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  4. 誌上発表(国際誌・査読有)2015年

研究成果

誌上発表(国際誌・査読有)2015年

重点課題1:

分子細胞育種研究グループ

  • Kaishima, M., Ishii, J., Fukuda, N., Kondo, A.: Gγ recruitment systems specifically select PPI and affinity-enhanced candidate proteins that interact with membrane protein targets. Sci. Rep., 5, 16723 (2015).
  • Shibakami, M., Tsubouchi, G., Sohma, M., Hayashi, M.: Preparation of self-standing transparent thin films made from acetylated euglenoid β-1,3-glucans. Carbohydr. Polym., 133, 421-428 (2015).
  • Watanabe, H., Honda, S.: Adaptive assembly: maximizing the potential of a given functional peptide with a tailor-made protein scaffold. Chem. Biol., 22(9) (2015).
  • Watanabe, M., Yoshida, E., Fukada, H., Inoue, H., Tokura, M., Ishikawa, K.: Characterization of a thermostable feruloyl esterase B from Talaromyces cellulolyticus. Biosci. Biotechnol. Biochem., 79(11), 1845-1851 (2015).
  • Senga, Y., Ishida, A., Shigeri, Y., Kameshita, I., Sueyoshi, N.: The phosphatase-resistant isoform of CaMKI, Ca²⁺/calmodulin-dependent protein kinase Iδ (CaMKIδ), remains in its "primed" form without Ca²⁺ stimulation. Biochemistry, 54(23), 3617-3630 (2015).
  • Inoue, H., Kishishita, S., Kumagai, A., Kataoka, M., Fujii, T., Ishikawa, K.: Contribution of a family 1 carbohydrate-binding module in thermostable GH10 xylanase from Talaromyces cellulolyticus on synergistic enzymatic hydrolysis of lignocellulose. Biotechnol. Biofuels, 8(77) (2015).
  • Ishikawa, K., Kataoka, M., Yanamoto, T., Nakabayashi, M., Watanabe, M., Ishihara, S., Yamaguchi, S.: Crystal structure of beta-galactosidase from Bacillus circulans ATCC 31382 (BgaD) and the construction of the thermophilic mutants. FEBS J., 282(13), 2540-2552 (2015).
  • Yageta, S., Lauer, T.M., Trout, B.L., Honda, S.: Conformational and colloidal stabilities of isolated constant domains of human immunoglobulin G and their impact on antibody aggregation under acidic conditions. Mol. Pharm., 12(5), 1443-1445 (2015).
  • Fukuda, N., Honda, S.: Rapid evaluation of tyrosine kinase activity of membrane-integrated human epidermal growth factor receptor using the yeast Gγ recruitment system. ACS Synth. Biol., 4(4), 421-429 (2015).
  • Shibakami, M., Tsubouchi, G., Sohma, M., Hayashi, M.: One-pot synthesis of thermoplastic mixed paramylon esters using trifuoroacetic anhydride. Carbohydr. Polym., 119, 1-7 (2015).
  • Fukuda, N., Honda, S.: Functional analyses and affinity-alteration of receptors and enzymes based on membrane recruitment of yeast guanine nucleotide-binding protein gamma subunit. Receptors & Clinical Investigation, 2(1), 373 (2015).

蛋白質デザイン研究グループ

  • Nakano, K., Chigira, T., Miyafusa, T., Nagatoishi, S., Caaveiro, J.M.M., Tsumoto, K.: Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus. Sci Rep., 5, 15337 (2015).

