res., 45(4), e23 (2017).
  • Zhu, Y., Kawaguchi, K., Kiyama, R.: Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. PLoS One, 12(2), e0171390 (2017).
  • Kiyama, R.: DNA Microarray-based screening and characterization of traditional chinese medicine. Microarrays, 2017(6), 4 (2017).

バイオアナリティカル研究グループ

  • Miyamoto, T., Ota, Y., Yokota, A., Suyama, T., Tsuneda, S., Noda, N.: Characterization of a Deinococcus radiodurans MazF: A UACA-specific RNA endoribonuclease. MicrobiologyOpen, e501 (2017).
  • Hermawan, I., Furuta, A., Higashi, M., Fujita, Y., Akimitsu, N., Yamashita, A., Moriishi, K., Tsuneda, S., Tani, H., Nakakoshi, M., Tsubuki, M., Sekiguchi, Y., Noda, N., Tanaka, J.: Four aromatic sulfates with an inhibitory effect against HCV NS3 helicase from the crinoid alloeocomatella polycladia. Mar. Drugs, 15(4), 117 (2017).

ナノバイオデバイス研究グループ

  • Kurinomaru, T., Kojima, N., Kuria, R.: An alkylating immobilization linker for immunochemical epigenetic assessment. Chem. Commun., 53, 8308-8311 (2017).
  • Kurita, R., Yanagisawa, H., Kamata, T., Kato, D., Niwa, O.: On-chip evaluation of DNA methylation with electrochemical combined bisulfite restriction analysis utilizing a carbon film containing a nanocrystalline structure. Anal. Chem, 89(11), 5976-5982 (2017).
  • Kurinomaru, T., Kurita, R.: Bisulfite-free approaches for DNA methylation profiling. Anal. Methods, 10 (2017).

セルメカニクス研究グループ

  • Iwase, K., Tanaka, M., Hirose, K., Uyeda TQP, Honda, H.: Acceleration of the sliding movement of actin filaments with the use of a non-motile mutant myosin in in vitro motility assays driven by skeletal muscle heavy meromyosin. PLoS One, 12(7), e0181171 (2017).
  • Kim, H., Yamagishi, A., Imaizumi, M., Onomura, Y., Nagasaki, A., Miyagi, Y., Okada, T., Nakamura, C.: Quantitative measurements of intercellular adhesion between a macrophage and cancer cells using a cup-attached AFM chip. Colloid Surf. B-Biointerfaces, 155, 366-372 (2017).
  • Girault, M., Kim, H., Arakawa, H., Matsuura, K., Odaka, M., Hattori, A., Terazono, H., Yasuda, K.: An on-chip imaging droplet-sorting system: a real-time shape recognition method to screen target cells in droplets with single cell resolution. Sci Rep, 7, 40072 (2017).

細胞マイクロシステム研究グループ

  • Nishitani, Y., Hosokawa, C., Mizuno-Matsumoto, Y., Miyoshi, T., Tamura, S.: Classification of spike wave propagations in a cultured neuronal network: Investigating a brain communication mechanism. Neuroscience, 4(1), 1-13 (2017).
  • Nerome, K., Matsuda, S., Maegawa, K., Sugita, S., Kuroda, K., Kawasaki, K., Nerome, R.: Quantitative analysis of the yield of avian H7 influenza virus haemagglutinin protein produced in silkworm pupae with the use of the codon-optimized DNA: A possible oral vaccine. Vaccine, 35(5), 738-746 (2017).

細胞・生体医工学研究グループ

  • Soeta, Y., Shimokura, R.: Sound quality evaluation of air-conditioner noise based on factors of the autocorrelation function. Appl. Acoust., 124, 11-19 (2017).