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  4. 誌上発表(国際誌・査読有)2016年

研究成果 Research Result

誌上発表(国際誌・査読有)2016年

部門研究戦略1:生物機能解明

脳遺伝子研究グループ

  • Shibata, K., Nagasaki, A., Adachi, H., Uyeda, T.Q.P.: Actin binding domain of filamin distinguishes posterior from anterior actin filaments in migrating Dictyostelium cells. Biophysics and Physicobiology. 13, 321-331 (2016).
  • Ohzono, T., Katoh, K., Fukuda, J.: Fluorescence microscopy reveals molecular localisation at line defects in nematic liquid crystals. Sci. Rep., 6, 36477 (2016).
  • Kien, X.N., Umeki, N., Kijima, S.T., Kodera, N., Ueno, H., Furutani-Umezu, N., Nakajima, J., Noguchi, T.Q.P., Nagasaki, A., Tokuraku, K., Uyeda, T.Q.: Allosteric regulation by cooperative conformational changes of actin laments drives mutually exclusive binding with co lin and myosin. Sci Rep (2016).
  • Chechetka, S., Doi, M., Pichon, B.P., Begin-Colin, S., Mayako, E.: Photothermal and mechanical stimulation of cells via dualfunctional nanohybrids. Nanotechnology, 27(47), 475102-475112 (2016).
  • Hashimoto, M., Doi, M., Kurebayashi, N., Furukawa, K., Hirawake-Mogi, H., Ohmiya, Y., Sakurai, T., Mita, T., Mikoshiba, K., Nara, T.: Inositol 1,4,5-trisphosphate receptor determines intracellular Ca2+ concentration in Trypanosoma cruzi throughout its life cycle. FEBS Open Bio, 6(12), 1178-1185 (2016).
  • Ochiishi, T., Doi, M., Yamasaki, K., Hirose, K., Kitamura, A., Urabe, T., Hattori, N., Kinjo, M., Ebihara, T., Shimura, H.: Development of new fusion proteins for visualizing amyloid-β oligomers in vivo. Sci Rep., 6, 22712 (2016).
  • Ochiishi, T., Itakura, A., Liu, L., Akatsu, H., Kohno, H., Nishimura, M., Yoshimune, K.: Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-β aggregates. Genes Cells, 21(2), 200-211 (2016).

脳機能調節因子研究グループ

  • Noguchi, H., Kimura, A., Murao, N., Namihira, M., Nakashima, K.: Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood. Neurogenesis, 3(1), e1232679 (2016).
  • Hirano, K., Namihira, M.: LSD1 mediates neuronal differentiation of human fetal neural stem cells by controlling the expression of a novel target gene, HEYL. Stem Cells, 34(7), 1872-1882 (2016).
  • Noguchi, H., Murao, N., Kimura, A., Matsuda, T., Namihira, M., Nakashima, K., DNA methyltransferase 1 is indispensable for development of the hippocampal dentate gyrus. J. Neurosci., 36(22), 6050-6068 (2016).
  • Yamauchi, Y., Kimoto, H., Yang, X., Filkin, S., Utkin, Y., Kubo, T., Inagaki, H.: Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε). Biosci. Biotechnol. Biochem., 80(1), 158-161 (2016).

細胞分子機能研究グループ

  • Asai, D., Murata, M., Toita, R., Kawano, T., Nakashima, H., Kang, J-H.: Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2). Amino Acids, 1-6 (2016).
  • Toita, R., Kawano, T., Murata, M., Kang, J-H.: Anti-obesity and anti-inflammatory effects of macrophage-targeted interleukin-10-conjugated liposome in obese mice. 110(3), 81-88 (2016).
  • Sunarso, Toita, R., Tsuru, K., Ishikawa, K.: Immobilization of calcium and phosphate ions improves the osteoconductivity of titanium implants. Mater. Sci. Eng. C-Mater. Biol. Appl., 68, 291-298 (2016).
  • Sunarso, Toita, R., Tsuru, K., Ishikawa, K.: A superhydrophilic titanium implant functionalized by ozone gas modulates bone marrow cell and macrophage responses. J. Mater. Sci., 27(8), 127-135 (2016).
  • Uechi, K., Kamachi, S., Akita, H., Mine, S., Watanabe, M.: Crystal structure of an acetyl esterase complexed with acetate ion provides insight into the catalytic mechanism. Biochem. Biophys. Res. Commun., 477(3), 383-387 (2016).