構造生理研究グループ

  • Takeda, S., Okazai, H., Kohro-Ikeda, E., Yoshida, K., Tokuyasu, M., Takemoto, Y., Mizunoe, R., Tanaka, S., Okada, T., Aramaki, H.: DNA microarray analysis of genes in highly metastatic 4T1E/M3 murine breast cancer cells following exposure to cannabidiolic acid. Fund. Toxicol. Sci., 2(2), 89-94 (2015).
  • Morikawa, M., Yajima, H., Nitta, R., Inoue, S., Ogura, T., Sato, C., Hirokawa, N.: X‐ray and Cryo‐EM structures reveal mutual conformational changes of Kinesin and GTP‐state microtubules upon binding. Embo J., 34(9), 1270-1286 (2015).
  • Ogura, T.: Nanoscale analysis of unstained biological specimens in water without radiation damage using high-resolution frequency transmission electric-field system based on FE-SEM. Biochem. Biophys. Res. Commun. , 459(3), 521-528 (2015).
  • Memtily, N., Okada, T., Ebihara, T., Sato, M., Kurabayashi, A., Furihata, M., Suga, M., Nishiyama, H., Mio, K., Sato, C.: Observation of tissues in open aqueous solution by atmospheric scanning electron microscopy: applicability to intraoperative cancer diagnosis. Int. J. Oncol. , 46(5), 1872-1882 (2015).
  • Fukuzawa, K., Kurisaki, I., Watanabe, C., Okiyama, Y., Mochizuki, Y., Tanaka, S., Komeiji, Y.: Explicit solvation modulates intra- and inter-molecular interactions within DNA: electronic aspects revealed by the ab initio fragment molecular orbital (FMO) method. Comput. Theor. Chem., 1054, 29-37 (2015).
  • Kato, M., Hanyu, Y.: Potentiation of antigen-specific antibody production by peptides derived from Ag85B of Mycobacterium tuberculosis. J. Immunol. Methods, 417, 45-51 (2015).

先端ゲノムデザイン研究グループ

  • Kawata, Y., Nojiri, M., Matsushita, I., Tsubota, J.: Improvement of (R)-3-hydroxybutyric acid secretion during Halomonas sp. KM-1 cultivation with saccharified Japanese cedar by the addition of urea. Lett. Appl. Microbiol. , 61(4), 397-402 (2015).

生体分子創製研究グループ

  • Nakamura, T., Niiyama, M., Hashimoto, W., Ida, K., Abe, M., Morita, J., Uegaki, K.: Multiple crystal forms of N,N′-diacetylchitobiose deacetylase from Pyrococcus furiosus. Acta Crystallogr. F-Struct. Biol. Commun., 71(6), 657-662 (2015).
  • Ando, H., Kawasaki, N., Yamano, N., Uegaki, K., Nakayama, A.: Biodegradation of a poly(ε-caprolactone-co-L-lactide)–visible-light-sensitive TiO2 composite with an on/off biodegradation function. Polym. Degrad. Stabil., 114, 65-71 (2015).

分子細胞病態研究特別チーム

  • Matsuoka, Y., Nishi, D., Tanima, Y., Itakura, M., Kojima, M., Hamazaki, K., Noguchi, H., Hamazaki, T.: Serum pro-BDNF/BDNF as a treatment biomarker for response to docosahexaenoic acid in traumatized people vulnerable to developing psychological distress: a randomized controlled trial. Transl. Psychiatr., e596 (2015).
  • Mizui, T., Ishikawa, Y., Kumanogoh, H., Lume, M., Matsumoto, T., Hara, T., Yamawaki, S., Takahashi, M., Shiosaka, S., Itami, C., Uegaki, K., Saarma, M., Kojima, M.: BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proc. Natl. Acad. Sci. U. S. A., 112(23), 3067-3074 (2015).
  • Mishima, Y., Shinoda, Y., Sadakata, T., Kojima, M., Wakana, S., Furuichi, T.: Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. Sci Rep., 5, 8932 (2015).
  • Yoshino, K., Umeno, A., Shichiri, M., Watanabe, H., Ishida, N., Kojima, M., Iwaki, S., Hagihara, Y., Nakamura, M., Yoshida, Y.: Biomarkers for the evaluation of immunological properties during the shikoku walking pilgrimage. J. Biol. Regul. Homeost. Agents, 29(1), 51-62 (2015).

  • 重点課題2:

