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  4. 誌上発表(国際誌・査読有)2015年

研究成果 Research Result

誌上発表(国際誌・査読有)2015年

部門研究戦略1:生物機能解明

脳遺伝子研究グループ

            
  • Shibata, T., Yamashita, S., Hirosaki, K., Katoh, K., Ohta, Y.: Isolation of mitochondria by gentle cell membrane   disruption, and their subsequent characterization. Biochem. Biophys. Res. Commun., 463(4), 536-568 (2015).
  • Miyako, E., Chechetka, S.A., Doi, M., Yuba, E., Kono, K.: In vivo remote control of reactions in caenorhabditis elegans by using supramolecular nanohybrids of carbon nanotubes and liposomes. Angew. Chem.-Int. Edit., 54(34), 9903-9906 (2015).
  • Nakahara, Y., Tatsumi, Y., Akimoto, I., Osaki, S., Doi, M., Kimura, K.: Fluorescent silica nanoparticles modified chemically with terbium complexes as potential bioimaging probes: their fluorescence and colloidal properties in water. New J. Chem. (2015).

脳機能調節因子研究グループ

  • Noguchi, H., Kimura, A., Murao, N., Matsuda, T., Namihira, M., Nakashima, K.: Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus. Neurosci. Res. (2015).
  • Murao, N., Matsuda, T., Noguchi, H., Koseki, H., Namihira, M., Nakashima, K.: Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells. Neurogenesis (2015).
  • Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M.: Identification of novel peptides from amphibian (Xenopus tropicalis) skin by direct tissue MALDI-MS analysis. FEBS J., 282(1), 102-113 (2015).

細胞分子機能研究グループ

  • Matsuda, C., Kiyosue, K., Nishino, I., Goto, Y., Hayashi, Y.K.: Dysferlinopathy fibroblasts are defective in plasma membrane repair. PLOS Currents Muscular Dystrophy, 1 (2015).
  • Ohnishi, H., Kawasaki, T., Deguchi, T., Yuba, S.: Generation of xeroderma pigmentosum-A patient-derived induced pluripotent stem cell line for use as future disease model. Cell. Reprogramm., 17(4), 268-274 (2015).
  • Kawasaki, T., Saka, T., Mine, S., Mizohata, E., Inoue, T., Matsumura, H., Sato, T.: N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein. FEBS Lett., 589(10), 1136-1142 (2015).