部門研究戦略2:生物機能計測

バイオアナリティカル研究グループ

  • Miyamoto, T., Yokota, A., Tsuneda, S., Noda, N.: AAU-specific RNA cleavage mediated by MazF toxin endoribonuclease conserved in Nitrosomonas europaea. Toxins, 8(6), 174 (2016).
  • Morikawa, T.J., Fujita, H., Kitamura, A., Horio, T., Yamamoto, J., Kinjo, M., Sasaki, A., Machiyama, H., Yoshizawa, K., Ichimura, T., Imada, K., Nagai, T., Watanabe, T.M.: Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it. Sci Rep, 6, 22342 (2016).
  • Goto, K., Kimura, T., Kitamura, N., Semba, S., Ohmiya, Y., Aburatani, S., Matsukura, S., Tsuda, M., Kurokawa, T., Gong, J.P., Tnaka, S., Yasuda, K.: Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 Cells, which plays a significant role in the gel-induced chondrogenic differentiation. J. Biomed. Mater. Res. Part A, 104(3), 734-746 (2016).
  • Miyamoto, T., Kato, Y., Sekiguchi, Y., Tsuneda, S., Noda, N.: Characterization of mazF-mediated sequence-specific RNA cleavage in pseudomonas putida using massive parallel sequencing. PLoS One, 11(2), e0149494 (2016).

細胞・生体医工学研究グループ

  • Kume, A., Anh, DTM., Shichiri, M., Ishida, N., Suzuki, H.: Probucol dramatically enhances dihydroartemisinin effect in murine malaria. Malar. J., 15, 472 (2016).
  • Otsuki, N., Homma, T., Fujiwara, H., Kaneko, K., Hozumi, Y., Shichiri, M., Takashima, M., Ito, J., Konno, T., Kurahashi, T., Yoshida, Y., Goto, K., Fujii, S., Fujii, J.: Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase. Regul. Toxicol. Pharmacol., 79, 83-90 (2016).
  • Saito, Y., Akazawa-Ogawa, Y., Matsumura, A., Saigoh, K., Itoh, S., Sutou, K., Kobayashi, M., Mita, Y., Shichiri, M., Hisahara, S., Hara, Y., Fujimura, H., Takamatsu, H., Hagihara, Y., Yoshida, Y., Hamakubo, T., Kusunoki, S., Shimohama, S., Noguchi, N.: Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients. Sci Rep., 6, 30793 (2016).
  • Noda, S., So, M., Adachi, M., Kardos, J., Akazawa-Ogawa, Y., Hagihara, Y., Goto, Y.: Thioflavin T-silent denaturation intermediates support the main-chain-dominated architecture of amyloid fibrils. Biochemistry, 55(28), 3937-3948 (2016).
  • Soeta, Y., Nakagawa, S., Kamiya, Y., Kamiya, M.: Subjective preference for air-conditioner sounds inside a car in summer and winter. J. Ergonomics, 6(4) (2016).
  • Akazawa-Ogawa, Y., Uegaki, K., Hagihara, Y.: The role of intra-domain disulfide bonds in heat-induced irreversible denaturation of camelid single domain VHH antibodies. J. Biochem., 159(1), 111-121 (2016).
  • Kume, A., Herbas, M.S., Shichiri, M., Ishida, N., Suzuki, H.: Effect of anti-hyperlipidemia drugs on the alpha-tocopherol concentration and their potential for murine malaria infection. Parasitol. Res., 115(1), 69-75 (2016).

次世代メディカルデバイス研究グループ

  • Ando, M., Kamimura, T., Uegaki, K., Biju, V., Shigeri, Y.: Sensing of ozone based on its quenching effect on the photoluminescence of CdSe-based core-shell quantum dots. Microchim. Acta, 183, 3019-3024 (2016).
  • Furutani, S., Naruishi, N., Hagihara, Y., Nagai, H.: Development of an on-site rapid real-time polymerase chain reaction system and the characterization of suitable DNA polymerases for TaqMan probe technology. Anal. Bioanal. Chem., 408(20), 5641-5649 (2016).
  • Ando, M., Horie, M., Akazawa-Ogawa, Y., Hagihara, Y., Murase, N., Shigeri, Y.: Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells. Biosci. Biotechnol. Biochem., 80(1), 210-213 (2016).
  • Furutani, S., Kajiya, M., Aramaki, N., Kubo, I.: Rapid detection of salmonella enterica in food using a compact disc-shaped device. Micromachines, 7(1) 2016.
  • Yamazoe, H., Nakanishi, H., Kashiwagi, Y., Nakamoto, M., Tachibana, A., Hagihara, Y., Tanabe, T.: Changes in cell adhesiveness and physicochemical properties of crosslinked albumin films after ultraviolet irradiation. Langmuir, 32(1), 203-210 (2016).
  • Yamazoe, H., Ichikawa, T., Hagihara, Y., Iwasaki, Y.: Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells. Acta Biomater., 31, 231-240 (2016).
  • Yamazoe, H., Hagihara, Y., Kobayashi, H.: Multi-component co-culture system of cancer cells and two types of stromal cells for in vitro evaluation of anticancer drugs. Tissue Eng., 22(1), 20-29 (2016).