    生物時計研究グループ

    • Ochi, A., Nakao, R., Yamamoto, Y., Kitahata, K., Takagi, M., Hirasaka, K., Ohno, A., Teshima-Kondo, S., Taesik, G., Choi, I., Kawamura, T., Nemoto, H., Mukai, R., Terao, J., Nikawa, T.: N-myristoylated ubiquitin ligase Cbl-b inhibitor prevents on glucocorticoid-induced atrophy in mouse skeletal muscle. Arch. Biochem. Biophys., 570, 23-31 (2015).
    • Wang, Q.S., Hanatani, I., Takeda, M., Oishi, K., Sakamoto, K.: D2-like dopamine receptors mediate regulation of pupal diapause in Chinese oak silkmoth Antheraea pernyi.. Entomol. Sci. , 18(2), 193-198 (2015).
    • Oishi, K., Higo, S., Yamamoto, S., Yasumoto, Y.: Disrupted light-dark cycle abolishes circadian expression of peripheral clock genes without inducing behavioral arrhythmicity in mice. Biochem. Biophys. Res. Commun., 458(2), 256-261 (2015).
    • Nakao, R., Yamamoto, S., Horikawa, K., Yasumoto, Y., Futagawa, K., Mukai, C., Oishi, K.: Atypical expression of circadian clock genes in denervated mouse skeletal muscle. Chronobiol. Int. (2015).
    • Ohkura, N., Oishi, K., Atsumi, G.: Blood coagulation and metabolic profiles in middle-aged male and female ob/ob mice. Blood Coagul. Fibrinolysis (2015).
    • Oishi, K., Yamamoto, S., Itoh, N., Nakao, R., Yasumoto, Y, Tanaka, K., Kikuchi, Y., Fukutome, S., Okita, K., Ishikawa, Y.: Wheat alkylresorcinols suppress high-fat high-sucrose diet-induced obesity with glucose intolerance by inducing insulin sensitivity and fecal cholesterol excretion in mice. J. Nutr. (2015).
    • Nakao, R., Oishi, K., Yamamoto, S., Yasumoto, Y.: Impact of denervation-induced muscle atrophy on housekeeping gene expression in mice. Muscle Nerve, 51(2), 276-281 (2015).
    • Wang, Q.S., Egi, Y., Takeda, M., Oishi, K., Sakamoto, K.: Melatonin pathway transmits information to terminate pupal diapause in the Chinese oak silkmoth, Antheraea pernyi, and through reciprocated inhibition of dopamine pathway functions as a photoperiodic counter. Entomol. Sci., 18(1), 74-84 (2015).
    • Yasumoto, Y., Nakao, R., Oishi, K.: Free access to a running-wheel advances the phase of behavioral and physiological circadian rhythms and peripheral molecular clocks in mice. PLoS One, 10(1), e0116476 (2015).

    DAILAB

    • Ohmiya, Y.: Simultaneous multicolor luciferase reporter assays for monitoring of multiple genes expressions. Comb. Chem. High Throughput Screen, 18(10) (2015).
    • Huang, C., Vaishnavi, K., Kalra, R.S., Zhang, Z., Sekar, K., Kaul, S.C., Wadhwa, R.: 3β-methoxy derivation of withaferin-A attenuates its anticancer potency: bioinformatics and molecular evidences. Medicinal & Aromatic Plants, 4(5), 1000219 (2015).
    • Kalra, R.S., Cheung, C.T., Chaudhary, A., Prakash, J., Kaul, S.C., Wadhwa, R.: CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis. 9(9), 1877-1889 (2015).
    • Nigam, N., Grover, A., Goyal, S., Katiyar, S.P., Bhargava, P., Wang, PC., Sundar, D., Kaul, S.C., Wadhwa, R.: Targeting mortalin by embelin causes activation of tumor suppressor p53 and deactivation of metastatic signaling in human breast cancer cells. PLos One, 10(9), e0138192 (2015).
    • Kimura, Y., Fujimura, C., Ito, Y., Takahashi, T., Nakajima, Y., Ohmiya, Y., Aiba, S.: Optimization of the IL-8 Luc assay as an in vitro test for skin sensitization. Toxicol. Vitro, 29(7), 1816-1830 (2015).
    • Gao, R., Singh, R., Kaul, Z., Kaul, S.C., Wadhwa, R.: Targeting of DNA damage signaling pathway induced senescence and reduced migration of cancer cells. J. Gerontol. Ser. A-Biol. Sci. Med. Sci., 70(6), 701-713 (2015).
    • Lu, W-J., Saxena, N., Luk, J.M., Kaul, S.C., Wadhwa, R.: Circulating mortalin autoantibody - a new serological marker of liver cirrhosis. Cell Stress Chaperones, 20, 715-719 (2015).
    • Singh, V., Kaul, S.C., Wadhwa, R., Pati, P.K: Evaluation and selection of candidate reference genes for normalization of quantitative RT-PCR in withania somnifera (L.) dunal. PLoS One, 10(3), e0118860 (2015).
    • Shah, N., Singh, R., Sarangi, U., Saxena, N., Chaudhary, A., Kaur, G., Kaul, S.C., Wadhwa, R.: Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells Against Oxidative Stress and Induce Differentiation. PLoS One, 10(3), e0120554 (2015).
    • Wadhwa, R., Jihoon, R., Hyo, M.A., Nishant, S., Anupama, C., Chae-Ok, Y., Kaul, S.C.: Functional significance of point mutations in stress chaperone mortalin and their relevance to parkinson disease. J. Biol. Chem., 290, 8447-8456 (2015).
    • Sato, K., Itoh, T., Kato, T., Kitamura, Y., Kaul, S.C., Wadhwa, R., Sato, F., Ohneda, O.: Serum-free isolation and culture system to enhance the proliferation and bone regeneration of adipose tissue-derived mesenchymal stem cells. In Vitro Cell. Dev. Biol.-Anim., 51, 515-529 (2015).

