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  4. 誌上発表(国際誌・査読有)2016年

研究成果

誌上発表(国際誌・査読有)2016年

重点課題1:

分子細胞育種研究グループ

  • Imamura, H., Honda, S.: Surface plasmon resonance biosensing of the monomer and the linked dimer of the variants of protein G under mass transport limitation. Data Brief, 9, 917-921 (2016).
  • Sugiyama, Y., Yamashita, S., Uezato, Y., Senga, Y., Katayama, S., Goshima, N., Shigeri, Y., Sueyoshi, N., Kameshita, I.: Phosphorylated TandeMBP: A unique protein substrate for protein phosphatase assay. Anal. Biochem., 513, 47-53 (2016).
  • Morita, T., Uehara, N., Kuwahata, K., Imamura, H., Shimada, T., Ookubo, K., Fujita, M., Sumi, T.: Interaction potential between biological sensing nanoparticles determined by combining small-angle X-ray scattering and model-potential-free liquid theory. J. Phys. Chem. C, 120(44), 25564-25571 (2016).
  • Kaishima, M., Ishii, J., Matsuno, T., Fukuda, N., Kondo, A.: Expression of varied GFPs in Saccharomyces cerevisiae: codon optimization yields stronger than expected expression and fluorescence intensity. Sci. Rep., 6, 35932 (2016).
  • Watanabe, H., Yageta, S., Imamura, H., Honda, S.: Biosensing probe for quality control monitoring of the structural integrity of therapeutic antibodies. Anal. Chem., 88(20), 10095-10101 (2016).
  • Watanabe, M., Fukada, H., Ishikawa, K.: Construction of thermophilic xylanase and its structural analysis. Biochemistry, 55(31), 4399-4409 (2016).
  • Imamura, H., Honda, S.: Kinetics of antibody aggregation at neutral pH and ambient temperatures triggered by temporal exposure to acid. J. Phys. Chem. B, 120(36), 9581-9589 (2016).
  • Fukuda, N., Kaishima, M., Ishii, J., Kondo, A., Honda, S.: Continuous crossbreeding of sake yeasts using growth selection systems for a-type and α-type cells. AMB Expr., 6,45 (2016).
  • Takeda, E., Kunimoto, K., Kawai, Y., Kataoka, M., Ishikawa, K., Nakamura, T.: Role of F225 in O-Phosphoserine sulfhydrylase from Aeropyrum pernix K1. Extremophiles, 20(5), 733-745 (2016).
  • Shibakami, M., Tsubouchi, G., Sohma, M., Hayashi, M.: Synthesis of nanofiber-formable carboxymethylated Euglena-derived β-1,3-glucan. Carbohydr. Polym. 152(18), 468-478 (2016).
  • Senga, Y., Akizuki, K., Katayama, S., Shigeri, Y., Kameshita, I., Ishida, A., Sueyoshi, N.: High-performance CaMKI: A highly active and stable form of CaMKIδ produced by high-level soluble expression in Escherichia coli. Biochem. Biophys. Res. Commun., 475(3), 277-282 (2016).
  • Odahara, T., Odahara, K.: Data in support of intermolecular interactions at early stage of protein/detergent particle association induced by salt/polyethylene glycol mixtures. Data in Brief, 7, 1283-1287 (2016).
  • Odahara, T., Odahara, K.: Intermolecular interactions at early stage of protein/detergent particle association induced by salt/polyethylene glycol mixtures. Protein Expr. Purif., 120, 72-86 (2016).
  • Katayama, S., Senga, Y., Oi, A., Miki, Y., Sugiyama, Y., Sueyoshi, N., Kameshita, I.: Expression analyses of splice variants of zebrafish cyclin-dependent kinase-like 5 and its substrate, amphiphysin 1. Gene, 583(1), 15-23 (2016).

蛋白質デザイン研究グループ

  • Muraki, M.: Preparation of a functional fluorescent human Fas ligand extracellular domain derivative using a three-dimensional structure guided site-specific fluorochrome conjugation. SpringerPlus, 5(1), 997 (2016).
  • Kado, Y., Mizohata, E., Nagatoishi, S., Iijima, M., Shinoda, K., Miyafusa, T., Nakayama, T., Yoshizumi, T., Sugiyama, A., Kawamura, T., Lee, Y-H., Matsumura, H., Doi, H., Fujitani, H., Kodama, T., Shibasaki, Y., Tsumoto, K., Inoue, T.: Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5 STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES. J. Biol. Chem., 291(5), 2319-2330 (2016).