部門研究戦略3:生物機能応用

分子細胞デザイン研究グループ

  • Imamura, H., Honda, S.: Surface plasmon resonance biosensing of the monomer and the linked dimer of the variants of protein G under mass transport limitation. Data Brief, 9, 917-921 (2016).
  • Sugiyama, Y., Yamashita, S., Uezato, Y., Senga, Y., Katayama, S., Goshima, N., Shigeri, Y., Sueyoshi, N., Kameshita, I.: Phosphorylated TandeMBP: A unique protein substrate for protein phosphatase assay. Anal. Biochem., 513, 47-53 (2016).
  • Morita, T., Uehara, N., Kuwahata, K., Imamura, H., Shimada, T., Ookubo, K., Fujita, M., Sumi, T.: Interaction potential between biological sensing nanoparticles determined by combining small-angle X-ray scattering and model-potential-free liquid theory. J. Phys. Chem. C, 120(44), 25564-25571 (2016).
  • Watanabe, H., Yageta, S., Imamura, H., Honda, S.: Biosensing probe for quality control monitoring of the structural integrity of therapeutic antibodies. Anal. Chem., 88(20), 10095-10101 (2016).
  • Imamura, H., Honda, S.: Kinetics of antibody aggregation at neutral pH and ambient temperatures triggered by temporal exposure to acid. J. Phys. Chem. B, 120(36), 9581-9589 (2016).
  • Shibakami, M., Tsubouchi, G., Sohma, M., Hayashi, M.: Synthesis of nanofiber-formable carboxymethylated Euglena-derived β-1,3-glucan. Carbohydr. Polym. 152(18), 468-478 (2016).
  • Senga, Y., Akizuki, K., Katayama, S., Shigeri, Y., Kameshita, I., Ishida, A., Sueyoshi, N.: High-performance CaMKI: A highly active and stable form of CaMKIδ produced by high-level soluble expression in Escherichia coli. Biochem. Biophys. Res. Commun., 475(3), 277-282 (2016).
  • Odahara, T., Odahara, K.: Data in support of intermolecular interactions at early stage of protein/detergent particle association induced by salt/polyethylene glycol mixtures. Data in Brief, 7, 1283-1287 (2016).
  • Odahara, T., Odahara, K.: Intermolecular interactions at early stage of protein/detergent particle association induced by salt/polyethylene glycol mixtures. Protein Expr. Purif., 120, 72-86 (2016).
  • Katayama, S., Senga, Y., Oi, A., Miki, Y., Sugiyama, Y., Sueyoshi, N., Kameshita, I.: Expression analyses of splice variants of zebrafish cyclin-dependent kinase-like 5 and its substrate, amphiphysin 1. Gene, 583(1), 15-23 (2016).

構造創薬研究グループ

  • Kang, J., Yamasaki, K., Sano, K., Tsutsui, K., Tsutsui, K.M., Tateno, M.: Simulated annealing-extended sampling for multicomponent decomposition of spectral data of DNA complexed with peptide. J. Phys. Soc. Jpn. 86, 014802 (2016).
  • Furuta, T., Miyake, S., Ishitobi, H., Ogura, T., Kato, Y., Kamei, N., Miyado, K., Higashi, Y., Ochi, M.: Mesenchymal stem cell-derived exosomes promote fracture healing in a mouse model. Stem Cells Transl. Med. 5(12), 1620-1630 (2016).
  • Yamasaki, K., Tani, O., Tateishi, Y., Tanabe, E., Namatame, I., Niimi, T., Furukawa, K., Sakashita, H.: An NMR biochemical assay for fragment-based drug discovery: evaluation of an inhibitor activity on spermidine synthase of Trypanosoma cruzi. J. Med. Chem., 59(5), 2261-2266 (2016).