    次世代メディカルデバイス研究グループ

    • Inoue, N., Hagihara, Y., Wright, D., Suzuki, T., Wada, I.: Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice. Nat. Commun., 6, 8858 (2015).
    • Saito, Y., Shichiri, M., Hamajima, T., Ishida, N., Mita, Y., Nakao, S., Hagihara, Y., Yoshida, Y., Takahashi, K., Niki, E., Noguchi, N.: Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene. J. Lipid Res., 56(11), 2172-2182 (2015).
    • Herbas, M.S., Shichiri, M., Ishida, N., Kume, A., Hagihara, Y., Yoshida, Y., Suzuki, H.: Probucol-induced α-tocopherol deficiency protects mice against malaria infection. PLoS One, 10(8), e0136014 (2015).
    • Miyazaki, N., Kiyose, N., Akazawa, Y., Takashima, M., Hagihara, Y., Inoue, N., Matsuda, T., Ogawa, R., Inoue, S., Ito, Y.: Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high throughput sequencing. J. Biochem., 158(3), 205-215 (2015).
    • Ando, M., Horie, M., Akazawa-Ogawa, Y., Hagihara, Y., Murase, N., Shigeri, Y.: Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells. Biosci. Biotechnol. Biochem., 80(1), 210-213 (2015).
    • Yoshino, K., Umeno, A., Shichiri, M., Watanabe, H., Ishida, N., Kojima, M., Iwaki, S., Hagihara, Y., Nakamura, M., Yoshida, Y.: Biomarkers for the evaluation of immunological properties during the Shikoku walking pilgrimage. J. Biol. Regul. Homeost. Agents, 29(1), 51-62 (2015).
    • Yagi, H., Mizuno, A., So, M., Hirano, M., Adachi, M., Akazawa-Ogawa, Y., Hagihara, Y., Ikenoue, T., Lee, Y-H., Kawata, Y., Goto, Y.: Ultrasonication-dependent formation and degradation of α-synuclein amyloid fibrils. BBA-Proteins Proteomics, 1854(3), 209-217 (2015).
    • Akazawa-Ogawa, Y., Shichiri, M., Nishio, K., Yoshida, Y., Niki, E., Hagihara, Y.: Singlet oxygen-derived products from linoleate activate Nrf2 signaling in skin cells. Free Radic. Biol. Med., 79, 164-175 (2015).

    重点課題3:

    脳遺伝子研究グループ

    • Shibata, T., Yamashita, S., Hirosaki, K., Katoh, K., Ohta, Y.: Isolation of mitochondria by gentle cell membrane disruption, and their subsequent characterization. Biochem. Biophys. Res. Commun., 463(4), 536-568 (2015).
    • Miyako, E., Chechetka, S.A., Doi, M., Yuba, E., Kono, K.: In vivo remote control of reactions in caenorhabditis elegans by using supramolecular nanohybrids of carbon nanotubes and liposomes. Angew. Chem.-Int. Edit., 54(34), 9903-9906 (2015).
    • Nakahara, Y., Tatsumi, Y., Akimoto, I., Osaki, S., Doi, M., Kimura, K.: Fluorescent silica nanoparticles modified chemically with terbium complexes as potential bioimaging probes: their fluorescence and colloidal properties in water. New J. Chem. (2015).

    脳機能調節因子研究グループ

    • Noguchi, H., Kimura, A., Murao, N., Matsuda, T., Namihira, M., Nakashima, K.: Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus. Neurosci. Res. (2015).
    • Murao, N., Matsuda, T., Noguchi, H., Koseki, H., Namihira, M., Nakashima, K.: Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells. Neurogenesis (2015).
    • Shigeri Y, Yasuda A, Hagihara Y, Nishi K, Watanabe K, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M.: Identification of novel peptides from amphibian (Xenopus tropicalis) skin by direct tissue MALDI-MS analysis. FEBS J., 282(1), 102-113 (2015).