部門研究戦略2:生物機能計測

バイオアナリティカル研究グループ

  • Fujimoto, N., Mizuno, K., Yokoyama, T., Ohnishi, A., Suzuki, M., Watanabe, S., Komatsu, K., Sakata, Y., Kishida, N., Akiba, M., Matsukura, S.: Community analysis of picocyanobacteria in an oligotrophic lake by cloning 16S rRNA gene and 16S rRNA gene amplicon sequencing. J. Gen. Appl. Microbiol., 61(5), 171-176 (2015).
  • Tourlousse DM., Natsuura, N., Sun, L., Toyonaga, M., Kuroda, K., Ohashi, A., Cruz, R., Yamaguchi, T., Sekiguchi, Y.: Draft genome sequence of bacteroidales strain TBC1, a novel isolate from a methanogenic wastewater treatment system. Genome Announc., 3(5), e01168 (2015).
  • Tourlousse DM., Honda, T., Matsuura, N., Ohashi, A., Tonouchi, A., Sekiguchi, Y.: Draft genome sequence of bacteroidales strain 6E, isolated from a rice paddy field in Japan. Genome Announc., 3(5), e01167 (2015).
  • Sasaki, A., Yamamoto, J., Takashi, J., Kinjo, M.: Raster image cross-correlation analysis for spatiotemporal visualization of intracellular degradation activities against exogenous DNAs. Sci Rep., 5, 14428 (2015).
  • Oasa, S., Sasaki, A., Yamamoto, J., Mikuni, S., Kinjo, M.: Homodimerization of glucocorticoid receptor from single cells investigated using fluorescence correlation spectroscopy and microwells. FEBS Lett., 589(17), 2171-2178 (2015).
  • Furuta, A., Tsubuki, M., Endoh, M., Miyamoto, T., Tanaka, J., Salam, K.A., Akimitsu, N., Tani, H., Yamashita, A., Moriishi, K., Nakakoshi, M., Sekiguchi, Y., Tsuneda, S., Noda, N.: Identification of hydroxyanthraquinones as novel inhibitors of hepatitis C virus NS3 helicase. Int. J. Mol. Sci., 16, 18439-18453 (2015).
  • Mikuni, S., Kodama, K., Sasaki, A., Kohira, N., Maki, H., Munetomo, M., Maenaka, K., Kinjo, M.: Screening for FtsZ dimerization inhibitors using fluorescence cross-correlation spectroscopy and surface resonance plasmon analysis. PLoS One, 10(7), e0130933 (2015).
  • Sasaki, A., Tsukasaki, Y., Komatsuzaki, A., Sakata, T., Yasuda, H., Jin, T.: Recombinant protein (EGFP-Protein G) coated PbS quantum dots for in vitro and in vivo dual fluorescence (visible and second-NIR) imaging of breast tumors. Nanoscale, 7(12), 5115-5119 (2015).
  • Shirane, S., Araki, M., Morishita, S., Edahiro, Y., Takei, H., Yoo, Y., Choi, M., Sunami, Y., Hironaka, Y., Noguchi, M., Koike, M., Noda, N., Ohsaka, A., Komatsu, N.: JAK2, CALR and MPL mutation spectrum in Japanese myeloproliferative neoplasms patients. Haematologica, 100(2), e46-48 (2015).
  • 細胞・生体医工学研究グループ

    • Soeta, Y., Nakagawa, S.: Prediction of optimal auditory signals using auditory evoked magnetic responses. Build. Environ. , 94, 924-929 (2015).
    • Saito, Y., Shichiri, M., Hamajima, T., Ishida, N., Mita, Y., Nakao, S., Hagihara, Y., Yoshida, Y., Takahashi, K., Niki, E., Noguchi, N.: Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene. J. Lipid Res., 56(11), 2172-2182 (2015).
    • Herbas, M.S., Shichiri, M., Ishida, N., Kume, A., Hagihara, Y., Yoshida, Y., Suzuki, H.: Probucol-induced α-tocopherol deficiency protects mice against malaria infection. PLoS One, 10(8), e0136014 (2015).
    • Miyazaki, N., Kiyose, N., Akazawa, Y., Takashima, M., Hagihara, Y., Inoue, N., Matsuda, T., Ogawa, R., Inoue, S., Ito, Y.: Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high throughput sequencing. J. Biochem., 158(3), 205-215 (2015).
    • Soeta, Y., Shimokura, R., Kim, Y.H., Ohsawa, T., Ito, K.: Characteristics of Buddhist chanting in Japanese temples. Appl. Acoust., 91, 73-76 (2015).
    • Soeta, Y., Bito, Y.: Detection of features of prosthetic cardiac valve sound by spectrogram analysis. Appl. Acoust., 89, 28-33 (2015).
    • Yoshino, K., Umeno, A., Shichiri, M., Watanabe, H., Ishida, N., Kojima, M., Iwaki, S., Hagihara, Y., Nakamura, M., Yoshida, Y.: Biomarkers for the evaluation of immunological properties during the Shikoku walking pilgrimage. J. Biol. Regul. Homeost. Agents, 29(1), 51-62 (2015).
    • Yagi, H., Mizuno, A., So, M., Hirano, M., Adachi, M., Akazawa-Ogawa, Y., Hagihara, Y., Ikenoue, T., Lee, Y-H., Kawata, Y., Goto, Y.: Ultrasonication-dependent formation and degradation of α-synuclein amyloid fibrils. BBA-Proteins Proteomics, 1854(3), 209-217 (2015).
    • Akazawa-Ogawa, Y., Shichiri, M., Nishio, K., Yoshida, Y., Niki, E., Hagihara, Y.: Singlet oxygen-derived products from linoleate activate Nrf2 signaling in skin cells. Free Radic. Biol. Med., 79, 164-175 (2015).