生体分子創製研究グループ

  • Kaishima, M., Ishii, J., Matsuno, T., Fukuda, N., Kondo, A.: Expression of varied GFPs in Saccharomyces cerevisiae: codon optimization yields stronger than expected expression and fluorescence intensity. Sci. Rep., 6, 35932 (2016).
  • Nakamura, T., Yonezawa, Y., Tsuchiya, Y., Niiyama, M., Ida, K., Oshima, M., Morita, J., Uegaki, K.: Substrate recognition of N,N′-diacetylchitobiose deacetylase from Pyrococcus horikoshii. J. Struct. Biol., 195(3), 286-293 (2016).
  • Castren, E., Kojima, M.: Brain-derived neurotrophic factor in mood disorders and antidepressant treatments. Neurobiol. Dis., 71, 193-198 (2016).
  • Fukuda, N., Kaishima, M., Ishii, J., Kondo, A., Honda, S.: Continuous crossbreeding of sake yeasts using growth selection systems for a-type and α-type cells. AMB Expr., 6,45 (2016).
  • Mizui, T., Ishikawa, Y., Kumanogoh, H., Kojima, M.: Neurobiological actions by three distinct subtypes of brain-derived neurotrophic factor: Multi-ligand model of growth factor signaling. Pharmacol. Res., 105, 93-98 (2016).

先端ゲノムデザイン研究グループ

  • Wu, C.: Biotinylation of deoxyguanosine at the abasic site in double-stranded oligodeoxynucleotides. J. Anal. Methods Chem., 2016 (2016).
  • Kawata, Y., Nishimura, T., Matsushita, I., Tsubota, J.: Efficient production and secretion of pyruvate from Halomonas sp. KM-1 under aerobic conditions. AMB Express, 6(1), 1-8 (2016).
  • Miyahara, D., Oishi, I., Makino, R., Kurumisawa, N., Nakaya, R., Ono, T., Kagami, H., Tagami, T.: Chicken stem cell factor enhances primordial germ cell proliferation cooperatively with fibroblast growth factor 2. J. Reprod. Dev., 2015, 128 (2016).
  • Oishi, I., Yoshii, K., Miyahara, D., Kagami, H., Tagami, T.: Targeted mutagenesis in chicken using CRISPR/Cas9 system. Sci Rep, 23980 (2016).

総括研究主幹・部門付き

関口総括研究主幹

  • Thandar, SM., Ushiki, N., Fujitani, H., Sekiguchi, Y., Tsuneda, S.: Ecophysiology and comparative genomics of nitrosomonas mobilis Ms1 isolated from autotrophic nitrifying granules of wastewater treatment bioreactor. Front. Microbiol., 7, 1869 (2016).
  • Noguchi, M., Kurisu, F., Sekiguchi, Y., Kasuga, I., Furumai, H.: Microbial community structure of methanogenic benzene-degrading cultures enriched from five different sediments. J. Gen. Appl. Microbiol. (2016).
  • Sun, L., Toyonaga, M., Ohashi, A., Matsuura, N., Tourlousse, D.M., Meng, X.Y., Tamaki, H., Hanada, S., Cruz, R., Yamaguchi, T., Sekiguchi, Y.: Isolation and characterization of Flexilinea flocculare gen. nov., sp. nov., a filamentous anaerobic bacterium belonging to the class Anaerolineae in the phylum Chloroflexi. Int. J. Syst. Evol. Microbiol. (2016).
  • Yeoh, Y.K., Sekiguchi, Y., Parks, D.H., Hugenholtz, P.: Comparative genomics of candidate phylum TM6 suggests that parasitism is widespread and ancestral in this lineage. Mol. Biol. Evol. (2016).
  • Matsuura, N., Ohashi, A., Toulousse, D.M., Sekiguchi, Y.: Draft genome sequence of thermodesulfovibrio aggregans TGE-P1T, an obligately anaerobic, thermophilic, sulfate-reducing bacterium in the phylum nitrospirae. Genome Announc., 4(2), e00089-16 (2016).
  • Matsuura, N., Ohashi, A., Toulousse, D.M., Sekiguchi, Y.: Draft genome sequence of the syntrophic lactate-degrading bacterium tepidanaerobacter syntrophicus JLT. Genome Announc., 4(1), e01712-15 (2016).
  • Nakata, T., Okimura, C., Mizuno, T., Iwadate, Y.: The role of stress fibers in the shape determination mechanism of fish keratocytes. Biophys. J., 110(2), 481-492 (2016).