    分子複合医薬研究グループ

    • Okazaki, T., Higuchi, M., Takeda, K., Iwatsuki-Horimoto, K., Kiso, M., Miyagishi, M., Yanai, H., Kato, A., Yoneyama, M., Fujita, T., Taniguchi, T., Kawaoka, Y., Ichijo, H., Gotoh, Y.: The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. Sci. Signal., 8(388), ra78 (2015).
    • Umemoto, N., Ohnuma, T., Osawa, T., Numata, T., Fukamizo, T.: Modulation of the transglycosylation activity of plant family GH18 chitinase by removing or introducing a tryptophan side chain. FEBS Lett., 589(18), 2327-2333 (2015).
    • Zhao, J., Katsube, S., Yamamoto, J., Yamasaki, K., Miyagishi, M., Iwai, S.: Analysis of ATP and AMP binding to a DNA aptamer and its imidazole-tethered derivatives by surface plasmon resonance. Analyst, 2015(140), 5881-5884 (2015).
    • Mizutaru, T., Sakuraba, T., Nakayama, T., Marzun, G., Wagener, P., Rehbock, C., Barcikowski, S., Murakami, K., Fujita, J., Ishii, N., Yamamoto, Y.: Cysteine-containing oligopeptide β-sheets as redispersants for agglomerated metal nanoparticles. J. Mater. Chem. A, 3(34). 17612-17619 (2015).
    • Osawa, T., Inanaga, H., Numata, T.: Crystallization and preliminary X-ray diffraction analysis of the CRISPR-Cas RNA-silencing Cmr complex. 71(6), 735-740 (2015).
    • Takahashi, J., Misawa, M., Iwahashi, H.: Gene expression profiling can predict the fate of HeLa cells exposed to X-ray irradiation with or without protoporphyrin accumulation. Genomics Data, 5, 192-194 (2015).
    • Osawa, T., Inanaga, H., Sato, C., Numata, T.: Crystal structure of the CRISPR-Cas RNA silencing Cmr complex bound to a target analog. Mol. Cell, 58(3), 418-430 (2015).
    • Kitaoka, Y., Umemoto, N., Ohnuma, T., Numata, T., Taira, T., Sakuda, S., Fukamizo, T.: A class III chitinase without disulfide bonds from the fern, Pteris ryukyuensis: crystal structure and ligand-binding studies. Planta (2015).
    • Yamashita, S., Martinez, A., Tomita, K.: Measurement of acceptor-TΨC helix length of tRNA for terminal A76-addition by A-adding enzyme. Structure, 23(5), 830-842 (2015).
    • Umemoto, N., Kanda, Y., Ohnuma, T., Osawa, T., Numata, T., Sakuda, S., Taira, T., Fukamizo, T.: Crystal structures and inhibitor binding properties of plant class V chitinases: the cycad enzyme exhibits unique structural and functional features. Plant J., 82(1), 54-66 (2015).
    • Nagasaki, R., Nagasaki, A., Hakamada, K., Uyeda, T., Miyake, M., Miyake, J., Fujita, S.: Identification of kinases and regulatory proteins required for cell migration using a transfected cell-microarray system. BMC Genet., 16(9) (2015).
    • Numata, T., Inanaga, H., Sato, C., Osawa, T.: Crystal structure of the Csm3-Csm4 subcomplex in the type III-A CRISPR-Cas interference complex. J. Molecular Biology, 427(2), 259-273 (2015).
    • Takahashi, J., Misawa, M., Iwahashi, H.: Transcriptome analysis of porphyrin-accumulated and X-ray irradiated cell cultures under limited proliferation and non-lethal conditions. Microarrays, 4, 25-40 (2015).

    細胞分子機能研究グループ

    • Matsuda, C., Kiyosue, K., Nishino, I., Goto, Y., Hayashi, Y.K.: Dysferlinopathy fibroblasts are defective in plasma membrane repair. PLOS Currents Muscular Dystrophy, 1 (2015).
    • Ohnishi, H., Kawasaki, T., Deguchi, T., Yuba, S.: Generation of xeroderma pigmentosum-A patient-derived induced pluripotent stem cell line for use as future disease model. Cell. Reprogramm., 17(4), 268-274 (2015).
    • Fujita, A., Sato, T., Koyama, Y., Misumi, Y.: A reporter gene system for the precise measurement of promoter activity in Thermus thermophilus HB27. Extremophiles, 19, 1193-1201 (2015).
    • Sato, T., Kobayakawa, R., Kobayakawa, K., Emura, M., Itohara, S., Kizumi, M., Hamana, H., Tsuboi, A., Hirono, J.: Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding. Sci. Rep. 5:14073 (2015).
    • Kawasaki, T., Saka, T., Mine, S., Mizohata, E., Inoue, T., Matsumura, H., Sato, T.: N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein. FEBS Lett., 589(10), 1136-1142 (2015).
    • Akiyama, R., Kawakami, H., Wong, J., Oishi, I., Nishinakamura, R., Kawakami, Y.: Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc. Natl. Acad. Sci. U. S. A., 112(16), 5075-5080 (2015).