    次世代メディカルデバイス研究グループ

    • Inoue, N., Hagihara, Y., Wright, D., Suzuki, T., Wada, I.: Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice. Nat. Commun., 6, 8858 (2015).
    • Ando, M., Horie, M., Akazawa-Ogawa, Y., Hagihara, Y., Murase, N., Shigeri, Y.: Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells. Biosci. Biotechnol. Biochem., 80(1), 210-213 (2015).

    部門研究戦略3:生物機能応用

    分子細胞デザイン研究グループ

    • Shibakami, M., Tsubouchi, G., Sohma, M., Hayashi, M.: Preparation of self-standing transparent thin films made from acetylated euglenoid β-1,3-glucans. Carbohydr. Polym., 133, 421-428 (2015).
    • Watanabe, H., Honda, S.: Adaptive assembly: maximizing the potential of a given functional peptide with a tailor-made protein scaffold. Chem. Biol., 22(9) (2015).
    • Senga, Y., Ishida, A., Shigeri, Y., Kameshita, I., Sueyoshi, N.: The phosphatase-resistant isoform of CaMKI, Ca²⁺/calmodulin-dependent protein kinase Iδ (CaMKIδ), remains in its "primed" form without Ca²⁺ stimulation. Biochemistry, 54(23), 3617-3630 (2015).
    • Yageta, S., Lauer, T.M., Trout, B.L., Honda, S.: Conformational and colloidal stabilities of isolated constant domains of human immunoglobulin G and their impact on antibody aggregation under acidic conditions. Mol. Pharm., 12(5), 1443-1445 (2015).
    • Shibakami, M., Tsubouchi, G., Sohma, M., Hayashi, M.: One-pot synthesis of thermoplastic mixed paramylon esters using trifuoroacetic anhydride. Carbohydr. Polym., 119, 1-7 (2015).

    生体分子創製研究グループ

    • Kaishima, M., Ishii, J., Fukuda, N., Kondo, A.: Gγ recruitment systems specifically select PPI and affinity-enhanced candidate proteins that interact with membrane protein targets. Sci. Rep., 5, 16723 (2015).
    • Kawasaki, N., Yamano, N., Nakayama, A.: Polyamide4-block-poly(vinyl acetate) via a polyamide4 azo macromolecular initiator: Thermal and mechanical behavior, biodegradation, and morphology. J. Appl. Polym. Sci., 132(37), 42466-42475 (2015).
    • Matsuoka, Y., Nishi, D., Tanima, Y., Itakura, M., Kojima, M., Hamazaki, K., Noguchi, H., Hamazaki, T.: Serum pro-BDNF/BDNF as a treatment biomarker for response to docosahexaenoic acid in traumatized people vulnerable to developing psychological distress: a randomized controlled trial. Transl. Psychiatr., e596 (2015).
    • Nakamura, T., Niiyama, M., Hashimoto, W., Ida, K., Abe, M., Morita, J., Uegaki, K.: Multiple crystal forms of N,N′-diacetylchitobiose deacetylase from Pyrococcus furiosus. Acta Crystallogr. F-Struct. Biol. Commun., 71(6), 657-662 (2015).
    • Mizui, T., Ishikawa, Y., Kumanogoh, H., Lume, M., Matsumoto, T., Hara, T., Yamawaki, S., Takahashi, M., Shiosaka, S., Itami, C., Uegaki, K., Saarma, M., Kojima, M.: BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proc. Natl. Acad. Sci. U. S. A., 112(23), 3067-3074 (2015).
    • Ando, H., Kawasaki, N., Yamano, N., Uegaki, K., Nakayama, A.: Biodegradation of a poly(ε-caprolactone-co-L-lactide)–visible-light-sensitive TiO2 composite with an on/off biodegradation function. Polym. Degrad. Stabil., 114, 65-71 (2015).
    • Fukuda, N., Honda, S.: Rapid evaluation of tyrosine kinase activity of membrane-integrated human epidermal growth factor receptor using the yeast Gγ recruitment system. ACS Synth. Biol., 4(4), 421-429 (2015).
    • Mishima, Y., Shinoda, Y., Sadakata, T., Kojima, M., Wakana, S., Furuichi, T.: Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. Sci Rep., 5, 8932 (2015).
    • Yoshino, K., Umeno, A., Shichiri, M., Watanabe, H., Ishida, N., Kojima, M., Iwaki, S., Hagihara, Y., Nakamura, M., Yoshida, Y.: Biomarkers for the evaluation of immunological properties during the shikoku walking pilgrimage. J. Biol. Regul. Homeost. Agents, 29(1), 51-62 (2015).
    • Fukuda, N., Honda, S.: Functional analyses and affinity-alteration of receptors and enzymes based on membrane recruitment of yeast guanine nucleotide-binding protein gamma subunit. Receptors & Clinical Investigation, 2(1), 373 (2015).