構造生理研究グループ

  • Yamazawa, T., Nakamura, N., Sato, M., Sato, C.: Secretory glands and microvascular systems imaged in aqueous solution by atmospheric scanning electron microscopy (ASEM). Microsc. Res. Tech., 79(12), 1179-1187 (2016).
  • Yamazawa, T., Nakamura, N., Mikami, Y., Sekiya, H., Sato, M., Sato, C.: Exocrine organs imaged in aqueous solution by Atmospheric Scanning Electron Microscopy (ASEM) . Microscopy, 65(1), i17 (2016).
  • Sugimoto, S., Okuda, K., Miyakawa, R., Sato, M., Chiba, A., Muzunoe, Y., Sato, C.: OB-IV-2 Imaging of bacterial biofilms in solution by atmospheric scanning electron microscopy. Microscopy, 65(Sup1), i17 (2016).
  • Sato, C., Memitily, N., Sato, M., Yamazawa, T., Sugimoto, S.: OM-III-3 Development of atmospheric scanning electron microscope (ASEM) and its applications. Microscopy, 65(Suppl_1), i19 (2016).
  • Tokuda, K., Watanabe, C., Okiyama, Y., Mochizuki, Y., Fukuzawa, K., Komeiji, Y.: Hydration of ligands of influenza virus neuraminidase studied by the fragment molecular orbital method. J. Mol. Graph., 69, 144-153 (2016).
  • Okada, T., Ogura, T.: Nanoscale imaging of untreated mammalian cells in a medium with low radiation damage using scanning electron-assisted dielectric microscopy. Sci. Rep., 6(29169), 1-8 (2016).
  • Sugimoto, S., Okuda, K., Miyakawa, R., Sato, M., Arita-Morioka, K., Chiba, A., Yamanaka, K., Ogura, T., Mizunoe, Y., Sato, C.: Imaging of bacterial multicellular behaviour in biofilms in liquid by atmospheric scanning electron microscopy. Sci. Rep., 6(25889), 1-13 (2016).
  • Zhao, C., Ichimura, A., Qian, N., Iida, T., Yamazaki, D., Noma, N., Asagiri, M., Yamamoto, K., Komazaki, S., Sato, C., Aoyama, F., Sawaguchi, A., Kakizaki, S., Nishi, M., Takeshima, H.: Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization. Sci. Signal., 9(428), 49 (2016).
  • Ogura, T., Nishiyama, H., Suga, M., Sato, C.: Development of an in-solution observation method using atmospheric scanning electron microscopy (ASEM). Synthesiology, 8(3), 116-126 (2016).
  • Kato, M., Hanyu, Y.: Fusion of Zif268 to the C-terminus of scFvs promotes expression of the active form in the cytoplasm of Escherichia coli. Biochemistry and Molecular Biology Journal, 2(1), 1-7 (2016).
  • Itoh, K., Akimoto, Y., Fuwa, T.J., Sato, C., Komatsu, A., Nishihara, S.: Mucin-type core 1 glycans regulate the localization of neuromuscular junctions and establishment of muscle cell architecture in Drosophila. Dev. Biol., 412(1), 114-127 (2016).

先端ゲノムデザイン研究グループ

  • Wu, C.: Biotinylation of deoxyguanosine at the abasic site in double-stranded oligodeoxynucleotides. J. Anal. Methods Chem., 2016 (2016).
  • Kawata, Y., Nishimura, T., Matsushita, I., Tsubota, J.: Efficient production and secretion of pyruvate from Halomonas sp. KM-1 under aerobic conditions. AMB Express, 6(1), 1-8 (2016).

生体分子創製研究グループ

  • Nakamura, T., Yonezawa, Y., Tsuchiya, Y., Niiyama, M., Ida, K., Oshima, M., Morita, J., Uegaki, K.: Substrate recognition of N,N′-diacetylchitobiose deacetylase from Pyrococcus horikoshii. J. Struct. Biol., 195(3), 286-293 (2016).

分子細胞病態研究特別チーム

  • Castren, E., Kojima, M.: Brain-derived neurotrophic factor in mood disorders and antidepressant treatments. Neurobiol. Dis., 71, 193-198 (2016).
  • Mizui, T., Ishikawa, Y., Kumanogoh, H., Kojima, M.: Neurobiological actions by three distinct subtypes of brain-derived neurotrophic factor: Multi-ligand model of growth factor signaling. Pharmacol. Res., 105, 93-98 (2016).

重点課題2:

生物時計研究グループ

  • Kamiya, T., Watanabe, Y., Makino, S., Kano, H., Tsuji, N.M.: Improvement of intestinal immune cell function by Lactic Acid Bacteria for dairy products. Microorganisms, 5(1) (2016).
  • Adachi, T., Kakuta, S., Aihara, Y., Kamiya, T., Watanabe, Y., Osakabe, N., Hazato, N., Miyawaki, A., Yoshikawa, S., Usamim T., Karasuyama, H., Kimoto-Nira, H., Hirayama, K., Tsuji, N.M.: Visualization of probiotic-mediated Ca2+ signaling in intestinal epithelial cells in vivo. Front. Immunol., 7, 601 (2016).
  • Ohkura, N., Oishi, K., Kihara-Negishi, F., Atsumi, G., Tatefuji, T.: Effects of a diet containing Brazilian propolis on lipopolysaccharide-induced increases in plasma plasminogen activator inhibitor 1 (PAI-1) levels in mice. J. Intercult. Ethnopharmacol., 5(4), 439-443 (2016).
  • Nakao, R., Shimba, S., Oishi, K.: Muscle Bmal1 is dispensable for the progress of neurogenic muscle atrophy in mice. J. Circadian Rhythms, 14(1), 6 (2016).
  • Ohno, A., Ochi, A., Maita, N., Ueji, T., Bando, A., Nakao, R., Hirasaka, K., Abe, T., Teshima-Kondo, S., Nemoto, H., Okumura, Y., Higashibata, A., Yano, S., Tochio, H., Nikawa, T.: Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin. Arch. Biochem. Biophys., 594, 1-7 (2016).
  • Yasumoto, Y., Hashimoto, C., Nakao, R., Yamazaki, H., Hiroyama, H., Nemoto, T., Yamamoto, S., Sakurai, M., Oike, H., Wada, N., Yoshida-Noro, C., Oishi, K.: Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice. Metab.-Clin. Exp., 65(5), 714-727 (2016).
  • Oishi, K., Higo-Yamamoto, S., Yasumoto, Y.: Moderately high-dose of the artificial sweetener saccharin potentially induces sleep disorders in mice. Nutrition, 32(10), 1159-1161 (2016).
  • Akimoto, S., Egi, Y., Nakamura, Y., Suetsugu, Y., Oishi, K., Sakamoto, K.: Genome-wide microarray screening for Bombyx mori genes related to transmitting the determination outcome of whether to produce diapause or non-diapause eggs. Insect Sci. (2016).

健康維持機能物質開発研究グループ

  • Ogawa, Y., Tanaka, M.: A fluorescent cholesterol analogue for observation of free cholesterol in the plasma membrane of live-cells. Anal, Biochem., 492, 49-55 (2016).

DAILAB

  • Kaul, S., Ishida, Y., Tamura, K., Wada, T., Iitsuka, T., Garg, S., Kim, M., Gao, R., Nakai, S., Okamoto, Y., Terao, K., Wadhwa, R.: Novel methods to generate active ingredients-enriched ashwagandha leaves and extracts. PLoS One, 11(12), e0166945 (2016).
  • Wadhwa, R., Nigam, N., Bhargava, P., Dhanjal, K.K., Goyal, S., Grover, A., Sundar, D., Ishida, Y., Terao, K., Kaul, S.C.: Molecular characterization and enhancement of anticancer activity of caffeic acid phenethyl ester by γ cyclodextrin. J. Cancer, 7(13), 1755-1771 (2016).
  • Yu, Y., Gao, R., Kaul, Z., Li, L., Kato, Y., Zhang, Z., Groden, J., Kaul, S.C., Wadhwa, R.: Loss-of-function screening to identify miRNAs involved in senescence: tumor suppressor activity of miRNA-335 and its new target CARF. 6, 30185 (2016).
  • Wadhwa, R., Priyandoko, D., Gao, R., Widodo, N., Nigam, N., Li, L., Ahn, H.M., Yun, C.O., Ando, N., Mahe, C., Kaul, S.C.: Stress chaperone mortalin regulates human melanogenesis. Cell Stress Chaperones, 21(4), 631-644 (2016).
  • Na, Y., Kaul, S.C., Ryu, J., Lee, J.S., Ahn, H.M., Kaul, Z., Kalra, R.S., Li, L., Widodo, N., Yun, C.O., Wadhwa, R.: Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis. Cancer Res., 76(9), 2754-2765 (2016).
  • Wadhwa, R., Konar, A., Kaul, S.C.: Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts. Neurochem. Int., 95, 109-118 (2016).
  • Li, K., Yu, Y., Sun, S., Liu, Y., Garg, S., Kaul, S.C., Lei, Z., Gao, R., Wadhwa, R.: Functional characterization of anticancer activity in the aqueous extract of helicteres angustifolia L. roots. PLoS One, 11(3), e0152017 (2016).
  • Gautam, A., Kaul, S.C., Thakur, M.K.: Alcoholic extract of ashwagandha leaves protects against amnesia by regulation of arc function. Mol. Neurobiol., 53(3), 1760-1769 (2016).
  • Sugaya, H., Mishima, H., Gao, R., Kaul, S.C., Wadhwa, R., Aoto, K., Li, M., Yoshioka, T., Ogawa, T., Ochiai, N., Yamazaki, M.: Fate of bone marrow mesenchymal stem cells following autologous transplantation in a rabbit model of osteonecrosis. Cytotherapy, 18(2), 198-204 (2016).