    重点課題4:

    先進バイオ計測研究グループ

    • Nishi, K., Isobe, S., Zhu, Y., Kiyama, R.: Fluorescence-based bioassays for detection and evaluation of food materials. Sensors, 15(10), 25831-25867 (2015).
    • Kiyama, R., Wada-Kiyama, Y.: Estrogenic endocrine disruptors: molecular mechanisms of action. Environ. Int., 83, 11-40 (2015).
    • Tourlousse DM., Natsuura, N., Sun, L., Toyonaga, M., Kuroda, K., Ohashi, A., Cruz, R., Yamaguchi, T., Sekiguchi, Y.: Draft genome sequence of bacteroidales strain TBC1, a novel isolate from a methanogenic wastewater treatment system. Genome Announc., 3(5), e01168 (2015).
    • Tourlousse DM., Honda, T., Matsuura, N., Ohashi, A., Tonouchi, A., Sekiguchi, Y.: Draft genome sequence of bacteroidales strain 6E, isolated from a rice paddy field in Japan. Genome Announc., 3(5), e01167 (2015).
    • Matsuura, N., Tourlousse, DM., Sun, L., Toyonaga, M., Kuroda, K., Ohashi, A., Cruz, R., Yamaguchi, T., Sekiguchi, Y.: Draft genome sequence of anaerolineae strain TC1, a novel isolate from a methanogenic wastewater treatment system. Genome Announc., 3(5), e01104 (2015).
    • Matsuura, N., Tourlousse, DM., Ohashi, A., Hugenholtz, P., Sekiguchi, Y.: Draft genome sequences of anaerolinea thermolimosa IMO-1, bellilinea caldifistulae GOMI-1, leptolinea tardivitalis YMTK-2, levilinea saccharolytica KIBI-1, longilinea arvoryzae KOME-1, previously described as members of the class anaerolineae (Chloroflexi). Genome Announc., 3(5), e00975-15 (2015).
    • Sun, L., Toyonaga, M., Ohashi, A., Tourlousse D.M., Matsuura, N., Meng, X.Y., Tamaki, H., Hanada, S., Cruz, R., Yamaguchi, T., Sekiguchi, Y.: Lentimicrobium saccharophilum gen. nov., sp. nov., a strictly anaerobic bacterium representing a new family in the phylum Bacteroidetes, and proposal of Lentimicrobiaceae fam. nov.. Int. J. Syst. Evol. Microbiol. (2015).
    • Sekiguchi, Y., Ohashi, A., Parks, D.H., Yamauchi, T., Tyson, G., Hugenholtz, P.: First genomic insights into members of a candidate bacterial phylum responsible for wastewater bulking. PEERJ, 3, e740 (2015).
    • Akiyama, H., Ueda, Y., Nobumasa, H., Ooshima, H., Ishizawa, Y., Kitahiro, K., Miyagawa, I., Watanabe, K., Nakamura, T., Tanaka, R., Yamamoto, N., Nakae, H., Kawase, M., Gemma, N., Sekiguchi, Y., Fujibuchi, W., Matoba, R.: A set of external reference controls/probes that enable quality assurance between different microarray platforms. Anal. Biochem. (2015).

