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Group Introduction

Subject 3

Development of Animal Models of Diseases and Detection Methodologies of Disease-Related Molecules for in-vivo Evaluation Systems

The mission of this subject is to produce innovative research technologies for understanding of disease-onset mechanism, by integrating all the knowledge from participating groups. Especially, ‘neuronal diseases’ and ‘neglected tropical diseases’ are focused on analysis because those are not actively targeted by major drug pharmaceutical industry, but a large demand exists.

Development of novel nucleotide-acid medicines

Based on the novel SELEX method, we are developing an isolation system for high-affinity aptamers and nucleotide enzymes such as DNAzyme or RNAzyme. By generating optimization-platform using structural-biology analyses, we are also trying to generate ‘next-generation’ nucleic acid aptamers for the practical applications in drug development. Development of novel radiosensitizers for drug discovery, diagnostic technologies using exosomes, are also on-going projects in this subject.

Genome-editing technology based on protein delivery

Genome-editing technologies to modify DNA sequences is one of the important methods for recent life science research. We are developing novel editing methods by directly introducing proteins in the cell. Our method can be an safety and low side-effect technology and applicable to generate unique disease-model animals, target-molecule identification and high-efficient bio-production for commercial applications.

Novel neuronal disease model animals and cells

To understand the disease-onset mechanism and to apply these understandings to diagnostic researches, we are developing novel model animals and cells for several neuronal diseases. These model animals/cells are used to isolate drug candidate molecules for several neuronal and psychiatric disorders.

Development of novel microscopic imaging systems

“Visualization” of molecular dynamics in living cells can tell us quite important things on life and will help to identify novel phenomena in organisms. We are proceeding to develop several live-imaging methods for super-resolution microscopies and for the observation of in-vivo neuronal activity in living animals.

Group:

  • Molecular Neurobiology Research Group

  • Molecular Neurophysiology Research Group

  • Molecular Composite Medicine Research Group

  • Structure-Based Drug Discovery Research Group

  • Functional Biomolecular Research Group