次世代メディカルデバイス研究グループ

  • Ando, M., Kamimura, T., Uegaki, K., Biju, V., Shigeri, Y.: Sensing of ozone based on its quenching effect on the photoluminescence of CdSe-based core-shell quantum dots. Microchim. Acta, 183, 3019-3024 (2016).
  • Kume, A., Anh, DTM., Shichiri, M., Ishida, N., Suzuki, H.: Probucol dramatically enhances dihydroartemisinin effect in murine malaria. Malar. J., 15, 472 (2016).
  • Otsuki, N., Homma, T., Fujiwara, H., Kaneko, K., Hozumi, Y., Shichiri, M., Takashima, M., Ito, J., Konno, T., Kurahashi, T., Yoshida, Y., Goto, K., Fujii, S., Fujii, J.: Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase. Regul. Toxicol. Pharmacol., 79, 83-90 (2016).
  • Saito, Y., Akazawa-Ogawa, Y., Matsumura, A., Saigoh, K., Itoh, S., Sutou, K., Kobayashi, M., Mita, Y., Shichiri, M., Hisahara, S., Hara, Y., Fujimura, H., Takamatsu, H., Hagihara, Y., Yoshida, Y., Hamakubo, T., Kusunoki, S., Shimohama, S., Noguchi, N.: Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients. Sci Rep., 6, 30793 (2016).
  • Noda, S., So, M., Adachi, M., Kardos, J., Akazawa-Ogawa, Y., Hagihara, Y., Goto, Y.: Thioflavin T-silent denaturation intermediates support the main-chain-dominated architecture of amyloid fibrils. Biochemistry, 55(28), 3937-3948 (2016).
  • Furutani, S., Naruishi, N., Hagihara, Y., Nagai, H.: Development of an on-site rapid real-time polymerase chain reaction system and the characterization of suitable DNA polymerases for TaqMan probe technology. Anal. Bioanal. Chem., 408(20), 5641-5649 (2016).
  • Kitamura, K., Murai, K., Wakida, S., Mitomo, N., Fukushi, K.: A ship navigator’s mental workload using salivary NO3− concentration for simulator-based experiment. Intell. Autom. Soft Comput. (2016).
  • Minami, T., Sasaki, Y., Minamiki, T., Wakida, S., Kurita, R., Niwa, O., Tokito, S.: Selective nitrate detection by an enzymatic sensor based on an extended-gate type organic field-effect transistor. Biosens. Bioelectron., 81, 87-91 (2016).
  • Ando, M., Horie, M., Akazawa-Ogawa, Y., Hagihara, Y., Murase, N., Shigeri, Y.: Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells. Biosci. Biotechnol. Biochem., 80(1), 210-213 (2016).
  • Furutani, S., Kajiya, M., Aramaki, N., Kubo, I.: Rapid detection of salmonella enterica in food using a compact disc-shaped device. Micromachines, 7(1) 2016.
  • Akazawa-Ogawa, Y., Uegaki, K., Hagihara, Y.: The role of intra-domain disulfide bonds in heat-induced irreversible denaturation of camelid single domain VHH antibodies. J. Biochem., 159(1), 111-121 (2016).
  • Kume, A., Herbas, M.S., Shichiri, M., Ishida, N., Suzuki, H.: Effect of anti-hyperlipidemia drugs on the alpha-tocopherol concentration and their potential for murine malaria infection. Parasitol. Res., 115(1), 69-75 (2016).
  • Yamazoe, H., Nakanishi, H., Kashiwagi, Y., Nakamoto, M., Tachibana, A., Hagihara, Y., Tanabe, T.: Changes in cell adhesiveness and physicochemical properties of crosslinked albumin films after ultraviolet irradiation. Langmuir, 32(1), 203-210 (2016).
  • Yamazoe, H., Ichikawa, T., Hagihara, Y., Iwasaki, Y.: Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells. Acta Biomater., 31, 231-240 (2016).
  • Yamazoe, H., Hagihara, Y., Kobayashi, H.: Multi-component co-culture system of cancer cells and two types of stromal cells for in vitro evaluation of anticancer drugs. Tissue Eng., 22(1), 20-29 (2016).

重点課題3:

脳遺伝子研究グループ

  • Ohzono, T., Katoh, K., Fukuda, J.: Fluorescence microscopy reveals molecular localisation at line defects in nematic liquid crystals. Sci. Rep., 6, 36477 (2016).
  • Chechetka, S., Doi, M., Pichon, B.P., Begin-Colin, S., Mayako, E.: Photothermal and mechanical stimulation of cells via dualfunctional nanohybrids. Nanotechnology, 27(47), 475102-475112 (2016).
  • Hashimoto, M., Doi, M., Kurebayashi, N., Furukawa, K., Hirawake-Mogi, H., Ohmiya, Y., Sakurai, T., Mita, T., Mikoshiba, K., Nara, T.: Inositol 1,4,5-trisphosphate receptor determines intracellular Ca2+ concentration in Trypanosoma cruzi throughout its life cycle. FEBS Open Bio, 6(12), 1178-1185 (2016).
  • Ochiishi, T., Doi, M., Yamasaki, K., Hirose, K., Kitamura, A., Urabe, T., Hattori, N., Kinjo, M., Ebihara, T., Shimura, H.: Development of new fusion proteins for visualizing amyloid-β oligomers in vivo. Sci Rep., 6, 22712 (2016).
  • Ochiishi, T., Itakura, A., Liu, L., Akatsu, H., Kohno, H., Nishimura, M., Yoshimune, K.: Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-β aggregates. Genes Cells, 21(2), 200-211 (2016).