    バイオアナリティカル研究グループ

    • Fujimoto, N., Mizuno, K., Yokoyama, T., Ohnishi, A., Suzuki, M., Watanabe, S., Komatsu, K., Sakata, Y., Kishida, N., Akiba, M., Matsukura, S.: Community analysis of picocyanobacteria in an oligotrophic lake by cloning 16S rRNA gene and 16S rRNA gene amplicon sequencing. J. Gen. Appl. Microbiol., 61(5), 171-176 (2015).
    • Sasaki, A., Yamamoto, J., Takashi, J., Kinjo, M.: Raster image cross-correlation analysis for spatiotemporal visualization of intracellular degradation activities against exogenous DNAs. Sci Rep., 5, 14428 (2015).
    • Oasa, S., Sasaki, A., Yamamoto, J., Mikuni, S., Kinjo, M.: Homodimerization of glucocorticoid receptor from single cells investigated using fluorescence correlation spectroscopy and microwells. FEBS Lett., 589(17), 2171-2178 (2015).
    • Furuta, A., Tsubuki, M., Endoh, M., Miyamoto, T., Tanaka, J., Salam, K.A., Akimitsu, N., Tani, H., Yamashita, A., Moriishi, K., Nakakoshi, M., Sekiguchi, Y., Tsuneda, S., Noda, N.: Identification of hydroxyanthraquinones as novel inhibitors of hepatitis C virus NS3 helicase. Int. J. Mol. Sci., 16, 18439-18453 (2015).
    • Mikuni, S., Kodama, K., Sasaki, A., Kohira, N., Maki, H., Munetomo, M., Maenaka, K., Kinjo, M.: Screening for FtsZ dimerization inhibitors using fluorescence cross-correlation spectroscopy and surface resonance plasmon analysis. PLoS One, 10(7), e0130933 (2015).
    • Sasaki, A., Tsukasaki, Y., Komatsuzaki, A., Sakata, T., Yasuda, H., Jin, T.: Recombinant protein (EGFP-Protein G) coated PbS quantum dots for in vitro and in vivo dual fluorescence (visible and second-NIR) imaging of breast tumors. Nanoscale, 7(12), 5115-5119 (2015).
    • Shirane, S., Araki, M., Morishita, S., Edahiro, Y., Takei, H., Yoo, Y., Choi, M., Sunami, Y., Hironaka, Y., Noguchi, M., Koike, M., Noda, N., Ohsaka, A., Komatsu, N.: JAK2, CALR and MPL mutation spectrum in Japanese myeloproliferative neoplasms patients. Haematologica, 100(2), e46-48 (2015).

    ナノバイオデバイス研究グループ

    • Kurita, R., Yanagisawa, H., Yoshioka, K., Niwa, O.: On-chip sequence-specific immunochemical epigenomic analysis utilizing outward turned cytosine in a DNA bulge with handheld surface plasmon resonance equipment. Anal. Chem., 87(22), 11581-11586 (2015).
    • Tomita, S., Sakao, M., Kurita, R., Niwa, O., Yoshimoto, K.: A polyion complex sensor array for markerless and noninvasive identification of differentiated mesenchymal stem cells from human adipose tissue. Chem. Sci., 6(10), 5831-5836 (2015).
    • Yanagisawa, H., Kurita, R., Yoshida, T., Kamata, T., Niwa, O.: Electrochemical assessment of local cytosine methylation in genomic DNA on a nanocarbon film electrode fabricated by unbalanced magnetron sputtering. Sens. Actuator B-Chem., 221, 816-822 (2015).
    • Minamiki, T., Minami, T., Sasaki, Y., Kurita, R., Niwa, O., Wakida, S., Tokito, S.: An organic field-effect transistor with an extended-gate electrode capable of detecting human immunoglobulin A. Anal. Sci., 31(7), 725-728 (2015).
    • Yanagisawa, H., Kurita, R., Kamata, T., Yoshioka, K., Kato, D., Iwasawa, A., Nakazato, T., Torimura, M., Niwa, O.: Effect of sp2/sp3 ratio in a hybrid nanocarbon thin film electrode for anodic strip-ping voltammetry fabricated by unbalanced magnetron sputtering equipment. Anal. Sci., 31(7), 635-641 (2015).
    • Kamata, T., Kato, D., Umemura, S., Niwa, O.: Structure and electroanalytical application of nitrogen-doped carbon thin film electrode with lower nitrogen concentrations. Anal. Sci., 31(7), 651-656 (2015).
    • Shiba, S., Inoue, J., Kato, D., Yoshioka, K., Niwa, O.: Graphene modified electrode for the direct electron transfer of bilirubin oxidase. Electrochemistry, 83(5), 332-334 (2015).
    • Kurita, R., Yanagisawa, H., Yoshioka, K., Niwa, O.: Site-specific immunochemical methylation assessment from genome DNA utilizing a conformational difference between looped-out target and stacked-in nontarget methylcytosines. Biosens. Bioelectron., 70, 366-371 (2015).
    • Kuraya, E., Nagatomo, S., Sakata, K., Kato, D., Niwa, O., Nishimi, T., Kunitake, M.: Direct analysis of lipophilic antioxidants of olive oils using bicontinuous microemulsions. Anal. Chem., 88(2), 1202-1209 (2015).
    • Kuraya, E., Nagatomo, S., Sakata, K., Kato, D., Niwa,O., Nishimi,T., Kunitake, M.: Simultaneous electrochemical analysis of hydrophilic and lipophilic antioxidants in bicontinuous microemulsion. Anal. Chem., 87(3), 1489-1493 (2015).