    先端ゲノムデザイン研究グループ

    • Kawata, Y., Nojiri, M., Matsushita, I., Tsubota, J.: Improvement of (R)-3-hydroxybutyric acid secretion during Halomonas sp. KM-1 cultivation with saccharified Japanese cedar by the addition of urea. Lett. Appl. Microbiol. , 61(4), 397-402 (2015).
    • Akiyama, R., Kawakami, H., Wong, J., Oishi, I., Nishinakamura, R., Kawakami, Y.: Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc. Natl. Acad. Sci. U. S. A., 112(16), 5075-5080 (2015).

    総括研究主幹・部門付き

    関口総括研究主幹

    • Matsuura, N., Tourlousse, DM., Sun, L., Toyonaga, M., Kuroda, K., Ohashi, A., Cruz, R., Yamaguchi, T., Sekiguchi, Y.: Draft genome sequence of anaerolineae strain TC1, a novel isolate from a methanogenic wastewater treatment system. Genome Announc., 3(5), e01104 (2015).
    • Matsuura, N., Tourlousse, DM., Ohashi, A., Hugenholtz, P., Sekiguchi, Y.: Draft genome sequences of anaerolinea thermolimosa IMO-1, bellilinea caldifistulae GOMI-1, leptolinea tardivitalis YMTK-2, levilinea saccharolytica KIBI-1, longilinea arvoryzae KOME-1, previously described as members of the class anaerolineae (Chloroflexi). Genome Announc., 3(5), e00975-15 (2015).
    • Sun, L., Toyonaga, M., Ohashi, A., Tourlousse D.M., Matsuura, N., Meng, X.Y., Tamaki, H., Hanada, S., Cruz, R., Yamaguchi, T., Sekiguchi, Y.: Lentimicrobium saccharophilum gen. nov., sp. nov., a strictly anaerobic bacterium representing a new family in the phylum Bacteroidetes, and proposal of Lentimicrobiaceae fam. nov.. Int. J. Syst. Evol. Microbiol. (2015).
    • Sekiguchi, Y., Ohashi, A., Parks, D.H., Yamauchi, T., Tyson, G., Hugenholtz, P.: First genomic insights into members of a candidate bacterial phylum responsible for wastewater bulking. PEERJ, 3, e740 (2015).
    • Akiyama, H., Ueda, Y., Nobumasa, H., Ooshima, H., Ishizawa, Y., Kitahiro, K., Miyagawa, I., Watanabe, K., Nakamura, T., Tanaka, R., Yamamoto, N., Nakae, H., Kawase, M., Gemma, N., Sekiguchi, Y., Fujibuchi, W., Matoba, R.: A set of external reference controls/probes that enable quality assurance between different microarray platforms. Anal. Biochem. (2015).