脳機能調節因子研究グループ

  • Noguchi, H., Kimura, A., Murao, N., Namihira, M., Nakashima, K.: Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood. Neurogenesis, 3(1), e1232679 (2016).
  • Hirano, K., Namihira, M.: LSD1 mediates neuronal differentiation of human fetal neural stem cells by controlling the expression of a novel target gene, HEYL. Stem Cells, 34(7), 1872-1882 (2016).
  • Noguchi, H., Murao, N., Kimura, A., Matsuda, T., Namihira, M., Nakashima, K., DNA methyltransferase 1 is indispensable for development of the hippocampal dentate gyrus. J. Neurosci., 36(22), 6050-6068 (2016).
  • Yamauchi, Y., Kimoto, H., Yang, X., Filkin, S., Utkin, Y., Kubo, T., Inagaki, H.: Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε). Biosci. Biotechnol. Biochem., 80(1), 158-161 (2016).

分子複合医薬グループ

  • Takahashi, J., Misawa, M., Iwahashi, H.: Combined treatment with X-ray irradiation and 5-aminolevulinic acid elicits better transcriptomic response of cell cycle-related factors than X-ray irradiation alone. Int. J. Radiat. Biol., 92(12), 774-789 (2016).
  • Miura, S., Takahashi, J., Iwahashi, H.: Evaluation of the physiology of miniature pig fed Shochu distillery waste using mRNA expression profiling. J. Mater. Cycles Waste Manag., 1-8 (2016).
  • Kitaoku, Y., Fukamizo, T., Numata, T., Ohnuma, T.: Chitin oligosaccharide binding to the lysin motif of a novel type of chitinase from the multicellular green alga, Volvox carteri. Plant Mol.Biol., 93(1), 97-108 (2016).
  • Shinya, S., Nishimura, S., Kitaoku, Y., Numata, T., Kimoto, H., Kusaoka, H., Ohnuma, T., Fukamizo, T.: Mechanism of chitosan recognition by CBM32 carbohydrate-binding modules from a Paenibacillus sp. IK-5 chitosanase/glucanase. Biochem. J., 473(8), 1085-1095 (2016).

構造創薬研究グループ

  • Akatsu, C., Shinagawa, K., Numoto, N., Liu, Z., Ucar, A.K., Aslam, M., Phoon, S., Adachi, T., Furukawa, K., Ito, N., Tsubata, T.: CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP. J. Exp. Med., 213(12), 2691-2706 (2016).
  • Kang, J., Yamasaki, K., Sano, K., Tsutsui, K., Tsutsui, K.M., Tateno, M.: Simulated annealing-extended sampling for multicomponent decomposition of spectral data of DNA complexed with peptide. J. Phys. Soc. Jpn. 86, 014802 (2016).
  • Furuta, T., Miyake, S., Ishitobi, H., Ogura, T., Kato, Y., Kamei, N., Miyado, K., Higashi, Y., Ochi, M.: Mesenchymal stem cell-derived exosomes promote fracture healing in a mouse model. Stem Cells Transl. Med. 5(12), 1620-1630 (2016).
  • Yamasaki, K., Tani, O., Tateishi, Y., Tanabe, E., Namatame, I., Niimi, T., Furukawa, K., Sakashita, H.: An NMR biochemical assay for fragment-based drug discovery: evaluation of an inhibitor activity on spermidine synthase of Trypanosoma cruzi. J. Med. Chem., 59(5), 2261-2266 (2016).

細胞分子機能研究グループ

  • Sato, T., Kawasaki, T., Mine, S., Matsumura, H.: Functional role of the C-terminal amphipathic helix 8 of olfactory receptors and other G protein-coupled receptors. Int. J. Mol. Sci., 17(11), 1930 (2016).
  • Uechi, K., Kamachi, S., Akita, H., Mine, S., Watanabe, M.: Crystal structure of an acetyl esterase complexed with acetate ion provides insight into the catalytic mechanism. Biochem. Biophys. Res. Commun., 477(3), 383-387 (2016).
  • Miyahara, D., Oishi, I., Makino, R., Kurumisawa, N., Nakaya, R., Ono, T., Kagami, H., Tagami, T.: Chicken stem cell factor enhances primordial germ cell proliferation cooperatively with fibroblast growth factor 2. J. Reprod. Dev., 2015, 128 (2016).
  • Oishi, I., Yoshii, K., Miyahara, D., Kagami, H., Tagami, T.: Targeted mutagenesis in chicken using CRISPR/Cas9 system. Sci Rep, 23980 (2016).
  • Sato, T., Kajiawara, R., Takashima, I., Iijma, T.: A novel method for quantifying similarities between oscillatory neural responses in wavelet time-frequency power profiles. Brain Res., 1636, 107-117 (2016).
  • Sato, T., Kobayakawa, R., Kobayakawa, K., Emura, M., Itohara, S., Kawasaki, T., Tsuboi, A., Matsumura, H.: Supersensitive odor discrimination is controlled in part by initial transient interactions between the most-sensitive dorsal olfactory receptors and G-proteins. Receptor Clin. Invest., 3, e1117(2016).
  • Matsukawa, M., Imada, M., Aizawa, S., Sato, T.: Habitat odor can alleviate innate stress responses in mice. Brain Res., 1631, 46-52 (2016).

