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Group Introduction

Subject 4

Development of Measurement and Analysis Technologies for Biomolecules and Upgrading of Standardization Infrastructure

We are carrying out a wide range of studies in the field of biomeasurement, (1) to develop methods, devices, and informatics for quantitative detection of particular biological substances, such as nucleic acid and cells, in rapid, cost effective, highly sensitive, and/or highly multiplexed manners, (2) to develop techniques for manipulating/separating the biological substances to be measured, and (3) to develop reference methods, reference materials, and reference data for biomeasurements.

(1) Development of methods, devices, and informatics for quantitative detection of particular biological substances

Sl-traceable RNA reference materials used for quantitative, highly multiplex RNA measurementsWe are interested in development of laboratory and bioinformatic tools for quantitative detection of particular biological substances, such as nucleic acid and cells, in rapid, cost effective, highly sensitive, and/or highly multiplexed manners. We are also interested in integrating biomeasurement tools into microfluidics devices and biochips to further facilitate practical applications of biomeasurement.

(2) Development of techniques for manipulating/ separating the biological substances.

In biomeasurements, techniques are often required to manipulate and separate biological substances of interest (i.e., measured). We are interested in development of laboratory methods to achieve precise detection and separation of different biological molecules and cells in highly efficient and specific manner.

(3) Standardization of biomeasurement

In order to facilitate development of economic activities in biotechnology and medical fields, it is essential to establish systems to assess biomeasurement confidence and to make biomeasurement data comparable among different laboratories and/or methods. To establish the systems, we are developing reference materials, reference methods, and reference data needed for biomeasurement.

Group:

  • Advanced Biomeasurements Research Group

  • Bioanalytical Research Group

  • Nano-Biodevice Research Group

  • Cell Mechanics Research Group

  • Cell Microsystem Research Group

  • Medical and Biological Engineering Research Group