    セルメカニクス研究グループ

    • Tachibana, K., Haghparast, S.M.A., Miyake, J.: Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/ Moesin. Celll Adhes. Migr., 9(6), 502-512 (2015).
    • Matsumoto, D., Sathuluri, R.R., Kato, Y., Silberberg, Y.R., Kawamura, R., Iwata, F., Kobayashi, T., Nakamura, C.: Oscillating high-aspect-ratio monolithic silicon nanoneedle array enables efficient delivery of functional bio-macromolecules into living cells. Sci. Rep., 5, 15325 (2015).
    • Noguchi, T.Q.P., Morimatsu, M., Iwane, A., Yanagida, T., Uyeda, T.Q.P.: The role of structural dynamics of actin in class-specific myosin motility. PLoS One, 10, e0126262 (2015).
    • Ngo, K.X., Kodera, N., Katayama, E., Ando, T., Uyeda, TQP.: Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed atomic force microscopy. eLife, 2015(4), e04806 (2015).
    • Plaza, G.R., Uyeda, T.Q.P., Mirzaei, Z., Simmons, C.A.: Study of the influence of actin-binding proteins using linear analyses of cell deformability. Soft Matter, 11, 5435-5446 (2015).

    細胞マイクロシステム研究グループ

    • Kawasaki, N., Yamano, N., Nakayama, A.: Polyamide4-block-poly(vinyl acetate) via a polyamide4 azo macromolecular initiator: Thermal and mechanical behavior, biodegradation, and morphology. J. Appl. Polym. Sci., 132(37), 42466-42475 (2015).
    • Qiu, F., Fujita, S., Mhanna, R., Zhang, L., Simona, B.R., Nelson, B.J.: Magnetic helical microswimmers functionalized with lipoplexes for targeted gene delivery. Adv. Funct. Mater. (2015).
    • Nerome, K., Sugita, S., Kuroda, K., Hirose, T., Matsuda, S., Majima, K., Kawasaki, K., Shibata, T., Poetri, O.N., Soejoedono, R.D., Mayasari, N.L.P., Agungriyono, S., Nerome, R.: The large-scale production of an artificial influenza virus-like particle vaccine in silkworm pupae. Vaccine, 33(1), 117-125 (2015).

    細胞・生体医工学研究グループ

    • Soeta, Y., Nakagawa, S.: Prediction of optimal auditory signals using auditory evoked magnetic responses. Build. Environ. , 94, 924-929 (2015).
    • Ito, K., Nakagawa, S.: Self-demodulation of amplitude-modulated signal components in amplitude-modulated bone-conducted ultrasonic hearing. Jpn. J. Appl. Phys., 54(7), 1-6 (2015).
    • Otsuka, A., Yumoto, M., Kuriki, S., Hotehama, T., Nakagawa, S.: Frequency characteristics of neuromagnetic auditory steady-state response to sinusoidally amplitude-modulated sweep tones. Clin. Neurophysiol. (2015).
    • Ueno, Y., Mine, S., Kawasaki, K.: A tilt-pair based method for assigning the projection directions of randomly oriented single-particle molecules. Microscopy, 64(2), 129-141 (2015).
    • Okamoto, Y., Nakagawa, S.: Effects of daytime light exposure on cognitive brain activity as measured by the ERP P300. Physiol. Behav., 138, 313-318 (2015).
    • Soeta, Y., Shimokura, R., Kim, Y.H., Ohsawa, T., Ito, K.: Characteristics of Buddhist chanting in Japanese temples. Appl. Acoust., 91, 73-76 (2015).
    • Tamura, S., Okamoto, Y., Nakagawa, S., Sakamoto, T., Shigeri, Y.: Practical color barrier-free illumination for deuteranopia using LEDs. Color Res. Appli., 40(3), 218-223 (2015).
    • Soeta, Y., Bito, Y.: Detection of features of prosthetic cardiac valve sound by spectrogram analysis. Appl. Acoust., 89, 28-33 (2015).