重点課題4:

先進バイオ計測研究グループ

  • Thandar, SM., Ushiki, N., Fujitani, H., Sekiguchi, Y., Tsuneda, S.: Ecophysiology and comparative genomics of nitrosomonas mobilis Ms1 isolated from autotrophic nitrifying granules of wastewater treatment bioreactor. Front. Microbiol., 7, 1869 (2016).
  • Yasuhara, N., Kumar, PK.: Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport. J. Biochem., 160(5), 259-268 (2016).
  • Kumar, PK.: Monitoring intact viruses using aptamers. Biosensors, 6(3), 40 (2016).
  • Kiyama, R.: Biological effects induced by estrogenic activity of lignans. Trends Food Sci. Technol., 54, 186-196 (2016).
  • Zhang, Y., Dong, S., Wang, H., Tao, S., Kiyama, R.: Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors. Environ. Pollut., 213, 809-824 (2016).
  • Noguchi, M., Kurisu, F., Sekiguchi, Y., Kasuga, I., Furumai, H.: Microbial community structure of methanogenic benzene-degrading cultures enriched from five different sediments. J. Gen. Appl. Microbiol. (2016).
  • Sun, L., Toyonaga, M., Ohashi, A., Matsuura, N., Tourlousse, D.M., Meng, X.Y., Tamaki, H., Hanada, S., Cruz, R., Yamaguchi, T., Sekiguchi, Y.: Isolation and characterization of Flexilinea flocculare gen. nov., sp. nov., a filamentous anaerobic bacterium belonging to the class Anaerolineae in the phylum Chloroflexi. Int. J. Syst. Evol. Microbiol. (2016).
  • Yeoh, Y.K., Sekiguchi, Y., Parks, D.H., Hugenholtz, P.: Comparative genomics of candidate phylum TM6 suggests that parasitism is widespread and ancestral in this lineage. Mol. Biol. Evol. (2016).
  • Matsuura, N., Ohashi, A., Toulousse, D.M., Sekiguchi, Y.: Draft genome sequence of thermodesulfovibrio aggregans TGE-P1T, an obligately anaerobic, thermophilic, sulfate-reducing bacterium in the phylum nitrospirae. Genome Announc., 4(2), e00089-16 (2016).
  • Matsuura, N., Ohashi, A., Toulousse, D.M., Sekiguchi, Y.: Draft genome sequence of the syntrophic lactate-degrading bacterium tepidanaerobacter syntrophicus JLT. Genome Announc., 4(1), e01712-15 (2016).
  • Nakata, T., Okimura, C., Mizuno, T., Iwadate, Y.: The role of stress fibers in the shape determination mechanism of fish keratocytes. Biophys. J., 110(2), 481-492 (2016).

バイオアナリティカル研究グループ

  • Miyamoto, T., Yokota, A., Tsuneda, S., Noda, N.: AAU-specific RNA cleavage mediated by MazF toxin endoribonuclease conserved in Nitrosomonas europaea. Toxins, 8(6), 174 (2016).
  • Morikawa, T.J., Fujita, H., Kitamura, A., Horio, T., Yamamoto, J., Kinjo, M., Sasaki, A., Machiyama, H., Yoshizawa, K., Ichimura, T., Imada, K., Nagai, T., Watanabe, T.M.: Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it. Sci Rep, 6, 22342 (2016).
  • Goto, K., Kimura, T., Kitamura, N., Semba, S., Ohmiya, Y., Aburatani, S., Matsukura, S., Tsuda, M., Kurokawa, T., Gong, J.P., Tnaka, S., Yasuda, K.: Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 Cells, which plays a significant role in the gel-induced chondrogenic differentiation. J. Biomed. Mater. Res. Part A, 104(3), 734-746 (2016).
  • Miyamoto, T., Kato, Y., Sekiguchi, Y., Tsuneda, S., Noda, N.: Characterization of mazF-mediated sequence-specific RNA cleavage in pseudomonas putida using massive parallel sequencing. PLoS One, 11(2), e0149494 (2016).

