Cell Microsystem Research Group
Introduction to research
Our group is developing the various technologies for understanding intra-cell, cellular interaction, cellular population and tissue as a system. Concretely, we are exploiting the cell microarray for analyzing cells, the sensing device, molecular manipulating technique, micro-machine and new microscopy technology. These are very applicable for diagnosis, drug discovery, drug evaluation and DDS.
Current Research 1: Construction of Cell Micro-devices and its Application
We have the original technologies to control the release of molecules from solid surface. It is very useful for making cell-microarray device to analyze cellular response and making micro-machine for delivery of gene and medicine. We aim to develop various kinds of tools for companion diagnostics, regenerative therapy and drug development.
Current Research 2: Electron Microscopic Observation of Biological Membranes and Soft Nanomaterials using Freeze-Replicas
Quick-freezing-replica method has been developed for observation of tissues, cells, cytoskeletons, and cell membranes. The method is also applicable to structural analysis of various kinds of newly created nanomaterials, such as artificial lipid membranes, nonofibers, and fine bubbles dispersed in water.
Current Research 3: Development of Novel Biomaterials by Introducing of Various Molecular Structures into Polymer Chain
Polyamide4 is synthesized by ring-opening polymerization of 2-pyrrolidone producible from biomass, and has excellent thermal and mechanical properties. With selecting the initiators in the polymerization system, the wide variation of polyamide4's structures could be obtained. Further, it is possible to modify the amide group on polyamide4's chain. Utilizing these features, we aim for the development of novel biomaterials.
Current Research 4: Molecular Imaging using Bioluminescent and Chemiluminescent System
Development of far-red bioluminescent probe using Cypridina bioluminescent system for visualization of biomarker in mouse. Development of chemiluminescent probe for the detection of DNA damage.
Current Research 5: Laser-induced Perturbation into Cellular Functions
In order to realize artificial control of living cellular network, we are developing novel methods using laser-induced perturbation into cellular system. Our approaches, such as optical trapping and assembling of molecular dynamics on neuronal cells and local modulation of living neuronal network with a focused femtosecond laser, will achieve optical control of cellular functions without any drugs and genes.
Current Research 6: Development of Functional Biomaterials and Its Clinical Application
We are interested in development of cells/tissues-specific drug delivery systems (DDS), imaging, and technique to regulate cell functions (e.g., cell phenotypes) using chemical systems. By using these systems, we will try to develop functional biomaterials that are applicable to disease treatment, regenerative medicine, preventive medicine, and disease diagnosis.
List of Publications
Satoshi FUJITA (Group Leader)
Kazunori KAWASAKI (Senior Researcher)
Norioki KAWASAKI (Senior Researcher)
Chun WU (Senior Researcher)
Chie HOSOKAWA (Senior Researcher)
Riki Toita (Researcher)