ナノバイオデバイス研究グループ

  • Furuhata, Y., Kikuchi, Y., Tomita, S., Yoshimoto, K.: Small spheroids of adipose-derived stem cells with time-dependent enhancement of IL-8 and VEGF-A secretion. Genes Cells, 21(12), 1380-1386 (2016).
  • Minamiki, T., Minami, T., Sasaki, Y., Wakida, S., Kurita, R., Niwa, O., Tokito, S.: Label-free detection of human glycoprotein (CgA) using an extended-gated organic transistor-based immunosensor. Sensors, 16(2033), 1-7 (2016).
  • Kawada, K., Kurinomaru, T., Tomita, S., Shiraki, K.: Noncovalent PEGylation-based enzyme switch in physiological saline conditions using quaternized polyamines. Colloid Polym. Sci., 294(10), 1551-1556 (2016).
  • Tomita, S., Niwa, O., Kurita, R.: Artificial modification of an enzyme for construction of cross-reactive polyion complexes to fingerprint signatures of proteins and mammalian cells. Anal. Chem., 88(18), 9079-9086 (2016).
  • Kurita, R., Niwa, O.: Microfluidic platforms for DNA methylation analysis. Lab Chip, 16, 3631-3644 (2016).
  • Shiba, S., Yoshioka, K., Kato, D., Ishihara, S., Anzai, H., Saito, N., Niwa, O.: Electrochemical microfluidic devices for evaluation of drug metabolism. J. Electroanal. Chem. (2016).
  • Shiba, S., Kato, D., Kamata, T., Niwa, O.: Co-sputter deposited nickel-copper bimetallic nanoalloy embedded carbon films for electrocatalytic biomarker detection. Nanoscale, 8(26), 12887-12891 (2016).
  • Oda, A., Kato, D., Yoshioka, K., Tanaka, M., Kamata, T., Todokoro, M., Niwa, O.: Fluorinated nanocarbon film electrode capable of signal amplification for lipopolysaccharide detection. Electrochim. Acta, 197, 152-158 (2016).
  • Kato, D., Kamata, T., Kato, D., Yanagisawa, H., Niwa, O.: Au nanoparticle-embedded carbon films for electrochemical As3+ detection with high sensitivity and stability. Anal. Chem., 88(5), 2944-2951 (2016).
  • Kuraya, E., Nagatomo, S., Sakata, K., Kato, D., Niwa, O., Nishimi, T., Kunitake, M.: Direct analysis of lipophilic antioxidants of olive oils using bicontinuous microemulsions. Anal. Chem., 88(2), 1202-1209 (2016).
  • Shiraki, K., Tomita, S., Inoue, N.: Small amine molecules: Solvent design toward facile improvement of protein stability against aggregation and inactivation. Curr. Pharm. Biotechnol., 17(2), 116-126 (2016).
  • Tomita, S., Yokoyama, S., Kurita, R., Niwa, O., Yoshimoto, K.: The use of an enzyme-based sensor array to fingerprint proteomic signatures of sera from different mammalian species. Anal. Sci., 32(2), 237-240 (2016).
  • Minami, T., Sasaki, Y., Minamiki, T., Wakida, S., Kurita, R., Niwa, O., Tokito, S.: Selective nitrate detection by an enzymatic sensor based on an extended-gate type organic field-effect transistor. Biosens. Bioelectron., 81, 87-91 (2016).
  • Shiraki, K., Kurinomaru, T., Tomita, S.: Wrap-and-strip technology of protein-polyelectrolyte complex for biomedical application. Curr. Med. Chem., 23(3), 276-289 (2016).

セルメカニクス研究グループ

  • Shibata, K., Nagasaki, A., Adachi, H., Uyeda, T.Q.P.: Actin binding domain of filamin distinguishes posterior from anterior actin filaments in migrating Dictyostelium cells. Biophysics and Physicobiology. 13, 321-331 (2016).
  • Nishio, M., Matsumoto, D., Kato, Y., Abe, K., Lee, J., Tsukakoshi, K., Yamagishi, A., Nakamura, C., Ikebukuro, K.: DNA aptamers against FokI nuclease domain for genome editing applications. Biosens. Bioelectron. (2016).
  • Kawamura, R., Shimizu, K., Matsumoto, Y., Yamagishi, A., Shilberberg, Y.R., Iijima, M., Kuroda, S., Fukazawa, K., Ishihara, K., Nakamura, C.: High efficiency penetration of antibody-immobilized nanoneedle thorough plasma membrane for in situ detection of cytoskeletal proteins in living cells. J. Nanobiotechnol., 14(4), 74 (2016).
  • Kien, X.N., Umeki, N., Kijima, S.T., Kodera, N., Ueno, H., Furutani-Umezu, N., Nakajima, J., Noguchi, T.Q.P., Nagasaki, A., Tokuraku, K., Uyeda, T.Q.: Allosteric regulation by cooperative conformational changes of actin laments drives mutually exclusive binding with co lin and myosin. Sci Rep (2016).
  • Han, S., Shin, H., Ryu, S., Nakamura, C.: Evaluation of DNA transcription of living cell during nanoneedle insertion. J. Nanosci. Nanotechnol., 16(8), 8674-8677 (2016).
  • Matsumoto, D., Yamagishi, A., Saito, M., Sathuluri, R.R., Silberberg, Y.R., Iwata, F., Kobayashi, T., Nakamura, C.: Mechanoporation of living cells for delivery of macromolecules using nanoneedle array. J. Biosci. Bioeng., 122(6), 748-752 (2016).
  • Matsumoto, D., Nishio, M., Kato, Y., Yoshida, W., Abe, K., Fukazawa, K., Ishihara, K., Iwata, F., Ikebukuro, K., Nakamura, C.: ATP-mediated release of a DNA-binding protein from a silicon nanoneedle array. Electrochemistry, 84(5), 305-307 (2016).
  • Umeki, N., Hirose, K., Uyeda, T.Q.P.: Cofilin-induced cooperative conformational changes of actin subunits revealed using cofilin-actin fusion protein. Sci Rep., 6, 20406 (2016).
  • Kijima, S., Hirose, K., Kong, S-G., Wada, M., Uyeda, T.Q.P.: Distinct biochemical properties of arabidopsis thaliana actin isoforms. Plant Cell Physiol., 57(1), 45-56 (2016).

細胞マイクロシステム研究グループ

  • Fujita, S., Onuki-Nagasaki, R., Ikuta, K., Hara, Y.: A simple method for producing multiple copies of controlled release small molecule microarrays for cell-based screening. Biofabrication (2016).
  • Asai, D., Murata, M., Toita, R., Kawano, T., Nakashima, H., Kang, J-H.: Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2). Amino Acids, 1-6 (2016).
  • Toita, R., Kawano, T., Murata, M., Kang, J-H.: Anti-obesity and anti-inflammatory effects of macrophage-targeted interleukin-10-conjugated liposome in obese mice. 110(3), 81-88 (2016).
  • Sunarso, Toita, R., Tsuru, K., Ishikawa, K.: Immobilization of calcium and phosphate ions improves the osteoconductivity of titanium implants. Mater. Sci. Eng. C-Mater. Biol. Appl., 68, 291-298 (2016).
  • Tamura, S., Nishitani, Y., Hosokawa, C.: Feasibility of multiplex communication in a 2D mesh asynchronous neural network with fluctuations. AIMS Neuroscience, 3(4), 385-397 (2016).
  • Suenaga, S., Nikaido, N., Totani, K., Kawasaki, K., Ito, Y., Yamashita, K., Osada, M.: Effect of purification method of β-chitin from squid pen on the properties of β-chitin nanofibers. Int. J. Biol. Macromol., 91, 987-993 (2016).
  • Sunarso, Toita, R., Tsuru, K., Ishikawa, K.: A superhydrophilic titanium implant functionalized by ozone gas modulates bone marrow cell and macrophage responses. J. Mater. Sci., 27(8), 127-135 (2016).
  • Miyauchi, K., Tawa, K., Suguru, K., Taguchi, T., Hosokawa, C.: Surface plasmon-enhanced optical trapping of quantum-dot-conjugated surface molecules on neurons cultured on a plasmonic chip. Jpn. J. Appl. Phys., 55, 06GN04 (2016).
  • Tamura, S., Nishitani, Y., Hosokawa, C., Miyoshi, T., Sawai, H.: Simulation of code spectrum and code flow of cultured neuronal networks. Comput. Intell. Neurosci., 2016, 7186092 (2016).
  • Tamura, S., Nishitani, Y., Hosokawa, C., Miyoshi, T., Sawai, H., Kamimura, T., Yagi, Y., Mizuno-Matsumoto, Y., Chen, Y-W-.: Spike code flow in cultured neuronal networks. Comput. Intell. Neurosci., 2016, 7267691 (2016).
  • Tawa, K., Sasakawa, C., Fujita, T., Kiyosue, K., Hosokawa, C., Nishii, J., Oike, M., Kakinuma, N.: Fluorescence microscopy imaging of cells with a plasmonic dish integrally molded. Jpn. J. Appl. Phys., 55(3S2), 03DF12 (2016).

細胞・生体医工学研究グループ

  • Tamura, S., Okamoto, Y., Nakagawa, S., Sakamoto, T., Ando, M., Shigeri, Y.: Light wavelengths of LEDs to improve the color discrimination in Ishihara test and Farnsworth Panel D-15 test for deutans. Color Res. Appl., 1-7 (2016).
  • Soeta, Y., Nakagawa, S., Kamiya, Y., Kamiya, M.: Subjective preference for air-conditioner sounds inside a car in summer and winter. J. Ergonomics, 6(4) (2016).
  • Okamoto, Y., Nakagawa, S.: Effects of light wavelengths on MEG ERD/ERS during a working memory task. Int. J. Psychophysiol. (2016).
  • Otsuka, A., Yumoto, M., Kuriki, S., Hotehama, T., Nakagawa, S.: Frequency characteristics of neuromagnetic auditory steady-state response to sinusoidally amplitude modulated sweep tones. Clin. Neurophysiol., 127(1), 790-801 (2016).